Allergy (and clinical immunology)
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Origins of peanut allergy-causing antibodies | Science

Origins of peanut allergy-causing antibodies | Science | Allergy (and clinical immunology) | Scoop.it
Some people produce immunoglobulin E (IgE) antibodies to proteins in common foods. As a result, these foods can trigger severe allergic inflammation (anaphylaxis). There are several structurally and functionally distinct antibody isotypes (IgM, IgD, IgG, IgA, and IgE), and which isotype binds to a target molecule (antigen) influences what happens next. For example, IgG that binds peanut proteins is harmless, but IgE bound to the same proteins can induce anaphylaxis and death. Therefore, how, where, and why allergen-reactive IgE is made are decades-old questions. Hoh et al. (1) found that gut tissue is a likely place for IgE development in peanut-allergic individuals. In addition, despite vast sequence possibilities, they found that many individuals share similar peanut-reactive IgE DNA sequences. This suggests that IgE antibodies in different individuals recognize peanut proteins in a similar manner, which could inform strategies for pharmacological interventions. Antibodies are produced by cells of the B lymphocyte lineage and consist of four Ig polypeptide chains—two identical heavy (H) chains and two identical light (L) chains—and each chain has a variable (V) region and a constant (C) region. The V region forms the surface that physically binds to antigens such as peanut proteins. The C region of IgH (CH) dictates antibody function largely by triggering processes that lead to neutralization, elimination, or induction of inflammation. Assembly of multiple IGH gene segments through the process of V(D)J recombination results in enormous sequence diversity, particularly in the exon encoding the V region, which comprises much of the antigen binding surface. Next to the V exon are a variety of C-region exons arranged in tandem (e.g., Cµ, Cγ, Cε, and Cα), which define the different antibody isotypes (2). Newly assembled Ig is produced as IgM. However, during an immune response, the same V region of IgH (VH) can be expressed in the context of another C-region isotype through a process called class switch recombination (CSR). This positions an alternative CH region next to the VH exon by permanent excision of the intervening DNA and associated CH-encoding exons. The position of CH exons relative to each other thus determines which IgH isotypes are available for secondary switch events. For example, an IgM-expressing B cell can switch to IgG1, and then that same IgG1+ B cell can switch to IgE because Cε is 3′ (downstream) to Cγ1 in the IGH locus. However, IgE-expressing B cells cannot switch to IgG1 (or any other isotype whose CH is positioned 5′ to Cε). Somatic hypermutation (SHM) further diversifies V regions by introducing mutations that can enhance affinity to antigen (3). The V(D)J recombination–, CSR-, and SHM-mediated processing of IGH enable phylogenetic mapping of how B-lineage cells and the antibodies they produce are related to one another. To gain insights into the origins of IgE production and the relationships between antibody-producing cells, Hoh et al. sequenced the IGH genes from B-lineage plasma cells in upper digestive tract tissues of 19 peanut-allergic individuals and compared them with those of nonallergic controls. They found more IgE-expressing cells in gut tissue in food-allergic individuals, confirming previous findings (4). Multiple clonally related VH-encoding sequences in IgE antibodies were also shared with other IgH isotypes. These findings suggest that B cells undergo CSR to IgE in the gut tissue as opposed to undergoing CSR to IgE elsewhere before migrating to the gut. This is different to the case of bone marrow, which is a major destination for antibody-producing cells after CSR elsewhere. This raises an important question: What features of the gut environment favor CSR to IgE? Moreover, because the bone marrow is a major location of antibody production, including IgE in allergic disease (5), the degree to which gut-derived versus bone marrow–derived IgE affects