AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
October 18, 2012 7:33 AM
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Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

Free #BloodJournal: Neutrophil extracellular traps trigger adaptive immune response relevant for autoimmunity http://t.co/5bo8FbWj...
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Scooped by Gilbert C FAURE
October 17, 2012 2:57 AM
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Multiple Sclerosis Research: Autoimmune hepatitis, daclizumab and ...

Multiple Sclerosis Research: Autoimmune hepatitis, daclizumab and ... | AUTOIMMUNITY | Scoop.it
Autoimmune hepatitis is just such an adverse event. I have personally seen two cases that occurred in MSers on interferon beta. In both cases they were considered by the hepatologist to be unrelated to the treatment.
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Scooped by Gilbert C FAURE
October 16, 2012 10:06 AM
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Bacteria as an Environmental Trigger of Type 1 Diabetes | Health-e ...

Bacteria as an Environmental Trigger of Type 1 Diabetes | Health-e ... | AUTOIMMUNITY | Scoop.it
A small U.S.-Finnish study including four DIPP children who eventually progressed to clinical T1D and four matched autoantibody-negative controls studied the intestinal microbiome in stool samples obtained before and at ...
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Scooped by Gilbert C FAURE
October 15, 2012 7:36 AM
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Rare B cells regulate immune responses; May offer novel treatment for

Rare B cells regulate immune responses; May offer novel treatment for | AUTOIMMUNITY | Scoop.it
Reproducing a rare type of B cell in the laboratory and infusing it back into the body may provide an effective treatment for severe autoimmune diseases such as multiple sclerosis or rheumatoid arthritis, according to ...
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Scooped by Gilbert C FAURE
October 14, 2012 3:29 AM
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Editorial: Natural killer cell-mediated augmentation of autoantibody production? - Journal of Leukocyte Biology (subscription)

Editorial: Natural killer cell-mediated augmentation of autoantibody production?Journal of Leukocyte Biology (subscription)Editorial: Natural killer cell-mediated augmentation of autoantibody production?
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Scooped by Gilbert C FAURE
October 14, 2012 3:29 AM
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Sanofi's Genzyme says making progress with MS drugs - Reuters

Sanofi's Genzyme says making progress with MS drugsReuters"Neurologists may feel threatened, but they will have to understand how the immune system works and how to handle, so I don't think autoimmunity will be a big problem," she said.
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Scooped by Gilbert C FAURE
October 13, 2012 2:26 PM
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Multiple Sclerosis Research: Research: Antibodies against Tysabri

Multiple Sclerosis Research: Research: Antibodies against Tysabri | AUTOIMMUNITY | Scoop.it
METHODS:Screening for anti-natalizumab antibodies was performed using a standardized bridging ELISA. Antibody-positive samples were further analyzed for IgM and IgG1-4 antibodies using ELISA and ImmunoCAP®.
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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A novel autoantibody against fibronectin leucine-rich transmembrane

Anti-endothelial cell antibodies (AECAs) are thought to be critical for vasculitides in collagen diseases, but most were directed against molecules localized within the cell and not expressed on the cell surface.
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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Autoantibody profiling to follow evolution of lupus syndromes

Identification of patients who are in early stages of lupus is currently done through clinical evaluation and is not greatly facilitated by available diagnostic tests.
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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Anti CD19/CD11c Bi-Specific Antibodies Target A Subset Of B Cells ...

Anti CD19/CD11c Bi-Specific Antibodies Target A Subset Of B Cells ... | AUTOIMMUNITY | Scoop.it
It is estimated that 23.5 million Americans suffer from autoimmune disease (AD) and that the prevalence is rising. Researchers have identified 80-100 different ADs and suspect at least 40 additiona...
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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American Thyroid Association to Award Sandra McLachlan, PhD ...

She also established the thyroid gland as the major site of thyroid autoantibody production, providing the basis for using thyroid tissue from patients with autoimmune thyroid disease in her subsequent cloning of human ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:51 AM
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Inflammablog6!: The first identified neurological autoimmune ...

