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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
July 19, 2014 4:00 PM
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Abatacept still an option for difficult SLE cases - Rheumatology Update

Abatacept still an option for difficult SLE cases - Rheumatology Update | AUTOIMMUNITY | Scoop.it
Abatacept still an option for difficult SLE cases Rheumatology Update It's the first drug targeting co-stimulation between T cells and antigen-presenting cells and, despite its short-comings, it is a possible therapeutic option as an off-label...
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Scooped by Gilbert C FAURE
July 19, 2014 3:06 AM
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Plasmonic chip diagnoses diabetes - nanotechweb.org

Plasmonic chip diagnoses diabetes - nanotechweb.org | AUTOIMMUNITY | Scoop.it
Plasmonic chip diagnoses diabetes nanotechweb.org T1D is different from T2D in that patients with the disorder have a much higher concentration of autoantibodies against one or more so-called pancreatic islet antigens (such as insulin, glutamic...
Gilbert C FAURE's insight:

with more technical details than the press release

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Scooped by Gilbert C FAURE
July 18, 2014 4:16 AM
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Diagnosing Type 1 Diabetes with Nanotechnology - Genetic Engineering News

Diagnosing Type 1 Diabetes with Nanotechnology - Genetic Engineering News | AUTOIMMUNITY | Scoop.it
Genetic Engineering News
Diagnosing Type 1 Diabetes with Nanotechnology
Genetic Engineering News
Type 1 diabetes is an autoimmune disease caused by an inappropriate immune-system attack on healthy tissue.
Gilbert C FAURE's insight:

bis, out of a large series of posts

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Scooped by Gilbert C FAURE
July 18, 2014 3:34 AM
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PEPperPRINT: Product Update: PEPperCHIP® Autoimmune Epitope Microarray 2.0 released

PEPperPRINT: Product Update: PEPperCHIP® Autoimmune Epitope Microarray 2.0 released | AUTOIMMUNITY | Scoop.it
Gilbert C FAURE's insight:

The new PEPperCHIP® Autoimmune Epitope Microarray 2.0 now covers 3,359 linear autoimmune epitopes including 192 citrullinated peptides as well as the corresponding arginine variants. The IEDB-derived epitopes correlate with a variety of autoimmune diseases including Crohn’s disease, diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, vitiligo and many more.

 

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Scooped by Gilbert C FAURE
July 17, 2014 3:49 PM
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Bristol University | School of Clinical Sciences | Islet cell autoantibodies

Bristol University | School of Clinical Sciences | Islet cell autoantibodies | AUTOIMMUNITY | Scoop.it
Nice explanation of research developments in autoantibody testing, in ppl at risk of developing type 1 #diabetes http://t.co/jhqv1JyuzJ
Gilbert C FAURE's insight:

nice review on type I diabetes immunology

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Scooped by Gilbert C FAURE
July 15, 2014 2:20 PM
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Stanford researchers believe microchip holds key to diabetes diagnoses - Washington Business Journal (blog)

Stanford researchers believe microchip holds key to diabetes diagnoses - Washington Business Journal (blog) | AUTOIMMUNITY | Scoop.it
Stanford researchers believe microchip holds key to diabetes diagnoses
Washington Business Journal (blog)
What's the key here? The technical way to find a way to objectively diagnose type 1 from type 2 is to detect an autoantibody in the blood.
Société Francaise d'Immunologie's comment, July 16, 2014 8:36 AM
What we have done is use state-of-the-art technology to come up with a cheap test that uses just a drop of blood and tells people in hours if they have autoantibodies or not.

We really think this technology can be pushed to the bedside very quickly to diagnose between type 1 and type 2.

These autoantibodies are the final say in type 1 diabetes? There are basically three autoantibodies that we can measure, simultaneously, and their risk is cumulative. If you have one present, your risk is increased 10 to 20 percent; if all three are present, you have greater than 90 percent risk of developing diabetes in the future.
Société Francaise d'Immunologie's comment, July 16, 2014 8:37 AM
it is not so difficult with IF technology, and cheaper in europe?
Scooped by Gilbert C FAURE
July 14, 2014 3:40 PM
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Molecular mechanisms underlying the prevention of autoimmunity by Roquin ... - Phys.Org

Molecular mechanisms underlying the prevention of autoimmunity by Roquin ... - Phys.Org | AUTOIMMUNITY | Scoop.it
Molecular mechanisms underlying the prevention of autoimmunity by Roquin ...
Gilbert C FAURE's insight:

roquin?