clinical disease, prognosis, and treatment approaches remains to be determined (see the figure). Hoh et al. identified antibody sequences that are reactive to the peanut protein Ara h 2 (Arachis hypogaea allergen 2) and found groups of similar sequences among multiple individuals. Similar sequences were also found in analyses of IgE+ B cells from peripheral blood in individuals with peanut allergy (6), further validating the concept of convergent IgE development to peanut proteins. Nonallergic individuals also had Ara h 2–reactive sequences, but only in non-IgE isotypes such as IgM, IgG, and IgA. These findings highlight how antibodies that induce a food-allergic response are generated. The production of antibodies that bind peanut proteins does not seem to be the problem per se; instead, the switching of that antibody to the IgE isotype appears to be key. This is consistent with observations that humans make IgG to a variety of dietary proteins without correlation to food allergy (7). In addition, it is possible that IgG to food antigens may be protective from food allergy by either blocking IgE binding or otherwise interfering with IgE function (8, 9). Perhaps an intervention that discourages gut IgE CSR could prevent food allergy. The convergence of IgE sequences in multiple peanut-allergic individuals suggests that immune recognition may occur through antibody binding to a few finite regions on key proteins. In this regard, drugs that block IgE binding to these regions holds promise as a therapy in allergic disease. There is proof of principle: Two therapeutic monoclonal IgG antibodies against a cat allergen inhibited IgE binding, and treatment with the combination of these two antibodies alone was sufficient to reduce allergic symptoms in 34 cat-allergic individuals in a clinical trial (10). Blocking IgE to peanut antigens may be similarly efficacious. Although seemingly innocuous, food allergens may influence the gut environment to generate conditions that induce CSR to IgE. In this regard, allergenic foods may have properties that induce allergic inflammation, as has been proposed (11, 12). Understanding the influences of the gut microbiota, age of exposure, and environment on the regulation of allergic responses to food (13, 14) promises to provide clues to elucidating how IgE CSR is regulated. http://www.sciencemag.org/about/science-licenses-journal-article-reuse This is an article distributed under the terms of the Science Journals Default License. References and Notes ↵ R. A. Hoh et al., Sci. Immunol. 5, eaay4209 (2020). ↵ P. Tong, D. R. Wesemann, Curr. Top. Microbiol. Immunol. 388, 21 (2015).OpenUrl ↵ L. Mesin, J. Ersching, G. D. Victora, Immunity 45, 471 (2016).OpenUrlPubMed ↵ C. Caffarelli, E. Romanini, P. Caruana, M. E. Street, G. De' Angelis, Pediatr. Res. 44, 485 (1998).OpenUrlPubMed ↵ S. Asrat et al., Sci. Immunol. 5, eaav8402 (2020). ↵ D. Croote, S. Darmanis, K. C. Nadeau, S. R. Quake, Science 362, 1306 (2018). ↵ J. Gocki, Z. Bartuzi, Postepy Dermatol. Alergol. 33, 253 (2016).OpenUrl ↵ O. T. Burton et al., J. Allergy Clin. Immunol. 134, 1310 (2014).OpenUrlCrossRef ↵ O. T. Burton, J. M. Tamayo, A. J. Stranks, K. J. Koleoglou, H. C. Oettgen, J. Allergy Clin. Immunol. 141, 189 (2018).OpenUrl ↵ J. M. Orengo et al., Nat. Commun. 9, 1421 (2018).OpenUrlCrossRef ↵ M. Profet, Q. Rev. Biol. 66, 23 (1991). ↵ N. W. Palm, R. K. Rosenstein, R. Medzhitov, Nature 484, 465 (2012). ↵ O. I. Iweala, C. R. Nagler, Annu. Rev. Immunol. 37, 377 (2019).OpenUrl ↵ D. R. Wesemann, C. R. Nagler, Immunity 44, 728 (2016).OpenUrl Acknowledgments: D.R.W. is supported by the NIH (AI121394, AI139538, and AI137940), the Burroughs Wellcome Fund, and an anonymous donor. C.R.N. is supported by the NIH (AI106302, AI134923, and AI146099) and the Sunshine Charitable Foundation. C.R.N. is president and co-founder of ClostraBio, Inc.
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Allergy (and clinical immunology)
Ressources et Actualités pour la spécialité Allergie
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Scooped by Gilbert C FAURE
December 2, 2013 9:13 AM
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A topic dedicated to allergy

