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Scooped by
Gilbert C FAURE
onto Immunology July 25, 2011 12:22 PM
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Scooped by
Gilbert C FAURE
August 16, 1:56 PM
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Antimicrobial resistance is one of the greatest threats facing humanity, making the need for new antibiotics more critical than ever. While most antibiotics originate from bacteria and fungi, archaea offer a largely untapped reservoir for antibiotic discovery. In this study, we leveraged deep learning to systematically explore the archaeome, uncovering promising candidates for combating antimicrobial resistance. By mining 233 archaeal proteomes, we identified 12,623 molecules with potential antimicrobial activity. These peptide compounds, termed archaeasins, have unique compositional features that differentiate them from traditional antimicrobial peptides, including a distinct amino acid profile. We synthesized 80 archaeasins, 93% of which showed antimicrobial activity in vitro against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus spp. Notably, in vivo validation identified archaeasin-73 as a lead candidate, significantly reducing A. baumannii loads in mouse infection models, with effectiveness comparable to that of established antibiotics such as polymyxin B. Our findings highlight the potential of archaea as a resource for developing next-generation antibiotics. Use of artificial intelligence to mine proteomes of archaea led to the discovery of archaeasins, antimicrobials that kill drug-resistant bacteria in laboratory and animal models, offering a promising source of future antibiotics.
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Gilbert C FAURE
August 16, 2:21 AM
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The immune system permeates and regulates organs and tissues across the body, and has diverse roles beyond pathogen control, including in development, tissue homeostasis and repair. The reshaping of the immune system that occurs during aging is therefore highly consequential. In this Focus issue, Nature Aging presents a collection of reviews of and opinions on recent advances in research into immune aging.
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Gilbert C FAURE
July 28, 1:19 PM
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Stromal cells are found in all tissues of the body. Among them, lymphoid stromal cells (LSCs) correspond to the cell subsets found in secondary and tertiar
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Gilbert C FAURE
July 21, 4:37 AM
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Targeting the innate immune complement system has long been pursued as a promising strategy for treating a wide spectrum of acute and chronic immune-mediated disorders.Nearly 2 decades since the approval of the first complement inhibitor targeting C5, the field of complement therapeutics has flouri...
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Gilbert C FAURE
August 26, 8:37 AM
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🦠 La liste OMS 2024 des bactéries les plus préoccupantes vient d'être publiée dans le Lancet infectious disease https://lnkd.in/eYmnPyAm
💬 Elle est établie par la consultation d'expert du secteur chargée de scorer chaque bactérie selon 8 critères (mortalité, contagiosité, incidence, traitements disponibles etc voir les items en haut de la figure)
Quelques commentaires par rapport au classement 2017 :
- Les bactéries à gram négatif continuent de dominer largement le classement
- Les entérobactéries ont pris les 2 premières places (occupées en 2017 par Acinetobacter et Pseudomonas) ce n'est pas un détail, les entérobactéries sont des bactéries "communautaires" alors que Acineto et Pseudomonas sont essentiellement retrouvées dans les infections hospitalière
- Ainsi les Klebsielles résistantes aux carbapénèmes est maintenant l'espèce bactérienne qui préoccupe le plus, souvent resistante à tous les antibiotiques et très virulentes (on voit son score de mortalité et sa difficulté de traitement élevé sur la figure)
- La tuberculose résistante a été rajoutée et apparait au rang n°4
💡 Ce classement est un bon outil
pour les décideurs pour cibler la recherche anti-bactérienne sur les problèmes les plus importants
et pour le public/les journalistes pour savoir comment interpréter certaines annonces "spectaculaires" de découverte de nouveaux traitements en fonction de la bactérie concernée
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Gilbert C FAURE
August 23, 8:04 AM
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Functional thymic structures are embedded in the mediastinal AT. To effectively evaluate thymic output in aged individuals, we first sought to characterized functional thymic tissue obtained from patients (≥50 years) undergoing common cardiac surgical procedures, where these tissues could be...
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Rescooped by
Gilbert C FAURE
from Hésitations Vaccinales: Observatoire HESIVAXs
August 16, 2:34 AM
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Gilbert C FAURE
August 14, 4:07 AM
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A new #ScienceReview offers an overview of recent research that reveals the immune system not only defends the body but also actively shapes and supports various life-sustaining processes through dynamic, reciprocal interactions with other physiological systems.
Learn more: https://scim.ag/40ZxtQw
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Gilbert C FAURE
August 8, 3:23 AM
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A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.
Learn more: https://scim.ag/4m6vHWp
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses
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Gilbert C FAURE
July 29, 1:55 AM
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Cui et al. discuss new molecular and cellular insights underlying the pathogenesis of rare human diseases that arise from genetic inborn errors of immunity.
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Gilbert C FAURE
July 21, 4:37 AM
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Acute myocardial infarction (AMI) is a serious heart disease with high fatality rates. The progress of AMI involves immune cell infiltration. However, suitable clinical diagnostic biomarkers and the roles of immune cells in AMI remain unknown.
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Gilbert C FAURE
July 14, 11:21 AM
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Not all lymphocytes come from the bone marrow: revisiting extramedullar lymphopoiesis ;)
CIML
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Gilbert C FAURE
June 27, 10:33 AM
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CHECK OUR CONFIRMEDKEYNOTE SPEAKERSMORE INFORMATION HERECHECK OUR CONFIRMEDPLENARY SPEAKERSMORE INFORMATION HERECME CREDITS AT IUIS 2025 IUIS is seeking Continuing Medical Education (CME) accreditation for the 19th International Congress of Immunology. Stay tuned for updates on the final accreditation details. Welcome To Vienna Welcome message On behalf of the Austrian Society for Allergology and Immunology (ÖGAI) […]
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Gilbert C FAURE
June 24, 8:14 AM
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Many inhibitory receptors that regulate immune cell function recognize a limited number of specific ligands. However, a subgroup of so-called inhibitory pattern recognition receptors (iPRRs) can bind a much larger array of ligands of structural similarity. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is one such iPRR that is expressed by most immune cells and recognizes a common structural pattern present in collagens and collagen domain-containing proteins. LAIR1 signalling regulates diverse immune cell populations and is currently the focus of multiple clinical trials for the treatment of cancer. We here review the current literature on LAIR1, as a prototypic example of how inhibitory PRRs contribute to immune balance and of how these receptors are regulated. We discuss the function of LAIR1 in homeostasis, infection, inflammation and cancer, and consider the advantages and potential pitfalls of targeting this receptor in human disease. Pattern recognition receptors (PRRs) are typically associated with innate immune activation, but there is an emerging subset of inhibitory pattern recognition receptors (iPRRs) that limit cell activation. This Review from Meyaard and colleagues highlights our growing understanding of iPRR biology, focusing on leukocyte-associated immunoglobulin-like receptor (LAIR1).
