AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Suggested by Société Francaise d'Immunologie
February 10, 2014 6:03 AM
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Bruton's Tyrosine Kinase Promotes Persistence of Mature Anti-Insulin B Cells [AUTOIMMUNITY]

Bruton's Tyrosine Kinase Promotes Persistence of Mature Anti-Insulin B Cells [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
Autoreactive B lymphocytes are essential for the development of T cell–mediated type 1 diabetes (T1D).
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Scooped by Gilbert C FAURE
February 7, 2014 2:51 PM
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Cell Therapy for Type 1 Diabetes. [QJM. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
February 6, 2014 3:04 PM
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What is the role of autoimmunity in type 1 diabetes? A clinical perspective - Springer

Sorry about another 'interesting', but this article questions the #autoimmunity of #type1diabetes...... http://t.co/vHAHG8rtVS
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Scooped by Gilbert C FAURE
February 1, 2014 2:27 PM
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Maternal Microchimerism: Increased in the Insulin Positive Compartment of Type 1 Diabetes Pancreas but Not in Infiltrating Immune Cells or Replicating Islet Cells

Maternal Microchimerism: Increased in the Insulin Positive Compartment of Type 1 Diabetes Pancreas but Not in Infiltrating Immune Cells or Replicating Islet Cells | AUTOIMMUNITY | Scoop.it
by Jody Ye, Marta Vives-Pi, Kathleen M. Gillespie
Background Maternal microchimeric cells (MMc) transfer across the placenta during pregnancy.
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Scooped by Gilbert C FAURE
January 28, 2014 4:53 AM
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The effect of childhood cow's milk intake and HLA-DR genotype on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young - Lamb - 2014 - Pediatric Diabetes - Wi...

The effect of childhood cow's milk intake and HLA-DR genotype on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young - Lamb - 2014 - Pediatric Diabetes - Wi... | AUTOIMMUNITY | Scoop.it
The effect of childhood cow's milk intake ... risk of islet autoimmunity and type 1 #diabetes: #abstract http://t.co/ig0JtOA2G9
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Scooped by Gilbert C FAURE
January 27, 2014 5:22 AM
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Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Coxsackievirus B1 Is Associated With Induction of {beta}-Cell Autoimmunity That Portends Type @JDRF #health http://t.co/0AHLHw7Pwa
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Scooped by Gilbert C FAURE
January 25, 2014 7:39 AM
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Researchers look to connect diabetes and cleanliness

Researchers look to connect diabetes and cleanliness | AUTOIMMUNITY | Scoop.it
In Finland, children are diagnosed with the disease at a surprising rate. Why? (Does cleaner living result in higher rates of autoimmune disease?
Gilbert C FAURE's insight:

the hygien hypthesis in the washington post!

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Rescooped by Gilbert C FAURE from diabetes and more
January 12, 2014 5:05 AM
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Type 1 diabetes—progress and prospects : The Lancet

Type 1 diabetes—progress and prospects. By - The Lancet

Via Ellen H Ullman, MSW
Gilbert C FAURE's insight:

link with a report on paediatric diabetes in UK

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Scooped by Gilbert C FAURE
January 10, 2014 1:24 PM
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Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes

Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes | AUTOIMMUNITY | Scoop.it
Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 #Diabetes http://t.co/r8Nh7yEYTe #stem #immunology
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Scooped by Gilbert C FAURE
January 9, 2014 2:08 PM
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Islet autoantibody seroconversion precedes type 1 diabetes | T1DF ...

Islet autoantibody seroconversion precedes type 1 diabetes | T1DF ... | AUTOIMMUNITY | Scoop.it
Link to original article Islet autoantibody seroconversion precedes type 1 diabetes By: MARY ANN MOON, Clinical Endocrinology News Digital Network In children at genetic risk for type 1 diabetes, the development of multiple ...
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Scooped by Gilbert C FAURE
January 4, 2014 8:49 AM
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Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes

Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes | AUTOIMMUNITY | Scoop.it
Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes [AUTOIMMUNITY] http://t.co/6dAZ7Ey5ZX #jimmTCB
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Scooped by Gilbert C FAURE
December 20, 2013 4:48 AM
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The Changing Landscape of Type 1 Diabetes

The Changing Landscape of Type 1 Diabetes | AUTOIMMUNITY | Scoop.it
Emerging research about autoantibodies in type 1 diabetes is redefining the natural history of this disease, and could lead to new diagnostic criteria.
Gilbert C FAURE's insight:

a major advance for natural history of the disease! relying on autoantibodies and implying early screening of children

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Scooped by Gilbert C FAURE
December 10, 2013 2:01 PM
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Type 1 diabetes in under 10s raises risk for siblings - Diabetes.co.uk

Type 1 diabetes in under 10s raises risk for siblings - Diabetes.co.uk | AUTOIMMUNITY | Scoop.it
Type 1 diabetes in under 10s raises risk for siblings Diabetes.co.uk However, when the researchers reviewed siblings of children who had been diagnosed before they were 10 years old, 23% of siblings developed type 1 diabetes and another 29% of the...
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Scooped by Gilbert C FAURE
February 9, 2014 1:28 PM
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Viacyte, Inc. – Clinical Trials

Viacyte, Inc. – Clinical Trials | AUTOIMMUNITY | Scoop.it
ViaCyte may file with FDA by July for trials of encapsulated cell therapy for T1 diabetes #T1D http://t.co/U9rz9PYR9i http://t.co/dyY7tysDvW
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Scooped by Gilbert C FAURE
February 7, 2014 2:17 PM
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Why the Wellcome Trust and JDRF believe in investing in ...