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Scooped by Gilbert C FAURE
July 14, 2014 2:45 PM
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Portable, microchip-based test for diagnosing type-1 diabetes

Portable, microchip-based test for diagnosing type-1 diabetes | AUTOIMMUNITY | Scoop.it
An inexpensive, portable, microchip-based test for diagnosing type-1 diabetes could improve patient care worldwide and help researchers better understand the disease, according to the device's inventors at the Stanford University School of Medicine.
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Scooped by Gilbert C FAURE
July 10, 2014 12:59 PM
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Pathogenesis of antineutrophil cytoplasmic... [Nat Rev Rheumatol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
July 9, 2014 3:19 PM
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Autoimmune Aquaporin-4 Myopathy in Neuromyelitis Optica Spectrum (NMO)

Autoimmune Aquaporin-4 Myopathy in Neuromyelitis Optica Spectrum (NMO) | AUTOIMMUNITY | Scoop.it
A recent article in JAMA Neurology features a case report by a team of Mayo Clinic researchers that implies involvement of organs beyond the central nervous system in neuromyelitis optica spectrum disorders.
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Scooped by Gilbert C FAURE
July 8, 2014 3:05 PM
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Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes

Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes | AUTOIMMUNITY | Scoop.it
Endocrinology Medical Article: Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes (Human mesenchymal stem cell-derived microvesicles modulate T...
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Scooped by Gilbert C FAURE
July 8, 2014 2:56 PM
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Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset

Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset | AUTOIMMUNITY | Scoop.it
Rheumatology Medical Article: Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset (Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and a...
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Scooped by Gilbert C FAURE
July 4, 2014 3:10 PM
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Glenmark’s Novel Monoclonal Antibody GBR 830 for Treatment of Autoimmune Diseases Entering Human Trials | CooldotzNet for #businessnews, #pressreleases, #companynews

Glenmark’s Novel Monoclonal Antibody GBR 830 for Treatment of Autoimmune Diseases Entering Human Trials | CooldotzNet for #businessnews, #pressreleases, #companynews | AUTOIMMUNITY | Scoop.it
MUMBAI,India, July 3, 2014 /PRNewswire/ -- GBR 830 is an antagonistic monoclonal antibody with first in class potential for the treatment of autoimmune diseases (Glenmark's Novel Monoclonal Antibody GBR 830 for Treatment of Autoimmune Diseases Entering...
Gilbert C FAURE's insight:

XmAb7195 targets IgE with its variable domain, and uses Xencor's XmAb® immune inhibitor Fc domain to target FcRIIb, resulting in three distinct mechanisms of action for reducing IgE levels. First, XmAb7195 sequesters free IgE and prevents activation of mast cells and basophils, the mediators of allergic inflammation and pathology. Second, it prevents IgE production by suppressing IgE-positive B-cell activation and differentiation into IgE-secreting plasma cells. Third, Xencor has discovered a new mechanism of action whereby high FcRIIb binding causes extremely rapid clearance of the complexes formed between XmAb7195 and IgE, resulting in rapid and marked reductions of the total IgE and free IgE in circulation.

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Scooped by Gilbert C FAURE
July 19, 2014 3:56 PM
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Interdisciplinary Autoimmune Summit Successfully Launches First National ... - Motor E magazine

Interdisciplinary Autoimmune Summit Successfully Launches First National ... - Motor E magazine | AUTOIMMUNITY | Scoop.it
Interdisciplinary Autoimmune Summit Successfully Launches First National ...
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Scooped by Gilbert C FAURE
July 18, 2014 1:25 PM
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JDRF Partner ViaCyte Announces Key Project Milestone to Advance Innovative ... - MarketWatch

JDRF Partner ViaCyte Announces Key Project Milestone to Advance Innovative ... - MarketWatch | AUTOIMMUNITY | Scoop.it
JDRF Partner ViaCyte Announces Key Project Milestone to Advance Innovative ...
Gilbert C FAURE's insight:

for type 1 diabetes

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Scooped by Gilbert C FAURE
July 18, 2014 4:15 AM
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Paraneoplastic Jaw Dystonia and Laryngospasm With Antineuronal Nuclear Autoantibody Type 2 (Anti-Ri)

