Immunology
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Scooped by Gilbert C FAURE
onto Immunology
September 7, 2011 7:53 AM
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Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms

Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms | Immunology | Scoop.it
From www.sciencedaily.com - May 28, 2011 11:22 PM
A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers have determined.
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Immunology
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Teaching and Learning Immunology. Information you never would have searched for!
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Scooped by Gilbert C FAURE
May 29, 2015 8:21 AM
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The TOP 10% information you need!

May 29, 2015 8:21 AM

 

The scoops deal with published (classical or OPEN) and grey literature (blogs, websites, social networks, press releases) allowing rapid access to recently published relevant information

 

May 29, 2015 you were 26796 visitors, viewing this topic 34.5K times., 4900 scoops

June 2020 : >7.3K scoops, >94.5K visitors, #121K views

December 2023: >8K scoops, >97,7K vis, >171,3K views

May 2025: >8.2K scoops, >98.2 visitors,  >177,8 views

Gilbert C FAURE's insight:

This topic is focusing mainly on fundamental systemic immunology.

Some subjects are particularly adressed, according to my personal interests in research or teaching, for instance

Lymph node 

https://www.scoop.it/topic/immunology?q=lymph+node

 

Feel free to browse other related topics!

Mucosal Immunity:

 http://www.scoop.it/t/mucosal-immunity

Immunology and Biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

Autoimmunity

http://www.scoop.it/t/autoimmunity

Allergy and clinical immunology:

http://www.scoop.it/t/allergy-and-clinical-immunology

History of Immunology

http://www.scoop.it/t/history-of-immunology

and more recently

Fake News and Vaccinations

https://www.scoop.it/topic/assim-actualites

 

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Kaupang's comment, October 8, 2021 9:31 AM
nice
wynndental's comment, January 25, 2023 1:44 AM
super
MortonDonaldson's comment, February 20, 2024 11:54 PM
good
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Scooped by Gilbert C FAURE
August 24, 8:13 AM
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https://www.cell.com/cell/fulltext/S0092-8674(25)00746-9?fbclid=IwY2xjawMX4QNleHRuA2FlbQIxMABicmlkETBJTGlmTTFOdmF0dVpKUlZ0AR6K3SHaMO903iIKV6xogyPDn1c3ggHHLzy4gbJyViDZDky-DtSaWY60XHur6Q_aem_kzZRJLup...

From www.cell.com - August 24, 8:13 AM
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Scooped by Gilbert C FAURE
August 16, 1:56 PM
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Deep learning reveals antibiotics in the archaeal proteome | Nature Microbiology

Deep learning reveals antibiotics in the archaeal proteome | Nature Microbiology | Immunology | Scoop.it
From www.nature.com - August 11, 8:00 PM
Antimicrobial resistance is one of the greatest threats facing humanity, making the need for new antibiotics more critical than ever. While most antibiotics originate from bacteria and fungi, archaea offer a largely untapped reservoir for antibiotic discovery. In this study, we leveraged deep learning to systematically explore the archaeome, uncovering promising candidates for combating antimicrobial resistance. By mining 233 archaeal proteomes, we identified 12,623 molecules with potential antimicrobial activity. These peptide compounds, termed archaeasins, have unique compositional features that differentiate them from traditional antimicrobial peptides, including a distinct amino acid profile. We synthesized 80 archaeasins, 93% of which showed antimicrobial activity in vitro against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus spp. Notably, in vivo validation identified archaeasin-73 as a lead candidate, significantly reducing A. baumannii loads in mouse infection models, with effectiveness comparable to that of established antibiotics such as polymyxin B. Our findings highlight the potential of archaea as a resource for developing next-generation antibiotics. Use of artificial intelligence to mine proteomes of archaea led to the discovery of archaeasins, antimicrobials that kill drug-resistant bacteria in laboratory and animal models, offering a promising source of future antibiotics.
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Scooped by Gilbert C FAURE
August 16, 2:21 AM
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The immune system offers a window into aging | Nature Aging

From www.nature.com - August 13, 8:00 PM
The immune system permeates and regulates organs and tissues across the body, and has diverse roles beyond pathogen control, including in development, tissue homeostasis and repair. The reshaping of the immune system that occurs during aging is therefore highly consequential. In this Focus issue, Nature Aging presents a collection of reviews of and opinions on recent advances in research into immune aging.
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Scooped by Gilbert C FAURE
August 13, 3:47 AM
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Tolerance requires diversity (of antigen presenting cells) | Stéphane Paul

Tolerance requires diversity (of antigen presenting cells) | Stéphane Paul | Immunology | Scoop.it
From www.linkedin.com - July 27, 3:23 PM
Tolerance requires diversity (of antigen presenting cells)
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Scooped by Gilbert C FAURE
July 29, 2:54 AM
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Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes

