Immunology
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Immunology
Teaching and Learning Immunology. Information you never would have searched for!
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The TOP 10% information you need!

 

The scoops deal with published (classical or OPEN) and grey literature (blogs, websites, social networks, press releases) allowing rapid access to recently published relevant information

 

May 29, 2015 you were 26796 visitors, viewing this topic 34.5K times., 4900 scoops

June 2020 : >7.3K scoops, >94.5K visitors, #121K views

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December 2023: >8K scoops, >97,7K vis, >171,3K views

 

Gilbert C FAURE's insight:

This topic is focusing mainly on fundamental systemic immunology.

Some subjects are particularly adressed, according to my personal interests in research or teaching, for instance

Lymph node 

https://www.scoop.it/topic/immunology?q=lymph+node

 

Feel free to browse other related topics!

Mucosal Immunity:

 http://www.scoop.it/t/mucosal-immunity

Immunology and Biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

Autoimmunity

http://www.scoop.it/t/autoimmunity

Allergy and clinical immunology:

http://www.scoop.it/t/allergy-and-clinical-immunology

History of Immunology

http://www.scoop.it/t/history-of-immunology

and more recently

Fake News and Vaccinations

https://www.scoop.it/topic/assim-actualites

 

Kaupang's comment, October 8, 2021 9:31 AM
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wynndental's comment, January 25, 2023 1:44 AM
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Juan Lama on LinkedIn: Human Transferrin Receptor Can Mediate SARS-CoV-2 Infection | Virus World

Juan Lama on LinkedIn: Human Transferrin Receptor Can Mediate SARS-CoV-2 Infection | Virus World | Immunology | Scoop.it
The human transferrin receptor (TfR) identified as an alternative receptor for SARS-CoV-2 infection in human cells. Human TfR, which is abundantly expressed…
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Olivier Adotevi on LinkedIn: Durable CD4+ T cell immunity: cherchez la stem

Olivier Adotevi on LinkedIn: Durable CD4+ T cell immunity: cherchez la stem | Immunology | Scoop.it
CD4 T cells are the the best ?
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https://www.science.org/doi/abs/10.1126/scisignal.adc9662?mi=0&af=R&target=default

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What do cancer-specific T cells ‘see’? | Discovery Immunology | Oxford Academic

What do cancer-specific T cells ‘see’? | Discovery Immunology | Oxford Academic | Immunology | Scoop.it
Summary. Complex cellular interactions between the immune system and cancer can impact tumour development, growth, and progression. T cells play a key role in t
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ontogenesis and heterogeneity of basophils | Discovery Immunology | Oxford Academic

ontogenesis and heterogeneity of basophils | Discovery Immunology | Oxford Academic | Immunology | Scoop.it
Summary. Basophils are the rarest leukocytes, but they have essential roles in protection against helminths, allergic disorders, autoimmune diseases, and some c
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https://www.cell.com/immunity/fulltext/S1074-7613(24)00038-4

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https://www.science.org/doi/10.1126/scitranslmed.adg6229

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Frontiers | Epstein-Barr virus: the mastermind of immune chaos

Frontiers | Epstein-Barr virus: the mastermind of immune chaos | Immunology | Scoop.it

The Epstein-Barr virus (EBV) is a ubiquitous human pathogen linked to various diseases, including infectious mononucleosis and multiple types of cancer

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John Gordon sur LinkedIn : #immunity #infection #cancer #immunotherapy #bregs #tregs #mdscs…

John Gordon sur LinkedIn : #immunity #infection #cancer #immunotherapy #bregs #tregs #mdscs… | Immunology | Scoop.it
#Immunity | #Infection | #Cancer | #Immunotherapy | #Bregs | #Tregs | #MDSCs | Mechanisms Underlying #Immunosuppression by #Regulatory Cells | Breaking OPEN…
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Adaptive immune receptor repertoire analysis | Nature Reviews Methods Primers

