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This study analyzed 84 on-farm trials comparing CA-based practices (CA) with farmers' conventional ones (CT) in rice-wheat systems of the Eastern Tarai region on Nepal. The objectives were to investigate crop and cropping systems productivity, profitability, yield stability, irrigation (WPi) and total water productivity (WP(r+i)), and fertilizer-use efficiencies of three CA- and one CT-based practice in R−W systems. The CT system was puddled transplanted rice (PTR) and tilled wheat (CTW). The three CA based systems were 1) PTR - ZTW; 2) Direct seeded rice (DSR) -ZTW; and 3) unpuddled transplanted rice (UPTR) - ZTW. There were no significant differences in rice or wheat yields between CT and CA treatments, but significant reduction in production cost due to reduced labor use and increased net gain (188−223 USD ha−1) in all CA-based R−W systems. DSR−ZTW showed the highest yield stability and net profit, demonstrating its adaptability in the region. CA based systems reduced production costs and increased farm profits, saved energy and water, increased land and labor productivity, and improved food security.