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Transmission of SARS-CoV-2 via fecal-oral and aerosols–borne routes: Environmental dynamics and implications for wastewater management in underprivileged societies

Transmission of SARS-CoV-2 via fecal-oral and aerosols–borne routes: Environmental dynamics and implications for wastewater management in underprivileged societies | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Although there is no current evidence showing that coronaviruses can be transmitted through contaminated drinking water, there is a growing concern on the impact of the current pandemic wave on underprivileged societies because of their poor wastewater treatment infrastructures, overpopulation, and outbreak management strategies. More research is encouraged to trace the actual fate of SARS-CoV-2 in the environment and to develop/revise the disinfection strategies accordingly.

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Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern

Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

In this study, a modified, HexaPro S protein subunit vaccine, delivered using a needle-free high-density microarray patch (HD-MAP), was investigated for its immunogenicity and virus-neutralizing abilities. Mice given two doses of the vaccine candidate generated potent antibody responses capable of neutralizing the parental SARS-CoV-2 virus as well as the variants of concern, Alpha and Delta. These results demonstrate that this alternative vaccination strategy has the potential to mitigate the effect of emerging viral variants.

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Study finds higher risk of thrombotic events after SARS-CoV-2 infection

Study finds higher risk of thrombotic events after SARS-CoV-2 infection | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

A study from Sweden published by The BMJ today finds an increased risk of deep vein thrombosis (a blood clot in the leg) up to three months after covid-19 infection, pulmonary embolism (a blood clot in the lung) up to six months, and a bleeding event up to two months. The findings also show a higher risk of events in patients with underlying conditions (comorbidities), patients with more severe covid-19, and during the first pandemic wave compared with the second and third waves.

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Plenty of Evidence for Recombination in SARS-CoV-2

Plenty of Evidence for Recombination in SARS-CoV-2 | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Recombination—the exchange of genetic material between genomes—is common in coronaviruses because of the way they copy their RNA genomes. During replication, the RNA-synthesizing enzyme these viruses use duplicates shorter sections close to the end of the genome in addition to making the long template it needs for generating whole-genome copies. Furthermore, the enzyme is prone to switching from one template to another, so if a cell has multiple viral genomes in it, the enzyme may stitch together bits from different viruses to create a kind of Frankenstein genome.

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Guillain–Barré Syndrome Associated with SARS-CoV-2

Guillain–Barré Syndrome Associated with SARS-CoV-2 | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

On the basis of this observational series involving five patients, it is not possible to determine whether severe deficits and axonal involvement are typical features of Covid-19–associated Guillain–Barré syndrome. We could not determine the effect of reduced vital capacity due to neuromuscular failure from Guillain–Barré syndrome in these patients, but such an effect might be considered if findings on chest imaging are not commensurate with the severity of respiratory insufficiency. Guillain–Barré syndrome with Covid-19 should be distinguished from critical illness neuropathy and myopathy, which tend to appear later in the course of critical illness than Guillain–Barré syndrome.

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SARS-CoV-2 detected using smartphone biosensor

SARS-CoV-2 detected using smartphone biosensor | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Although the majority of individuals who are infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will remain asymptomatic, they are still capable of transmitting the virus the others. In addition to the widespread prevalence of asymptomatic carriers, the coronavirus disease 2019 (COVID-19) can also be difficult to diagnose, as those who are asymptomatic often experience symptoms similar to both the flu and pneumonia.

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SARS-CoV-2 mutations capable of widespread T-cell escape

SARS-CoV-2 mutations capable of widespread T-cell escape | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Both natural infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization against this virus can generate SARS-CoV-2-specific neutralizing antibodies and T-cells. However, the level of immunity provided by these methods is challenged by the evolution of SARS-CoV-2, which has led to the emergence of new genetic variants like the Omicron variant.

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Role of natural immunity to SARS-CoV-2 on post-vaccination antibody responses in staff and residents of long-term care facilities

Role of natural immunity to SARS-CoV-2 on post-vaccination antibody responses in staff and residents of long-term care facilities | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that has led to the coronavirus disease 2019 (COVID-19) pandemic, has caused 400 million infections throughout the world, with 78 million infections in the United States (US) alone. Two million of those infections are reported in staff and residents of long-term care facilities (LTCFs). They represent around 16% of total deaths in the US.

