AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
April 11, 2014 5:30 AM
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The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies ...

The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies ... | AUTOIMMUNITY | Scoop.it
Abstract. Autoantibodies directed to chromatin components date back to the discovery of the LE cell and the LE cell phenomenon circa 1950, and subsequent evidence that major components of that reaction were chromatin ...
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Scooped by Gilbert C FAURE
April 10, 2014 2:38 PM
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Child Health Advocate Claire Dwoskin Wins "Lifetime Contribution to ... - PR Web (press release)

Child Health Advocate Claire Dwoskin Wins "Lifetime Contribution to ... - PR Web (press release) | AUTOIMMUNITY | Scoop.it
Child Health Advocate Claire Dwoskin Wins "Lifetime Contribution to ...
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Scooped by Gilbert C FAURE
April 10, 2014 9:17 AM
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College of American Pathologists - Diagnostic Immunology

Gilbert C FAURE's insight:

focusing mainly on autoimmunity

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Scooped by Gilbert C FAURE
April 10, 2014 8:36 AM
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Immune Dysregulation as a Cause of Autoinflammation in Fragile X Premutation Carriers: Link between FMRI CGG Repeat Number and Decreased Cytokine Responses

Immune Dysregulation as a Cause of Autoinflammation in Fragile X Premutation Carriers: Link between FMRI CGG Repeat Number and Decreased Cytokine Responses | AUTOIMMUNITY | Scoop.it
by Milo Careaga, Destanie Rose, Flora Tassone, Robert F.
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Scooped by Gilbert C FAURE
April 10, 2014 8:34 AM
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Autoantibody and Human Leukocyte Antigen Profiles in Childre... : Journal of Pediatric Gastroenterology and Nutrition

Autoantibody and Human Leukocyte Antigen Profiles in Childre... : Journal of Pediatric Gastroenterology and Nutrition | AUTOIMMUNITY | Scoop.it
Objective: Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families.
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Scooped by Gilbert C FAURE
April 9, 2014 10:54 AM
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Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes -- Redondo et al. 2 (1) -- BMJ Open Diabetes Research & Care

Just published: TCF7L2 variation and single islet autoantibody expression in children with type 1 diabetes. http://t.co/ckJYK4LGKl #diabetes
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Scooped by Gilbert C FAURE
April 7, 2014 9:00 AM
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An age-related numerical and functional deficit in CD19+CD24hiCD38hi B cells is associated with an increase in systemic autoimmunity - Duggal - 2013 - Aging Cell - Wiley Online Library

An age-related numerical and functional deficit in CD19+CD24hiCD38hi B cells is associated with an increase in systemic autoimmunity - Duggal - 2013 - Aging Cell - Wiley Online Library | AUTOIMMUNITY | Scoop.it
RT @brainsnstyle: Our new work on ageing and the mechs behind the increase in autoimmunity http://t.co/cHmPFEDMJ7 @unibirmingham #ageingres…
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Scooped by Gilbert C FAURE
April 5, 2014 2:19 PM
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Theradiag unveils a new automated solution at the International ...

Theradiag unveils a new automated solution at the International ... | AUTOIMMUNITY | Scoop.it
Theradiag unveils a new automated solution at the International Auto-immunity Congress in Nice, France. 28 March 2014. With Theralis®, its fully automated system, Theradiag is strengthening its positioning in the diagnosis of auto-immune ...
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Rescooped by Gilbert C FAURE from NeuroImmunology
April 5, 2014 1:50 PM
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Th17 cells in central nervous system autoimmunity. [Exp Neurol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
April 5, 2014 5:16 AM
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Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies

Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies | AUTOIMMUNITY | Scoop.it
by Christie Fitch-Rogalsky, Whitney Steber, Michael Mahler, Terri Lupton, Liam Martin, Susan G. Barr, Dianne P. Mosher, James Wick, Marvin J.
Gilbert C FAURE's insight:

This is the first study to evaluate the serological and clinical features of patients referred through a CT system because of a positive ANA. The spectrum of autoantibody specificities was wide with anti-Ro52/TRIM21 being the most common autoantibody detected. Approximately 15% of referrals had only antibodies to DFS70, the vast majority of which did not have clinical evidence for an AARD. These findings provide insight into the utility of autoantibody testing in a CT system.

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Scooped by Gilbert C FAURE
April 4, 2014 6:04 AM
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Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody

New in STM: Yervoy induces pituitary tox by a type II hypersensitivity reaction
http://t.co/P4W3fATZob #Immunotherapy http://t.co/3FRHOpBniw
Gilbert C FAURE's insight:

Pituitary glands indeed expressed CTLA-4 at both RNA and protein levels, particularly in a subset of prolactin- and thyrotropin-secreting cells. Notably, these cells became the site of complement activation, featuring deposition of C3d and C4d components and an inflammatory cascade akin to that seen in type II hypersensitivity. In summary, the study offers a mechanism to explain the pituitary toxicity observed in patients receiving ipilimumab, and highlights the utility of measuring pituitary antibodies in this form of secondary hypophysitis.

