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Vaccine Breakthrough Infections with SARS-CoV-2 Variants | NEJM

Vaccine Breakthrough Infections with SARS-CoV-2 Variants | NEJM | Bioscience News - GEG Tech top picks | Scoop.it
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Summary Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of clinical concern. In a cohort of 417 persons who had received the second dose of BNT162b
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Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO

Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO | Bioscience News - GEG Tech top picks | Scoop.it
Moffitt Cancer Center, a national leader in cancer care and research and the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, is presenting new data from dozens of clinical research studies at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, the world's largest clinical cancer research meeting.
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Moffitt Cancer Center, a national leader in cancer care and research and the only National Cancer Institute-designated cancer center in Florida, is presenting new data from dozens of clinical research studies at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, the largest clinical cancer research meeting in the world. Moffitt investigators will lead 25 abstract presentations, five educational sessions, two cancer panels and two clinical science symposia. The virtual meeting will take place June 4-8, 2021. Among those presenting will be Dr. Bijal Shah, who will discuss the results of the Phase 2 ZUMA-3 trial evaluating CAR T-cell therapy for adults with acute lymphoblastic leukemia, a difficult-to-treat malignancy in this patient population. Also on hand will be Dr. Frederick Locke, who will present data from the ALPHA2 trial evaluating ALLO-501, an allogeneic CAR T-cell therapy product, in combination with ALLO-647, a monoclonal antibody that depletes lymphocytes in the body to help prepare the patient to receive new immune cells, in patients with large B-cell lymphoma.

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Vaccine Breakthrough Infections with SARS-CoV-2 Variants | NEJM

Vaccine Breakthrough Infections with SARS-CoV-2 Variants | NEJM | Bioscience News - GEG Tech top picks | Scoop.it
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Summary Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of clinical concern. In a cohort of 417 persons who had received the second dose of BNT162b
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Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 - Nature

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 - Nature | Bioscience News - GEG Tech top picks | Scoop.it
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The recent emergence of new SARS-CoV-2 variants B.1.1.7 in the UK11 and B.1.351 in South Africa12 is of concern because of their purported ease of transmission and extensive mutations in the spike protein. This study reports that B.1.1.7 is refractory to neutralization by most mAbs to the N-terminal domain (NTD) of the spike and relatively resistant to a few mAbs to the receptor-binding domain (RBD). It is not more resistant to convalescent plasma or vaccinee sera. Findings on B.1.351 are more worrisome in that this variant is not only refractory to neutralization by most NTD mAbs but also by multiple individual mAbs to the receptor-binding motif on RBD, largely owing to an E484K mutation. Moreover, B.1.351 is markedly more resistant to neutralization by convalescent plasma (9.4 fold) and vaccinee sera (10.3-12.4 fold). B.1.351 and emergent variants13,14 with similar spike mutations present new challenges for mAb therapy and threaten the protective efficacy of current vaccines.

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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection | Science | Bioscience News - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. Scientists analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, they observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

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WHO looking at how a Covid mutation among minks may impact a vaccine

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LONDON — The World Health Organization said on Friday it would review biosecurity measures across the globe after Danish health authorities found a mutated form of the coronavirus present in the country’s mink farms.

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A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.
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The ‘D614G’ mutation (Aspartate-to-Glycine change at position 614) of the SARS-CoV-2 spike protein has been speculated to adversely affect the efficacy of most vaccines and countermeasures that target this glycoprotein, necessitating frequent vaccine matching. Virus neutralisation assays were performed using sera from ferrets which received two doses of the INO-4800 COVID-19 vaccine, and Australian virus isolates (VIC01, SA01 and VIC31) which either possess or lack this mutation but are otherwise comparable. Through this approach, supported by biomolecular modelling of this mutation and the commonly-associated P314L mutation in the RNA-dependent RNA polymerase, the authors have shown that there is no experimental evidence to support this speculation. They additionally demonstrate that the putative elastase cleavage site introduced by the D614G mutation is unlikely to be accessible to proteases.

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Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells

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Axicabtagene Ciloleucel Approved in Japan for Relapsed/Refractory LBCL

Axicabtagene Ciloleucel Approved in Japan for Relapsed/Refractory LBCL | Bioscience News - GEG Tech top picks | Scoop.it
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January 22, 2021 — The Japan Ministry of Health, Labour and Welfare has approved the CAR T-cell therapy axicabtagene ciloleucel for use in the treatment of adult patients with certain relapsed/refractory large B-cell lymphomas.

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Global human-made mass exceeds all living biomass - Nature 

Global human-made mass exceeds all living biomass - Nature  | Bioscience News - GEG Tech top picks | Scoop.it
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Humanity has become a dominant force in shaping the face of Earth1–9. An emerging question is how the overall material output of human activities compares to the overall natural biomass. Here we quantify the human-made mass, referred to as ‘anthropogenic mass’, and compare it to the overall living biomass on Earth, which currently equals approximately 1.1 teratonnes10,11. We find that Earth is exactly at the crossover point; in the year 2020 (± 6), the anthropogenic mass, which has recently doubled roughly every 20 years, will surpass all global living biomass. On average, for each person on the globe, anthropogenic mass equal to more than his or her bodyweight is produced every week. This quantification of the human enterprise gives a mass-based quantitative and symbolic characterization of the human-induced epoch of the Anthropocene. Estimates of global total biomass (the mass of all living things) and anthopogenic mass (the mass embedded in inanimate objects made by humans) over time show that we are roughly at the timepoint when anthropogenic mass exceeds total biomass.

