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This book chapter notes that wheat is a major food crop of the World and India. It is a major crop in the rice-wheat systems of the IndoGangetic Plains of South Asia. The chapter discusses the breeding of wheat-adapted genotypes for CA since this management system offers solutions for future food security. They suggest that capacity to germinate when seeded deep, better emergence through residue load, longer and stronger coleoptile, stronger root system architecture, early vigor, and multiple disease resistance are important in CA-adapted genotypes. They conclude that modern breeding tools like genomic-assisted breeding will play an important role in developing genotypes better adapted to CA environments. With advanced genomic tools and the availability of large genomic information, it is expected that newer QTLs will be identified and the molecular mechanism controlling CA responsive traits will be explained.