From
www
Renier Brentjens, MD, PhD, discusses the current landscape of CAR T-cell agents in patients with solid tumors.
Your new post is loading...
The first CAR T-cell therapy was approved for pediatric acute lymphoblastic leukemia back in 2017. CAR T-cell therapies are now advancing beyond hematologic malignancies, showing early efficacy in solid tumors. Agents like satricabtagene autoleucel (satri-cel) and ALLO-316 have demonstrated promising activity in gastrointestinal cancer and renal cell carcinoma, respectively. They have received FDA designations such as fast track and regenerative medicine advanced therapy (RMAT). Solid tumors present unique challenges, including antigen heterogeneity, immunosuppressive microenvironments, and fibrotic structures that hinder CAR T-cell infiltration and function. To address these, researchers are exploring combination strategies, such as pairing CAR T-cells with immune checkpoint inhibitors, to enhance efficacy. These developments suggest a promising future for CAR T-cell therapies in treating solid tumors, with ongoing research focused on improving targeting precision and reducing toxicity. The field is moving toward more effective and safer treatments for patients with solid malignancies.