Hésitations Vaccinales: Observatoire HESIVAXs

Preparing the European Commission for the next health crisis : a Medical Countermeasures Strategy

 Strengthening detection and identification of health threats requiring medical countermeasures

Key Actions:
The Commission will:
• Operationalise and expand, in collaboration with the European Centre for Disease Prevention and Control (ECDC), an EU #Wastewater Sentinel System and a Global #Wastewater Sentinel System [2026]
• Consider expanding DURABLE network geographical coverage to partners across other regions of the globe [2027]

The Commission will, in cooperation with Member States:
• Develop medical countermeasures preparedness roadmaps for specific health emergencies scenarios [2026]
• Establish an EU List of Medical Countermeasures for priority threats [2026]

#HERA #GLOWACON

Full document: https://lnkd.in/e_ukuZF4
 

Review of PEG immunogenicity and potential solutions. After literature research and review in the past two decades, it was found that the many clinical trial failures (BIND-014, RB006 fell in phase II) of PEG modified delivery system or PEGylated drug were related to the high expression of anti-PEG IgM and IgG. After #mRNA-LNP vaccination in billions of people, the level of anti-PEG antibodies in the population may have significantly increased, which brings potential risks for PEG-modified drug development and clinical safety. There are ways to reduce PEG immunogenicity, such designing different PEG (branched structure, terminal group) and using alternative polymers.
 

The global childhood vaccination rate in 2024 held steady with 85% of infants and children receiving three doses of the vaccine for diphtheria, pertussis and tetanus (DPT), used as a global benchmark for immunization rates overall. However large, continued gaps in coverage are propelling outbreaks, including the highest rate of measles cases since 2019.

“In 2024 85% of infants around the world, about 109 million infants received three doses of the core vaccine, the DTP-containing vaccine that is the global marker for routine childhood immunization coverage,” said WHO’s Katherine O’Brien, head of Immunizations, Vaccines and Biologicals. She spoke to reporters just ahead of Tuesday’s publication of 2024 data on global vaccination rates by WHO and UNICEF, the UN children’s organization. 

https://lnkd.in/gTKJr3u6

Children's Health Defense: like a SuperPAC for RFK Jr ?
Questions of how money was directed…

I am not sure why this post was removed. The time we spend generating research and responding to antivaxxers is time which could be spent in other areas of research. I do not see a repeal process so I am reposting for reconsideration.

Ever wondered to what Sec Kennedy is referring when he talks about a congressional report on conflict of interest a
among ACIP members? Well, someone dug up the report and wrote about it. And the article is worth a read. This was not an official committee report. It was a partisan report written almost 25 years ago….


https://lnkd.in/e4VMWA3g

"* The Amish community, often cited by anti-vaccine proponents, has experienced outbreaks of vaccine-preventable diseases like polio due to low vaccination rates.
* Contrary to some claims, Amish children do suffer from autism, highlighting the lack of evidence linking vaccines to autism.
* RFK Jr.'s focus should be on proven public health measures, not conspiracy theories or misleading reports."
https://lnkd.in/gaKgTVZc

In an article published by WELT, it was revealed that the Paul Ehrlich Institute (PEI) has notified the European Medicines Agency of at least 3,506 suspected serious COVID-19 vaccine side effects in Germany. This data came from a smartphone app developed by the German Health Ministry, used by over 739,000 vaccinated individuals. If accurate, the app data suggests a 0.5% rate of serious adverse reactions (or 1 in every 210 participants), which is significantly higher than previous official estimates by Health Minister Karl Lauterbach (0.01%) and the Robert Koch Institute (0.00027%).

https://lnkd.in/gKZMZA7r

Dr. Patrick Soon-Shiong is a surgeon who made billions inventing cancer drugs. He discusses here with Tucker Carlson the global epidemic of aggressive cancers and the importance of the immune system in controlling cancer.

Great introduction to Vaxine's cancer vaccine trial which is moving forward strongly with over 60 patients now recruited. Great safety data and look forward to analysing the data in due course.

https://lnkd.in/gMBW9qq4

In 2024, Gavi, the Vaccine Alliance helped lower-income countries to protect more than 72 million children against a range of diseases, more than any previous year on record. More girls in lower-income countries were protected with the HPV vaccine in 2024 than the previous decade combined, and coverage rates improved across all the vaccines Gavi supports.

And yet population growth, fragility and conflict present major hurdles to achieving equity, leaving the most vulnerable children and communities at risk. Continued commitment from governments and partners will be critical to saving lives and protecting the world from infectious disease threats: https://bit.ly/4lYUlI6

About Vaccines-2026 It is our pleasure to invite all scientists, academicians, young researchers, business delegates and students from all over the world to attend the 4th International Conference on Vaccines Research and Development will be held in Paris, France during April 13-15, 2026.The...

