Intra-Dermal drug delivery: Opportunities and Challenges?
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Dissolving undercut microneedle arrays for multicomponent cutaneous vaccination

Dissolving undercut microneedle arrays for multicomponent cutaneous vaccination | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Cutaneous vaccination of mice using these MNAs induces more potent antigen-specific cellular and humoral immune responses than those elicited by traditional intramuscular injection. Together, the unique geometric features of these undercut MNAs and the associated manufacturing strategy, which is compatible with diverse drugs and biologics, could enable a broad range of non-cutaneous and cutaneous drug delivery applications, including multicomponent vaccination.

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Localised light delivery on melanoma cells using optical microneedles

Localised light delivery on melanoma cells using optical microneedles | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Light-based therapy is an emerging treatment for skin cancer, which has received increased attention due to its drug-free and non-invasive approach. However, the limitation of current light therapy methods is the inability for light to penetrate the skin and reach deep lesions. As such, we have developed a polylactic acid (PLA) microneedles array as a novel light transmission platform to perform in vitro evaluation regarding the effect of light therapy on skin cancer. For the first time, we designed and fabricated a microneedle array system with a height fixation device that can be installed in a cell culture dish and an LED array for blue light irradiation. The effect of the blue light combined with the microneedles on cell apoptosis was evaluated using B16F10 melanoma cells and analyzed by Hoechst staining. Our results demonstrate that blue light can be transmitted by microneedles to skin cells and effectively affect cell viability

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Painless drug delivery via melting ice microneedle patches

Painless drug delivery via melting ice microneedle patches | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Experiments using this groundbreaking invention on mice with cancers have shown that the animals’ immune responses were much better than those seen in conventional vaccination methods. The technology paves the way for developing an easy-to-use cell therapy and other therapeutics against cancers and other diseases. Made from a cryogenic solution, these icy microneedles are less than 1mm long and can deliver living mammalian cells into the skin. The device is like a skin patch and the microneedles can detach from the patch base, melt and then penetrate the skin.

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Recent progress in silk fibroin-based flexible electronics

Recent progress in silk fibroin-based flexible electronics | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Silk fibroin has been widely used as fundamental components for the construction of biocompatible flexible electronics, particularly for wearable and implantable devices. Furthermore, in recent years, more attention has been paid to the investigation of the functional characteristics of silk fibroin, such as the dielectric properties, piezoelectric properties, strong ability to lose electrons, and sensitivity to environmental variables. Here, this paper not only reviews the preparation technologies for various forms of silk fibroin and the recent progress in the use of silk fibroin as a fundamental material but also focuses on the recent advanced works in which silk fibroin serves as functional components. Additionally, the challenges and future development of silk fibroin-based flexible electronics are summarized.

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Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis

Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Conclusion. Acupuncture is an effective and safe treatment for CPRD, and acupuncture combined with drug therapy is more effective than single-drug therapy. Nevertheless, the conclusions were limited due to the low quality and a small number of included studies.

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Nearly pain-free microneedle patch can test for antibodies and more in the fluid between cells

Nearly pain-free microneedle patch can test for antibodies and more in the fluid between cells | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19; or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and sepsis.

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Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays

Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Autoimmune-mediated inflammatory skin diseases, such as psoriasis, alopecia areata, and vitiligo, have been reported as the 4th leading cause of nonfatal disease burden worldwide. This is mainly related to the poor quality of life experienced by these patients. Although topical and systemic steroids represent the most common treatment, the variability in success rates and side effects often lead to treatment discontinuation.

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Smart Skin Patches Created to Inoculate COVID-19 Vaccine

Smart Skin Patches Created to Inoculate COVID-19 Vaccine | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

The team at Swansea University in Wales is developing the first coronavirus vaccine in the form of a "smart patch." The device is disposable and administers the vaccine through microneedles, which simultaneously monitor its efficacy by measuring each individual's immune response.

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A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy

A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

A novel device for enhancing wound healing, the detachable hybrid microneedle depot. It is the first device to use a microneedle array to facilitate localized mesenchymal stem cell delivery with a minimal dose of cells.

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Additive Manufacturing of Core-Shell Microneedles

Additive Manufacturing of Core-Shell Microneedles for Single-Administration Vaccines

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Antibacterial And Angiogenic Chitosan Microneedle Array Patch For Promoting Wound Healing

Antibacterial And Angiogenic Chitosan Microneedle Array Patch For Promoting Wound Healing | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Vascular endothelial growth factor (VEGF) is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel. Therefore, the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds.

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A single-use, self-administered microneedle technology has recently been validated to provide immunization against infectious diseases

A single-use, self-administered microneedle technology has recently been validated to provide immunization against infectious diseases | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

The microneedle patch avoids any painful injections, offering a significant enhancement from the perspective of patients. Extensive research has shown microneedle skin patches are almost painless, and could even be self-administered by patients at home. The patch is small, portable, and similar to a nicotine patch, which could be easily distributed to all people over the world for self-administration in the case of a pandemic such as the COVID-19 crisis to quickly create a pan-immunity at the global scale.

