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Compared to sAxl, sMer showed closer relations with specific aspects of SLE immunopathogenesis, such as production of lupus-specific autoantibodies and reduction of free ProS in circulation. Strong correlations with ... 
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Few cutaneous lupus erythematosus patients developed SLE Healio Researchers in Philadelphia conducted a prospective, longitudinal study of 77 patients with cutaneous lupus erythematosus (CLE) who enrolled between January 2007 and April 2011 in a...
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Scientific American
Gilbert C FAURE's insight:
Fc gamma RII
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Using the Immune System to Fight Lupus
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Lupus Organizations Unite to Stimulate Advances in Lupus Research
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Belimumab exhibited a satisfactory profile regarding efficacy, safety, and tolerability. Rituximab showed no superiority over placebo in terms of efficacy, despite its suitable safety profile. Biologic agents exhibited a good safety profile for SLE treatment, indicating that these agents are promising therapies and should be further investigated. Via Krishan Maggon
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Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Gaetano Zizzo, Justus Guerrieri, Lindsay M Dittman, Joan T Merrill and Philip L ...
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Li Zhang, Anne M. Bertucci, Rosalind Ramsey-Goldman, Elizabeth Randall Harsha-Strong, Richard K. Burt, Syamal K. Datta
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UPI.com
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Clinical Trials - clinicaltrials.gov This study enrolled over 400 unaffected sisters of young women diagnosed with SLE. These unaffected sisters are being follo...
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Lupus Research Institute Announces New Global Research on Fundamental ...
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Abstract. Although a population of T cells with CD3ζ chain deficiency has been found in patients with systemic lupus erythematosus, rheumatoid arthritis, cancer, and infectious disease, the role of CD3ζ chain in the disease ...
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Scientists unravel how DNA damage may trigger lupus erythematosus News-Medical.net Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following...
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by Anna Acheva, Mihaela Ghita, Gaurang Patel, Kevin M.
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a bit far away from lupus but ... related
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The intracellular tyrosine kinase Lyn mediates inhibitory receptor function in B cells and myeloid cells, and Lyn–/– mice spontaneously develop an autoimmune and inflammatory disease that closely resembles human systemic lupus erythematosus.
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Rheumatology Medical Article: Distinct antibody profile: A clue to primary antiphospholipid syndrome evolving into systemic lupus erythematosus?
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Gilbert C FAURE
December 19, 2013 4:28 AM
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A newly identified immune protein influences each person's response to vaccines and risk for autoimmune diseases like lupus and multiple sclerosis.
which one?...press release not so clear in fact FcR!
The research team found that people with a genetic variant present in approximately 15 percent of the world population can express an additional immune system receptor on their B cells, the cells that make antibodies. This additional receptor, called an Fc receptor, binds the antibodies made by B cells and plays a key role in regulating their production. Part of the immune system, antibodies can recognize invaders like bacteria and remove them from the body. In individuals with autoimmune diseases, however, they can also attack the body's own cells, causing disease.
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Gilbert C FAURE
December 14, 2013 11:56 AM
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Systemic lupus erythematosus (SLE) is characterized by impaired efferocytosis and aberrant activation of innate immunity.
nice LBT
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Gilbert C FAURE
December 5, 2013 3:05 PM
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Patients with systemic lupus erythematosus (SLE) have persistent platelet activation and an increased risk of thrombotic events, which cannot be accounted for by traditional cardiovascular risk factors.
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Gilbert C FAURE
November 26, 2013 6:11 AM
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Identifying targets of autoantibodies
EurekAlert (press release)
Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems.
link to JCI for anti-BAFF autoantibodies in severe lupus.
protein arrays become rewarding!
and lupus patients are making all autoantibodies they want, the ones we know and others we don't know yet!
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Gilbert C FAURE
November 5, 2013 2:34 PM
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Missed It? Antinuclear antibody staining patterns and clinical features of Systemic Lupus Erythematosus: BMJ: http://t.co/ACD4DoYpwk
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Gilbert C FAURE
October 17, 2013 3:10 PM
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Rheumatology Medical Article: Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment (RT @MDLinx: Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment: Inte...
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Gilbert C FAURE
October 7, 2013 1:45 PM
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The characteristic serologic feature of systemic lupus erythematosus (SLE) is autoantibodies against one’s own nucleic acid or nucleic acid-binding proteins - DNA and RNA-binding nuclear proteins.
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Gilbert C FAURE
September 1, 2013 11:32 AM
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The online version of Clinical Immunology at ScienceDirect.com, the world's leading platform for high quality peer-reviewed full-text journals.
tretment of lupus, special issue
