Rheumatology-Rhumatologie
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Scooped by Gilbert C FAURE
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RHUMATOLOGIE - RHEUMATOLOGY

Obviously a topic of interest for so many people:

for the patient, it includes aching muscles, tendons and joints..

for MDs and researchers, it covers degenerative diseases as well as arthritis, often associated with various autoimmune diseases (see autoimmunity http://www.scoop.it/t/autoimmunity)

fortunately,

new diagnostic tools are available

and new biotherapies allowed to improve the prognosis and the quality of life of patients

Gilbert C FAURE's insight:

January 2016

still few viewers (#650) for this topic, but >1280 posts and 2000 views

much less than other immunology topics, but growing!


July 2016

2300 posts and 2700 views

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Changes in peripheral blood lymphocyte subsets during arthritis development in arthralgia patients

Changes in peripheral blood lymphocyte subsets during arthritis development in arthralgia patients | Rheumatology-Rhumatologie | Scoop.it
Multiple lymphocyte subsets like T and B cells have been connected to joint infiltration and inflammation in rheumatoid arthritis (RA).
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Interleukin-Blocking RA Drugs Leave Patients More Exposed to Flesh-Eating Strep Infections

Interleukin-Blocking RA Drugs Leave Patients More Exposed to Flesh-Eating Strep Infections | Rheumatology-Rhumatologie | Scoop.it
Interleukin-1β (IL-1beta), a cytokine that plays in important role in the body’s immune response, turns out to be part of the body’s early defense system for bacterial infections.
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Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System. - PubMed - NCBI

Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System. - PubMed - NCBI | Rheumatology-Rhumatologie | Scoop.it
J Immunol. 2016 Sep 14. pii: 1601006. [Epub ahead of print]
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Romosozumab Treatment in Postmenopausal Women with Osteoporosis — NEJM

Romosozumab Treatment in Postmenopausal Women with Osteoporosis — NEJM | Rheumatology-Rhumatologie | Scoop.it
Original Article from The New England Journal of Medicine — Romosozumab Treatment in Postmenopausal Women with Osteoporosis
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T cell subsets: an immunological biomarker to predict progression to clinical arthritis in ACPA-positive individuals

Objectives
Anticitrullinated protein antibody (ACPA)+ individuals with non-specific musculoskeletal symptoms are at risk of inflammatory arthritis (IA).
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Interpretation of the evidence for the efficacy and safety of statin therapy

Interpretation of the evidence for the efficacy and safety of statin therapy | Rheumatology-Rhumatologie | Scoop.it
This Review is intended to help clinicians, patients, and the public make informed
decisions about statin therapy for the prevention of heart attacks and strokes. It
explains how the evidence that is available from randomised controlled trials yields
reliable information about both the efficacy and safety of statin therapy. In addition,
it discusses how claims that statins commonly cause adverse effects reflect a failure
to recognise the limitations of other sources of evidence about the effects of treatment.
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Education and Training Courses for Rheumatologists | The British Society for Rheumatology

Education and Training Courses for Rheumatologists | The British Society for Rheumatology | Rheumatology-Rhumatologie | Scoop.it
Education courses from the British Society for Rheumatology supporting the training needs of rheumatologists and health professionals with interest in rheumatology, arthritis and rheumatic diseases.
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Risk of malignancy in ankylosing spondylitis: a systematic review and meta-analysis. - PubMed - NCBI

Risk of malignancy in ankylosing spondylitis: a systematic review and meta-analysis. - PubMed - NCBI | Rheumatology-Rhumatologie | Scoop.it
Sci Rep. 2016 Aug 18;6:32063. doi: 10.1038/srep32063.
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JCI - Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation

RT @jclinicalinvest: GM-CSF drives #inflammation through IRF4-induced CCL17 production https://t.co/GuLTmyR4ir @SciMelb #autoimmunity https…
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ACC Liverpool beats Athens and Lisbon to host key medical conference

ACC Liverpool beats Athens and Lisbon to host key medical conference | Rheumatology-Rhumatologie | Scoop.it
ACC Liverpool has beaten Athens and Lisbon to be selected to host the UK’s first World Congress on Osteoarthritis in 2018.
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Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment

Open Access: Prediction of disease relapses by multibiomarker disease activity and autoantibody status in pat... https://t.co/hwJylVfvzk
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Non-Esterified Fatty Acids Profiling in Rheumatoid Arthritis: Associations with Clinical Features and Th1 Response

Objectives Since lipid compounds are known to modulate the function of CD4 + T-cells and macrophages, we hypothesize that altered levels of serum non-esterified fatty acids (NEFA) may underlie rheumatoid arthritis (RA) pathogenesis.
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Tweet from @britsocimm

Tweet from @britsocimm | Rheumatology-Rhumatologie | Scoop.it
Brit Soc Imm: Porphyromonas gingivalis infection exacerbates the onset of… https://t.co/zecvgy5EEt #MedicBoard https://t.co/7Cf4G3Ji4h
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Scleroderma renal crisis and renal involvement in systemic sclerosis : Nature Reviews Nephrology : Nature Research