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SARS-CoV-2 mutations capable of widespread T-cell escape

Both natural infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization against this virus can generate SARS-CoV-2-specific neutralizing antibodies and T-cells. However, the level of immunity provided by these methods is challenged by the evolution of SARS-CoV-2, which has led to the emergence of new genetic variants like the Omicron variant.

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A massive study finds diabetes risk rises after COVID-19

A massive study finds diabetes risk rises after COVID-19 | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

The researchers saw that the risk of developing diabetes rose as COVID-19 severity increased. When compared to people who did not have COVID-19 and were not hospitalized or admitted to intensive care, those who were hospitalized or admitted to intensive care had roughly four times the risk.

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Partnering with Big Tech didn't help governments fight COVID. But it did waste a lot of money.

Partnering with Big Tech didn't help governments fight COVID. But it did waste a lot of money. | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Basic public health initiatives—such as hiring contact tracers, providing facilities and financial compensation for quarantining, knocking on doors to decrease vaccine hesitancy, and providing free masks, tests, and vaccines—have proven to be the best ways to save lives during the pandemic. Unfortunately, many governments have chosen instead to partner with Big Tech to implement needlessly complex initiatives that do little more than boost large companies’ profits and increase surveillance.

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Sanofi, GSK Covid-19 vax is now ready for regulators; its future may be as a booster

Sanofi, GSK Covid-19 vax is now ready for regulators; its future may be as a booster | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Sanofi and GlaxoSmithKline weathered clinical trial delays for their Covid-19 vaccine, but the partners now have data to support filings seeking regulatory authorizations. Key features of the vaccine may be able to persuade the vaccine hesitant; it may also be well-suited for use as a booster.

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China Believes That Omicron Variant Found Its Way to the Country via Mail

China Believes That Omicron Variant Found Its Way to the Country via Mail | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Chinese authorities have already decided that the general public will not be sold tickets at the Games but the detection of the first Omicron case weeks before the grand event will raise alarm bells. BBC reported that China follows a "dynamic zero COVID" policy which includes mass vaccinations, constant testing, and tracking people's movements using smartphones to stay on top of outbreaks. In November last year, city officials in Shanghai had tested 33,000 people after one case of COVID was reported in Disneyland.

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FDA expands Covid-19 boosters for kids using real-world data in much older adults

FDA expands Covid-19 boosters for kids using real-world data in much older adults | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it
The FDA has expanded emergency authorization of Covid-19 boosters to include children 12 to 15 vaccinated with the Pfizer and BioNTech messenger RNA shot. The decision is based on a study that found boosting reduced deaths by 90%, but that Israeli analysis only evaluated these shots in people 50 and older.
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Omicron infection induces cross-reactive immune responses

Omicron infection induces cross-reactive immune responses | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

The massive surge in coronavirus disease-2019 (COVID-19) infections across the globe due to the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron variant (B.1.1.529) has resulted in a new health crisis. The Omicron variant is highly transmissible due to immune evasive characteristics which have led to Omicron replacing the other variants of concern (VOCs) such as the Delta variant in several African and European countries. The neutralizing antibodies (NAbs) elicited by vaccines or passive antibody therapies have been found to have diminished neutralizing ability against the Omicron variant.

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The US Army Made a Coronavirus Vaccine That Works Against All Variants

The US Army Made a Coronavirus Vaccine That Works Against All Variants | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it
Vaccine makers are racing against time to develop a variant-specific booster should previously administered vaccines fail against the Frankenstein mix of mutations that the Omicron variant possesses. Although preliminary data shows that vaccines and boosters are likely to offer protection, for now, the possibility of another variant cannot be dismissed.
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Pfizer Covid Pill: The FDA Just Authorized Pfizer’s First Covid-19 Pill

Pfizer Covid Pill: The FDA Just Authorized Pfizer’s First Covid-19 Pill | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

The drug will be made available to patients 12 years and older who are at high risk for developing a severe infection, the FDA said in its announcement. Patients who are prescribed the treatment will take 30 pills over five days. The prescription-only medicine should be taken as soon as possible after diagnosis, according to the agency. This is the first anti-viral pill researchers have approved to treat covid-19. The federal government has agreed to pay Pfizer $5.3B for 10 million courses of the treatment, NPR reports.

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BioNTech CEO: omicron is partial escape variant, but booster may restore protection

BioNTech CEO: omicron is partial escape variant, but booster may restore protection | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Preliminary data suggest the BioNTech and Pfizer Covid-19 vaccine may have diminished protection against the omicron variant, but that levels of neutralizing antibodies can be restored with a third shot. Real-world data are needed to further assess the vaccine’s efficacy against the new variant and whether an omicron-specific version of the shot is needed.

