AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
April 3, 2014 3:49 AM
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An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation

An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation | AUTOIMMUNITY | Scoop.it
by Silvana Zgraggen, Reto Huggenberger, Katrin Kerl, Michael Detmar Inflammatory angiogenesis and vascular remodeling play key roles in the chronic inflammatory skin disease psoriasis, but little is known about the molecular mediators of vascular...
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Scooped by Gilbert C FAURE
April 1, 2014 2:11 PM
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Antibiotics A Potential Mechanism For Autoimmunity - Science 2.0

Antibiotics A Potential Mechanism For Autoimmunity
Science 2.0
Autoimmune diseases such as Crohn's disease, eczema, or lupus are caused by an immune system that attacks normal components of various tissues of the body.
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Scooped by Gilbert C FAURE
April 1, 2014 6:00 AM
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Characterization Analysis of Human Anti-Ferritin Autoantibodies

These results suggest that human serum contains anti-ferritin autoantibodies (IgG, IgM and IgA) which bind zinc ions and preferentially bind ferritin over both the H and L subunits, and that a portion of, but not all, the IgM ...
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Scooped by Gilbert C FAURE
April 1, 2014 4:51 AM
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XTL Biopharmaceuticals Retains Expert Consultants in Rheumatology for Phase II Lupus Trial - Applied Clinical Trials

XTL Biopharmaceuticals Retains Expert Consultants in Rheumatology for Phase II Lupus Trial - Applied Clinical Trials | AUTOIMMUNITY | Scoop.it
XTL Biopharmaceuticals Retains Expert Consultants in Rheumatology for Phase II Lupus Trial http://t.co/gt3ML0FZE1
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Scooped by Gilbert C FAURE
March 31, 2014 1:23 PM
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Engineering of a Novel Anti-CD40L Domain Antibody ... [J Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
March 31, 2014 9:53 AM
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Autoimmune diseases briefly explained - Phadia - Setting the Standard - Phadia.com

Autoimmune diseases briefly explained - Phadia - Setting the Standard - Phadia.com | AUTOIMMUNITY | Scoop.it
Autoimmune diseases can be divided into two groups: organ-specific diseases and systemic diseases. (We've all heard of them, but just what are autoimmune diseases?
Gilbert C FAURE's insight:

for laypeople

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Scooped by Gilbert C FAURE
March 30, 2014 2:59 PM
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Theradiag unveils a new automated solution at the International Auto-immunity ... - Business Wire (press release)

Theradiag unveils a new automated solution at the International Auto-immunity ... - Business Wire (press release) | AUTOIMMUNITY | Scoop.it
Theradiag unveils a new automated solution at the International Auto-immunity ...
Gilbert C FAURE's insight:

Theralis® is the new CE Marked fully automated system resulting from Theradiag’s research, providing one of the market’s most comprehensive multiplex set of assays. Steered by the new Solinium® multi-platform software, this new tool incorporates multiplex FIDIS®, immunofluorescence and ELISA technologies. All of a laboratory’s auto-immune analyses can thus be carried out using the same instrument. This new solution is unique on its market.

Polyvalent, Theralis® enables up to 120 samples and 60 tests to be loaded and 3 analysis methodologies to be carried out simultaneously. Theralis® thus meets the demands of public and private laboratories, which need greater polyvalence and speed to cope with their requirements, but also enhanced precision and reliability for patient diagnostics. This new platform further consolidates the multiple Fidis portfolio.

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Scooped by Gilbert C FAURE
March 30, 2014 11:45 AM
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Diagnostic criteria in Autoimmune diseases - Autoimmunity Reviews - Elsevier

Diagnostic criteria in Autoimmune diseases - Autoimmunity Reviews - Elsevier | AUTOIMMUNITY | Scoop.it
Special Issues in Autoimmunity Reviews and Journal of Autoimmunity

Autoimmunity Reviews and the Journal of Autoimmunity both feature a special... (Buenas revisiones, gratis hasta junio.
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Rescooped by Gilbert C FAURE from Cancer Immunotherapy Review and Collection
March 27, 2014 3:11 AM
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Immunology: A tolerant approach

Immunology: A tolerant approach | AUTOIMMUNITY | Scoop.it
Despite a long record of failure, a few immunologists continue to pursue precisely targeted therapies for autoimmune diseases.

