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(Medical Xpress)—What do rheumatoid arthritis, type I diabetes, myasthenia gravis, multiple sclerosis, rheumatic heart disease, and narcolepsy have in common? 
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Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the CNS that has a strong sex bias, with the female to male ratio currently ranging from 3:1 to 4:1 (1–3). Relapsing-remitting MS (RRMS), the most common ...
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Experimental autoimmune encephalomyelitis (EAE) is a valuable model for studying immunopathology in multiple sclerosis (MS) and for exploring the interface between autoimmune responses and CNS tissue that ultimately leads to lesion development.
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No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS).
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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med. 2013 Dec. [Epub ahead of print]. Whether B cells serve as antigen-presenting ...
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Multiple sclerosis (MS), an inflammatory autoimmune disease affecting more than one million people worldwide, is caused by an immune reaction to myelin proteins, the proteins that help form the...
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... nasopharygeal flora, the leptomeninges and CNS parenchyma acquire the characteristics of a persistently stimulated lymphoid organ. Using an extensive panel of bacterial antibodies, tissues from exceptionally early cases, ...
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Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal ... Via Krishan Maggon , Alfredo Corell
Alfredo Corell's curator insight,
December 13, 2013 12:42 PM
Original article: http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3411.html NATURE MEDICINE | LETTER Regulatory T cell proliferative potential is impaired in human autoimmune diseaseFortunata Carbone,Veronica De Rosa,Pietro B Carrieri,Silvana Montella,Dario Bruzzese,Antonio Porcellini,Claudio Procaccini,Antonio La Cava& Giuseppe Matarese
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Receptos to Initiate Phase 3 Trial of RPC1063 in Relapsing Multiple Sclerosis Wall Street Journal RPC1063 is a novel, oral, once daily, selective and potent sphingosine 1-phosphate 1 receptor (S1P1R) modulator in development for autoimmune...
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Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to autoimmune diseases such as Type 1 Diabetes (T1D), Multiple Sclerosis (MS), and...
Gilbert C FAURE's insight:
... This review provides an update on current advances in our understanding of the mechanisms underlying MHC class II-associated autoimmune disease susceptibility and/or resistance and attempts to reconcile these seemingly opposing concepts.
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... well as intracellular antigens. Similar to myelin autoimmunity, pathogenic immune response to neuroaxonal components such as neurofilaments may contribute to neurodegeneration in multiple sclerosis.
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Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple ... - http://t.co/KMIyumyEKW
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OBJECTIVE:To profile the reactivity of CSF-derived immunoglobulin from patients with multiple sclerosis (MS) against a large panel of antigens, to identify disease-specific reactivities. METHODS: CSF from subjects with MS ...
Gilbert C FAURE's insight:
looking for autoantibodies in CSF...
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Gilbert C FAURE's insight:
The new PEPperCHIP® Autoimmune Epitope Microarray 2.0 now covers 3,359 linear autoimmune epitopes including 192 citrullinated peptides as well as the corresponding arginine variants. The IEDB-derived epitopes correlate with a variety of autoimmune diseases including Crohn’s disease, diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, vitiligo and many more.
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Junctional protein problems more indications of autoimmunity. Shimizu F, Tasaki A, Sano Y, Ju M, Nishihara H, Oishi M, Koga M, Kawai M, Kanda T. Sera from remitting and secondary progressive multiple sclerosis patients ...
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The docs at Cambridge have been investigating this and have ways to stop the neutralising antibodies and have found a marker they think shows your risk of developing autoimmunity. This type of study has not been reported ...
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Under normal conditions antigen-activated lymphocytes are capable of low-level surveillance throughout the CNS and this limited entry is regulated not by the presence of a vascular barrier but largely by the restricted expression of endothelial...
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So you add blood which contains IL-21 that is bound to the capture antibody and then you add the detect antibody that can now bind to the captured IL-21 and the more IL-21 in the blood the more that is captured the more ...
Gilbert C FAURE's insight:
elisa dependant.
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Gilbert C FAURE
December 19, 2013 4:28 AM
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A newly identified immune protein influences each person's response to vaccines and risk for autoimmune diseases like lupus and multiple sclerosis.
which one?...press release not so clear in fact FcR!
The research team found that people with a genetic variant present in approximately 15 percent of the world population can express an additional immune system receptor on their B cells, the cells that make antibodies. This additional receptor, called an Fc receptor, binds the antibodies made by B cells and plays a key role in regulating their production. Part of the immune system, antibodies can recognize invaders like bacteria and remove them from the body. In individuals with autoimmune diseases, however, they can also attack the body's own cells, causing disease.
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Gilbert C FAURE
December 5, 2013 2:43 PM
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People with multiple sclerosis treated with the lymphocyte-depleting monoclonal antibody alemtuzumab offer a unique opportunity to study this phenomenon; one in three people develops clinical autoimmunity, and one in ...
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Gilbert C FAURE
November 15, 2013 3:15 PM
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RT @GreenJournal: Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with MS
http://t.co/QHzAbHjHWv #Neurology htt…
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Gilbert C FAURE
September 27, 2013 1:53 PM
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Clinical and Developmental Immunology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas related to developmental immunology and clinical immunologic studies.
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Gilbert C FAURE
September 7, 2013 2:56 AM
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Piccio L, Cantoni C, Henderson JG, Hawiger D, Ramsbottom M, Mikesell R, Ryu J, Hsieh CS, Cremasco V, Haynes W, Dong LQ, Chan L, Galimberti D, Cross AH; (2013) European Journal of Immunology, 43 (8), pp.
multiple sclerosis mouse model
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Gilbert C FAURE
September 4, 2013 11:06 AM
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Hunting for antibodies in tissue fluids is a pass-time for immunologists. This study adds yet one more to the growing list, a bit of a light chain of antibodies, but as ever, this occurs in a minority of Mers so what is the real ...
