AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Suggested by Société Francaise d'Immunologie
January 20, 2014 5:13 AM
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Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice [AUTOIMMUNITY]

Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
From www.jimmunol.org - January 17, 2014 4:02 PM
The intracellular tyrosine kinase Lyn mediates inhibitory receptor function in B cells and myeloid cells, and Lyn–/– mice spontaneously develop an autoimmune and inflammatory disease that closely resembles human systemic lupus erythematosus.
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Scooped by Gilbert C FAURE
January 15, 2014 2:37 PM
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Distinct antibody profile: A clue to primary antiphospholipid syndrome evolving into systemic lupus erythematosus?

Distinct antibody profile: A clue to primary antiphospholipid syndrome evolving into systemic lupus erythematosus? | AUTOIMMUNITY | Scoop.it
From www.mdlinx.com - January 15, 2014 5:35 AM
Rheumatology Medical Article: Distinct antibody profile: A clue to primary antiphospholipid syndrome evolving into systemic lupus erythematosus?
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Scooped by Gilbert C FAURE
December 27, 2013 5:57 AM
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Autoimmunity

December 27, 2013 5:57 AM

Pathology, Diagnosis and Therapy

Gilbert C FAURE's insight:

Autoimmunity is indeed one of the biggest challenge of Immunology!

Understanding the mechanisms of this physiological immune phenomenon inducing such a diverse array of diseases, joint and muscular, digestive, endocrinological, neurological, cutaneous..

 

Among covered diseases

Lupus (>550 posts)

https://www.scoop.it/topic/autoimmunity?q=lupus

Scleroderma

https://www.scoop.it/topic/autoimmunity?q=scleroderma

Polymyositis

Sjögren's (>150)

https://www.scoop.it/topic/autoimmunity?q=sjogren

 

 

Diabetes (>400 posts)

https://www.scoop.it/topic/autoimmunity?q=diabetes

Mutiple sclerosis (>100 posts)

https://www.scoop.it/topic/autoimmunity?q=multiple+sclerosis

Thyroid disorders

https://www.scoop.it/topic/autoimmunity?q=thyroid

 

Improving the molecular and cellular tools in use for a few decades for diagnosis and follow-up of patients, perhaps screening in the future

Autoantibodies

https://www.scoop.it/topic/autoimmunity?q=autoantibody

 

Mastering the molecular and cellular mechanisms to treat patients.

Tregs

https://www.scoop.it/topic/autoimmunity?q=tregs

 

You can also find relevant informations on some other topics curated  here such as

Rheumatology

http://www.scoop.it/t/rheumatology-rhumatologie

Immunology and biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

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Scooped by Gilbert C FAURE
December 19, 2013 4:28 AM
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Newly identified immune receptor may activate B cells in autoimmunity

From www.eurekalert.org - December 18, 2013 3:51 PM
A newly identified immune protein influences each person's response to vaccines and risk for autoimmune diseases like lupus and multiple sclerosis.
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Gilbert C FAURE's insight:

which one?...press release not so clear in fact FcR!

The research team found that people with a genetic variant present in approximately 15 percent of the world population can express an additional immune system receptor on their B cells, the cells that make antibodies. This additional receptor, called an Fc receptor, binds the antibodies made by B cells and plays a key role in regulating their production. Part of the immune system, antibodies can recognize invaders like bacteria and remove them from the body. In individuals with autoimmune diseases, however, they can also attack the body's own cells, causing disease.

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Scooped by Gilbert C FAURE
December 14, 2013 11:56 AM
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Circulating levels of soluble MER in lupus refl...

Circulating levels of soluble MER in lupus refl... | AUTOIMMUNITY | Scoop.it
From www.scoop.it - December 13, 2013 5:07 AM
Systemic lupus erythematosus (SLE) is characterized by impaired efferocytosis and aberrant activation of innate immunity.
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Gilbert C FAURE's insight:

nice LBT

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December 5, 2013 3:05 PM
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Arthritis Research & Therapy | Abstract | Contact activation products ...

From arthritis-research.com - December 3, 2013 7:00 PM
Patients with systemic lupus erythematosus (SLE) have persistent platelet activation and an increased risk of thrombotic events, which cannot be accounted for by traditional cardiovascular risk factors.
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Scooped by Gilbert C FAURE
November 26, 2013 6:11 AM
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Identifying targets of new autoantibodies in SLE with protein array - JCI via EurekAlert

From www.eurekalert.org - November 25, 2013 12:05 PM
Identifying targets of autoantibodies
EurekAlert (press release)
Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems.
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Gilbert C FAURE's insight:

link to JCI for anti-BAFF autoantibodies in severe lupus.

protein arrays become rewarding!

and lupus patients are making all autoantibodies they want, the ones we know and others we don't know yet!

