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This paper looks at the issues of sustainable nitrogen management using no-till practices using a Global Meta-analysis. They used 2,268 pairs of data points from 327 peer-reviewed articles. Increases of 21 and 16% in total N concentration and N stock, respectively, were noted under NT compared to conventional tillage (CT) in the surface soil layer (0–10 cm) but little change below this surface soil. Continental and temperate climates recorded significant gains in total N in NT while the effect was negligible in tropical and dry climates. An incremental rise in soil-N was found with an increase in the duration of NT. No-tillage favoured the soil N and as a consequence, fertilizer-N use under no-till condition, must take into account of the potential N release from SOM for achieving higher N-use efficiency.