Via Krishan Maggon
Krishan Maggon 's curator insight, March 27, 2014 2:57 AM

Article links full text

 

Immunology: A tolerant approach

Despite a long record of failure, a few immunologists continue to pursue precisely targeted therapies for autoimmune diseases.

Ken Garber26 March 2014 Nature 507, 418–420 (27 March 2014) doi:10.1038/507418a
Scooped by Gilbert C FAURE
March 26, 2014 5:13 PM
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Can-Fite to Present at the 9th International Congress of Autoimmunity - MarketWatch

Can-Fite to Present at the 9th International Congress of Autoimmunity - MarketWatch | AUTOIMMUNITY | Scoop.it
Can-Fite to Present at the 9th International Congress of Autoimmunity MarketWatch About 9th International Congress On Autoimmunity The 9th International Congress on Autoimmunity is the world's foremost gathering of top experts in immunology,...
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Scooped by Gilbert C FAURE
March 25, 2014 10:12 AM
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Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review

RT @SjogrensCa: Infection and autoimmunity in Sjogrens syndrome: A clinical study and comprehensive review http://t.co/mOU8AvBrYK #sjogrens…
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Suggested by Société Francaise d'Immunologie
March 22, 2014 3:39 PM
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The Degree of CD4+ T Cell Autoreactivity Determines Cellular Pathways Underlying Inflammatory Arthritis [AUTOIMMUNITY]

The Degree of CD4+ T Cell Autoreactivity Determines Cellular Pathways Underlying Inflammatory Arthritis [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
Although therapies targeting distinct cellular pathways (e.g., anticytokine versus anti–B cell therapy) have been found to be an effective strategy for at least some patients with inflammatory arthritis, the mechanisms that determine which pathways...
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Suggested by Société Francaise d'Immunologie
March 22, 2014 3:39 PM
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Inhibitory Fc{gamma} Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms [AUTOIMMUNITY]

Inhibitory Fc{gamma} Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
The inhibitory FcR FcRIIB is widely expressed on B cells, dendritic cells (DCs), and myeloid effector cells and modulates a variety of Ab-driven in vivo functions.
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Scooped by Gilbert C FAURE
April 2, 2014 12:26 PM
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Increased Risk of Epilepsy Among Autoimmune Disease Patients - PR Newswire (press release)

Increased Risk of Epilepsy Among Autoimmune Disease Patients PR Newswire (press release) BOSTON, March 31, 2014 /PRNewswire-USNewswire/ -- Patients with an autoimmune disease have a 3.8-fold increased risk of developing epilepsy, according to a new...
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Scooped by Gilbert C FAURE
April 1, 2014 1:38 PM
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Passive transfer of narcolepsy: anti-TRIB2 autoa... [J Autoimmun. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
April 1, 2014 5:55 AM
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MLabs :: Clinical Immunology

MLabs :: Clinical Immunology | AUTOIMMUNITY | Scoop.it
The Clinical Immunology Laboratory offers a wide variety of autoantibody tests and protein electrophoresis  http://t.co/sBwyI0bR2H
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Scooped by Gilbert C FAURE
March 31, 2014 1:32 PM
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Lupus nephritis: update on mecha... [Curr Opin Nephrol Hypertens. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
March 31, 2014 9:54 AM
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Kadmon Corporation Presents Results at the 9th International Congress on ... - Marketwired (press release)

Kadmon Corporation Presents Results at the 9th International Congress on ... - Marketwired (press release) | AUTOIMMUNITY | Scoop.it
Kadmon Corporation Presents Results at the 9th International Congress on ...
Gilbert C FAURE's insight:

Kadmon Corporation, LLC, today announced the presentation of data demonstrating the effects of KD025, the Company's Phase 2, orally bioavailable, potent and highly selective inhibitor of ROCK 2 (Rho-associated coiled-coiled kinase 2), on immune homeostasis. The data were presented at the "T Cells and Autoimmunity" session by Alexandra Zanin-Zhorov, Ph.D., Kadmon's Senior Director of Immunology, at the 9th Annual International Congress on Autoimmunity held March 26 - 30 in Nice, France.

