AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
January 25, 2014 7:36 AM
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Autoimmune Complications after Hematopoietic Stem Cell ...

Autoimmune Complications after Hematopoietic Stem Cell ... | AUTOIMMUNITY | Scoop.it
However, none had autoimmune markers such as anti-nuclear antibodies (ANA), antismooth muscle, and scleroderma (Scl-70) antibody. Histological examination was necessary to make the diagnosis in three patients, which ...
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Scooped by Gilbert C FAURE
December 28, 2013 1:47 PM
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10 Questions: Robert Spiera, MD - MedPage Today

10 Questions: Robert Spiera, MD - MedPage Today | AUTOIMMUNITY | Scoop.it
MedPage Today
10 Questions: Robert Spiera, MD
MedPage Today
Spiera is director of the Scleroderma and Vasculitis Center at the Hospital for Special Surgery and professor of clinical medicine at Weill Cornell Medical College in New York City.
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Scooped by Gilbert C FAURE
December 20, 2013 3:25 PM
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Marker Predicts Poor Outcomes in Scleroderma - MedPage Today

Marker Predicts Poor Outcomes in Scleroderma - MedPage Today | AUTOIMMUNITY | Scoop.it
Marker Predicts Poor Outcomes in Scleroderma MedPage Today Patients with systemic sclerosis who had high levels of circulating CXCL4 were more than three times as likely to develop early pulmonary fibrosis as shown by a 30% or more loss in forced...
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Scooped by Gilbert C FAURE
October 28, 2013 2:29 PM
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Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort, systematic review and meta-analysis

Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort, systematic review and meta-analysis | AUTOIMMUNITY | Scoop.it
Rheumatology Medical Article: Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort, systematic review and meta-analysis (#scleroderma I just have added an exclusive commentary on our manuscript on anti...
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Scooped by Gilbert C FAURE
May 31, 2013 6:45 AM
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Arthritis Research & Therapy | Abstract | Early systemic sclerosis: marker autoantibodies and videocapillaroscopy patterns are each associated with distinct clinical, functional and cellular activa...

Early systemic sclerosis (SSc) is characterized by Raynaud's phenomenon together with scleroderma marker autoantibodies and/or a scleroderma pattern at capillaroscopy and no other distinctive feature of SSc.
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Scooped by Gilbert C FAURE
January 23, 2014 11:08 AM
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Giantin is the Major Golgi Autoantigen in Human Anti-Golgi

Giantin is the Major Golgi Autoantigen in Human Anti-Golgi | AUTOIMMUNITY | Scoop.it
The Golgi complex is an elaborate cytoplasmic organelle that has a prominent function in the processing, transporting, and sorting of intracellular proteins subsequent to their synthesis in the rough endoplasmic reticulum.
Gilbert C FAURE's insight:

got one scleroderma and sjogren's patient with very unusual triple substrate pattern and difficult to resolve, mearly misleading aspect on HEP-2 associating centromeric and Golgi labelling.

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Scooped by Gilbert C FAURE
December 27, 2013 5:57 AM
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Autoimmunity

Pathology, Diagnosis and Therapy

Gilbert C FAURE's insight:

Autoimmunity is indeed one of the biggest challenge of Immunology!

Understanding the mechanisms of this physiological immune phenomenon inducing such a diverse array of diseases, joint and muscular, digestive, endocrinological, neurological, cutaneous..

 

Among covered diseases

Lupus (>550 posts)

https://www.scoop.it/topic/autoimmunity?q=lupus

Scleroderma

https://www.scoop.it/topic/autoimmunity?q=scleroderma

Polymyositis

Sjögren's (>150)

https://www.scoop.it/topic/autoimmunity?q=sjogren

 

 

Diabetes (>400 posts)

https://www.scoop.it/topic/autoimmunity?q=diabetes

Mutiple sclerosis (>100 posts)

https://www.scoop.it/topic/autoimmunity?q=multiple+sclerosis

Thyroid disorders

https://www.scoop.it/topic/autoimmunity?q=thyroid

 

Improving the molecular and cellular tools in use for a few decades for diagnosis and follow-up of patients, perhaps screening in the future

Autoantibodies

https://www.scoop.it/topic/autoimmunity?q=autoantibody

 

Mastering the molecular and cellular mechanisms to treat patients.

Tregs

https://www.scoop.it/topic/autoimmunity?q=tregs

 

You can also find relevant informations on some other topics curated  here such as

Rheumatology

http://www.scoop.it/t/rheumatology-rhumatologie

Immunology and biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

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Scooped by Gilbert C FAURE
December 19, 2013 3:59 PM
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Tumors May Give Rise to Autoimmunity

Tumors May Give Rise to Autoimmunity | AUTOIMMUNITY | Scoop.it
The complex interplay between the immune system and cancer -- specifically, an anti-tumor immune response that leads to tissue damage -- may underlie the development of scleroderma, current research s (Tumors May Give Rise to Autoimmunity (CME/CE)...
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Scooped by Gilbert C FAURE
October 12, 2013 3:09 PM
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Getting Under the Skin of Scleroderma - Howard Hughes Medical Institute

Getting Under the Skin of Scleroderma - Howard Hughes Medical Institute | AUTOIMMUNITY | Scoop.it
Getting Under the Skin of Scleroderma
Howard Hughes Medical Institute
To see if they could stop the observed cascade of events, Dietz's group turned to an antibody that promotes the interaction between integrins and their matrix-binding partners.
Gilbert C FAURE's insight:

mouse model of scleroderma

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Scooped by Gilbert C FAURE
December 6, 2012 2:49 PM
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Harvard University Expert to Host Scleroderma Webinar: New Directions for ... - The Herald | HeraldOnline.com

Harvard University Expert to Host Scleroderma Webinar: New Directions for ... - The Herald | HeraldOnline.com | AUTOIMMUNITY | Scoop.it
Harvard University Expert to Host Scleroderma Webinar: New Directions for ...The Herald | HeraldOnline.comThis free webinar will describe current scleroderma clinical trials and new treatments on the horizon.
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