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Scoop.it!
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Scooped by
Gilbert C FAURE
January 9, 11:11 AM
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The IEI Committee consists of experts in all aspects of primary immunodeficiencies.
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Gilbert C FAURE
December 31, 2024 4:03 AM
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SLAMF7: Unlocking the Potential of T Memory Stem Cells for the New Year
T memory stem cells (T_SCM) have redefined immunology, overturning the long-held…
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Scooped by
Gilbert C FAURE
December 31, 2024 3:58 AM
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Breaking Study | #DendriticCells #Type1 control the formation, maintenance, & function of #TertiaryLymphoidStructures in #Cancer | Targeting of #cDC1s to…
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Gilbert C FAURE
December 31, 2024 3:56 AM
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The Immune Synapse: Key to T Cell Activation and Immune Response ⚔️🧬
The immune synapse is a critical structure that enables T cells to communicate…
classique maintenant mais lisible
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Scooped by
Gilbert C FAURE
December 23, 2024 4:54 AM
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𝐓𝐡𝐞 𝐈𝐦𝐦𝐮𝐧𝐞 𝐒𝐲𝐬𝐭𝐞𝐦: 𝐀 𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐎𝐯𝐞𝐫𝐯𝐢𝐞𝐰
Innate Immunity: This section highlights the body's first line of defense… | 12 comments on LinkedIn
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Gilbert C FAURE
December 7, 2024 12:45 PM
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#Immunotherapy | Role of #DendriticCells in #TertiaryLymphoidStructures | Implications for #Cancer and #AutoImmuneDiseases | OPEN ACCESS Review from Mariana…
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Gilbert C FAURE
December 5, 2024 4:06 AM
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Fibrosis, an excessive self-repair response, is an age-related pathological process that universally affects various major organs such as the heart, liver, kidney, and lungs. Continuous accumulation of pathological tissue fibrosis destroys structural integrity and causes loss of function, with...
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Gilbert C FAURE
January 12, 3:33 AM
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#Inflammation | #Autoimmunity | #SARSCoV2 - the #Virus that keeps on giving | Identification of a #Spike-derived #Peptide with #SuperAntigen-like properties…
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Scooped by
Gilbert C FAURE
January 5, 4:59 AM
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𝗧𝗬𝗣𝗘𝗦 𝗢𝗙 𝗜𝗠𝗠𝗨𝗡𝗘 𝗖𝗘𝗟𝗟𝗦 𝗔𝗡𝗗 𝗧𝗛𝗘𝗜𝗥 𝗙𝗨𝗡𝗖𝗧𝗜𝗢𝗡𝗦
1. Mast Cell
🔵 Dilates blood vessels.
🔵 Induces inflammation via… | 14 comments on LinkedIn
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Scooped by
Gilbert C FAURE
December 31, 2024 3:59 AM
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🌟 The Unsung Heroes of the Immune System: Antigen-Presenting Cells (APCs) 🌟
Our immune system is a masterpiece of coordination, with Antigen-Presenting…
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Gilbert C FAURE
December 31, 2024 3:57 AM
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🛡️ Cross-Presentation: A Key to Unlocking Cytotoxic T Cell Responses
🔍 What is Cross-Presentation?
Cross-presentation is a unique immunological process…
didactique aussi
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Gilbert C FAURE
December 14, 2024 5:22 AM
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Cellular senescence is an aging mechanism characterized by cell cycle arrest and a senescence-associated secretory phenotype (SASP). Preclinical studies demonstrate that senolytic drugs, which target survival pathways in senescent cells, can counteract age-associated conditions that span several organs. The comparative efficacy of distinct senolytic drugs for modifying aging and senescence biomarkers in vivo has not been demonstrated. Here, we established aging- and senescence-related plasma proteins and tissue transcripts that changed in old versus young female and male mice. We investigated responsivity to acute treatment with venetoclax, navitoclax, fisetin or luteolin versus transgenic senescent cell clearance in aged p16-InkAttac mice. We discovered that age-dependent changes in plasma proteins, including IL-23R, CCL5 and CA13, were reversed by senotherapeutics, which corresponded to expression differences in tissues, particularly in the kidney. In plasma from humans across the lifespan, IL-23R increased with age. Our results reveal circulating factors as candidate mediators of senescence-associated interorgan signal transduction and translationally impactful biomarkers of systemic senescent cell burden. Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They identify IL-23R as a senescence-associated, age-increased circulating biomarker.
la page wikipedia est très pauvre,
pas grand chose sur IL-23R
https://www.scoop.it/topic/immunology?q=IL-23R
beaucoup plus sur IL-23
mais mériterait peut être un webcast?
Structure, Famille, Récepteurs
Actions
Pathologie
Thérapeutique (Acs monoclonaux)
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Gilbert C FAURE
December 2, 2024 9:45 AM
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As a pivotal cytokine, IL-22 plays a crucial role in the pathogenesis of autoimmune diseases. In this comprehensive review, we initially provide an overvie
sujet couvert non seulement dans ce sujet
mais aussi
https://www.scoop.it/topic/mucosal-immunity?q=IL-22
This topic is focusing mainly on fundamental systemic immunology.
Some subjects are particularly adressed, according to my personal interests in research or teaching, for instance
Lymph node
https://www.scoop.it/topic/immunology?q=lymph+node
Feel free to browse other related topics!
Mucosal Immunity:
http://www.scoop.it/t/mucosal-immunity
Immunology and Biotherapies
http://www.scoop.it/t/immunology-and-biotherapies
Autoimmunity
http://www.scoop.it/t/autoimmunity
Allergy and clinical immunology:
http://www.scoop.it/t/allergy-and-clinical-immunology
History of Immunology
http://www.scoop.it/t/history-of-immunology
and more recently
Fake News and Vaccinations
https://www.scoop.it/topic/assim-actualites