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Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles

Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it
Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed microneedles with efficient amounts of FITC as the drug model. Importantly, the vacuum process, which could influence the capturing of FITC diffusion from the tip, was evaluated during the manufacturing process.
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Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern

Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

In this study, a modified, HexaPro S protein subunit vaccine, delivered using a needle-free high-density microarray patch (HD-MAP), was investigated for its immunogenicity and virus-neutralizing abilities. Mice given two doses of the vaccine candidate generated potent antibody responses capable of neutralizing the parental SARS-CoV-2 virus as well as the variants of concern, Alpha and Delta. These results demonstrate that this alternative vaccination strategy has the potential to mitigate the effect of emerging viral variants.

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Skin co-delivery of contact sensitizers and neurokinin-1 receptor antagonists integrated in microneedle arrays suppresses allergic contact dermatitis

Skin co-delivery of contact sensitizers and neurokinin-1 receptor antagonists integrated in microneedle arrays suppresses allergic contact dermatitis | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Our findings demonstrate that immune-regulation by engineering localized skin neuroimmune networks can be used to treat cutaneous diseases that like CD, are caused by type-1 immunity.

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Clinical trial of needle-free COVID-19 vaccine underway in Australia

Clinical trial of needle-free COVID-19 vaccine underway in Australia | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Researchers and biotechnology company Vaxxas are studying if the new delivery technology, called a high-density microarray patch, can protect participants from diseases including measles and rubella. If successful, the needle-less technology could be used for a number of other vaccinations including influenza and COVID-19.

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Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis

Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

A need-based layered dissolving microneedle system loading tacrolimus (TAC) and diclofenac sodium (DIC) in different layers specifically delivers TAC and DIC to skin and articular cavity, simultaneously alleviating psoriatic skin and arthritic joint lesions.

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3D-printed microneedles in biomedical applications

3D-printed microneedles in biomedical applications | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

3D printing offers customization, cost-efficiency, a rapid turnaround time between design iterations, and enhanced accessibility. Increasing the printing resolution, the accuracy of the features, and the accessibility of low-cost raw printing materials have empowered 3D printing to be utilized for the fabrication of microneedle platforms. The development of 3D-printed microneedles has enabled the evolution of pain-free controlled release drug delivery systems, devices for extracting fluids from the cutaneous tissue, biosignal acquisition, and point-of-care diagnostic devices in personalized medicine.

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Researchers 3D print hollow microneedles for controlled transdermal drug delivery

Researchers 3D print hollow microneedles for controlled transdermal drug delivery | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Researchers from the University of Kent and the University of Strathclyde have developed a novel device that combines 3D printing, microneedles, and microelectromechanical systems (MEMS) for controllable transdermal drug delivery.

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3D-Printed Microneedles in Biomedical Applications

3D-Printed Microneedles in Biomedical Applications | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

3D printing offers customization, cost-efficiency, a rapid turnaround time between design iterations, and enhanced accessibility. Increasing the printing resolution, the accuracy of the features, and the accessibility of low-cost raw printing materials have empowered 3D printing to be utilized for the fabrication of microneedle platforms. The development of 3D-printed microneedles has enabled the evolution of pain-free controlled release drug delivery systems, devices for extracting fluids from the cutaneous tissue, biosignal acquisition, and point-of-care diagnostic devices in personalized medicine.

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Engineering Microneedles for Therapy and Diagnosis: A Survey

Engineering Microneedles for Therapy and Diagnosis: A Survey | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy.

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Development of lysozyme loaded microneedles for dermal applications

Development of lysozyme loaded microneedles for dermal applications | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Microneedles are being widely explored for dermal delivery of macromolecules. They have the capability and the potential for entrapping enzymes such as lysozyme within a polymeric matrix that do not alter the protein integrity, enable a bolus or a sustained release.

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SINOMED Is Hiring! 3D Polymeric Archirecture & Micromolding Scientist

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Microneedle technology: Oxford NanoDelivery

OND are developing novel techniques and materials to produce low cost needle patches to deliver vaccines and drugs to the immune system http://www.oxfordnanodelivery.com

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Microneedles Could Enable Painless Injections and Blood Draws

Microneedles Could Enable Painless Injections and Blood Draws | Intra-Dermal drug delivery: Opportunities and Challenges? | Scoop.it

Barely visible needles, or “microneedles,” are poised to usher in an era of pain-free injections and blood testing. Whether attached to a syringe or a patch, microneedles prevent pain by avoiding contact with nerve endings. Typically 50 to 2,000 microns in length (about the depth of a sheet of paper) and one to 100 microns wide (about the width of human hair), they penetrate the dead, top layer of skin to reach into the second layer—the epidermis—consisting of viable cells and a liquid known as interstitial fluid.

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