Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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Scooped by Gilbert Faure au nom de l'ASSIM
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Mucosal Immunity

is the most recent part of Immunology!

It appeared less than 40 years ago, while systemic immunity exploded 60  years ago.

It is still a minor part of Immunology teaching and research, while the mucosal immune system is at the frontline of encounters with germs, antigens... in other words the environment.

Gilbert Faure au nom de l'ASSIM's insight:

This topic complements the more general Immunology topic.

 

It includes also reproductive immunology and  covers lung immunology

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The mucosal inflammatory response to non-typhoidal Salmonella in the intestine ... - Nature.com

The mucosal inflammatory response to non-typhoidal Salmonella in the intestine ...
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Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development - Nature.com

Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development
Nature.com
In this issue of Nature Immunology, Schneider et al.
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Natural gut viruses join bacterial cousins in maintaining health and fighting infections

Natural gut viruses join bacterial cousins in maintaining health and fighting infections | Mucosal Immunity | Scoop.it
Microbiologists say they have what may be the first strong evidence that the natural presence of viruses in the gut — or what they call the ‘virome’ — plays a health-maintenance and infection-fighting role similar to that of the intestinal bacteria that dwell there and make up the “microbiome.”
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Mononuclear phagocytes of the intestine, the skin, and the lung - Scott - 2014 - Immunological Reviews - Wiley Online Library

Mononuclear phagocytes of the intestine, the skin, and the lung Scott 2014 Immunological Reviews Wiley Online http://t.co/2I1JgU0NCi
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Mucosal immunology Sick of the flu - Nature.com

Mucosal immunology Sick of the flu
Nature.com
Respiratory infection with influenza virus is often associated with gastroenteritis-like symptoms such as vomiting and diarrhoea.
Gilbert Faure au nom de l'ASSIM's insight:

This study provides a mechanism for such symptoms by showing that CD4 T cells from the respiratory mucosa are recruited to the intestinal mucosa during influenza virus infection, where they induce dysbiosis that stimulates T helper 17 (TH17) cell-mediated inte…

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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion - Nature.com

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion Nature.com T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell...
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Genocea Kicks Off Phase 2 Trial For Pneumococcus Vaccine - BioResearch Online (press release)

Genocea Kicks Off Phase 2 Trial For Pneumococcus Vaccine - BioResearch Online (press release) | Mucosal Immunity | Scoop.it
Genocea Kicks Off Phase 2 Trial For Pneumococcus Vaccine
BioResearch Online (press release)
TH17 is a rare type of cell that provides immunity at epithelial and mucosal surfaces.
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How to Live with the Enemy: Understanding Tolerance to Parasites

How to Live with the Enemy: Understanding Tolerance to Parasites | Mucosal Immunity | Scoop.it
by Lars Råberg
How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance—the ability to prevent infection or limit parasite replication.
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Exposure to cigarette smoke impacts myeloid-derived regulatory cell function ... - Nature.com

Exposure to cigarette smoke impacts myeloid-derived regulatory cell function ...
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Breast milk stem cells may be incorporated into baby - health - 03 November 2014 - New Scientist

Breast milk stem cells may be incorporated into baby - health - 03 November 2014 - New Scientist | Mucosal Immunity | Scoop.it
Stem cells in the breast milk of mice develop into a range of different tissues in the offspring, including the brain, liver and kidneys. The same may also
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Design Aspects of a Case-Control Clinical Investigation of the Effect of HIV on Oral and Gastrointestinal Soluble Innate Factors and Microbes

Design Aspects of a Case-Control Clinical Investigation of the Effect of HIV on Oral and Gastrointestinal Soluble Innate Factors and Microbes | Mucosal Immunity | Scoop.it
by Joan A. Phelan, William R. Abrams, Robert G. Norman, Yihong Li, Maura Laverty, Patricia M. Corby, Jason Nembhard, Dinah Neri, Cheryl A. Barber, Judith A. Aberg, Gene S. Fisch, Michael A.
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GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment

GPR18 is required for a normal CD8{alpha}{alpha} intestinal intraepithelial lymphocyte compartment http://t.co/pWrG5jdWMS #JEMTCB
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Targeting α 4 β 7 integrin reduces mucosal transmission of simian ... - Nature.com

Targeting α 4 β 7 integrin reduces mucosal transmission of simian ...
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Nasal immunity is an ancient adaptation of the mucosal immune system of vertebrates

Nasal immunity is an ancient adaptation of the mucosal immune system of vertebrates | Mucosal Immunity | Scoop.it
(Phys.org) —Researchers at the University of New Mexico recently discovered an olfactory immune system in fish previously thought to be associated with terrestrial vertebrates only.
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Société Francaise d'Immunologie's comment, November 27, 9:30 AM
NALT in trouts
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The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells - Scanlon - Clinical & Experimental Allergy - Wiley Online Library

The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells - Scanlon - Clinical & Experimental Allergy - Wiley Online Library | Mucosal Immunity | Scoop.it
The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells: ... http://t.co/94LRN5TAm6
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Gilbert Faure au nom de l'ASSIM's curator insight, November 26, 3:48 AM
Abstract

Although type-2 immune responses evolved primarily to defend against extracellular helminths, in part through the co-opting of tissue repair and remodelling mechanisms, it is often inappropriately directed towards relatively innocuous allergens resulting in conditions including asthma, allergic rhinitis, food allergy, and atopic dermatitis. The recent discovery of group 2 innate lymphoid cells (ILC2) has increased our understanding of the initiation of these responses and the roles played by CD4+ T helper (TH) 2 cells in their modulation. This review focuses on the important messenger role of ILC2 in translating epithelial-derived alarmins into downstream adaptive type-2 responses via dendritic cells and T cells, with special emphasis on their roles in allergic disease.