From www.science.org - July 29, 2:54 AM
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Scooped by Gilbert C FAURE
July 28, 1:19 PM
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Frontiers | Lymphoid stroma in all its states

Frontiers | Lymphoid stroma in all its states | Immunology | Scoop.it
From www.frontiersin.org - July 15, 8:00 PM
Stromal cells are found in all tissues of the body. Among them, lymphoid stromal cells (LSCs) correspond to the cell subsets found in secondary and tertiar
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Scooped by Gilbert C FAURE
July 25, 3:12 AM
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https://www.nature.com/articles/s41586-025-09166-w

From www.nature.com - July 25, 3:12 AM
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Scooped by Gilbert C FAURE
July 21, 4:37 AM
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The complement system: Biology, pathology, and therapeutic interventions

The complement system: Biology, pathology, and therapeutic interventions | Immunology | Scoop.it
From pubmed.ncbi.nlm.nih.gov - July 18, 8:00 PM
Targeting the innate immune complement system has long been pursued as a promising strategy for treating a wide spectrum of acute and chronic immune-mediated disorders.Nearly 2 decades since the approval of the first complement inhibitor targeting C5, the field of complement therapeutics has flouri...
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Scooped by Gilbert C FAURE
July 17, 12:02 PM
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Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients

From rupress.org - July 17, 12:02 PM
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Scooped by Gilbert C FAURE
July 12, 1:56 AM
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Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

From www.science.org - July 12, 1:56 AM
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Scooped by Gilbert C FAURE
July 7, 3:04 AM
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https://academic.oup.com/discovimmunology/article/4/1/kyaf006/8117346?login=false

From academic.oup.com - July 7, 3:04 AM
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Scooped by Gilbert C FAURE
June 25, 9:16 AM
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Muscle samples from... - Journal of Clinical Investigation

Muscle samples from... - Journal of Clinical Investigation | Immunology | Scoop.it
From www.facebook.com - June 25, 9:16 AM
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Scooped by Gilbert C FAURE
August 26, 8:37 AM
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🦠 La liste OMS 2024 des bactéries les plus préoccupantes vient d'être publiée dans le Lancet infectious disease https://lnkd.in/eYmnPyAm 💬 Elle est établie par la consultation d'expert du secte...

🦠 La liste OMS 2024 des bactéries les plus préoccupantes vient d'être publiée dans le Lancet infectious disease https://lnkd.in/eYmnPyAm 💬 Elle est établie par la consultation d'expert du secte... | Immunology | Scoop.it
From fr.linkedin.com - August 22, 5:30 AM
🦠 La liste OMS 2024 des bactéries les plus préoccupantes vient d'être publiée dans le Lancet infectious disease https://lnkd.in/eYmnPyAm

💬 Elle est établie par la consultation d'expert du secteur chargée de scorer chaque bactérie selon 8 critères (mortalité, contagiosité, incidence, traitements disponibles etc voir les items en haut de la figure)

Quelques commentaires par rapport au classement 2017 :

- Les bactéries à gram négatif continuent de dominer largement le classement

- Les entérobactéries ont pris les 2 premières places (occupées en 2017 par Acinetobacter et Pseudomonas) ce n'est pas un détail, les entérobactéries sont des bactéries "communautaires" alors que Acineto et Pseudomonas sont essentiellement retrouvées dans les infections hospitalière

- Ainsi les Klebsielles résistantes aux carbapénèmes est maintenant l'espèce bactérienne qui préoccupe le plus, souvent resistante à tous les antibiotiques et très virulentes (on voit son score de mortalité et sa difficulté de traitement élevé sur la figure)

- La tuberculose résistante a été rajoutée et apparait au rang n°4

💡 Ce classement est un bon outil
pour les décideurs pour cibler la recherche anti-bactérienne sur les problèmes les plus importants
et pour le public/les journalistes pour savoir comment interpréter certaines annonces "spectaculaires" de découverte de nouveaux traitements en fonction de la bactérie concernée
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Scooped by Gilbert C FAURE
August 23, 8:04 AM
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JCI Insight - Heterogeneity of thymic output in the elderly and its association with sex and smoking

JCI Insight - Heterogeneity of thymic output in the elderly and its association with sex and smoking | Immunology | Scoop.it
From insight.jci.org - August 7, 8:00 PM
Functional thymic structures are embedded in the mediastinal AT. To effectively evaluate thymic output in aged individuals, we first sought to characterized functional thymic tissue obtained from patients (≥50 years) undergoing common cardiac surgical procedures, where these tissues could be...
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Rescooped by Gilbert C FAURE from Hésitations Vaccinales: Observatoire HESIVAXs
August 16, 2:34 AM
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Neuro–immune crosstalk: focus on innate lymphoid cells

From www.cell.com - August 16, 2:34 AM
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Scooped by Gilbert C FAURE
August 14, 4:07 AM
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A new #ScienceReview offers an overview of recent research that reveals the immune system not only defends the body but also actively shapes and supports various life-sustaining processes through… ...