ouvert dans le contexte du DESC d'Immunologie clinique et allergologie en France

 

opened for 10 years, 

> 2800 Highly selected scoops in an evolving and controversial field

 >14.4 K Views by > 4.4 K viewers

 

Gilbert C FAURE's insight:

Il peut être complêté par les topics suivants, couvrant des domaines fondamentaux et/ou appliqués

 

Immunology: http://www.scoop.it/t/immunology

 

Mucosal immunity: http://www.scoop.it/t/mucosal-immunity

 

Immunology and Biotherapies: http://www.scoop.it/t/immunology-and-biotherapies

 

quelques pistes de ressources

 

IgE https://www.scoop.it/topic/allergy-and-clinical-immunology?q=IgE

 

asthma  https://www.scoop.it/topic/allergy-and-clinical-immunology?q=asthma

 

peanut https://www.scoop.it/topic/allergy-and-clinical-immunology?q=peanut

 

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Scooped by Gilbert C FAURE
October 2, 2:39 AM
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#allergy_journal #allergy | Allergy EAACI

#allergy_journal #allergy | Allergy EAACI | Allergy (and clinical immunology) | Scoop.it
✨One of the most appreciated/liked articles in the social media of Allergy published in 2025:

Hypereosinophilia and Hypereosinophilic Syndromes: First Findings From a Nationwide Multicenter Cohort. Corresponding author: Guillaume Lefèvre

Read the article here: doi.org/10.1111/all.16463

The COHESion study is the first prospective large-scale multicenter study dedicated to all hypereosinophilia/hypereosinophilic syndrome (HE/HES) subtypes. The final diagnoses were idiopathic HES (HES-I, 47%), HE/HES-reactive (16%), HE-uncertain significance (15%), HE/HES-neoplastic (7%), HE/HES-lymphocytic (6%), IgG4-related disease (2%), and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis (EGPA) (7%). Considering all HES subtypes, the most frequent symptoms were cutaneous, respiratory and digestive symptoms (42%, 30% and 25%, respectively) followed by cardiac manifestations, vascular manifestations and ear, nose, throat (ENT) symptoms (12%, 9% and 7%, respectively).

#Allergy_journal
Read more articles published in #Allergy on clinical immunology here: https://lnkd.in/ex3Y69tY
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Scooped by Gilbert C FAURE
October 1, 10:11 AM
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Alpha-Gal Syndrome, the Meat Allergy, Expands Its Reach

Alpha-Gal Syndrome, the Meat Allergy, Expands Its Reach | Allergy (and clinical immunology) | Scoop.it
The tick-borne allergy to animal products is on the move north and west from the Mid-Atlantic and Southern states.
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Scooped by Gilbert C FAURE
September 15, 3:57 AM
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Rêve ou cauchemar ? L’intelligence artificielle s’invite dans le futur de l’allergologie | Philippe Auriol

Rêve ou cauchemar ? L’intelligence artificielle s’invite dans le futur de l’allergologie | Philippe Auriol | Allergy (and clinical immunology) | Scoop.it
https://lnkd.in/eF54n794 Intelligence artificielle et allergologie : où en est on? (Pour les Parisiens je fais demain soir une intervention sur le sujet avec Paris-Allergie merci à Marmouz Farid Christian MARTENS
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Scooped by Gilbert C FAURE
August 28, 2:36 PM
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Food Anaphylaxis: Eight Food Allergens Without Mandatory Labelling Highlighted by the French Allergy‐Vigilance Network | Luu-Ly Do-Quang

Food Anaphylaxis: Eight Food Allergens Without Mandatory Labelling Highlighted by the French Allergy‐Vigilance Network | Luu-Ly Do-Quang | Allergy (and clinical immunology) | Scoop.it
#allergies Le réseau d'allergovigilance souhaite rendre obligatoire, en Europe, la déclaration de quatre allergènes alimentaires émergents supplémentaires, sur la base d'une étude rapportée dans APMnews en décembre 2023, publiée dans Clinical & Experimental Allergy

https://lnkd.in/erY6v8_M?
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Scooped by Gilbert C FAURE
August 9, 1:37 PM
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Exploring the Diversity and Emerging Powers of Eosinophil Subpopulations

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Scooped by Gilbert C FAURE
August 7, 3:35 AM
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Allergy, Asthma and Immunology: The Evolution of IgE-Based Allergy Testing in Atopic Dermatitis: Where Do We Stand?

Allergy, Asthma and Immunology: The Evolution of IgE-Based Allergy Testing in Atopic Dermatitis: Where Do We Stand? | Allergy (and clinical immunology) | Scoop.it
"A blog about allergy, asthma & immunology"
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Scooped by Gilbert C FAURE
July 30, 4:30 AM
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The immunology of asthma and chronic rhinosinusitis | Nature Reviews Immunology

