Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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Mucosal Immunity

is the most recent part of Immunology!

It appeared less than 40 years ago, while systemic immunity exploded 60  years ago.

It is still a minor part of Immunology teaching and research, while the mucosal immune system is at the frontline of encounters with germs, antigens... in other words the environment.

major keywords

IgA http://www.scoop.it/t/mucosal-immunity?q=IgA

tolerance http://www.scoop.it/t/mucosal-immunity?q=tolerance

microbiome http://www.scoop.it/t/mucosal-immunity?q=microbiome

 

almost 2100 scoops, more than 1700 visitors, more than 3900 views

in july 2015

in december 2015, more than 4700 views by more than 2000 visitors of more than 2300 scoops

Gilbert C FAURE's insight:

This topic complements the more general Immunology topic.

 http://www.scoop.it/t/immunology

 

It includes also reproductive immunology

http://www.scoop.it/t/mucosal-immunity?q=reproductive

and  also covers lung immunology

http://www.scoop.it/t/mucosal-immunity?q=lung

 

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Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells | Mucosal Immunity | Scoop.it
Notch inhibition leads to loss of adult intestinal stem cells & secretory cell hyperplasia @Dev_journal 2012 https://t.co/fwSRWr2f8d
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Study advances understanding of colon cancer and colitis

Study advances understanding of colon cancer and colitis | Mucosal Immunity | Scoop.it
The transcription factor hepatocyte nuclear factor 4-alpha (HNF4-alpha) plays a key role in colon cancer and colitis. HNF4-alpha comes in two major isoforms, P1 and P2, but how these are distributed in the gut is not understood.
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Clinical & Translational Immunology - Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Clinical & Translational Immunology - Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases | Mucosal Immunity | Scoop.it
Clinical & Translational Immunology focuses on the general functioning of the immune system in its broadest sense, with a particular emphasis on its cell biology. Areas that are covered include but are not limited to: Cellular immunology, Innate and adaptive immunity, Immune responses to pathogens,Tumour immunology,Immunopathology, Immunotherapy, Immunogenetics, Immunological studies in humans and model organisms (including mouse, rat, Drosophila etc)
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Siblings of patients with Crohns disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities

Objective To determine the existence of mucosal dysbiosis in siblings of patients with Crohn's disease (CD) using 454 pyrosequencing and to comprehensively characterise and determine the influence of genotypical and phenotypical factors, on that...
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches | Mucosal Immunity | Scoop.it
[Research Article] IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches https://t.co/fU6dmdgzWB
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America's New Plan to Zoom In on the Planet's Microbes

America's New Plan to Zoom In on the Planet's Microbes | Mucosal Immunity | Scoop.it
Half a billion dollars are being pledged to study the microbes in humans, crops, soils, oceans, and more.
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches | Mucosal Immunity | Scoop.it
Gilbert C FAURE's insight:
The subepithelial dome (SED) area of intestinal Peyer’s patches is a major hub for serial interactions between B cells and DCs that play a critical role in the induction of secretory IgA. Reboldi et al. report in the May 13 issue of Science that pre-germinal center B cells require the CCR6 chemokine receptor to follow a CCL20 gradient and efficiently enter the SED “workspace”. Once they reach the SED, CCR6+ B cells undergo a series of intimate interactions with αvβ8 integrin-expressing DCs. The DC αvβ8 converts latent TGF-β to active TGF-β, which is the key cytokine driving IgA class switching by the B cells. http://science.sciencemag.org/content/352/6287/aaf4822.full
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Subgingival bacterial clusters and serum antibody response as markers of extent and severity of periodontitis in adult Chinese

Subgingival bacterial clusters and serum antibody response as markers of extent and severity of periodontitis in adult Chinese | Mucosal Immunity | Scoop.it
This study evaluated the associations between clinical, microbiological, and antibody activity manifestations of periodontitis in 123 adult rural Chinese subjects with no dental intervention.
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Breastfeeding: Why WHO wants to restrict marketing of breast milk substitutes

Breastfeeding: Why WHO wants to restrict marketing of breast milk substitutes | Mucosal Immunity | Scoop.it
Report shows many countries yet to ban aggressive marketing of breast milk substitutes.
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Some Crohn’s genes make cells deaf to messages from good gut bacteria

Some Crohn’s genes make cells deaf to messages from good gut bacteria | Mucosal Immunity | Scoop.it
Genes linked to Crohn’s disease, an inflammatory bowel disease, might make people’s immune cells miss out on helpful messages sent by friendly gut bacteria.
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A diagnostic method for herpes simplex keratitis by simultaneous measurement of viral DNA and virus-specific secretory IgA in tears: an evaluation. - PubMed - NCBI