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Discovery Of New Cell May Be Key To Treating Incurable Neurological Diseases | Ohio State Medical Center

Discovery Of New Cell May Be Key To Treating Incurable Neurological Diseases | Ohio State Medical Center | Bioscience News - GEG Tech top picks | Scoop.it

COLUMBUS, Ohio – Research led by investigators at The Ohio State University Wexner Medical Center provides new hope for recovery from degenerative neurological diseases — such as ALS and multiple sclerosis — as well from as damage caused by traumatic brain and spine injuries and stroke.

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COLUMBUS, Ohio – Research led by investigators at The Ohio State University Wexner Medical Center provides new hope for recovery from degenerative neurological diseases — such as ALS and multiple sclerosis — as well from as damage caused by traumatic brain and spine injuries and stroke. 
 
Using a mouse model, researchers at Ohio State and the University of Michigan discovered a new type of immune cell that not only rescues damaged nerve cells from death, but partially reverses nerve fiber damage. The research team also identified a human immune cell line, with similar characteristics, that promotes nervous system repair.
 
Study findings are published in the journal Nature Immunology.
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AstraZeneca shares turn negative after Brazilian health authority says volunteer in Covid vaccine study dies

AstraZeneca shares turn negative after Brazilian health authority says volunteer in Covid vaccine study dies | Bioscience News - GEG Tech top picks | Scoop.it
Shares of AstraZeneca, a front-runner in the Covid-19 vaccine race, gave up a slight gain after the news broke.
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AstraZeneca shares turned negative Wednesday after a Brazilian health authority said a volunteer in its coronavirus vaccine study died.

The Federal University of Sao Paulo, which is helping coordinate late-stage trials in Brazil, separately said that the volunteer was Brazilian, according to Reuters.

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How to fix the GDPR's frustration of global biomedical research | Science

How to fix the GDPR's frustration of global biomedical research | Science | Bioscience News - GEG Tech top picks | Scoop.it
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Since the advent of the European Union (EU) General Data Protection Regulation (GDPR) in 2018, the biomedical research community has struggled to share data with colleagues and consortia outside the EU, as the GDPR limits international transfers of personal data. A July 2020 ruling of the Court of Justice of the European Union (CJEU) reinforced obstacles to sharing, and even data transfer to enable essential research into coronavirus disease 2019 (COVID-19) has been restricted in a recent Guidance of the European Data Protection Board (EDPB).  In this article, the authors examine whether there is room under the GDPR for EU biomedical researchers to share data from the EU with the rest of the world to facilitate biomedical research. They then propose solutions for consideration by either the EU legislature, the EU Commission, or the EDPB in its planned Guidance on the processing of health data for scientific research. Finally, they urge the EDPB to revisit its recent Guidance on COVID-19 research.

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First artificial enzyme created with two non-biological groups - Nature

First artificial enzyme created with two non-biological groups - Nature | Bioscience News - GEG Tech top picks | Scoop.it
Scientists at the University of Groningen turned a non-enzymatic protein into a new, artificial enzyme by adding two abiological catalytic components
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University of Groningen scientists created a new enzyme that can catalyse (speed up) an important reaction in organic chemistry. They added a copper complex to a protein that had no enzymatic properties. Next, they inserted an unnatural amino acid into the protein. Together with the copper, a side chain of the amino acid was able to catalyse the required reaction. The method to add unnatural groups to a protein could be used to design many other new enzymes. These could replace standard chemical catalysis and thereby contribute to making chemistry cleaner and more energy efficient.

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Penn Engineering’s Blinking Eye-on-a-Chip Used for Disease Modeling and Drug Testing

Penn Engineering’s Blinking Eye-on-a-Chip Used for Disease Modeling and Drug Testing | Bioscience News - GEG Tech top picks | Scoop.it
People who spend eight or more hours a day staring at a computer screen may notice their eyes becoming tired or dry, and, if those conditions are severe enough, they may eventually develop dry eye…
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This eye-on-a-chip, complete with a blinking eyelid, is helping scientists and drug developers to improve their understanding and treatment of DED, among other potential uses. The research, published in Nature Medicine, outlines the accuracy of the eye-on-a-chip as an organ stand-in and demonstrates its utility as a drug testing platform.

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Nerve cells from the brain invade prostate tumours - Nature

Nerve cells from the brain invade prostate tumours - Nature | Bioscience News - GEG Tech top picks | Scoop.it
The source found of newly formed nerve cells in prostate cancer.
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Prostate cancer contains nerve cells that are linked to disease progression, but their source was unknown. A mouse study reveals that cells from the brain invade prostate tumours and give rise to this nerve-cell population.

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HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

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