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Scooped by
Gilbert C FAURE
September 9, 2011 4:36 AM
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The Food and Drug Administration has updated the boxed warning for all tumor necrosis factor-alpha inhibiting drugs to reflect the risk of infection from the bacteria Legionella and Liste (RT @robbwolf: Common #autoimmunity #drugs increase dangerous...
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Scooped by
Gilbert C FAURE
September 9, 2011 4:30 AM
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revolution antibody drugs to enter the brain Antibodies, from molecules to high therapeutic potential, typically cannot penetrate into the brain, but withscientists have developed a method to lift this blockade.
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Gilbert C FAURE
September 7, 2011 7:52 AM
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Scientists Develop Prototype Bactericidal Tuberculosis Vaccine that Elicits ...Genetic Engineering NewsA team at the Albert Einstein College of Medicine's Howard Hughes Medical Institute (HHMI) removed the bacterium's own esx-3 gene region, which...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:22 AM
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MEDICAL PPTX: Acquired Immunity,Free online medical powerpoint presentations for medical students and post graduates (Acquired Immunity: Defensive mechanisms include :
1) Innate immunity (Natural or Non specific)
2) Acquired...)...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:19 AM
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Immunobiology of Organ Transplantation (Price: $253.97, Pages: 672). Isbn: 0306483289, 9780306483288. Publisher: Springer. Publication date: 2004-06-24.
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Gilbert C FAURE
September 6, 2011 4:16 AM
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As splenectomy is a cornerstone treatment of ITP, the immune effect of RTX on this major secondary lymphoid organ were investigated in 18 spleens removed from ITP patients that were treated or not with RTX.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:12 AM
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Antiphospholipid antibodies are directed against phospholipid-protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Antiphospholipid antibody syndrome is a ...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:07 AM
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Previous research had suggested that mycobacteria need esx-3 to protect themselves from their hosts' innate immune systems, a first-line defense against pathogens that responds to invaders quickly, but non-specifically.
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Scooped by
Gilbert C FAURE
September 2, 2011 7:58 AM
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Los Angeles TimesBaruj Benacerraf dies at 90; Nobelist made key discoveries about immune systemLos Angeles TimesHe was injecting the animals with a specific foreign substance similar to an antigen, intending to provoke an immune response in them.
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Gilbert C FAURE
September 2, 2011 7:46 AM
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Two different projects to use viruses to fight cancerNext Big FutureWild type measles virus attaches to and infects lymphocytes using the receptor CD150 (signaling lymphocyte activation molecule, SLAM).
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Gilbert C FAURE
September 2, 2011 7:44 AM
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Pevion, CSL in therapeutic Candida vaccine agreementPharmaceutical Business ReviewPEV7 is a therapeutic vaccine based on a protein antigen, Sap2, a key virulence factor of vulvovaginal candidiasis, presented on the surface of virosomes.
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Gilbert C FAURE
August 31, 2011 5:03 AM
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Uploaded and shared in Youtube by: EinsteinCollegeofMed — Lecture 2 of 14: "Innate Immunity." Harris Goldstein, M.D., director, Einstein-Montefiore Center for AIDS Research, professor of pediatrics and microbiology & immunology and the Charles...
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Gilbert C FAURE
August 29, 2011 6:33 AM
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Washington University in St. Louis NewsRare immune cell is asset and liability in fighting infectionWashington University in St. Louis NewsResearchers at Washington University School of Medicine in St.
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Gilbert C FAURE
September 9, 2011 4:32 AM
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Perspective from The New England Journal of Medicine — HIV Vaccine Development — Improving on Natural Immunity (@NIAIDNews in @NEJM on #HIV #vaccines: Neu antibody induction "gold standard for vaccine-induced protection"
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Gilbert C FAURE
September 7, 2011 7:53 AM
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A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers have determined.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:24 AM
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Specific immune responses include immunoglobulin class switching and secretion by B lymphocytes/plasma cells and T lympho- cyte responses (including antigen recognition, clonal proliferation, and cytokine synthesis resulting in B cell ...
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Gilbert C FAURE
September 6, 2011 4:20 AM
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Amazon.com: Autoimmunity eBook: Andrzej Górski, Hubert Krotkiewski, Michal Zimecki: Kindle Store (Autoimmunity: This book presents an excellent review of the mechanisms underlying the phenomena of autoimmunit...)...
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Gilbert C FAURE
September 6, 2011 4:17 AM
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PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:13 AM
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The market for antibody-drug conjugates (ADC) has mostly been cornered Seattle Genetics and Immunogen. Each boasts a long list of corporate partners and extensive clinical pipeline fueled by collaborations.
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Gilbert C FAURE
September 6, 2011 4:08 AM
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Through five best selling editions, readers worldwide have appreciated this books in depth yet straightforward, richly illustrated approach to this complex subject. Now, sweeping updates incorporate the latest discoveries about innate immunity ...
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Scooped by
Gilbert C FAURE
September 5, 2011 4:54 AM
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Human Solid Tumors Contain High Endothelial Venules: Association with Lymphocyte Infiltration in Breast Cancer http://t.co/hFcOQIc...
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Scooped by
Gilbert C FAURE
September 2, 2011 7:49 AM
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Dr.(Md) Magdalena Trzcinska, "Kidney Transplantation - New Perspectives" InTech | 2011 | ISBN: 9789533076843 | 334 pages | PDF | 14,7 MB.
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Gilbert C FAURE
September 2, 2011 7:45 AM
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I summarized the complement slides. My notes may be in a little more detail than we have to know but it helped me make sense of all the nonsense letter and numbers. Hope it helps! –Ann Dobry. pdf icon Complement pg ...
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Gilbert C FAURE
September 1, 2011 4:02 AM
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Gene therapy treats immune diseaseLittlehampton GazetteIt is caused by a mutation in a protein required for the development and differentiation of two types of white blood cell that protect the body from infection, the T and B lymphocyte cells.
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Gilbert C FAURE
August 29, 2011 7:33 AM
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T Lymphocytes Subpopulations in Immunotoxicology T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central (T Lymphocytes Subpopulations in Immunotoxicology: T Lymphocytes Subpopulations in Immunotoxicology...
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A total of 80 cases of Legionella pneumonia have been reported to the FDA among patients receiving TNFα inhibitors, most often for rheumatoid arthritis.
Median age of affected patients was 56.
Median duration of TNFα inhibitor treatment was 10.4 months, but cases occurred as early as within one month and as late as 73 months after beginning treatment.
Many of the patients were also being treated with methotrexate and corticosteroids, and 14 deaths occurred.
Thus far there also have been 23 published cases of Legionella pneumonia in patients ages 26 to 71, with three deaths.
In four of these cases, the pneumonia was severe enough to warrant mechanical ventilation, and in five cases, intensive care treatment was needed.
One patient had a second episode of Legionella pneumonia after treatment with the TNFα inhibitor was restarted.
There are also now 26 published cases of serious infections -- meningitis, endophthalmitis, bacteremia, and sepsis -- with Listeria monocytogenes in patients receiving these drugs.
Seven patients died of the infection.
In addition, FDA cautioned that Listeria infections also occurred during clinical trials of the TNFα inhibitors.