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This review looks at the challenges of meeting food demands in South Asia complicated by climate change. They contend that CA can help resolve challenges of soil health, climate change, water scarcity, pollution, profitability and human health. This review uses published literature to look at how CA affects SOC and therefore soil health, carbon sequestration and GHG emissions. The results from several studies show CA increased SOC and improved soil health mainly in the surface layer. CA also made a positive impact on nutrient availability. The present gaps in knowledge of soil health assessment and research to fill the gaps are also included in this chapter.