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Scooped by
Gilbert C FAURE
December 16, 2013 2:45 AM
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Resources for DIU Immunologie et Biothérapies
DIU Immunologie et Biotherapies is a french diploma associating french universities and immunology laboratories. It is dedicated to the involvement of immunology in new biotherapies, either molecular or cellular.
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Scooped by
Gilbert C FAURE
July 22, 2:03 PM
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For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1–7. Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age. Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes. In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan. We suggest that anti-IL-11 therapy, which is currently in early-stage clinical trials for fibrotic lung disease, may provide a translational opportunity to determine the effects of IL-11 inhibition on ageing pathologies in older people. IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
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Scooped by
Gilbert C FAURE
July 20, 8:29 AM
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Humans also have the protein, called IL-11, offering hope for a future longevity treatment.
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Scooped by
Gilbert C FAURE
July 16, 1:21 PM
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Nipocalimab showed a significant decrease in Clinical European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index.
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Scooped by
Gilbert C FAURE
July 7, 8:44 AM
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Scooped by
Gilbert C FAURE
May 27, 11:42 AM
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Le 24 mai, des chercheurs chinois ont annoncé avoir transplanté avec succès un foie de porc génétiquement modifié sur un patient humain vivant atteint d’un cancer du foie.
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Scooped by
Gilbert C FAURE
May 5, 2:48 AM
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A l'Institut de recherche sur les dispositifs médicaux de Suzhou de l'Université du Sud-Est, situé à Suzhou, dans la province chinoise du Jiangsu (est), on a...
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Gilbert C FAURE
April 28, 12:56 PM
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SignificanceRespiratory virus infections in humans are a significant global health concern, causing a wide range of diseases with substantial morbidity and mortality worldwide. This underscores the...
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Scooped by
Gilbert C FAURE
April 24, 5:04 AM
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Aspirin, taken by around 29 million Americans daily, has increasingly been linked to inhibiting the growth of certain cancers – but we didn't quite know how. Now, scientists have uncovered how it helps the immune system see and kill cancer cells.
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Scooped by
Gilbert C FAURE
April 9, 9:22 AM
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Scooped by
Gilbert C FAURE
April 4, 1:43 PM
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Biotechnology firm LyGenesis has injected donor cells into a person with liver failure for the first time.
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Gilbert C FAURE
March 29, 6:15 AM
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Protection results from GSK Shingrix vaccines against #Shingles are impressive. Guess which adjuvant was used?
👉A #TLR4 agonist of course 🦠
The results…
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Scooped by
Gilbert C FAURE
March 8, 6:13 AM
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🔸 Actualisation de la stratégie vaccinale contre le zona :
Le zona, causé par la réactivation du virus varicelle-zona, est une maladie virale touchant…
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Scooped by
Gilbert C FAURE
July 23, 10:23 AM
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Insurance claims data showed that patients with autoimmune disorders who took Janus kinase (JAK) inhibitors had lower rates of age-related macular degeneration (AMD), hinting that the drugs might treat the common eye disease.
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Scooped by
Gilbert C FAURE
July 21, 6:31 AM
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Despite significant advances in biologic and small molecule treatments and the emergence of combination therapies to treat inflammatory bowel diseases (IBD) a large unmet need remains to control intestinal inflammation.
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Scooped by
Gilbert C FAURE
July 16, 1:56 PM
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Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic applications that cannot be achieved using conventional IgG-based antibodies. Consequently, development of these molecules has garnered substantial interest in the past decade and, as of the end of 2023, 14 bsAbs have been approved: 11 for the treatment of cancer and 3 for non-oncology indications. bsAbs are available in different formats, address different targets and mediate anticancer function via different molecular mechanisms. Here, we provide an overview of recent developments in the field of bsAbs for cancer therapy. We focus on bsAbs that are approved or in clinical development, including bsAb-mediated dual modulators of signalling pathways, tumour-targeted receptor agonists, bsAb–drug conjugates, bispecific T cell, natural killer cell and innate immune cell engagers, and bispecific checkpoint inhibitors and co-stimulators. Finally, we provide an outlook into next-generation bsAbs in earlier stages of development, including trispecifics, bsAb prodrugs, bsAbs that induce degradation of tumour targets and bsAbs acting as cytokine mimetics. Bispecific antibodies (bsAbs) can mediate therapeutic effects beyond those of natural monospecific antibodies. This Review provides an overview of recent developments in the field of bsAbs for cancer therapy and an outlook into next-generation bsAbs in earlier stages of development.
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Scooped by
Gilbert C FAURE
July 16, 4:37 AM
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Millions of pregnant women get the pitch through their OB-GYN: Put a bit of your newborn’s umbilical cord on ice,...
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Scooped by
Gilbert C FAURE
June 4, 3:48 AM
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Notre nouvelle revue sur le monitoring des biothérapies
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Scooped by
Gilbert C FAURE
May 12, 10:15 AM
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There are other ways to therapeutically stimulate intratumoral innate immunity - with encouraging clinical results -, including in situ vaccination against the…
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Scooped by
Gilbert C FAURE
May 2, 5:25 AM
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Scooped by
Gilbert C FAURE
April 25, 10:11 AM
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Targeting claudin-1 offers a promising approach for treating solid tumours by selectively killing cancer cells and breaking down barriers to immunotherapy.
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Scooped by
Gilbert C FAURE
April 9, 11:28 AM
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Antibody–drug conjugates have emerged as a powerful tool to deliver highly targeted cancer therapies. Next-generation antibody-drug conjugate designs aim to push the envelope even further.
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Scooped by
Gilbert C FAURE
April 5, 3:02 AM
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✨ Discovering New Horizons on #XENOTRANSPLANTATION ✨
We’re on an exhilarating journey to unravel the mysteries of xeno immune response. Our passion for… | 17 comments on LinkedIn
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Scooped by
Gilbert C FAURE
March 30, 5:13 AM
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The study unveils that potent combination therapies remodel TAMs to antitumor proinflammatory M1-like macrophages crucial for their therapeutic efficacy. I
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Scooped by
Gilbert C FAURE
March 22, 8:08 AM
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The future of vaccine development in light of accelerated technological advances through the COVID-19 pandemic.
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Scooped by
Gilbert C FAURE
March 7, 11:30 AM
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A description of H. Golding's research program and related publications.
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