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The Coronavirus in a Tiny Drop

The Coronavirus in a Tiny Drop | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

To better understand the coronavirus’s journey from one person to another, a team of 50 scientists has for the first time created an atomic simulation of the coronavirus nestled in a tiny airborne drop of water.

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Antidote COVID-19: A Vaccine Awareness Game

Antidote COVID-19: A Vaccine Awareness Game | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Antidote COVID-19 is an addictive tower defence game, where the player helps the human immune system fight off bacteria and viruses, including the dreaded SARS-CoV-2, the culprit behind the COVID-19 pandemic. Antidote COVID-19 is not only a fun game to play but also a brilliant way to learn more about the immune system, pathogens and how to stay safe from COVID-19.

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COVID T-Cell Skin Patch Vaccine With Prolonged Immunity To Begin Clinical Trials

COVID T-Cell Skin Patch Vaccine With Prolonged Immunity To Begin Clinical Trials | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Emergex, a medical company based in Oxfordshire, has just been given the go-ahead to begin clinical trials for a skin patch vaccine against COVID-19, which uses T-Cells to kill cells infected with the virus. This second-generation solution could provide individuals with longer-lasting immunity as compared to the current options available.

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Monetary incentives increase COVID-19 vaccinations

Monetary incentives increase COVID-19 vaccinations | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

Stalling COVID-19 vaccination rates threaten public health. To increase vaccination rates, governments across the globe are considering using monetary incentives. We present evidence on the effect of guaranteed payments on COVID-19 vaccination uptake. We ran a large pre-registered randomized controlled trial (N = 8,286) in Sweden and linked the data to population-wide administrative vaccination records. We found that modest monetary payments of $24 (SEK 200) increased vaccination rates by 4.2 percentage points (p = 0.005), from a baseline rate of 71.6%. In contrast, behavioral nudges increased stated intentions to vaccinate but had only small and not statistically significant impacts on vaccination rates. The results highlight the potential of modest monetary incentives to increase vaccination rates.

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Researchers explain why decaying SARS-CoV-2 antibodies in blood are not a problem after vaccination

Researchers explain why decaying SARS-CoV-2 antibodies in blood are not a problem after vaccination | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

When there is antigenic stimulation, naive B cells can differentiate into plasmablasts with low-affinity antibodies or with the use of lymphoid structures known as germinal centers, naive B cells can gain affinity-enhancing somatic hypermutations that later differentiate into memory B cells and long-lived bone marrow plasma cells. However, whether the vaccine-induced germinal center response is the underlying cause for the increase in affinity-matured bone marrow-resident plasma cells after immunization remains under investigation.

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Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

We show that the vaccine is thermostable on the patches, with patch delivery enhancing both cellular and antibody immune responses. Elicited antibodies potently neutralize clinically relevant isolates including the Alpha and Beta variants. Last, a single dose of HD-MAP–delivered spike provided complete protection from a lethal virus challenge in an ACE2-transgenic mouse model. Collectively, these data show that HD-MAP delivery of a SARS-CoV-2 vaccine was superior to traditional needle-and-syringe vaccination and may be a significant addition to the ongoing COVID-19 (coronavirus disease 2019) pandemic.

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Vaccin à ARN messager : comment l'industrie pharmarceutique française tente de sauver la face

Vaccin à ARN messager : comment l'industrie pharmarceutique française tente de sauver la face | Covid-19, SARS-Cov-2, vaccines, Remdesivir, Chloroquine...and all that Jazz | Scoop.it

C'est avec un acteur de moindre envergure, Translate Bio, que le laboratoire français a fini par signer un partenariat en 2018, avant de l'acquérir à grands frais à la fin de 2020. Le groupe bâtit aujourd'hui un "centre d'excellence dédié aux vaccins à ARN messager" dans lequel il compte investir 400 millions d'euros par an. Mais Sanofi a déjà dû abandonner son projet de vaccin anti-Covid, qui serait arrivé bien trop tard par rapport à la concurrence. Il lui reste désormais un produit antigrippal, dont les essais viennent de démarrer, pour prouver qu'il peut encore prendre une place dans ce domaine.

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BEEYOND is a consulting company in the field of disruptive innovation, accompanying established companies on out-of-the-core growth strategy, from creation of new concepts to product launch. Reach us at: contact@beeyond.fr.