Inflammablog6!: The first identified neurological autoimmune ... | AUTOIMMUNITY | Scoop.it
In 1960, Simpson was the first to propose that the pathogenesis of MG was an autoimmune reaction that involved an antibody specific for a neuromuscular junction protein. Which turned out to be correct, the most common ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:41 AM
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MCW researcher receives grant to investigate autoantibody production in autoimmune disorders

MCW researcher receives grant to investigate autoantibody production in autoimmune disorders | AUTOIMMUNITY | Scoop.it
Stephen Gauld, PhD, MCW assistant professor of pediatrics in allergy and immunology, and microbiology and molecular genetics, will study the factors involved in regulating the production of autoantibodies, which target an individual’s own tissues...
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Scooped by Gilbert C FAURE
October 17, 2012 2:57 AM
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WO2012139051A2 AUTOANTIBODY BIOMARKERS FOR IGA NEPHROPATHY

WO2012139051A2 AUTOANTIBODY BIOMARKERS FOR IGA NEPHROPATHY | AUTOIMMUNITY | Scoop.it
WIPO patent: Aspects of the present invention include methods for diagnosing and monitoring IgAN in a subject.
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Scooped by Gilbert C FAURE
October 17, 2012 2:57 AM
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Vitamin D supplements may benefit lupus patients | Science Codex

Vitamin D supplements may benefit lupus patients | Science Codex | AUTOIMMUNITY | Scoop.it
SLE is a T- and B-cell-dependent disease that causes an appearance of autoantibodies, causing the body to attack itself. Patients present with a depletion of regulatory T cells (Tregs) that normally protect against autoimmune ...
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Scooped by Gilbert C FAURE
October 16, 2012 10:06 AM
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PLOS ONE: Soluble IL-2Rα (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice

PLOS ONE: Soluble IL-2Rα (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice | AUTOIMMUNITY | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Scooped by Gilbert C FAURE
October 14, 2012 3:39 AM
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Immunofluorescence antigen mapping for hereditary epidermolysis bullosa Rao R, Mellerio J, Bhogal BS, Groves R - Indian J Dermatol Venereol Leprol

Immunofluorescence antigen mapping for hereditary epidermolysis bullosa Rao R, Mellerio J, Bhogal BS, Groves R - Indian J Dermatol Venereol Leprol | AUTOIMMUNITY | Scoop.it
Open Access Peer-Reviewed Publication of IADVL (Immunofluorescence antigen mapping for hereditary epidermolysis bullosa: This article describes the technicaliti...)...
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Scooped by Gilbert C FAURE
October 14, 2012 3:29 AM
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Validation of a multiplex chip-based for the detection of autoantibodies ... - 7thSpace Interactive (press release)

Validation of a multiplex chip-based for the detection of autoantibodies ...7thSpace Interactive (press release)IntroductionAutoantibodies directed against citrullinated proteins/peptides (ACPA) are highly specific and predictive for the...
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Scooped by Gilbert C FAURE
October 14, 2012 3:28 AM
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New institute seeks cures for autoimmune diseases - EastDay.com

New institute seeks cures for autoimmune diseasesEastDay.comTHE Shanghai Institute for Advanced Immunochemical Studies was established today to boost the research and development of antibody drugs for cancer, diabetes, infectious diseases and...
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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Female mouse fetal loss mediated by maternal autoantibody

It represents a novel mechanism by which maternal autoantibodies can severely affect fetal health in a gender-specific fashion and raises the question of how many maternal antibodies affect brain development or exhibit ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:53 AM
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Auto-antibody that causes neurological damage in multiple sclerosis ...

Auto-antibody that causes neurological damage in multiple sclerosis ... | AUTOIMMUNITY | Scoop.it
Attacks potassium channels in glial cells – the brain's myelin forming neuron protectors.
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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Genetic Determinants of 21-Hydroxylase Autoantibodies Amongst ...

Background: Autoantibodies to 21-hydroxylase (21OH-AA) precede the onset of autoimmune Addison's disease (AD) and are found in 1.5% of individuals with type 1 diabetes mellitus (T1DM). The greatest genetic risk for both ...
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Scooped by Gilbert C FAURE
October 13, 2012 4:52 AM
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Autoantibody detection in bullous pemphigoid: Clinical evaluation of ...

Bullous pemphigoid (BP) is an autoimmune blistering skin disease. Autoantibodies to BP180 and BP230 can be detected by indirect immunofluorescence (IIF)...
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Scooped by Gilbert C FAURE
October 13, 2012 4:51 AM
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Genalyte to Host Webinar on Chip-Based Multiplex Autoantibody ...

Genalyte to Host Webinar on Chip-Based Multiplex Autoantibody ... | AUTOIMMUNITY | Scoop.it
SAN DIEGO, CA – September 24, 2012— Genalyte, Inc. today announced that it is hosting a webinar to show participants how they can generate multiplexed autoantibody assay results in a one-step, 15 minute process.
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Scooped by Gilbert C FAURE
October 13, 2012 4:47 AM
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Intricate Interplay | Now@NEJM

Intricate Interplay | Now@NEJM | AUTOIMMUNITY | Scoop.it
Two types of autoimmune hepatitis have been proposed; type 1 is defined by positive results on testing for antinuclear antibodies and smooth-muscle antibodies, and type 2 by positive results on testing for antibodies against ...
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