The immunology of asthma and chronic rhinosinusitis | Nature Reviews Immunology | Allergy (and clinical immunology) | Scoop.it
Asthma and chronic rhinosinusitis (CRS) are common chronic inflammatory diseases of the respiratory tract that have increased in prevalence over the past five decades. The clinical relationship between asthma and CRS has been well recognized, suggesting a common pathogenesis between these diseases. Both diseases are driven by complex airway epithelial cell and immune cell interactions that occur in response to environmental triggers such as allergens, microorganisms and irritants. Advances, including a growing understanding of the biology of the cells involved in the disease, the application of multiomics technologies and the performance of large-scale clinical studies, have led to a better understanding of the pathophysiology and heterogeneity of asthma and CRS. This research has promoted the concept that these diseases consist of several endotypes, in which airway epithelial cells, innate lymphoid cells, T cells, B cells, granulocytes and their mediators are distinctly involved in the immunopathology. Identification of the disease heterogeneity and immunological markers has also greatly improved the protocols for biologic therapies and the clinical outcomes in certain subsets of patients. However, many clinical and research questions remain. In this Review, we discuss recent advances in characterizing the immunological mechanisms of asthma and CRS, with a focus on the main cell types and molecules involved in these diseases. In this Review, Kato and Kita discuss the complex interactions between airway epithelial cells and immune cells that contribute to the development of asthma and chronic rhinosinusitis. They highlight recent advances in understanding the clinical heterogeneity of these diseases and explain the progress that has been made in developing new therapies.
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Scooped by Gilbert C FAURE
July 19, 8:06 AM
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EAACI

https://publish.twitter.com/?query=https%3A%2F%2Ftwitter.com%2FAllergyEaaci%2Fstatus%2F1945397278644011353&widget=TweetClick here to edit the content

Gilbert C FAURE's insight:

Type 2 #allergic #respiratory diseases are driven by a coordinated immune response that begins with epithelial cell activation and alarmin release, triggering innate lymphoid cells, dendritic cells, and macrophages, ultimately directing adaptive immune responses involving Th2 cells and IgE-producing B cells. Type 2 cytokines orchestrate the recruitment and activation of eosinophils, mast cells, and basophils, perpetuating inflammation and disrupting the epithelial barrier. Although biologic therapies targeting IL-4/IL-13, IL-5, and IgE pathways have demonstrated broad efficacy, the lack of response in some patients with severe disease highlights the need for more tailored, precision-based treatment approaches.

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Scooped by Gilbert C FAURE
July 8, 8:34 AM
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8th July is World Allergy Day. | Dr. Barnali Das

8th July is World Allergy Day. | Dr. Barnali Das | Allergy (and clinical immunology) | Scoop.it
8th July is World Allergy Day.
This article in Times Of India mentioned about our old study: Allergic diseases have significant impact on the quality-of-life, social life, and economy. Inadequate knowledge about allergic testing further add on to the burden of the disease. Reposting this for awareness about harmonisation of allergens testing.
The clinical suspicion of allergic sensitization can be confirmed by demonstrating the presence of allergen specific immunoglobulin-E (IgE) antibodies in vivo (skin prick test) or in vitro methods (Blood tests: FEIA, ELISA, CRD etc). There is a lack of well-defined protocols and guidelines for the diagnosis of respiratory allergy testing in India. Therefore, the evidence-based guidelines is the need of the hour.
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Scooped by Gilbert C FAURE
June 23, 6:49 AM
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In JCI insight:... - Journal of Clinical Investigation

In JCI insight:... - Journal of Clinical Investigation | Allergy (and clinical immunology) | Scoop.it
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Scooped by Gilbert C FAURE
May 28, 10:55 AM
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#allergie #bilanbiologique | La Revue du Praticien

#allergie #bilanbiologique | La Revue du Praticien | Allergy (and clinical immunology) | Scoop.it
#Allergie #BilanBiologique

Avec 33 % d’allergiques pour un peu plus de 1 000 allergologues en France, les délais de rendez-vous s’allongent. Les MG doivent alors assurer la prise en charge en attendant le bilan complet chez le spécialiste (tests cutanés, de provocation orale…). Faisons le point sur les bonnes pratiques en termes de bilan biologique, d’après les recos de la Société française d’allergologie.