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Scooped by Gilbert C FAURE
November 5, 2013 2:34 PM
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http://bmjopen.bmj.com/content/3/10/e003608.full

From ht.ly - November 5, 2013 12:32 PM
Missed It? Antinuclear antibody staining patterns and clinical features of Systemic Lupus Erythematosus: BMJ: http://t.co/ACD4DoYpwk
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Scooped by Gilbert C FAURE
October 17, 2013 3:10 PM
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Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment

Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment | AUTOIMMUNITY | Scoop.it
From www.mdlinx.com - October 16, 2013 5:49 PM
Rheumatology Medical Article: Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment (RT @MDLinx: Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment: Inte...
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Scooped by Gilbert C FAURE
October 7, 2013 1:45 PM
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Frontiers | Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus | Frontiers in Molecular Innate Immunity

From www.frontiersin.org - October 7, 2013 8:08 AM
The characteristic serologic feature of systemic lupus erythematosus (SLE) is autoantibodies against one’s own nucleic acid or nucleic acid-binding proteins - DNA and RNA-binding nuclear proteins.
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Scooped by Gilbert C FAURE
September 1, 2013 11:32 AM
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Clinical Immunology | Vol 148, Iss 3, Pgs 301-376, (September, 2013) | ScienceDirect.com

From www.sciencedirect.com - September 1, 2013 11:18 AM
The online version of Clinical Immunology at ScienceDirect.com, the world's leading platform for high quality peer-reviewed full-text journals.
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Gilbert C FAURE's insight:

tretment of lupus, special issue

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Scooped by Gilbert C FAURE
August 28, 2013 2:37 AM
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Clinical features and prognostic factors of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a literature review of 105 cases from 1999 to 2011

Clinical features and prognostic factors of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a literature review of 105 cases from 1999 to 2011 | AUTOIMMUNITY | Scoop.it
From www.mdlinx.com - August 27, 2013 11:54 PM
Rheumatology Medical Article: Clinical features and prognostic factors of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a literature review of 105 cases from 1999 to 2011 (RT @MDLinx: Clinical features and...
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Rescooped by Gilbert C FAURE from Immunology for University Students
August 16, 2013 3:01 PM
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The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology -

The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology - | AUTOIMMUNITY | Scoop.it
From www.sciencedirect.com - November 4, 2012 7:27 AM

The pathogenesis of systemic lupus erythematosus—an update

Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2,

1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States

http://dx.doi.org/10.1016/j.coi.2012.10.004,

 

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

 

The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...


Via Alfredo Corell
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Gilbert C FAURE's comment, August 17, 2013 11:26 AM
november 2012, a synthetic review of uptodate hypothesis
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Scooped by Gilbert C FAURE
January 18, 2014 6:59 AM
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New Genetic Clue to Lupus Is Found - Scientific American

From news.google.com - January 17, 2014 6:37 AM
Scientific American
New Genetic Clue to Lupus Is Found
Scientific American
In many autoimmune disorders antibodies run amok, targeting not invading microbes, but a person's organs.
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Gilbert C FAURE's insight:

Fc gamma RII

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Scooped by Gilbert C FAURE
December 29, 2013 2:56 PM
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Using the Immune System to Fight Lupus - dailyRx

Using the Immune System to Fight Lupus - dailyRx | AUTOIMMUNITY | Scoop.it
From www.dailyrx.com - December 29, 2013 8:46 AM
Using the Immune System to Fight Lupus
dailyRx
A new review of biologic agents developed for lupus and other autoimmune diseases has highlighted several new therapies that have shown some promise for use in SLE.
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Scooped by Gilbert C FAURE
December 19, 2013 6:44 AM
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Lupus Organizations Unite to Stimulate Advances in Lupus Research - 4-traders (press release)

Lupus Organizations Unite to Stimulate Advances in Lupus Research - 4-traders (press release) | AUTOIMMUNITY | Scoop.it
From www.4-traders.com - December 18, 2013 11:09 AM
Lupus Organizations Unite to Stimulate Advances in Lupus Research
4-traders (press release)
The Request for Nominations will open December 18, 2013, with applications due by February 20, 2014.
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Rescooped by Gilbert C FAURE from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
December 17, 2013 2:32 PM
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Efficacy and Safety of Biologic Therapies for Systemic Lupus Erythematosus Treatment: Systematic Review and Meta-Analysis. [BioDrugs. 2013] - PubMed - NCBI

From www.ncbi.nlm.nih.gov - December 17, 2013 9:04 AM

Belimumab exhibited a satisfactory profile regarding efficacy, safety, and tolerability. Rituximab showed no superiority over placebo in terms of efficacy, despite its suitable safety profile. Biologic agents exhibited a good safety profile for SLE treatment, indicating that these agents are promising therapies and should be further investigated.