A diagnostic method for herpes simplex keratitis by simultaneous measurement of viral DNA and virus-specific secretory IgA in tears: an evaluation. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Jpn J Ophthalmol. 2016 Apr 28. [Epub ahead of print]
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Determination of chloramphenicol in milk by ten chemiluminescent immunoassays: influence of assay format applied

Determination of chloramphenicol in milk by ten chemiluminescent immunoassays: influence of assay format applied | Mucosal Immunity | Scoop.it
Anal. Methods, 2016, Advance Article
DOI: 10.1039/C6AY00792A, PaperXiaoqi Tao, Song Zhou, Xiameng Yuan, Hongjun Li
Development of 10 chemiluminescent immunoassays for the detection of CAP for a comparison study.
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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Bruno Lamas, Mathias L Richard, Valentin Leducq, Hang-Phuong Pham, Marie-Laure Michel, Gregory Da Costa, Chantal Bridonneau, Sarah Jegou, Thomas W Hoffmann, Jane M Natividad, Loic Brot, Soraya Taleb, Aurélie Couturier-Maillard, Isabelle Nion-Larmurier, Fatiha Merabtene, Philippe Seksik, Anne Bourrier, Jacques Cosnes, Bernhard Ryffel, Laurent Beaugerie, Jean-Marie Launay, Philippe Langella, Ramnik J Xavier & Harry Sokol
Gilbert C FAURE's insight:
Nature Medicine (2016) doi:10.1038/nm.4102 Received 19 December 2015 Accepted 08 April 2016 Published online 09 May 2016

Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene for inflammatory bowel disease (IBD) that functions in the immune response against microorganisms. CARD9 promotes recovery from colitis by promoting interleukin (IL)-22 production, and Card9−/− mice are more susceptible to colitis. The microbiota is altered in Card9−/− mice, and transfer of the microbiota from Card9−/− to wild-type, germ-free recipients increases their susceptibility to colitis. The microbiota from Card9−/− mice fails to metabolize tryptophan into metabolites that act as aryl hydrocarbon receptor (AHR) ligands. Intestinal inflammation is attenuated after inoculation of mice with three Lactobacillus strains capable of metabolizing tryptophan or by treatment with an AHR agonist. Reduced production of AHR ligands is also observed in the microbiota from individuals with IBD, particularly in those with CARD9 risk alleles associated with IBD. Our findings reveal that host genes affect the composition and function of the gut microbiota, altering the production of microbial metabolites and intestinal inflammation.
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The private fertility treatments that are ‘widely discredited’, ‘hotly debated’ and sound ‘like a good idea’

The private fertility treatments that are ‘widely discredited’, ‘hotly debated’ and sound ‘like a good idea’ | Mucosal Immunity | Scoop.it
The Human Fertilisation & Embryology Authority and several leading experts have warned that some treatments offered by private fertility clinics do not have a sound evidence base. Here are some of the treatments that have been questioned...
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Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum. - PubMed - NCBI

Gut. 2016 Feb;65(2):256-70. doi: 10.1136/gutjnl-2014-307916. Epub 2015 Feb 9. Comparative Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Mucosal Immunology - CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation

Mucosal Immunology - CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation | Mucosal Immunity | Scoop.it
Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
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Immunology: You Remind Me of a Microbe I Know

Publication date: 9 May 2016 Source:Current Biology, Volume 26, Issue 9 Author(s): Ray Soto, June Round The majority of bacteria found within the gut are commensals, although it is unclear whether these organisms can elicit systemic...
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Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets: Immunity

Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets: Immunity | Mucosal Immunity | Scoop.it
RT @JurisGrasis: An integrated systems-wide view of the immune system using CyTOF. Truly really cool work!
https://t.co/2B3AFOykm0
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Inflammasomes in the Urinary Tract: A disease based review. - PubMed - NCBI

Inflammasomes in the Urinary Tract: A disease based review. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Am J Physiol Renal Physiol. 2016 May 11:ajprenal.00607.2016. doi: 10.1152/ajprenal.00607.2015. [Epub ahead of print]
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There's 10 trillion microbes on you; the White House wants to figure them out

There's 10 trillion microbes on you; the White House wants to figure them out | Mucosal Immunity | Scoop.it
White House initiative will advance research into using bacteria to fight disease, pollution
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Breast Milk Primes Gut for Microbes | The Scientist Magazine®

Breast Milk Primes Gut for Microbes | The Scientist Magazine® | Mucosal Immunity | Scoop.it
Maternal antibodies engender a receptive gut environment for beneficial bacteria in newborn mice.
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Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial responses

Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial responses | Mucosal Immunity | Scoop.it
Secretory immunoglobulin A (SIgA) antibodies play an important role in protecting the mucosal surfaces against pathogens and maintaining homeostasis with the commensal microbiota.
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Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life: Cell

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life: Cell | Mucosal Immunity | Scoop.it
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of mice and men?
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