Arch Neurol. 2010;67(9):1109-1115. doi: 10.1001/archneurol.2010.209. Read the article here: http://dx.doi.org/10.1001/archneurol.2010.209.
Gilbert C FAURE's insight:

clinic of two patients published in 2010

no image of IF on cerebellum, too bad

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Scooped by Gilbert C FAURE
July 17, 2014 4:05 PM
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Restaurant Servers: "Your Gluten Allergy Is Fake and I Hate You" - Restaurant Marketing, Website, & Consulting Solutions | Dineability

Restaurant Servers: "Your Gluten Allergy Is Fake and I Hate You" - Restaurant Marketing, Website, & Consulting Solutions | Dineability | AUTOIMMUNITY | Scoop.it
Tweet TweetThis week has been very controvesial for the gluten-free food craze that has … (Restaurant Servers: "Your Gluten Allergy Is Fake and I Hate You" Study Immunology Idiot before you rant and Rave!
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Scooped by Gilbert C FAURE
July 17, 2014 11:10 AM
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IMI2 1st call for proposals 2014 - Cordis News

IMI2 1st call for proposals 2014
Cordis News
With regards to Type 1 diabetes, the aims to bring together leading clinicians and researchers from the areas of immunology, beta cell biology, and biomarker research from academia and industry.
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Scooped by Gilbert C FAURE
July 14, 2014 3:45 PM
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A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes - Nature.com

A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes
Nature.com
Type 1 diabetes (T1D) is an autoimmune disease, whereas type 2 diabetes (T2D) results from insulin resistance and beta cell dysfunction.
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Rescooped by Gilbert C FAURE from Immunology and Biotherapies
July 14, 2014 3:21 PM
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Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 ...

OBJECTIVE Previous studies demonstrated that the anti-CD3 monoclonal antibody otelixizumab, administered at a total dose of 48–64 mg, can slow the loss of C-peptide in recent-onset type 1 diabetes patients, with frequent ...
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Scooped by Gilbert C FAURE
July 11, 2014 3:27 PM
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Treatment (biotherapy excluded) of psoriatic arthritis: an appraisal of methodological quality of international guidelines - Sevrain - 2014 - Journal of the European Academy of Dermatology and Vene...

Treatment (biotherapy excluded) of psoriatic arthritis: an appraisal of methodological quality of international guidelines - Sevrain - 2014 - Journal of the European Academy of Dermatology and Vene... | AUTOIMMUNITY | Scoop.it
Treatment (biotherapy excluded) of psoriatic arthritis: an appraisal of methodological quality of international ... http://t.co/xLC85MzJPT
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Scooped by Gilbert C FAURE
July 9, 2014 3:23 PM
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PTPN22: the archetypal non-HLA autoimmunity gene : Nature Reviews Rheumatology : Nature Publishing Group

PTPN22: the archetypal non-HLA autoimmunity gene : Nature Reviews Rheumatology : Nature Publishing Group | AUTOIMMUNITY | Scoop.it
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Scooped by Gilbert C FAURE
July 9, 2014 2:43 PM
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Biological Sciences M121. Immunology with Hematology. Lecture 24. Autoimmune Diseases.

UCI BioSci M121: Immunology with Hematology (Fall 2013) Lec 24. Immunology with Hematology -- Autoimmune Diseases -- View the complete course: http://ocw.uci.edu/courses/biosci_m121_immunology_with...
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Scooped by Gilbert C FAURE
July 8, 2014 2:57 PM
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Genetic Risks Link Autoimmune Hepatitis to Other Autoimmune Liver Disease

http://t.co/yiT7BLz6hz
Editorial in this months Gastroenterology covers common mechanisms in liver autoimmunity http://t.co/ec08SjSrI1
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Scooped by Gilbert C FAURE
July 8, 2014 4:08 AM
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AUTOIMMUNITY Site

AUTOIMMUNITY Site | AUTOIMMUNITY | Scoop.it
AUTOIMMUNITY 10th International Congress on Autoimmunity. Site http://t.co/TwCGM3poig
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