4% of treated patients!

Gilbert C FAURE's curator insight, April 4, 2014 6:05 AM

Pituitary glands indeed expressed CTLA-4 at both RNA and protein levels, particularly in a subset of prolactin- and thyrotropin-secreting cells. Notably, these cells became the site of complement activation, featuring deposition of C3d and C4d components and an inflammatory cascade akin to that seen in type II hypersensitivity. In summary, the study offers a mechanism to explain the pituitary toxicity observed in patients receiving ipilimumab, and highlights the utility of measuring pituitary antibodies in this form of secondary hypophysitis.

Scooped by Gilbert C FAURE
April 3, 2014 2:05 PM
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Autoimmunity Reviews | Vol 13, Isss 4–5, Pgs 331-594, (April–May, 2014) | ScienceDirect.com

The online version of Autoimmunity Reviews at ScienceDirect.com, the world's leading platform for high quality peer-reviewed full-text journals.
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Scooped by Gilbert C FAURE
April 11, 2014 5:16 AM
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New lupus journal - Rheumatology Update

New lupus journal - Rheumatology Update | AUTOIMMUNITY | Scoop.it
New lupus journal Rheumatology Update Professor Jill Buyon, Director of Rheumatology at the New York School of Medicine, and Professor Ronald van Vollenhoven, Head of Clinical Therapy Research, Inflammatory Diseases at the Karolinska Institutet,...
Gilbert C FAURE's insight:

The first online open-access journal for lupus research is now seeking submissions.

Published by BMJ Group, Lupus Science & Medicine “provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases”, according to its website.

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Scooped by Gilbert C FAURE
April 10, 2014 2:02 PM
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Multiple Sclerosis Research: Mitigating Lemtrada Risks with a ...

Multiple Sclerosis Research: Mitigating Lemtrada Risks with a ... | AUTOIMMUNITY | Scoop.it
The docs at Cambridge have been investigating this and have ways to stop the neutralising antibodies and have found a marker they think shows your risk of developing autoimmunity. This type of study has not been reported ...
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Scooped by Gilbert C FAURE
April 10, 2014 8:40 AM
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Bugs & us: the role of the gut in autoimmun... [Indian J Med Res. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
April 10, 2014 8:35 AM
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The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update. http://t.co/pPG96gVcBT #hygiene #autoimmune #autoimmunity #MS
Gilbert C FAURE's insight:

2010 but useful for teaching

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Scooped by Gilbert C FAURE
April 9, 2014 11:48 AM
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Serum antinucleosome-specific antibody a... [J Neuroinflammation. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Suggested by Société Francaise d'Immunologie
April 8, 2014 9:22 AM
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Inflammation in dry eye associated with rheumat... [Innate Immun. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
April 7, 2014 9:00 AM
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La Jolla Institute discovers new mechanism for unleashing immune system ... - EurekAlert (press release)

La Jolla Institute discovers new mechanism for unleashing immune system ... - EurekAlert (press release) | AUTOIMMUNITY | Scoop.it
La Jolla Institute discovers new mechanism for unleashing immune system ...
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Scooped by Gilbert C FAURE
April 6, 2014 10:29 AM
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TNT003, an inhibitor of the serine protease C1s, prevents ... - Blood

TNT003, an inhibitor of the serine protease C1s, prevents ... - Blood | AUTOIMMUNITY | Scoop.it
Activation of the classical pathway of complement (CP) is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. One such disorder is cold agglutinin disease ...
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Scooped by Gilbert C FAURE
April 5, 2014 1:51 PM
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Autoimmune Etiology of Epilepsy

Autoimmune Etiology of Epilepsy | AUTOIMMUNITY | Scoop.it
Four fold increased risk of epilepsy in a number of common autoimmune diseases #neuroimmunology http://t.co/aQYEcdJsjG
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Scooped by Gilbert C FAURE
April 5, 2014 1:49 PM
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JNI | Abstract | Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism

Increasing evidence of autoimmune phenomena in some individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder.
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Rescooped by Gilbert C FAURE from Immunology and Biotherapies
April 4, 2014 6:11 AM
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Trials | Full text | The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) Trial protocol and baseline cohort characteristics: an open-label pre-test : post-test study with blinded outcome asse...

No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS).
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Scooped by Gilbert C FAURE
April 3, 2014 3:09 PM
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Central Clinical School News Blog: The BAFF/APRIL system in SLE pathogenesis: Nature Reviews Rheumatology

Central Clinical School News Blog: The BAFF/APRIL system in SLE pathogenesis: Nature Reviews Rheumatology | AUTOIMMUNITY | Scoop.it
RT @CCSMonash: The BAFF/APRIL system in SLE pathogenesis: Nature Reviews Rheumatology @fabOzy @FabienneMackay http://t.co/qNWUoyumTb
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