👇👇
https://lnkd.in/gfcHxzaB
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Scooped by Gilbert C FAURE
May 16, 2:00 PM
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Allergies : les différences d’incidences entre la ville et la campagne expliquées

Allergies : les différences d’incidences entre la ville et la campagne expliquées | Allergy (and clinical immunology) | Scoop.it
Allergies : les différences d’incidences entre la ville et la campagne expliquées
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Scooped by Gilbert C FAURE
October 2, 2:42 AM
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Allergen Chip Challenge: a nationwide open database supporting allergy prediction algorithms | Julien Goret

Allergen Chip Challenge: a nationwide open database supporting allergy prediction algorithms | Julien Goret | Allergy (and clinical immunology) | Scoop.it
✨✨✨ Nous sommes très heureux d’annoncer la publication des résultats de #AllergenChipChallenge dans la prestigieuse revue Journal of Allergy and Clinical Immunology https://lnkd.in/e_Mn4c73

Ce projet est le fruit d’un travail collectif remarquable, qui a rassemblé cliniciens, biologistes, data scientists et chercheurs autour d’un objectif commun : mieux comprendre et interpréter les données issues des puces à allergènes et de générer par #MachineLearning un #algorithme de prédiction des #allergies à partir d'un profil d'IgE et de données cliniques.

La base de données et l'algorithme sont en libre accès au bénéfice de la recherche et des patients allergiques.

Un grand merci 🙏 à Joana Vitte et Pascal Demoly pour avoir initié ce passionnant projet, la Société Française d'Allergologie - SFA, AllergoBioNet, Health Data Hub et Bpifrance pour leur soutien déterminant, ainsi qu’à toutes celles et ceux qui ont contribué à rendre cette aventure possible Guillaume Martinroche Amir Guemari Pol André APOIL Isabella Annesi-Maesano Eric Fromentin @Laurent Guilleminault Davide Caimmi Caroline Klingebiel @Céline Beauvillain Alain Didier Jeremy Corriger Lauriane Armand Agathe Delaune Trustii.io Naama BAK CHU de Bordeaux.

➡️ Ces avancées montrent la puissance de la collaboration et de l’ouverture des données pour faire progresser la recherche en allergologie et au-delà. Le projet continue.

#OpenData #Database #Allergie #Allergologie #Allergy #Immunologie #Recherche #IA #MachineLearning #SFA #GTESIA
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Scooped by Gilbert C FAURE
October 1, 10:12 AM
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AAP Releases Guidance on Managing Food Allergies in Schools

AAP Releases Guidance on Managing Food Allergies in Schools | Allergy (and clinical immunology) | Scoop.it
The report updates the AAP’s 2010 guidance and emphasizes a proactive role for pediatricians in collaborating to manage student food allergies.
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Scooped by Gilbert C FAURE
September 27, 5:56 AM
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Référentiel Métier Allergologue | céline palussière

Référentiel Métier Allergologue | céline palussière | Allergy (and clinical immunology) | Scoop.it
➡️ Le CNPA a finalisé l’actualisation du Référentiel Métier d’Allergologue.
Ce travail initié sous la présidence du Dr Sébastien LEFEVRE précise les compétences et missions de l’allergologue, sa place dans le parcours de soins du patient, ses liens avec les autres spécialités et professionnels de santé.

✅ L’Allergologie se structure pour répondre aux enjeux actuels, en particulier l’augmentation de la prévalence et de la sévérité des allergies.
Ce document témoigne de l’expertise médicale et de l’engagement de notre spécialité.

Merci à toute l'équipe de rédacteurs coordonnée par LEZMI Guillaume et celle des relecteurs coordonnée par Edouard Sève.

Bonne lecture !
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Scooped by Gilbert C FAURE
August 31, 9:17 AM
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#classification #diagnosis #nsaids #hypersensitivity | Luciana Tanno

#classification #diagnosis #nsaids #hypersensitivity | Luciana Tanno | Allergy (and clinical immunology) | Scoop.it
Glad to have contributed to this international 🌎🌍🌏effort to update the #Classification and #Diagnosis of #NSAIDs 💊 #Hypersensitivity
Available: https://lnkd.in/gWQtqFAN
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Suggested by LIGHTING
August 11, 4:46 AM
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Podcast : la rhinite allergique Allergique.org - Actualités des allergies

Podcast : la rhinite allergique Allergique.org - Actualités des allergies | Allergy (and clinical immunology) | Scoop.it


Aujourd’hui, je vais vous parler de la rhinite allergique.

