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This paper presents the results of a global meta-analysis of studies assessing SOC and total N (TN) storage and dynamics in NT and tilled soils from the most important agricultural regions of the world. Overall, their results show that NT soils stored 6.7 ± 1.9 Mg C ha–1 and 1.1 ± 0.4 Mg N ha–1 more than tilled soils (0-to-100-cm depth) with an average of 16 yr of NT, in contrast with previous findings that found little or no soil organic C (SOC) accrual in NT soils as compared with full inversion tillage when soils are sampled deeper than 30 cm. However, C sequestration (+4.7 ± 1.9 Mg C ha–1 in the 0-to-60-cm depth with an average of 11 yr of NT) depended on the association of NT with increased crop frequency and the inclusion of legumes cover crops. Briefly, their findings indicate that NT can avoid SOC losses from tilled soils, partially offsetting CO2 emissions from agriculture.