Scleroderma renal crisis and renal involvement in systemic sclerosis : Nature Reviews Nephrology : Nature Research | Rheumatology-Rhumatologie | Scoop.it
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RheumNow: Complexities of Diagnosing and Treating RA

RheumNow: Complexities of Diagnosing and Treating RA | Rheumatology-Rhumatologie | Scoop.it
It's the engine that kills ya', not the caboose
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Rheumatology Guidelines | The British Society for Rheumatology

Rheumatology Guidelines | The British Society for Rheumatology | Rheumatology-Rhumatologie | Scoop.it
Guidelines for the use of intravenous tocilizumab in the treatment of adult patients with rheumatoid arthritis and guidelines for the treatment of psoriatic arthritis with biologics.
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What rheumatologists need to know about innate lymphocytes : Nature Reviews Rheumatology : Nature Research

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Stem Cells Behind Calcified Blood Vessels in Kidney Disease Identified

Stem Cells Behind Calcified Blood Vessels in Kidney Disease Identified | Rheumatology-Rhumatologie | Scoop.it
Gli1 stem cells develop into osteoblasts in arteries leading to deposition of calcium and increased risk of atherosclerosis in chronic kidney patients.
Gilbert C FAURE's insight:
Calcification

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Rheumatology Journal | The British Society for Rheumatology

Rheumatology Journal | The British Society for Rheumatology | Rheumatology-Rhumatologie | Scoop.it
Rheumatology is the flagship journal of the British Society for Rheumatology, which is published by Oxford University Press. The Journal has received its highest ever impact factor of 4.435 along with increased submissions.
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All-Cause Mortality Associated with Tumor Necrosis Factor-Alpha Inhibitor in Patients with Rheumatoid Arthritis

Poiroux et al1 reported a meta-analysis for the risk assessment of tumor necrosis factor-alpha (TNF-α) inhibitor on all-cause mortality in patients with rheumatoid arthritis.
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Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis

Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis | Rheumatology-Rhumatologie | Scoop.it
(2016). Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis. Expert Opinion on Biological Therapy. Ahead of Print. doi: 10.1080/14712598.2016.1217988
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Rescooped by Gilbert C FAURE from Immunology and Biotherapies
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NATURE REVIEWS RHEUMATOLOGY | Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?

Michiel van der Vlist, Jurgen Kuball, Timothy R. D. Radstake & Linde Meyaard AffiliationsContributionsCorresponding author Nature Reviews Rheumatology (2016)
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Gilbert C FAURE's curator insight, August 19, 10:14 AM
The recent success of immune checkpoint blockade in cancer therapy illustrates the importance of the inhibitory receptors cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in the regulation of antitumour immune responses. However, blocking signalling by these inhibitory immune checkpoint receptors is also associated with substantial inflammatory effects that can resemble autoimmune responses, which is consistent with the role of these receptors in protecting the host from excessive inflammation. The human genome encodes over 300 inhibitory receptors, which represent as many opportunities to modulate inflammation in a disease-specific and tissue-specific manner. We argue that rheumatologists and oncologists should join forces to study these inhibitory immune molecules. An improved understanding of these immune checkpoints will enable both fields to make progress in exploiting inhibitory immune receptors therapeutically. In this Review, we discuss data from studies reporting the adverse inflammatory effects of cancer therapies that target immune checkpoints. We discuss the potential implications of these findings on the biological understanding of autoimmune rheumatic diseases and highlight therapeutic strategies that could be used to target inhibitory receptors for the treatment of these conditions.
Krishan Maggon 's curator insight, August 20, 2:44 AM
NATURE REVIEWS RHEUMATOLOGY | REVIEW 

Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us? 

 Michiel van der Vlist, Jurgen Kuball, Timothy R. D. Radstake & Linde Meyaard 
Nature Reviews Rheumatology (2016) doi:10.1038/nrrheum.2016.131 Published online 19 August 2016
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Leading the way in rheumatology | The British Society for Rheumatology

Leading the way in rheumatology | The British Society for Rheumatology | Rheumatology-Rhumatologie | Scoop.it
The British Society for Rheumatology is the professional medical association for rheumatology and musculoskeletal medicine.
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Zika virus infection in the womb linked to severe joint condition in new study

Zika virus infection in the womb linked to severe joint condition in new study | Rheumatology-Rhumatologie | Scoop.it
Scientists in Brazil studying a possible link between Zika virus infection in the womb and severe joint abnormalities in babies say they should be added to the growing list of conditions to watch for.
Gilbert C FAURE's insight:
arthrogryposes!
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Mixed Connective Tissue Disease Symptoms, Treatment & Prognosis

Mixed Connective Tissue Disease Symptoms, Treatment & Prognosis | Rheumatology-Rhumatologie | Scoop.it
Get information on mixed connective tissue disease (MCTD) symptoms, types, treatment, and prognosis. MCTD is an overlap of lupus, scleroderma, and polymyositis.
Gilbert C FAURE's insight:
for laypeople?
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