A new #ScienceReview offers an overview of recent research that reveals the immune system not only defends the body but also actively shapes and supports various life-sustaining processes through… ... | Immunology | Scoop.it
From www.linkedin.com - August 13, 2:45 PM
A new #ScienceReview offers an overview of recent research that reveals the immune system not only defends the body but also actively shapes and supports various life-sustaining processes through dynamic, reciprocal interactions with other physiological systems.

Learn more: https://scim.ag/40ZxtQw
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Scooped by Gilbert C FAURE
August 8, 3:23 AM
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A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. | Science Magazine

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. | Science Magazine | Immunology | Scoop.it
From www.linkedin.com - August 7, 2:05 PM
A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.

Learn more: https://scim.ag/4m6vHWp
Gilbert C FAURE's insight:

Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses

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Scooped by Gilbert C FAURE
July 29, 1:55 AM
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The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer | Nature Immunology

The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer | Nature Immunology | Immunology | Scoop.it
From www.nature.com - July 27, 8:00 PM
Cui et al. discuss new molecular and cellular insights underlying the pathogenesis of rare human diseases that arise from genetic inborn errors of immunity.
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Scooped by Gilbert C FAURE
July 25, 4:39 AM
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Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity

From www.science.org - July 25, 4:39 AM
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Scooped by Gilbert C FAURE
July 22, 9:45 AM
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Cortical Thymic Epithelial Cells: Key Developers of the Code of T-Cell Selection and TCR Repertoire Diversity

From onlinelibrary.wiley.com - July 22, 9:45 AM
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Scooped by Gilbert C FAURE
July 21, 4:37 AM
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Identification of clinical diagnostic and immune cell infiltration characteristics of acute myocardial infarction with machine learning approach | Scientific Reports

Identification of clinical diagnostic and immune cell infiltration characteristics of acute myocardial infarction with machine learning approach | Scientific Reports | Immunology | Scoop.it
From www.nature.com - July 19, 8:00 PM
Acute myocardial infarction (AMI) is a serious heart disease with high fatality rates. The progress of AMI involves immune cell infiltration. However, suitable clinical diagnostic biomarkers and the roles of immune cells in AMI remain unknown.
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Scooped by Gilbert C FAURE
July 14, 11:21 AM
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Not all lymphocytes come from the bone marrow: revisiting extramedullar lymphopoiesis ;) | Eric Vivier

Not all lymphocytes come from the bone marrow: revisiting extramedullar lymphopoiesis ;) | Eric Vivier | Immunology | Scoop.it
From www.linkedin.com - July 11, 2:14 PM
Not all lymphocytes come from the bone marrow: revisiting extramedullar lymphopoiesis ;)
CIML
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Scooped by Gilbert C FAURE
June 27, 10:33 AM
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Home - IUIS 2025

Home - IUIS 2025 | Immunology | Scoop.it
From iuis2025.org - February 1, 2024 6:37 AM
CHECK OUR CONFIRMEDKEYNOTE SPEAKERSMORE INFORMATION HERECHECK OUR CONFIRMEDPLENARY SPEAKERSMORE INFORMATION HERECME CREDITS AT IUIS 2025 IUIS is seeking Continuing Medical Education (CME) accreditation for the 19th International Congress of Immunology. Stay tuned for updates on the final accreditation details. Welcome To Vienna Welcome message On behalf of the Austrian Society for Allergology and Immunology (ÖGAI) […]
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Scooped by Gilbert C FAURE
June 24, 8:14 AM
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Inhibitory pattern recognition receptors: lessons from LAIR1 | Nature Reviews Immunology

Inhibitory pattern recognition receptors: lessons from LAIR1 | Nature Reviews Immunology | Immunology | Scoop.it
From www.nature.com - May 26, 8:00 PM
Many inhibitory receptors that regulate immune cell function recognize a limited number of specific ligands. However, a subgroup of so-called inhibitory pattern recognition receptors (iPRRs) can bind a much larger array of ligands of structural similarity. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is one such iPRR that is expressed by most immune cells and recognizes a common structural pattern present in collagens and collagen domain-containing proteins. LAIR1 signalling regulates diverse immune cell populations and is currently the focus of multiple clinical trials for the treatment of cancer. We here review the current literature on LAIR1, as a prototypic example of how inhibitory PRRs contribute to immune balance and of how these receptors are regulated. We discuss the function of LAIR1 in homeostasis, infection, inflammation and cancer, and consider the advantages and potential pitfalls of targeting this receptor in human disease. Pattern recognition receptors (PRRs) are typically associated with innate immune activation, but there is an emerging subset of inhibitory pattern recognition receptors (iPRRs) that limit cell activation. This Review from Meyaard and colleagues highlights our growing understanding of iPRR biology, focusing on leukocyte-associated immunoglobulin-like receptor (LAIR1).
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