Allergy (and clinical immunology)

Very proud to present our November issue. Drug #hypersensitivity reactions (DHRs) constitute a major concern in clinical practice, as they compromise patient safety and restrict the use of essential medications. These immune-mediated adverse drug reactions occur after exposure to therapeutic doses and can manifest with a broad clinical spectrum, ranging from mild cutaneous reactions to severe, potentially fatal conditions.

This issue opens with an editorial by Li et al., highlighting the inaugural EAACI Hong Kong Allergy School where global experts in drug allergy gathered under the theme “East Meets West” to call for harmonized international definitions of drug hypersensitivity and standardized criteria for identifying low-risk penicillin allergy, underscoring the urgent need to reduce mislabelling and advance safe, evidence-based delabelling practices worldwide. Leonardi et al. provide a comprehensive overview of the clinical presentations, diagnostic approaches, and treatment strategies for drug-induced ocular adverse events. Cortellini et al. present data and recommendations on the characteristics of hypersensitivity reactions to antiplatelet drugs and the associated diagnostic procedures, to maximize their safety and effectiveness. Gelincik et al. review current knowledge on the pathomechanisms of hypersensitivity reactions to quinolones, including diagnostic tests and cross-reactivities, and propose a practical diagnostic approach for clinicians. Hutten et al. highlight significant discrepancies between studies on cross-allergy to beta-lactam antibiotics, particularly concerning recommendations for safe alternatives. Labella et al. investigate the utility of direct single-dose drug provocation testing without prior skin testing in adult European patients at low risk of penicillin allergy. Bilgic-Eltan et al. analyze the discrepancies between suspected and confirmed drug hypersensitivity in a well-defined cohort of patients with inborn errors of immunity. Helevä et al. evaluate the benefits of aspirin treatment after desensitization in patients with chronic rhinosinusitis with nasal polyps, asthma, and N-ERD. Goh et al. explore haptenated ligands presented by HLA-A*02:01, characterize the T cell repertoire involved in penicillin-induced reactions in a hypersensitive patient, and investigate whether a dominant penicillin-specific T cell receptor clonotype recognizes haptenated HLA peptides. Bertolotti et al. present the thoroughly documented case of a patient with delayed cross-reactivity to all seven available iodinated contrast media. Cho, Jo, and Park et al. leverage the WHO global pharmacovigilance database to identify the ten drugs most frequently associated with severe cutaneous adverse reactions, providing large-scale epidemiological insights into delayed drug hypersensitivities and contributing to global drug safety. Céspedes and Pérez-Moreno et al. demonstrate that IgG removal enhances…………..

journalallergy.com

Asthma and chronic rhinosinusitis (CRS) are common chronic inflammatory diseases of the respiratory tract that have increased in prevalence over the past five decades. The clinical relationship between asthma and CRS has been well recognized, suggesting a common pathogenesis between these diseases. Both diseases are driven by complex airway epithelial cell and immune cell interactions that occur in response to environmental triggers such as allergens, microorganisms and irritants. Advances, including a growing understanding of the biology of the cells involved in the disease, the application of multiomics technologies and the performance of large-scale clinical studies, have led to a better understanding of the pathophysiology and heterogeneity of asthma and CRS. This research has promoted the concept that these diseases consist of several endotypes, in which airway epithelial cells, innate lymphoid cells, T cells, B cells, granulocytes and their mediators are distinctly involved in the immunopathology. Identification of the disease heterogeneity and immunological markers has also greatly improved the protocols for biologic therapies and the clinical outcomes in certain subsets of patients. However, many clinical and research questions remain. In this Review, we discuss recent advances in characterizing the immunological mechanisms of asthma and CRS, with a focus on the main cell types and molecules involved in these diseases. In this Review, Kato and Kita discuss the complex interactions between airway epithelial cells and immune cells that contribute to the development of asthma and chronic rhinosinusitis. They highlight recent advances in understanding the clinical heterogeneity of these diseases and explain the progress that has been made in developing new therapies.

Background Google Trends (GT) is a free tool that provides insights into the public’s interest and information-seeking behavior on specific topics. In this study, we utilized GT data on patients’ search history to better understand their questions and information needs regarding asthma.

"A blog about allergy, asthma & immunology"

IL-36γ was upregulated in the lungs of chronic asthma mice, and it contributed to the airway remodeling. IL-38 can alleviate the airway remodeling in asthma by

"A blog about allergy, asthma & immunology"

📢 One of the most appreciated/liked articles in the social media of Allergy published in 2024:

Open Access: Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration. Claudia Traidl-Hoffmann

Read the article here:  doi.org/10.1111/all.16247

With over 170 references and 6 figures, this article summarizes the key points discussed during the Global Allergy Forum in Davos. During this event, scientific experts and stakeholders met to address the increasing prevalence of #atopicdermatitis (AD). Topics covered include: #epithelialbarrier maintenance and disturbances in atopic diseases; #environmental changes as a driving force of atopic diseases; immunological march along the course of AD; neuroimmunology, systemic inflammation and comorbidities; therapeutic, educational, and global economic aspects; future directions

Read more articles published in #Allergy on #asthma here: https://lnkd.in/dvHaYziZ

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The inflammation process plays a crucial role in allergic respiratory diseases, such as asthma and allergic rhinitis. Although the pulmonary epithelium, the carpet of cells that forms the inner surface of the lungs, is recognized as a major player in the respiratory inflammation that causes these diseases, the underlying mechanisms are still poorly understood.