"Vaccines work, actually. But that’s not all. Depending on the specific vaccine we’re talking about, that jab might also prevent cancer, heal herpes lesions, help you keep most of your marbles, prevent your kids from dying in early childhood, improve your skin and so much more. These surprising bonuses that can come with vaccination, called beneficial non-specific effects, are common, but not widely understood. In fact, no one knew about them until relatively recently — and when researchers first discovered all this, no one believed them at first.

Before we look at that, let’s consider just how good these non-specific effects can get. Well, the Shingrix (or Zoster vaccine recombinant) vaccine, which is recommended for all adults in later middle age, prevents up to 95 percent of shingles cases. But that’s not all. It also reduces your risk of dementia, with a 20 percent relative risk reduction over seven years. (Shingles is the long-term result of a childhood chicken pox infection, which can hide inside you for decades before re-emerging in notoriously painful fashion.)"

https://lnkd.in/gGViAG2z

This report describes 2024–2025 COVID-19 vaccine effectiveness against COVID-19-associated emergency department or urgent care encounters.

🔍 𝐕𝐚𝐜𝐜𝐢𝐧𝐚𝐭𝐢𝐨𝐧 𝐝𝐞𝐬 𝐜𝐡𝐢𝐞𝐧𝐬 𝐞𝐭 𝐝𝐞𝐬 𝐜𝐡𝐚𝐭𝐬 𝐞𝐧 𝐅𝐫𝐚𝐧𝐜𝐞 : où en est-on ?

L’Observatoire national de la vaccination des animaux, lancé par le SIMV (Syndicat de l’industrie du médicament et diagnostic vétérinaires), vient de livrer une synthèse précieuse sur la couverture vaccinale des carnivores domestiques entre 2017 et 2024.

🐶 𝐂𝐡𝐞𝐳 𝐥𝐞 𝐜𝐡𝐢𝐞𝐧 :
• Une stagnation globale des taux.
• Une bonne couverture pour les valences essentielles (Carré, Rubarth, parvovirose).
• Une vigilance constante sur la leptospirose, maladie bactérienne grave et zoonotique. Aujourd’hui, seuls 6️⃣ chiens sur 1️⃣0️⃣ sont correctement vaccinés contre cette maladie.
Les taux de vaccination contre la rage et contre la toux de chenil sont de 13% et 7% respectivement en 2024.

🐱 𝐂𝐡𝐞𝐳 𝐥𝐞 𝐜𝐡𝐚𝐭 :
• Une évolution insuffisante même si en progression (25% à 30% des félins sont vaccinés contre les valences essentielles - Typhus, herpèsvirus et calicivirus).
• Une faible couverture pour la leucose avec 18% de vaccination en 2024.
• La vaccination chlamydiose se justifiant dans les élevages ou lors de clinique avérée.

💡Deux points clés à retenir :

✅ la baisse apparente de certains rappels n’est pas une chute de la vaccination mais une adaptation raisonnée des protocoles selon les recommandations internationales
✅ la 4ème injection pour les maladies virales est désormais recommandée à 6 mois (recommandation de la WSAVA (World Small Animal Veterinary Association))

📣 Sensibiliser les propriétaires et valoriser les pratiques vétérinaires en proposant un protocole de vaccination adapté au mode de vie de l’animal est un levier essentiel pour renforcer la prévention et la santé animale.

#Vaccination #Veterinaire #Chiens #Chats #OneHealth #MedecinePreventive #ObservatoireVaccination

Hearing a lot about the Vaccine Injury Compensation Program and not sure why you should care? Well, you should and ProPublica explains why.

https://lnkd.in/eyZCMNcD

"RFK Jr alleged that there was a study that was manipulated because it showed “1135% INCREASE in autism risk from hepatitis B,” and referred to the “Verstraeten study.”

Not only is he wrong about that, but he’s really confusing his studies and the conspiracy theories around them. The Verstraeten study was not about hepatitis B. Note that it’s about thimerosal-containing vaccines generally, and finds no link to autism, anti-vaccine conspiracy theories aside.

My best guess is that he’s confusing this old conspiracy theory with a study from the early 2000s that anti-vaccine activists like to misuse. And here is a critical analysis of this study.

But at any rate, he got even the basics of his claims wrong. Reminder, as our friend Dr. Iannelli told us, there is abundant evidence that hepatitis B vaccines are safe and effective." | 17 comments on LinkedIn

The Lancet Commission on One Health is live ⚡

Over the past few years, One Health—highlighting the fundamental links between human, animal, and environmental health—has grown in visibility and importance.