« Non mais arrête, il a juste un rhume ! ». C’est vrai que cela peut paraître banal, sans intérêt, même les médecins ont tendance à banaliser le « rhume ». Un nez qui coule, un nez bouché, des éternuements ? Rien de bien méchant…ça encombre les consultations des médecins traitants qui ne savent souvent pas quoi en faire… Et pourtant…nombre de ces « rhumes » sont en réalité des rhinites allergiques et les négliger ce n’est pas vous (…) , actualités des allergies : publications scientifiques lues et analysées pour vous, annonce et compte-rendus d'événements sur les allergies.
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August 8, 10:03 AM
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Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens

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Scooped by Gilbert C FAURE
August 1, 3:34 AM
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Nous avons uni notre expertise à celle de la SFAR pour co-construire un référentiel commun dédié au diagnostic et à la prise en charge des réactions d’hypersensibilité immédiate (HSI) en contexte… ...

Nous avons uni notre expertise à celle de la SFAR pour co-construire un référentiel commun dédié au diagnostic et à la prise en charge des réactions d’hypersensibilité immédiate (HSI) en contexte… ... | Allergy (and clinical immunology) | Scoop.it
Nous avons uni notre expertise à celle de la SFAR pour co-construire un référentiel commun dédié au diagnostic et à la prise en charge des réactions d’hypersensibilité immédiate (HSI) en contexte périopératoire.

Découvrez quelques messages clés ci-dessous ou accédez à la ressource ici : https://lnkd.in/eKmfa9sj
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Scooped by Gilbert C FAURE
July 28, 9:48 AM
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Have you already thought about how #terminology can influence #practice and #epidemiology? | Luciana Tanno

Have you already thought about how #terminology can influence #practice and #epidemiology? | Luciana Tanno | Allergy (and clinical immunology) | Scoop.it
Have you already thought about how #terminology can influence #practice and #epidemiology? Here is a publication in #JAHD ❣️as a good example
#OccupationalHypersensitivity #HypersensitivityPneumonitis 🐦🐦‍⬛
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Scooped by Gilbert C FAURE
July 15, 10:42 AM
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🚨 La T2A (Tarification à l’activité) a profondément transformé notre système de santé, mais pas toujours pour le mieux. | Pierre B.

🚨 La T2A (Tarification à l’activité) a profondément transformé notre système de santé, mais pas toujours pour le mieux. | Pierre B. | Allergy (and clinical immunology) | Scoop.it
🚨 La T2A (Tarification à l’activité) a profondément transformé notre système de santé, mais pas toujours pour le mieux.

Résultat ? Des services d’urgence surchargés, souvent mobilisés pour des cas bénins ou des demandes sociales, faute d’outils accessibles pour comprendre les symptômes en amont.

Chez BrightNTech.AI, nous pensons qu’il est urgent d’outiller la population générale avec des assistants éthiques, capables de décoder les signaux du corps et de réorienter intelligemment vers le bon niveau de soins.

💡 C’est le rôle d’AllergIA™, notre assistant IA spécialisé en allergologie et immunologie :

✅ Analyse interactive des symptômes
✅ Aide à différencier allergies, intolérances, et autres causes
✅ Préparation d’un résumé structuré pour le pharmacien ou médecin
✅ Surtout : ne remplace jamais le diagnostic médical mais facilite un accès éclairé aux soins

📍 Ne pas saturer les urgences pour une “bobologie” n’est pas un jugement. C’est une urgence systémique. Il faut des ponts intelligents entre la technologie, le soin, et les citoyens.

👉 Découvrez #AllergIA™ ici :
https://lnkd.in/eXy5FGZ7

🔐 Développé dans le respect strict du RGPD, de l’éthique médicale et des normes européennes (MDR Class I - non diagnostic).

📋 En savoir plus sur notre approche de conformité et de santé publique : BrightNTech.AI
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Scooped by Gilbert C FAURE
July 7, 5:48 AM
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🔬 Et si on arrêtait de réduire les mastocytes à l’IgE ? | Lucie WETCHOKO

🔬 Et si on arrêtait de réduire les mastocytes à l’IgE ? | Lucie WETCHOKO | Allergy (and clinical immunology) | Scoop.it
🔬 Et si on arrêtait de réduire les mastocytes à l’IgE ?
Pendant des décennies, la triade « mastocyte - IgE - allergie » a structuré notre compréhension des réactions d’hypersensibilité immédiate.
Mais aujourd’hui, nous savons que cette vision est incomplète.