Adaptive immune receptor repertoire analysis | Nature Reviews Methods Primers | Immunology | Scoop.it
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire (AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that drives adaptive immune responses, which in turn is imprinted in each individual AIRR. This supports the concept that the AIRR could determine disease outcomes, for example in autoimmunity, infectious disease and cancer. AIRR analysis could therefore assist the diagnosis, prognosis and treatment of human diseases towards personalized medicine. High-throughput sequencing, high-dimensional statistical analysis, computational structural biology and machine learning are currently employed to study the shaping and dynamics of the AIRR as a function of time and antigenic challenges. This Primer provides an overview of concepts and state-of-the-art methods that underlie experimental and computational AIRR analysis and illustrates the diversity of relevant applications. The Primer also addresses some of the outstanding challenges in AIRR analysis, such as sampling, sequencing depth, experimental variations and computational biases, while discussing prospects of future AIRR analysis applications for understanding and predicting adaptive immune responses. The adaptive immune receptor repertoire (AIRR) drives adaptive immune responses, which could determine disease outcomes, infectious disease and cancer. Mhanna, Bashour et al. outline the approaches and challenges in AIRR analysis, as well as future developments towards predicting adaptive immune responses.
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Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies | Critical Care | Full Text

Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies | Critical Care | Full Text | Immunology | Scoop.it
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1 activation leads to the production and release of proinflammatory cytokines, chemokines, as well as its own expression and circulating levels of the cleaved soluble extracellular portion of TREM-1 (sTREM-1). Because patients with sepsis and septic shock show elevated sTREM-1 levels, TREM-1 has attracted attention as an important contributor to the inadequate immune response in this often-deadly condition. Since 2001, when the first blockade of TREM-1 in sepsis was performed, many potential TREM-1 inhibitors have been established in animal models. However, only one of them, nangibotide, has entered clinical trials, which have yielded promising data for future treatment of sepsis, septic shock, and other inflammatory disease such as COVID-19. This review discusses the TREM-1 pathway and important ligands, and highlights the development of novel inhibitors as well as their clinical potential for targeted treatment of various inflammatory conditions.
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https://www.science.org/doi/10.1126/science.adg7942

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Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α | Scientific Reports

Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α | Scientific Reports | Immunology | Scoop.it
The cGAS-STING pathway appears to contribute to dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related to long COVID are still being investigated. In the present study, we evaluated the association of cGAS and STING gene expression levels and plasma IFN-α, TNF-α and IL-6 levels with COVID-19 severity in acute infection and long COVID, based on analysis of blood samples from 148 individuals, 87 with acute COVID-19 and 61 in the post-COVID-19 period. Quantification of gene expression was performed by real-time PCR, and cytokine levels were quantified by ELISA and flow cytometry. In acute COVID-19, cGAS, STING, IFN-α, TNF-α, and IL-6 levels were higher in patients with severe disease than in those with nonsevere manifestations (p < 0.05). Long COVID was associated with elevated cGAS, STING and IFN-α levels (p < 0.05). Activation of the cGAS-STING pathway may contribute to an intense systemic inflammatory state in severe COVID-19 and, after infection resolution, induce an autoinflammatory disease in some tissues, resulting in long COVID.
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Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes | Discovery Immunology | Oxford Academic

Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes | Discovery Immunology | Oxford Academic | Immunology | Scoop.it
Summary. There is an intriguing dichotomy in the function of cytokine interleukin-15—at low levels, it is required for the homeostasis of the immune system, yet
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Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid

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Mechanistic insights from inflammasome structures | Nature Reviews Immunology