Now, there is a landmark Pandemic Agreement embracing a One Health approach.

But what does One Health mean for antimicrobial resistance, non-communicable diseases, food systems, and our most pressing health and sustainability challenges?

And what needs to happen to ensure a One Health approach fit for the future?

🗨️ “The Lancet One Health Commission provides a cutting-edge appraisal of where One Health has come from, where it is now, and what a viable future should be”, say authors of the new report.

Discover their 10 expert recommendations in the comments section.

Figure: A map of the socioecological system | 21 comments on LinkedIn

🔴 𝗨𝗻𝗲 𝘃𝗮𝗴𝘂𝗲 𝗺𝗮𝘀𝘀𝗶𝘃𝗲 𝗱𝗲 𝗱𝗲́𝘀𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗼𝗻 sur la vaccination COVID pendant la grossesse déferle actuellement sur les réseaux, 𝗮𝗹𝗶𝗺𝗲𝗻𝘁𝗲́𝗲 𝗽𝗮𝗿 𝗹𝗮 𝗱𝗲́𝗰𝗶𝘀𝗶𝗼𝗻 𝗱𝘂 𝗖𝗗𝗖 de 𝗿𝗲𝘁𝗶𝗿𝗲𝗿 𝗹𝗲𝘀 𝘃𝗮𝗰𝗰𝗶𝗻𝘀 𝗖𝗢𝗩𝗜𝗗-𝟭𝟵 𝗱𝘂 𝗰𝗮𝗹𝗲𝗻𝗱𝗿𝗶𝗲𝗿 𝘃𝗮𝗰𝗰𝗶𝗻𝗮𝗹 𝗿𝗲𝗰𝗼𝗺𝗺𝗮𝗻𝗱𝗲́ 𝗽𝗼𝘂𝗿 𝗹𝗲𝘀 𝗳𝗲𝗺𝗺𝗲𝘀 𝗲𝗻𝗰𝗲𝗶𝗻𝘁𝗲𝘀.

📉 𝗖𝗲𝘁𝘁𝗲 𝗱𝗲́𝗰𝗶𝘀𝗶𝗼𝗻, saluée par le nouveau ministre américain de la Santé 𝗥𝗼𝗯𝗲𝗿𝘁 𝗙. 𝗞𝗲𝗻𝗻𝗲𝗱𝘆 𝗝𝗿., connu pour ses positions antivaccins, 𝘀𝗲̀𝗺𝗲 𝗹𝗮 𝗰𝗼𝗻𝗳𝘂𝘀𝗶𝗼𝗻 et alimente une défiance dangereuse envers la vaccination, en particulier chez les femmes enceintes.

📢 En réaction, 𝗽𝗹𝘂𝘀 𝗱𝗲 𝟯𝟬 𝘀𝗼𝗰𝗶𝗲́𝘁𝗲́𝘀 𝘀𝗮𝘃𝗮𝗻𝘁𝗲𝘀 𝗲𝘁 𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻𝘀 𝗽𝗿𝗼𝗳𝗲𝘀𝘀𝗶𝗼𝗻𝗻𝗲𝗹𝗹𝗲𝘀 𝗮𝗺𝗲́𝗿𝗶𝗰𝗮𝗶𝗻𝗲𝘀 — parmi lesquelles l’American College of Obstetricians and Gynecologists (ACOG), l’American Academy of Pediatrics, l’American Medical Association, ou encore la Society for Maternal-Fetal Medicine — ont publié le 11 juin 2025 une 𝗹𝗲𝘁𝘁𝗿𝗲 𝗼𝘂𝘃𝗲𝗿𝘁𝗲 𝗮𝗽𝗽𝗲𝗹𝗮𝗻𝘁 𝘀𝗮𝗻𝘀 𝗲́𝗾𝘂𝗶𝘃𝗼𝗾𝘂𝗲 𝗮̀ 𝘃𝗮𝗰𝗰𝗶𝗻𝗲𝗿 𝗹𝗲𝘀 𝗳𝗲𝗺𝗺𝗲𝘀 𝗲𝗻𝗰𝗲𝗶𝗻𝘁𝗲𝘀 𝗰𝗼𝗻𝘁𝗿𝗲 𝗹𝗮 𝗖𝗢𝗩𝗜𝗗-𝟭𝟵 :
👉 https://lnkd.in/eBUvEm6S

🧬 Leur message est fondé sur des données solides : 𝗹𝗮 𝘃𝗮𝗰𝗰𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗽𝗲𝗻𝗱𝗮𝗻𝘁 𝗹𝗮 𝗴𝗿𝗼𝘀𝘀𝗲𝘀𝘀𝗲 𝗽𝗿𝗼𝘁𝗲̀𝗴𝗲 𝗹𝗮 𝗺𝗲̀𝗿𝗲 𝗰𝗼𝗻𝘁𝗿𝗲 𝗹𝗲𝘀 𝗳𝗼𝗿𝗺𝗲𝘀 𝗴𝗿𝗮𝘃𝗲𝘀 𝗲𝘁 𝗽𝗿𝗼𝘁𝗲̀𝗴𝗲 𝗮𝘂𝘀𝘀𝗶 𝗹𝗲 𝗻𝗼𝘂𝗿𝗿𝗶𝘀𝘀𝗼𝗻 dans ses premiers mois de vie.

