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Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
October 14, 2012 3:29 AM
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Sanofi's Genzyme says making progress with MS drugs - Reuters

Sanofi's Genzyme says making progress with MS drugsReuters"Neurologists may feel threatened, but they will have to understand how the immune system works and how to handle, so I don't think autoimmunity will be a big problem," she said.
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Scooped by Gilbert C FAURE
October 13, 2012 2:26 PM
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Multiple Sclerosis Research: Research: Antibodies against Tysabri

Multiple Sclerosis Research: Research: Antibodies against Tysabri | AUTOIMMUNITY | Scoop.it
METHODS:Screening for anti-natalizumab antibodies was performed using a standardized bridging ELISA. Antibody-positive samples were further analyzed for IgM and IgG1-4 antibodies using ELISA and ImmunoCAP®.
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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A novel autoantibody against fibronectin leucine-rich transmembrane

Anti-endothelial cell antibodies (AECAs) are thought to be critical for vasculitides in collagen diseases, but most were directed against molecules localized within the cell and not expressed on the cell surface.
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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Autoantibody profiling to follow evolution of lupus syndromes

Identification of patients who are in early stages of lupus is currently done through clinical evaluation and is not greatly facilitated by available diagnostic tests.
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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Anti CD19/CD11c Bi-Specific Antibodies Target A Subset Of B Cells ...

Anti CD19/CD11c Bi-Specific Antibodies Target A Subset Of B Cells ... | AUTOIMMUNITY | Scoop.it
It is estimated that 23.5 million Americans suffer from autoimmune disease (AD) and that the prevalence is rising. Researchers have identified 80-100 different ADs and suspect at least 40 additiona...
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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American Thyroid Association to Award Sandra McLachlan, PhD ...

She also established the thyroid gland as the major site of thyroid autoantibody production, providing the basis for using thyroid tissue from patients with autoimmune thyroid disease in her subsequent cloning of human ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:51 AM
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Inflammablog6!: The first identified neurological autoimmune ...

Inflammablog6!: The first identified neurological autoimmune ... | AUTOIMMUNITY | Scoop.it
In 1960, Simpson was the first to propose that the pathogenesis of MG was an autoimmune reaction that involved an antibody specific for a neuromuscular junction protein. Which turned out to be correct, the most common ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:41 AM
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MCW researcher receives grant to investigate autoantibody production in autoimmune disorders

MCW researcher receives grant to investigate autoantibody production in autoimmune disorders | AUTOIMMUNITY | Scoop.it
Stephen Gauld, PhD, MCW assistant professor of pediatrics in allergy and immunology, and microbiology and molecular genetics, will study the factors involved in regulating the production of autoantibodies, which target an individual’s own tissues...
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Scooped by Gilbert C FAURE
October 12, 2012 2:20 PM
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Compugen Drug Candidate Demonstrates Attenuation of - Drugs.com

Compugen Drug Candidate Demonstrates Attenuation of - Drugs.com | AUTOIMMUNITY | Scoop.it
Suggested mode of action for CGEN-15001 directly impacts key pathogenic aspects of autoimmune disease Results from pre-clinical studies for CGEN-15001 immune ch.
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Scooped by Gilbert C FAURE
October 12, 2012 2:19 PM
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NIH scientist helped solve a frightening bone marrow mystery - Washington Post

NIH scientist helped solve a frightening bone marrow mystery - Washington Post | AUTOIMMUNITY | Scoop.it
NIH scientist helped solve a frightening bone marrow mysteryWashington PostHis Bethesda clinic draws young and old from around the world who cannot make the blood cells they need to survive.
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Scooped by Gilbert C FAURE
October 12, 2012 10:49 AM
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National Institutes of Health renews contract with La Jolla Institute to ... - La Jolla Light

National Institutes of Health renews contract with La Jolla Institute to ... - La Jolla Light | AUTOIMMUNITY | Scoop.it
National Institutes of Health renews contract with La Jolla Institute to ...La Jolla LightHowever, the team began adding epitope data on autoimmune and other immune-mediated diseases over the last few years and the database now contains information...
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Scooped by Gilbert C FAURE
October 12, 2012 10:48 AM
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Medical College of Wisconsin and Children’s Hospital of Wisconsin to investigate autoantibody production in autoimmune disorders - WauwatosaNow

Medical College of Wisconsin and Children’s Hospital of Wisconsin to investigate autoantibody production in autoimmune disorders - WauwatosaNow | AUTOIMMUNITY | Scoop.it
RT @ArthritisUMR: MT @AARDATweets: Medical Col. & Childrens Hosp.
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Scooped by Gilbert C FAURE
October 12, 2012 10:48 AM
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Heat Shock Proteins, Autoimmunity, and Cancer Treatment