Mechanistic insights from inflammasome structures | Nature Reviews Immunology | Immunology | Scoop.it
Inflammasomes are supramolecular complexes that form in the cytosol in response to pathogen-associated and damage-associated stimuli, as well as other danger signals that perturb cellular homoeostasis, resulting in host defence responses in the form of cytokine release and programmed cell death (pyroptosis). Inflammasome activity is closely associated with numerous human disorders, including rare genetic syndromes of autoinflammation, cardiovascular diseases, neurodegeneration and cancer. In recent years, a range of inflammasome components and their functions have been discovered, contributing to our knowledge of the overall machinery. Here, we review the latest advances in inflammasome biology from the perspective of structural and mechanistic studies. We focus on the most well-studied components of the canonical inflammasome — NAIP–NLRC4, NLRP3, NLRP1, CARD8 and caspase-1 — as well as caspase-4, caspase-5 and caspase-11 of the noncanonical inflammasome, and the inflammasome effectors GSDMD and NINJ1. These structural studies reveal important insights into how inflammasomes are assembled and regulated, and how they elicit the release of IL-1 family cytokines and induce membrane rupture in pyroptosis. This Review highlights new insights into the biology of inflammasomes from the perspective of structural and mechanistic studies, revealing how the supramolecular complexes that activate inflammatory caspases are assembled and regulated, to induce cytokine maturation and release, as well as pyroptotic cell death.
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Frontiers | Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues

Frontiers | Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues | Immunology | Scoop.it

Invariant natural killer T (iNKT) cells are a distinct subpopulation of innate-like T lymphocytes. They are characterized by semi-invariant T cel

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Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism | Nature Immunology

Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism | Nature Immunology | Immunology | Scoop.it
Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis and glucose tolerance. Here, we show that the VAT harbors two distinct Treg cell populations: prototypical serum stimulation 2-positive (ST2+) Treg cells that are enriched in males and a previously uncharacterized population of C–X–C motif chemokine receptor 3-positive (CXCR3+) Treg cells that are enriched in females. We show that the transcription factors GATA-binding protein 3 and peroxisome proliferator-activated receptor-γ, together with the cytokine interleukin-33, promote the differentiation of ST2+ VAT Treg cells but repress CXCR3+ Treg cells. Conversely, the differentiation of CXCR3+ Treg cells is mediated by the cytokine interferon-γ and the transcription factor T-bet, which also antagonize ST2+ Treg cells. Finally, we demonstrate that ST2+ Treg cells preserve glucose homeostasis, whereas CXCR3+ Treg cells restrain inflammation in lean VAT and prevent glucose intolerance under high-fat diet conditions. Overall, this study defines two molecularly and developmentally distinct VAT Treg cell types with unique context- and sex-specific functions. Here, the authors characterize two distinct Treg cell populations in the visceral adipose tissue of lean and high-fat diet-fed mice. ST2+ Treg cells are dominant in male mice and are transcriptionally driven by GATA3 and PPARγ, regulators that limit the differentiation of the more female-dominant population of CXCR3+ Treg cells that are T-bet dependent. Functional distinctions are also evident in glucose tolerance and adipose inflammation.
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Decoding the Thymus Gland: Unveiling Its Role in Immune Function and Myasthenia Gravis

Decoding the Thymus Gland: Unveiling Its Role in Immune Function and Myasthenia Gravis | Immunology | Scoop.it
Explore the thymus gland, a vital organ for immune function and T cell development. Learn about its connection to Myasthenia Gravis and recent advancements in treatment.
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TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation | Journal of Experimental Medicine

TCR signaling (signal 1) induces STAT3 phosphorylation through Lck/Fyn and, synergistically with cytokine signal (signal 3), induces optimal STAT3 phosphorylati
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Inborn errors of immunity illuminate mechanisms of human immunology and pave the road to precision medicine

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An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development | bioRxiv

An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development | bioRxiv | Immunology | Scoop.it
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Tissue-resident immune cells in health and disease

Tissue-resident immune cells in health and disease | Immunology | Scoop.it
Resident immune cells are present in all organs of the body. They span both myeloid and lymphoid cell lineages and include macrophages, mast cells, innate lymphoid cells, memory T and B cells and non…
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High-Dimensional Single-Cell Analysis of Natural Killer Cell Heterogeneity in Human Blood | Research Square

Natural killer (NK) cells are innate lymphoid cells (ILCs) that serve as a first line of defense against pathogens and tumors. Historically, their classification hinged on a limited array of surface protein markers. However, recent advancements in single-cell technologies, such as single-cel
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