🛑 Face aux discours pseudo-scientifiques et aux décisions politiques idéologiques, il est essentiel de rappeler que 𝗹𝗲𝘀 𝗽𝗿𝗼𝗳𝗲𝘀𝘀𝗶𝗼𝗻𝗻𝗲𝗹𝘀 𝗱𝗲 𝘀𝗮𝗻𝘁𝗲́ 𝗲𝘁 𝗹𝗲𝘀 𝘀𝗼𝗰𝗶𝗲́𝘁𝗲́𝘀 𝘀𝗮𝘃𝗮𝗻𝘁𝗲𝘀 𝗽𝗮𝗿𝗹𝗲𝗻𝘁 𝗱’𝘂𝗻𝗲 𝘀𝗲𝘂𝗹𝗲 𝘃𝗼𝗶𝘅 : 𝗹𝗮 𝘃𝗮𝗰𝗰𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗽𝗿𝗼𝘁𝗲̀𝗴𝗲.
𝗠𝗼𝗯𝗶𝗹𝗶𝘀𝗼𝗻𝘀-𝗻𝗼𝘂𝘀 pour défendre une information médicale fondée sur la science.

Avec nos collègues médecins, universitaires, enseignants, soignants, chercheurs, journalistes de santé, sociétés savantes, collèges d'enseignants, autorités responsables , responsables politiques, engageons-nous contre la désinformation qui menace la santé publique.

Yannick NEUDER, Lise ALTER, Dinh-Phong Nguyen, Fabrice Moreau, Catherine Vautrin, Jérôme Marchand-Arvier, Sebastien Delescluse, PHILIPPE BAPTISTE, Pauline Pannier, Société Francaise de Pharmacologie et de Thérapeutique, CNGOF, SYNGOF - Syndicat des Gynécologues et Obstétriciens de France; CNSF - Collège National des Sages-Femmes de France | 34 comments on LinkedIn

Illustration du biais de surconfiance par une étude dans Science Advances

Les personnes les plus opposées au consensus scientifique sont souvent celles qui en savent le moins objectivement… mais pensent en savoir le plus

📊 Résultats clés
1. Plus l’opposition est forte, plus la connaissance réelle est faible.
Mais plus la confiance en sa propre connaissance est élevée.

→ Cela crée un écart de confiance : les plus opposés sont aussi les plus sûrs d’eux, malgré leur ignorance

2. Ce phénomène est généralisé, sauf pour certains sujets très politisés comme le changement climatique, où l’idéologie joue un rôle plus fort

3. Même lorsqu’on incite financièrement les participants à évaluer honnêtement leur connaissance, les plus opposés surestiment encore leurs capacités

4. Ce biais s’applique aussi au COVID-19 : les opposants aux vaccins ou aux mesures sanitaires pensent mieux comprendre le sujet que les scientifiques, tout en ayant un score de connaissance plus bas

Source : Nicholas Light et al. ,Knowledge overconfidence is associated with anti-consensus views on controversial scientific issues.Sci. Adv.8,eabo0038(2022).DOI:10.1126/sciadv.abo0038

#ThibSciences

When most people think of vaccines, they picture a needle. But nasal vaccines have been around since the 17th century. Despite some obvious advantages, only a few have been developed for humans.

While human medical sector is still only exploring the potential of nasal vaccines, veterinarians have embraced this approach for years. Attaining herd immunity is one of the main considerations in disease control for vets. Herd immunity depends on the use of efficacious vaccines of course, but also good vaccination coverage of the population (whether human or animal). Therefore, an important aspect of vaccine development and design for veterinary use is the ease of vaccine delivery. The veterinary world offers impressive examples of what's possible with nasal delivery.

These include vaccines against rinderpest, foot and mouth disease, bovine enteric coronavirus, haemorrhagic septicaemia in cattle and buffaloes, Newcastle disease, infectious bronchitis in chickens or swine flu in pigs.

#AnimalResearch #AnimalTesting #Vaccine #NasalVaccine #immunity #herdImmunity

More information in our latest news article dedicated to nasal vaccines : https://lnkd.in/e-Gm3my5