Autoimmune Diseases is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of autoimmune diseases.
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Scooped by Gilbert C FAURE
October 14, 2012 3:28 AM
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New institute seeks cures for autoimmune diseases - EastDay.com

New institute seeks cures for autoimmune diseasesEastDay.comTHE Shanghai Institute for Advanced Immunochemical Studies was established today to boost the research and development of antibody drugs for cancer, diabetes, infectious diseases and...
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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Female mouse fetal loss mediated by maternal autoantibody

It represents a novel mechanism by which maternal autoantibodies can severely affect fetal health in a gender-specific fashion and raises the question of how many maternal antibodies affect brain development or exhibit ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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Auto-antibody that causes neurological damage in multiple sclerosis ...

Auto-antibody that causes neurological damage in multiple sclerosis ... | AUTOIMMUNITY | Scoop.it
Attacks potassium channels in glial cells – the brain's myelin forming neuron protectors.
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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Genetic Determinants of 21-Hydroxylase Autoantibodies Amongst ...

Background: Autoantibodies to 21-hydroxylase (21OH-AA) precede the onset of autoimmune Addison's disease (AD) and are found in 1.5% of individuals with type 1 diabetes mellitus (T1DM). The greatest genetic risk for both ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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Autoantibody detection in bullous pemphigoid: Clinical evaluation of ...

Bullous pemphigoid (BP) is an autoimmune blistering skin disease. Autoantibodies to BP180 and BP230 can be detected by indirect immunofluorescence (IIF)...
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Scooped by Gilbert C FAURE
October 13, 2012 4:51 AM
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Genalyte to Host Webinar on Chip-Based Multiplex Autoantibody ...

Genalyte to Host Webinar on Chip-Based Multiplex Autoantibody ... | AUTOIMMUNITY | Scoop.it
SAN DIEGO, CA – September 24, 2012— Genalyte, Inc. today announced that it is hosting a webinar to show participants how they can generate multiplexed autoantibody assay results in a one-step, 15 minute process.
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Scooped by Gilbert C FAURE
October 13, 2012 4:47 AM
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Intricate Interplay | Now@NEJM

Intricate Interplay | Now@NEJM | AUTOIMMUNITY | Scoop.it
Two types of autoimmune hepatitis have been proposed; type 1 is defined by positive results on testing for antinuclear antibodies and smooth-muscle antibodies, and type 2 by positive results on testing for antibodies against ...
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Scooped by Gilbert C FAURE
October 12, 2012 2:20 PM
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Dual-reactive B cells are autoreactive and highly enriched in the ...

These cells are generated more often in autoreactive mice, leading us to hypothesize they might be relevant in autoimmunity. Using mice bearing Igk allotypic markers and a wild-type Ig repertoire, we demonstrate that the ...
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Scooped by Gilbert C FAURE
October 12, 2012 2:19 PM
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New Grant Awards Aim to Prevent Autoimmune Diseases - Newswise (press release)

New Grant Awards Aim to Prevent Autoimmune DiseasesNewswise (press release)Newswise — SEATTLE – (Sept.
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Scooped by Gilbert C FAURE
October 12, 2012 2:19 PM
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Symposier - External Content

Extrapancreatic Autoantibody Profiles in Type I Diabetes http://t.co/nS3Yiv3G...
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Scooped by Gilbert C FAURE
October 12, 2012 10:49 AM
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Scientists uncover genetic clues to common autoimmune liver disease - Balkans.com Business News

Scientists uncover genetic clues to common autoimmune liver disease - Balkans.com Business News | AUTOIMMUNITY | Scoop.it
Scientists uncover genetic clues to common autoimmune liver diseaseBalkans.com Business NewsThe aim of the study was to survey more thoroughly regions of the genome known to underlie other autoimmune diseases, to discover if they also play a role...
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Scooped by Gilbert C FAURE
October 12, 2012 10:48 AM
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Biochemical Journal (2012) 447, 205-215 - M. Blech and others - Molecular structure of an anti-GM-CSF autoantibody in complex with its antigen

Biochemical Journal (2012) 447, 205-215 - M. Blech and others - Molecular structure of an anti-GM-CSF autoantibody in complex with its antigen | AUTOIMMUNITY | Scoop.it
The Biochemical Journal publishes important new findings and reviews across all areas of the molecular biosciences by authors in the international scientific community (Structure of human GM-CSF in complex with an anti-human GM-CSF autoantibody
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