Why the Wellcome Trust and JDRF believe in investing in ... | AUTOIMMUNITY | Scoop.it
Beat autoimmunity The Wellcome Trust recently hosted a joint meeting with the Juvenile Diabetes Research Foundation (JDRF) to discuss the common mechanisms of autoimmune disease and look at how collaborative ...
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Rescooped by Gilbert C FAURE from Cancer Immunotherapy Review and Collection
February 5, 2014 1:49 PM
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PLOS ONE: Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies

PLOS ONE: Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies | AUTOIMMUNITY | Scoop.it

This meta-analysis demonstrated that the G49A and C60T polymorphism of CTLA4 is a risk factor associated with increased T1D susceptibility, but these associations vary in different ethnic populations.


Via Krishan Maggon
Krishan Maggon 's curator insight, February 5, 2014 1:27 AM

For full text article, go to

 

Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 StudiesJingnan Wang equal contributor,  Lianyong Liu equal contributor,  Junhua Ma,  Fei Sun,  Zefei Zhao,  Mingjun Gu mail Published: January 23, 2014DOI: 10.1371/journal.pone.0085982

 

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0085982

Scooped by Gilbert C FAURE
January 29, 2014 9:59 AM
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Imaging dynamics of CD11c+ cells and Foxp3+ cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes - Springer

Imaging dynamics of CD11c+ cells and Foxp3+ cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes - Springer | AUTOIMMUNITY | Scoop.it
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Scooped by Gilbert C FAURE
January 28, 2014 4:53 AM
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JDRF’s 2013 UK Type 1 Diabetes Research Roadmap

JDRF’s 2013 UK Type 1 Diabetes Research Roadmap | AUTOIMMUNITY | Scoop.it
RT @JDRFUK: In fact, we reported that #autoimmunity research was a UK strength in our Roadmap http://t.co/Dq5kRSRVA5 #beatautoimmunity
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Scooped by Gilbert C FAURE
January 25, 2014 7:39 AM
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PLOS ONE: Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies

PLOS ONE: Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies | AUTOIMMUNITY | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Rescooped by Gilbert C FAURE from Type 1 diabetes
January 24, 2014 1:14 PM
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Low HERV-K(C4) Copy Number is Associated with Type 1 Diabetes

Here we investigate the relationship between C4 variation/copy number and type 1 diabetes. We find that individuals with type 1 diabetes have significantly fewer copies of HERV-K(C4), and that this effect is not solely due to ...

Via Remi Creusot
Remi Creusot's curator insight, January 24, 2014 12:45 PM

An integrated retroviral element protective against T1D? One of the most peculiar genetic associations I have seen so far...

Rescooped by Gilbert C FAURE from diabetes and more
January 12, 2014 5:04 AM
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What is the role of autoimmunity in type 1 diabetes? A clinical perspective - Springer


Via Ellen H Ullman, MSW
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Scooped by Gilbert C FAURE
January 9, 2014 2:23 PM
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Standards of hygiene may also contribute to development of auto-immune diseases in children

Standards of hygiene may also contribute to development of auto-immune diseases in children | AUTOIMMUNITY | Scoop.it
The incidence of auto-immune diseases like type 1 diabetes and allergies has risen dramatically in developed countries over the past fifty years.
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Rescooped by Gilbert C FAURE from Immunology and Biotherapies
January 7, 2014 4:24 PM
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Trials in type 1 diabetes: Antigen-specific therapies

Trials in type 1 diabetes: Antigen-specific therapies | AUTOIMMUNITY | Scoop.it

Via Marcelo de Carvalho Bittencourt
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Scooped by Gilbert C FAURE
December 27, 2013 5:57 AM
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Autoimmunity

Pathology, Diagnosis and Therapy

Gilbert C FAURE's insight:

Autoimmunity is indeed one of the biggest challenge of Immunology!

Understanding the mechanisms of this physiological immune phenomenon inducing such a diverse array of diseases, joint and muscular, digestive, endocrinological, neurological, cutaneous..

 

Among covered diseases

Lupus (>550 posts)

https://www.scoop.it/topic/autoimmunity?q=lupus

Scleroderma

https://www.scoop.it/topic/autoimmunity?q=scleroderma

Polymyositis

Sjögren's (>150)

https://www.scoop.it/topic/autoimmunity?q=sjogren

 

 

Diabetes (>400 posts)

https://www.scoop.it/topic/autoimmunity?q=diabetes

Mutiple sclerosis (>100 posts)

https://www.scoop.it/topic/autoimmunity?q=multiple+sclerosis

Thyroid disorders

https://www.scoop.it/topic/autoimmunity?q=thyroid

 

Improving the molecular and cellular tools in use for a few decades for diagnosis and follow-up of patients, perhaps screening in the future

Autoantibodies

https://www.scoop.it/topic/autoimmunity?q=autoantibody

 

Mastering the molecular and cellular mechanisms to treat patients.

Tregs

https://www.scoop.it/topic/autoimmunity?q=tregs

 

You can also find relevant informations on some other topics curated  here such as

Rheumatology

http://www.scoop.it/t/rheumatology-rhumatologie

Immunology and biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

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Scooped by Gilbert C FAURE
December 15, 2013 1:37 AM
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Cell Pouch System - Dramatic Diabetes Breakthrough in 2014? - The Market Oracle

Cell Pouch System - Dramatic Diabetes Breakthrough in 2014?
Gilbert C FAURE's insight:

a survey for layinvestors

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