📌 L’article-clé paru en janvier 2025 (Int J Mol Sci. 26(3):927) montre que les mastocytes (MC) disposent d’un répertoire de récepteurs bien plus vaste que FcεRI, et que leur activation peut suivre des voies non-IgE, dites "pseudoallergiques", via des récepteurs comme MRGPRX2.

💥 Résultat ?
➡️ Des réactions cliniques rapides, sans sensibilisation préalable ni IgE spécifique détectable.
➡️ Une dégranulation induite par des médicaments (fluoroquinolones, vancomycine, morphine...), des neuropeptides (substance P), ou des stimuli physiques.
➡️ Une inflammation neurogène amplifiée par l’interaction étroite entre MC et terminaisons nerveuses périphériques.

🧠 Les implications dépassent largement le champ allergologique classique :
- Urticaire chronique, dermatite atopique, prurit rebelle
- Syndrome d’activation mastocytaire (MCAS)
- Rosacée, asthme non contrôlé, inflammation cérébrale...

💡Comprendre MRGPRX2, c’est élargir notre cadre diagnostique et thérapeutique.
👉 De nouveaux traitements ciblent déjà cette voie : antagonistes de MRGPRX2, cannabinoïdes non-psychoactifs (PEA, CBD), anticorps anti-Siglec-8...

🧬 Les mastocytes sont bien plus que des effecteurs allergiques.
Ils sont au carrefour de l’immunité, du système nerveux et des interfaces barrière.
Et si l’on actualisait nos réflexes cliniques ?
Source : https://lnkd.in/etTeyKBh
Dr Lucie WETCHOKO
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Scooped by Gilbert C FAURE
June 12, 11:14 AM
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On behalf of the Allergy Diagnosis Working Group Of the French Society of Allergology (GTBA – SFA), I’m proud to have contributed to the dissemination of the EAACI guidelines on the diagnosis of… |...

On behalf of the Allergy Diagnosis Working Group Of the French Society of Allergology (GTBA – SFA), I’m proud to have contributed to the dissemination of the EAACI guidelines on the diagnosis of… |... | Allergy (and clinical immunology) | Scoop.it
On behalf of the Allergy Diagnosis Working Group Of the French Society of Allergology (GTBA – SFA), I’m proud to have contributed to the dissemination of the EAACI guidelines on the diagnosis of IgE-mediated Food Allergy within the French-speaking medical community:
- French translation of the food allergy guidelines on diagnosis for a special issue of the French Allergy Journal (RFA) dedicated to Food Allergy: https://lnkd.in/dBAxRQXC
- Plenary presentation at the French National Congress of Allergology (CFA 2025) in Paris with a focus on methodology based on the accuracy of diagnostic tests to understand the recommended diagnostic approach: https://lnkd.in/dGAEc7PK
- Presentation at a workshop/controversy at the 30th National Congress of AMAFORCAL in Rabat, Morocco


Julien Goret, Joana Vitte, Alexandra Santos, MD PhD, Société Française d'Allergologie - SFA, European Academy of Allergy and Clinical Immunology - EAACI, @GTBA, Youness EL GUEDDARI, Elleni-Sofia Vaia
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May 24, 2:13 AM
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Navigating atopic dermatitis: Challenges and future opportunities | Allergy EAACI posted on the topic | LinkedIn

Navigating atopic dermatitis: Challenges and future opportunities | Allergy EAACI posted on the topic | LinkedIn | Allergy (and clinical immunology) | Scoop.it
📢 One of the most appreciated/liked articles in the social media of Allergy published in 2024:

Open Access: Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration. Claudia Traidl-Hoffmann

Read the article here:  doi.org/10.1111/all.16247

With over 170 references and 6 figures, this article summarizes the key points discussed during the Global Allergy Forum in Davos. During this event, scientific experts and stakeholders met to address the increasing prevalence of #atopicdermatitis (AD). Topics covered include: #epithelialbarrier maintenance and disturbances in atopic diseases; #environmental changes as a driving force of atopic diseases; immunological march along the course of AD; neuroimmunology, systemic inflammation and comorbidities; therapeutic, educational, and global economic aspects; future directions

Read more articles published in #Allergy on #asthma here: https://lnkd.in/dvHaYziZ

#Allergy_journal
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May 11, 3:46 AM
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Journal Watch

Journal Watch | Allergy (and clinical immunology) | Scoop.it
The best critical care literature, updated daily - CCR Journal Watch
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