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Most of the lymphoproliferative diseases involving the salivary glands represent indolent non-Hodgkin B-cell lymphoma (marginal zone lymphoma) related to chronic autoimmune sialadenitis (Sjogren disease). 
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by Marie Karlsen, Torbjørn Hansen, Hilde H. Nordal, Johan G. Brun, Roland Jonsson, Silke Appel
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Study says further randomized, controlled trials needed to gauge effectiveness.
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Interaction between innate immunity and Ro52-induced antibody causes Sjogren's syndrome-like disorder in mice http://t.co/jCJKhqIDfC
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by Bing Xiao, Yu Wang, Peter S. Reinach, Yueping Ren, Jinyang Li, Shanshan Hua, Huihui Lu, Wei Chen Dry eye disease can be a consequence of lacrimal gland insufficiency in Sjögren’s Syndrome or increased tear film evaporation despite normal...
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by Elisa Corsiero, Nurhan Sutcliffe, Costantino Pitzalis, Michele Bombardieri
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Gilbert C FAURE's insight:
The new PEPperCHIP® Autoimmune Epitope Microarray 2.0 now covers 3,359 linear autoimmune epitopes including 192 citrullinated peptides as well as the corresponding arginine variants. The IEDB-derived epitopes correlate with a variety of autoimmune diseases including Crohn’s disease, diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, vitiligo and many more.
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IntroductionIgG4-related disease (IgG4-RD) is a multisystem-involved autoimmune disease. Abnormally activated and differentiated B cells may play important roles.
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RT @SjogrensCa: Infection and autoimmunity in Sjogrens syndrome: A clinical study and comprehensive review http://t.co/mOU8AvBrYK #sjogrens…
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The Golgi complex is an elaborate cytoplasmic organelle that has a prominent function in the processing, transporting, and sorting of intracellular proteins subsequent to their synthesis in the rough endoplasmic reticulum.
Gilbert C FAURE's insight:
got one scleroderma and sjogren's patient with very unusual triple substrate pattern and difficult to resolve, mearly misleading aspect on HEP-2 associating centromeric and Golgi labelling.
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Gilbert C FAURE
November 6, 2013 1:39 PM
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Image: PD 1. 66% of patients with Sjögren’s Syndrome (SS) in this study had autoantibodies detected in the serum prior to symptom onset and diagnosis of SS. 2.
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Gilbert C FAURE
November 3, 2013 2:37 PM
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Autoantibodies a Big Deal in Sjogren's MedPage Today Over the past 20 years, Sjogren's syndrome has increasingly been recognized as an autoimmune disease, with the presence of autoantibodies and focal lymphocytic sialadenitis as evidence of an...
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Gilbert C FAURE
April 26, 2015 4:24 AM
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Ann Rheum Dis. 2015 Feb 5. pii: annrheumdis-2014-206297. doi: 10.1136/annrheumdis-2014-206297. [Epub ahead of print]
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Gilbert C FAURE
March 4, 2015 3:32 AM
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by Aristea Papageorgiou, Dimitrios C. Ziogas, Clio P. Mavragani, Elias Zintzaras, Athanasios G. Tzioufas, Haralampos M.
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Gilbert C FAURE
February 14, 2015 4:13 AM
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Despite the prevalence of Sjögren’s syndrome – an autoimmune disease most commonly known for causing dry eyes and mouth - a lack of knowledge about how the condition starts has stalled the development of new treatments.
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Gilbert C FAURE
January 22, 2015 2:11 PM
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J Autoimmun. 2014 Jun;51:17-22. doi: 10.1016/j.jaut.2014.02.008. Epub 2014 Mar 15.
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Société Francaise d'Immunologie
January 6, 2015 3:54 PM
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In this study, we sought to understand the selective pressures shaping the Ig-producing cell repertoire in the parotid glands of primary Sjögren’s syndrome (pSS) patients before and after rituximab treatment (RTX).
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Société Francaise d'Immunologie
December 21, 2014 3:08 PM
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The nuclear receptor retinoic acid–related orphan receptor (ROR)t is required for the generation of Th17 cells, which are involved in various autoimmune diseases, including Sjögren’s syndrome (SS).
However, the pathological role of RORγt in SS remains to be elucidated. The present study was designed to clarify the role of RORγt in the pathogenesis of sialadenitis-like SS. Histological analysis of RORγt transgenic (Tg) mice was determined, and then Tg mice developed severe spontaneous sialadenitis-like SS. The analysis of infiltrating cells showed that most infiltrating cells were CD4+ T cells. RORγt-overexpressing CD4+ T cells induced sialadenitis as a result of transferred CD4+ T cells from Tg mice into Rag2−/− mice. The examination of IL-17–deficient Tg mice indicated that IL-17 was not essential for the development of sialadenitis. The number of CD4+CD25+Foxp3+ regulatory T (Treg) cells was significantly decreased in Tg mice, and CD25 expression and IL-2 stimulated STAT5 activation were inhibited in Treg cells. The inhibitory function of Treg cells of Tg mice was equal to that of wild-type mice in vitro. The abundant Treg cells of Tg mice could suppress the development of sialadenitis, but the reduced Treg cells of Tg mice could not inhibit the induction of sialadenitis in Rag2−/− mice transferred with effector cells from Tg mice. These results suggest that both RORγt-overexpressed CD4+ T cells and reduced Treg cells might contribute to the development of SS-like sialadenitis.
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Gilbert C FAURE
from Rheumatology-Rhumatologie
July 2, 2014 8:55 AM
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not much information on anti salivary ducts sometimes very nice but out of fashion or anti-fodrin without success?
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Gilbert C FAURE
June 18, 2014 3:04 AM
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![Early events in Sjögren's Syndrome pathogenesis: th... [Cytokine. 2014] - PubMed - NCBI | AUTOIMMUNITY | Scoop.it](https://img.scoop.it/CfPBmfNyLSMjwh46LuyacTl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Gilbert C FAURE
February 20, 2014 11:12 AM
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Rituximab not beneficial long-term in Sjorgen's Syndrome
2 Minute Medicine
Study Rundown: Primary Sjogren's Syndrome (pSS) is a chronic autoimmune condition mainly characterized by diminished salivary and lacrimal function.
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Gilbert C FAURE
January 20, 2014 5:14 AM
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
the brest group pursue the sjögren projects
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Gilbert C FAURE
December 7, 2013 3:24 AM
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Drug Discovery & Development Shire Reports Mixed Phase III Results for Dry Eye Candidate Genetic Engineering News Lifitegrast is a small-molecule integrin antagonist, designed to work by reducing inflammation through binding inhibition of two...
focusing on immunologicla synapse in Sjögren's syndrom
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Gilbert C FAURE
November 6, 2013 11:02 AM
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Autoantibodies found in blood years before symptom onset of autoimmune disease Medical Xpress Autoantibodies are present many years before symptom onset in patients with primary Sjögren syndrome, an autoimmune disease, according to a Research...
4 to 6 years before symptoms!!
