Neurovascular Intervention

Mechanical thrombectomy is a minimally invasive procedure that offers positive benefits to ischemic stroke patients – which account for 85 percent of all strokes – in the first few hours after stroke onset.

The infarct growth rate (IGR) measures ischemic stroke progression and varies among patients. Clinicoradiological phenotypes of IGR are poorly understood. We evaluated the association of presentation stroke severity and early ischemic changes with infarct progression in patients who underwent successful thrombectomy.

In conclusion, Tandem occlusions (Extracranial and Intracranial) represent challenging high-risk scenarios with potential for devastatingly poor outcomes. Combination approaches of mechanical thrombectomy and Carotid PTA and Stent may result in favorable independent outcomes in as many as 1 out of 2 patients if performed early. These patients should be managed cautiously in follow-up in that as many as 3-20% of patients may experience ISR (majority asymptomatic), that may place them at higher risk for Recurrent Stroke. Many of these patients should be strongly considered for early intervention, especially if presenting with very high grade ISR (>70%) or recurrent symptoms.

Ischemic stroke is a debilitating disease and one of the leading causes of long-term disability. During the early phase after ischemic stroke, the blood-brain barrier (BBB) exhibits increased permeability and disruption, leading to an influx of immune cells and inflammatory molecules that exacerbate the damage to the brain tissue. Mesenchymal stem cells have been investigated as a promising therapy to improve the recovery after ischemic stroke.

The global flow diverters market size was valued at USD 252.92 million in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 16.9% from 2021 to 2028. The rising prevalence of brain aneurysm and risk factors associated with it and the growing inclination towards minimally invasive procedures are among the key factors driving the market

Nogueira began his presentation by noting that, in spite of the “overwhelming” proof of its benefit in treating anterior circulation large vessel occlusion (LVO) strokes, it remains unknown whether EVT offers the same advantages in acute BAOs—despite “Herculean” efforts seen in the BEST and BASICS trials. He also noted positive signals seen with EVT in these studies, and said they “paved the way” for the ATTENTION study by demonstrating the importance of consecutive recruitment, fast enrolment and minimal crossover, as well as confirming the ideal target population.

Intracranial wide-neck aneurysms at the arterial bifurcations, especially in the aneurysms where the bifurcating branches emanate directly from the base of the aneurysm, have been particularly difficult on which to perform endovascular treatment. The ‘Y’-configuration, double stent-assisted coil embolization is an option for the treatment of these difficult aneurysms, allowing the closure of the aneurysm, preserving the parent arteries.

The best way to succeed in China is to focus on selling unique products there; unique products that are needed, where the reimbursements are still relatively good, and VBP will not reduce prices, yet can still yield large sales. Western brands are still perceived as higher quality than locally made products, and are popular with Chinese patients as long as the pricing is reasonable. Other strategies to be successful in China include licensing or selling your technology since there is more Chinese capital available these days. Another improved factor, although still not great, includes better intellectual property protection in China. Some Western companies are also making more of their products in China, which can help the company to be closer to their customers, in some cases make registration easier, and may reduce manufacturing costs.

We performed a one-point, lipophilic cell-tracer injection to track endothelial cells, followed by an arteriotomy and suturing of sidewall aneurysms on the abdominal rat aorta. Neointima formation seemed dependent on the parent artery in decellularized aneurysms and was promoted by the recruitment from aneurysm wall cells in vital cell-rich walls.

MicroVention, Inc., a wholly owned subsidiary of Terumo Corporation, announced the successful completion of its first enrollment in a multi-center, prospective EU observational study called STRAIT, to evaluate the Safety and Performance of the BOBBY Balloon Guide Catheter for Endovascular Treatment of Acute Ischemic Stroke. The BOBBY Balloon Guide Catheter is currently approved in Europe and in North America. It has been designed to streamline balloon preparation, while improving navigability and ensuring compatibility with the SOFIA™ Plus 6Fr Aspiration Catheter.

The branches of the porcine subclavian artery are frequently used in endovascular stroke training and research. This study aimed to determine a porcine weight group, in which the arterial diameters most closely match human cerebral artery diameters, and thus optimize the porcine in-vivo model for neuroendovascular purposes.

MIVI Neuroscience, Inc., innovator of the next generation of neurointerventional medical devices, today announced the first patient enrollments in a multicenter clinical study to assess the safety and performance of the Q Aspiration Catheter used in a combined aspiration with stent-retriever technique for thrombus removal in patients who have suffered an acute ischemic stroke.

Wallaby, with its main offices in Laguna Hills, California and Shanghai, China achieves a significant portion of sales of its world-class and premier-quality products in the U.S. and other major developed markets. phenox, headquartered in Bochum, Germany, provides a broad portfolio of neurovascular devices to treat ischemic and hemorrhagic strokes that are sold in over 45 countries worldwide. The two companies have been strategic partners since 2019. phenox has been the exclusive distributor for Wallaby’s Avenir® Coil System in the U.S. and European markets as well as for Wallaby’s Esperance™ Aspiration Catheters in the U.S. market.

Intracranial wide-neck aneurysms at the arterial bifurcations, especially in the aneurysms where the bifurcating branches emanate directly from the base of the aneurysm, have been particularly difficult on which to perform endovascular treatment. The ‘Y’-configuration, double stent-assisted coil embolization is an option for the treatment of these difficult aneurysms, allowing the closure of the aneurysm, preserving the parent arteries.

The BOBBY Balloon Guide Catheter is currently approved in Europe and in North America. It has been designed to streamline balloon preparation, while improving navigability and ensuring compatibility with the SOFIA™ Plus 6Fr Aspiration Catheter.

In conclusion, in this cohort of patients with AF and DM, HbA1c levels were associated with the risk of stroke in a dose-dependent manner even after accounting for other recognized risk factors for stroke.

There is no significant difference in overall aneurysm occlusion rates between aneurysms treated initially with single versus multiple overlapping PEDs nor are there significant differences in procedure‐related complications. Single PED flow diversion may be preferred whenever possible, with multiple PED constructs reserved for extenuating clinical circumstances as may be encountered with giant aneurysms.

A study from Sweden published by The BMJ today finds an increased risk of deep vein thrombosis (a blood clot in the leg) up to three months after covid-19 infection, pulmonary embolism (a blood clot in the lung) up to six months, and a bleeding event up to two months. The findings also show a higher risk of events in patients with underlying conditions (comorbidities), patients with more severe covid-19, and during the first pandemic wave compared with the second and third waves.

As the filter is located within the sterile field, it allows the clinician to immediately identify when the clot has been aspirated, and avoids the need to try to find the clot after the procedure has been completed by opening a sealed aspiration canister. If clinicians wish to further analyze the aspirated clot, they can simply send the sealed Zoom POD to the lab and avoid further exposure to body fluids or clot disruption through handling.

The risk for ischemic stroke is increased in association with the use of antidopaminergic antiemetics (ADAs), according to a study published online March 23 in The BMJ.