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This chapter in a new book entitled "Microbiome Under Changing Climate" looks at how microorganisms are affected by climate smart practices. This includes affects on GHG emissions. They provide a systematic selection of novel experimental studies to highlight the impact of climate change consequences such as elevated CO2, temperature, and drought on microbial functions in different agroecosystems. They also describe the role of microbes in CSA strategies that influence yield, carbon sequestration, GHG mitigation and climate change adaptation.