by Si Chen, Qian Wang, Ziyan Wu, Qingjun Wu, Ping Li, Yuan Li, Jing Li, Chuiwen Deng, Chanyuan Wu, Lei Gao, Fengchun Zhang, Yongzhe Li Background Some surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on...
To examine the long-term effect of high-frequency IAS combined with standard immunosuppression on patient and renal survival in patients with anti-GBM-disease and to quantify antibody removal and kinetics through IAS.
In the small town of Libby in northwestern Montana, prospectors in 1916 discovered an unusual mineral known as vermiculite that appeared to be resistant to fire after initial exposure to high heat. Bu (Asbestos Revisited: A New Autoimmune Disease?
Medical Xpress Network of experts join forces to fight rare disease Youris.com Let alone to recruit enough patients into clinical trials. To side step this problem, the EU funded project FIGHT-MG ...
Medical Xpress How rare models suggest new treatment strategies Medical Xpress I think that the first clinical trial could be done in less than 3 years.
CD1d-restricted NKT cells can be divided into two groups: type I NKT cells use a semi-invariant TCR, whereas type II express a relatively diverse set of TCRs.
Obstacles to Care in Patients with Autoimmune Disease Doctor Tipster The American Autoimmune Related Diseases Association (AARDA) reports that there are as many as 80 to 100 types of autoimmune diseases.
by Ingrid Kikkas, Roberto Mallone, Etienne Larger, Hervé Volland, Nathalie Morel Type 1 diabetes (T1D) results from the destruction of pancreatic insulin-producing beta cells and is strongly associated with the presence of islet autoantibodies.
In the current study, they describe the development of a novel LFIA for detection of IA-2As.... this could be the first LFIA format described, detecting T1D-associated autoantibodies in human serum samples.
Genes and Immunity is a journal dedicated to functional genetics of the immune response. Emphasizing studies that demonstrate genetic, genomic or functional variation in the immune system, Genes and Immunity assists our understanding of how the basic control over the immune system varies between individuals both in health and disease.
A genome-wide significant association with cryoglobulin-related vasculitis was identified with SNPs near NOTCH4 and MHC Class II genes. The two regions are correlated and it is difficult to disentangle which gene is responsible for the association with mixed cryoglobulinemia vasculitis in this extended major histocompatibility complex region.
by Yanxia Fu, Hailing Zhou, Shuangyan Wang, Qun Wei Glycyrol is a natural compound extracted from Glycyrrhiza uralensis, first reported by us to be a new immunosuppressant.
As you consider autoimmune epilepsy in the differential diagnosis, the following may be clues leading to an autoimmune cause and use of the autoantibody profiles. Subacute onset of cognitive or other neuropsychiatric ...
Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate. Sven Jarius, Friedemann Paul, Kai Fechner, Klemens ...
National Geographic Study linking narcolepsy to autoimmunity retracted Science News But in subsequent experiments, the scientists have been unable to replicate their main result: a stronger autoimmune reaction in T cells from people with narcolepsy...
The 10th International Congress on Autoimmunity is the only meeting where you can learn about more than 80 autoimmune diseases from a variety of perspectives, both research-based and clinical....
FIGHT-MG is a European consortium aiming to shed light on the course of Myasthenia Gravis (MG) disease, but also on the etiological and pathological mechanisms of MG.
Myasthenia Gravis is a rare and heterogeneous neuromuscular disease affecting the neuromuscular junction and leading to abnormal fatigability of various skeletal muscles. The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies.
Inflammasome-driven inflammation extends into the extracellular space and to neighboring cells through the passive release of specks consisting of the adaptor ASC
Increasing evidence suggests that type 1 IFN (IFN-αβ) is associated with pathogenesis of Th1-mediated type 1 diabetes (T1D). A major source of IFN-αβ is plasmacytoid dendritic cells (pDCs).
Teacher friends, help spread the word about autoimmune diseases and educate your students about their immune systems with free, Common Core-aligned reading passages plus free activities and student project ideas from the American Autoimmune Related Diseases Association. Check it out.
Dr. Mark Wener from the University of Washington discusses recent trends in autoantibody testing, which includes testing for such conditions as lupus, rheumatoid arthritis, and other autoimmune...
As you consider autoimmune dementia in the differential diagnosis, the following may be clues leading to an autoimmune cause and use of the autoantibody profiles. Subacute onset of cognitive or other neuropsychiatric ...
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