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Scooped by Gilbert C FAURE
March 31, 2014 9:52 AM
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Interferon-γ Induces Senescence in Normal Human Melanocytes

Interferon-γ Induces Senescence in Normal Human Melanocytes | AUTOIMMUNITY | Scoop.it
by Suiquan Wang, Miaoni Zhou, Fuquan Lin, Dongyin Liu, Weisong Hong, Liangjun Lu, Yiping Zhu, Aie Xu
Background Interferon-γ (IFN-γ) plays an important role in the proceedings of vitiligo through recruiting lymphocytes to the lesional skin.
Gilbert C FAURE's insight:

vitiligo and autoimmunity?

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Scooped by Gilbert C FAURE
March 30, 2014 11:47 AM
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Immunology: A tolerant approach

Immunology: A tolerant approach | AUTOIMMUNITY | Scoop.it
Despite a long record of failure, a few immunologists continue to pursue precisely targeted therapies for autoimmune diseases.
Gilbert C FAURE's insight:

at last, some cautiousness on clinical trials

Remi Creusot's curator insight, March 31, 2014 10:43 AM

Excellent overview of the current state of tolerance-inducing therapies.

Scooped by Gilbert C FAURE
March 30, 2014 11:41 AM
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Smell and Autoimmunity: A Comprehensive Review - Springer

Smell and Autoimmunity: A Comprehensive Review - Springer | AUTOIMMUNITY | Scoop.it
RT @SjogrensCa: Smell and autoimmunity: a comprehensive review. http://t.co/OE7Q2KVBBt #sjogrens #rheum
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Scooped by Gilbert C FAURE
March 26, 2014 5:14 PM
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Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products

Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products | AUTOIMMUNITY | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Scooped by Gilbert C FAURE
March 25, 2014 4:10 PM
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Shingles Vaccine OK in Mild Lupus - MedPage Today

Shingles Vaccine OK in Mild Lupus - MedPage Today | AUTOIMMUNITY | Scoop.it
Shingles Vaccine OK in Mild Lupus
MedPage Today
The zoster vaccine Zostavax has been available since 2006, but there are no data on either immunogenicity or safety for patients with autoimmune diseases.
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Scooped by Gilbert C FAURE
March 24, 2014 2:04 PM
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A non complement-fixing antibody to β2 glycoprotein I as a novel ...

A non complement-fixing antibody to β2 glycoprotein I as a novel ... | AUTOIMMUNITY | Scoop.it
Key points. A recombinant antibody recognizing the D1 domain of β2 glycoprotein I induces fetal loss and clot formation in animal models. The CH2-deleted antibody fails to activate complement and prevents the ...
Gilbert C FAURE's insight:
as a novel therapy to control abortions and thrombosis in antiphospholipid syndrome
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Suggested by Société Francaise d'Immunologie
March 22, 2014 3:39 PM
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In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis [AUTOIMMUNITY]

In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
Autoreactive B cells are essential for the pathogenesis of type 1 diabetes. The genesis and dynamics of autoreactive B cells remain unknown.
Gilbert C FAURE's insight:

..... analyzed the immune response in the NOD mouse model to the neuronal protein peripherin (PRPH) http://en.wikipedia.org/wiki/Peripherin,

a target Ag of islet-infiltrating B cells. PRPH autoreactive B cells recognized a single linear epitope of this protein, in contrast to the multiple epitope recognition commonly observed during autoreactive B cell responses. Autoantibodies to this epitope were also detected in the disease-resistant NOR and C57BL/6 strains.

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