Via Krishan Maggon
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Gilbert C FAURE's insight:

see also lupus

http://www.scoop.it/t/autoimmunity?q=lupus

 

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Scooped by Gilbert C FAURE
December 12, 2013 4:10 AM
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Arthritis Research & Therapy | Abstract | Circulating levels of soluble ...

From arthritis-research.com - December 9, 2013 7:00 PM
Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Gaetano Zizzo, Justus Guerrieri, Lindsay M Dittman, Joan T Merrill and Philip L ...
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Scooped by Gilbert C FAURE
December 5, 2013 2:37 PM
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Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity (Syamal K. Datta) - Clinical Immunology - Elsevier

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity (Syamal K. Datta) - Clinical Immunology - Elsevier | AUTOIMMUNITY | Scoop.it
From www.journals.elsevier.com - December 5, 2013 3:16 AM
Li Zhang, Anne M. Bertucci, Rosalind Ramsey-Goldman, Elizabeth Randall Harsha-Strong, Richard K. Burt, Syamal K. Datta
Clinical Immunology,...
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Scooped by Gilbert C FAURE
November 12, 2013 2:31 PM
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Putting Lupus in permanent remission - Medical Xpress

Putting Lupus in permanent remission - Medical Xpress | AUTOIMMUNITY | Scoop.it
From medicalxpress.com - November 11, 2013 3:10 PM
UPI.com
Putting Lupus in permanent remission
Medical Xpress
The study was published online in Clinical Immunology, the journal of the Federation of Clinical Immunology Societies.
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Scooped by Gilbert C FAURE
October 28, 2013 8:32 AM
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Autoimmunity in Sisters of Lupus Patients

Autoimmunity in Sisters of Lupus Patients | AUTOIMMUNITY | Scoop.it
From www.bioportfolio.com - October 28, 2013 2:30 AM
Clinical Trials - clinicaltrials.gov This study enrolled over 400 unaffected sisters of young women diagnosed with SLE. These unaffected sisters are being follo...
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Scooped by Gilbert C FAURE
October 10, 2013 4:01 AM
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Lupus Research Institute Announces New Global Research on Fundamental ... - Sacramento Bee

Lupus Research Institute Announces New Global Research on Fundamental ... - Sacramento Bee | AUTOIMMUNITY | Scoop.it
From www.sacbee.com - October 9, 2013 5:11 PM
Lupus Research Institute Announces New Global Research on Fundamental ...
Sacramento Bee
Dr. Tarlinton will explore new ways to kill the cells responsible for producing autoantibodies that damage tissue and organs in lupus.
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Scooped by Gilbert C FAURE
September 27, 2013 1:59 PM
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Abstract - The Journal of Immunology

Abstract - The Journal of Immunology | AUTOIMMUNITY | Scoop.it
From www.jimmunol.org - August 26, 2013 3:00 AM
Abstract. Although a population of T cells with CD3ζ chain deficiency has been found in patients with systemic lupus erythematosus, rheumatoid arthritis, cancer, and infectious disease, the role of CD3ζ chain in the disease ...
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Scooped by Gilbert C FAURE
August 30, 2013 2:59 PM
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Scientists unravel how DNA damage may trigger lupus erythematosus - News-Medical.net

From www.news-medical.net - August 30, 2013 12:50 AM
Scientists unravel how DNA damage may trigger lupus erythematosus News-Medical.net Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following...
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Scooped by Gilbert C FAURE
August 23, 2013 4:27 AM
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Biome | Linking Lupus and NETosis

Biome | Linking Lupus and NETosis | AUTOIMMUNITY | Scoop.it
From www.biomedcentral.com - August 22, 2013 4:30 AM
Researchers reveal how defective degradation of neutrophil extracellular traps in SLE patients impacts disease phenotype | Research published by BioMed Central (Defective degradation of neutrophil extracellular traps in Lupus patients - latest research...
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