  
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Up to 80 million bacteria sealed with a kiss

Up to 80 million bacteria sealed with a kiss | Mucosal Immunity | Scoop.it
As many as 80 million bacteria are transferred during a 10 second kiss, according to new research. The study also found that partners who kiss each other at least nine times a day share similar communities of oral bacteria.
Gilbert Faure au nom de l'ASSIM's insight:

quantifying promiscuity

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Frontiers | Multiple receptor-ligand interactions direct tissue resident gamma delta T cell activation | T Cell Biology

Gamma delta T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first li...
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The Expression of Serum Antibodies Against Gonadotropin-releasing Horm

The Expression of Serum Antibodies Against Gonadotropin-releasing Horm | Mucosal Immunity | Scoop.it
The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus...
Gilbert Faure au nom de l'ASSIM's insight:

Abstract

Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Healthy blood donors served as controls. Medical records were scrutinized. Our conclusion was that IgM antibodies against GnRH1, progonadoliberin-2, and/or GnRH receptors were more prevalent in patients with functional gastrointestinal disorders, gastrointestinal dysmotility, and/or diabetes mellitus, whereas IgG antibodies against these peptides, and LH- and LH receptor antibodies, were expressed in the same magnitude as in controls.

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India's Potty Problem

India's Potty Problem | Mucosal Immunity | Scoop.it

Which statement is true? 

 

A. 60% of all households without toilets in the world are in India.
B. India’s Muslims are less affected by the sanitation problem than Hindus.
C. India’s lack of toilets is worse than China’s.
D. Lack of toilets in India puts women at especially high risk.


Via Seth Dixon
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Seth Dixon's curator insight, November 20, 2:42 PM

This is the ultimate trick question because unfortunately, ALL of these statements are true.  India is a country of tremendous economic growth, but also filled with squalor; there are more cellphones than toilets in India.  The lack of adequate sanitation and toilets is serious enough that that Prime Minister Narendra Modi has made building toilets a national priority.  Comics are using their platform to bring this issue of uneven development to light.    


Tagsdevelopment, poverty, India.

Linda Lee King's curator insight, November 23, 2:55 PM

Call Matt Damion! 

Matt Davidson's curator insight, November 25, 5:55 PM

a nice article for year 7 (water) and 10 (global wellbeing)

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Understanding PEDV Diagnostic Tests and Tools - National Hog Farmer

Understanding PEDV Diagnostic Tests and Tools - National Hog Farmer | Mucosal Immunity | Scoop.it
National Hog Farmer
Understanding PEDV Diagnostic Tests and Tools
National Hog Farmer
Similarly, the absence of antibody in serum does not mean there is no immunity, particularly for mucosal pathogens such as PEDV.
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The Role of miRNAs in Alcohol-Induced Endotoxemia, Dysfunction of Mucosal Immunity, and Gut Leakiness. - Addiction - NewsLocker

The Role of miRNAs in Alcohol-Induced Endotoxemia, Dysfunction of Mucosal Immunity, and Gut Leakiness. - Addiction - NewsLocker | Mucosal Immunity | Scoop.it
Authors: Tang Y, Forsyth CB, Keshavarzian A
PMID: 25257284 [PubMed - in process] (Source: Alcoholism, Clinical and Experimental Research) (The Role of miRNAs in Alcohol-Induced Endotoxemia, Dysfunction of Mucosal Immunity, and Gut Leakiness.
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Grants awarded for pneumococcal research - Healio

Grants awarded for pneumococcal research - Healio | Mucosal Immunity | Scoop.it
Infectious Disease | Two grants totaling more than $6 million were awarded to an institution in the United Kingdom for pneumococcal carriage research, according to a press release.
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Distinctive Colonic Mucosal Cytokine Signature in New-Onset,... : Journal of Pediatric Gastroenterology and Nutrition

Distinctive Colonic Mucosal Cytokine Signature in New-Onset,... : Journal of Pediatric Gastroenterology and Nutrition | Mucosal Immunity | Scoop.it
Objective: The aim of the study was to compare the colonic mucosal immune response in children with new, untreated Crohn disease (CD-New), CD in remission (CD-Remission), and unaffected children (CTRL [controls]).
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IL-17A and Serum Amyloid A Are Elevated in a Cigarette Smoke Cessation Model Associated with the Persistence of Pigmented Macrophages, Neutrophils and Activated NK Cells

IL-17A and Serum Amyloid A Are Elevated in a Cigarette Smoke Cessation Model Associated with the Persistence of Pigmented Macrophages, Neutrophils and Activated NK Cells | Mucosal Immunity | Scoop.it
by Michelle J. Hansen, Sheau Pyng J. Chan, Shenna Y. Langenbach, Lovisa F. Dousha, Jessica E. Jones, Selcuk Yatmaz, Huei Jiunn Seow, Ross Vlahos, Gary P.
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Immunological basis in the pathogenesis and treatment of bladder cancer, Expert Review of Clinical Immunology, Informa Healthcare

Immunological basis in the pathogenesis and treatment of bladder cancer, Expert Review of Clinical Immunology, Informa Healthcare | Mucosal Immunity | Scoop.it
Immunological basis in the pathogenesis and treatment of bladder cancer: Expert Review of Clinical Immunology,... http://t.co/XjCpH8DGDO
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