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immunology
teaching and learning immunology, fundamental and clinical
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Scooped by Gilbert Faure au nom de l'ASSIM
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Immunology: teaching and learning immunology

Our first and ambitious Scoop.it topic.

 

It covers mainly fundamental immunology, molecular and cellular with more than 4300 posts

 

Thanks viewers (> 13600 views ! ), visitors (8245) and followers!

We have been GOLD twice in the past months!

GOLD again may 13!

GOLD again, september 14!! thanks

Gilbert Faure au nom de l'ASSIM's insight:

Other successful topics in the field, either general or regional

Mucosal Immunity: http://www.scoop.it/t/mucosal-immunity

as well as

Autoimmunity

http://www.scoop.it/t/autoimmunity

Allergy and (so-called) clinical immunology:

 http://www.scoop.it/t/allergy-and-clinical-immunology

Immunology and Biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

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Scooped by Gilbert Faure au nom de l'ASSIM
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Skin DCs cluster for efficient T cell activation - Nature.com

Skin DCs cluster for efficient T cell activation
Nature.com
In this issue of Nature Immunology, Natsuaki et al.
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Scooped by Gilbert Faure au nom de l'ASSIM
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Lymph node stromal cells negatively regulate antig... [J Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert Faure au nom de l'ASSIM
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Dengue Virus Neutralizing Antibody Levels Associated with Protection from Infection in Thai Cluster Studies

Dengue Virus Neutralizing Antibody Levels Associated with Protection from Infection in Thai Cluster Studies | immunology | Scoop.it
PLOS Neglected Tropical Diseases is an open-access journal publishing peer-reviewed research on the world\'s most neglected tropical diseases, such as elephantiasis, river blindness, leprosy, hookworm, schistosomiasis, and African sleeping sickness...
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Mast Cell Function

RT @SAGEHealthInfo: The importance of #mastcells in innate and adaptive #immunity http://t.co/Y0miqqqem7 @AllerGen_NC
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Cutting Edge: Discrete Functions of mTOR Signaling in Invariant NKT Cell Development and NKT17 Fate Decision [CUTTING EDGE]

Invariant NKT (iNKT) cells recently were classified into NKT1, NKT2, and NKT17 lineages with distinct transcription factor and cytokine profiles, but the mechanisms underlying such fate decisions remain elusive.
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Scooped by Gilbert Faure au nom de l'ASSIM
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Frontiers | Immunological Relevance of the Coevolution of IDO1 and AHR | Immunological Tolerance

The Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recentl...
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Alarmins, inflammasomes and immunity Saïd-Sadier N, Ojcius DM - Biomed J

Alarmins, inflammasomes and immunity Saïd-Sadier N, Ojcius DM - Biomed J | immunology | Scoop.it
Biomed J, Official publication of Chang Gung University
Gilbert Faure au nom de l'ASSIM's insight:

The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs). Ligation of the PRRs leads to synthesis and secretion of pro-inflammatory cytokines and chemokines. Infected cells and other stressed cells also release host-cell derived molecules, called damage-associated molecular patterns (DAMPs, danger signals, or alarmins), which are generic markers for damage. DAMPs are recognized by specific receptors on both immune and nonimmune cells, which, depending on the target cell and the cellular context, can lead to cell differentiation or cell death, and either inflammation or inhibition of inflammation. Recent research has revealed that DAMPs and PAMPs synergize to permit secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β): PAMPs stimulate synthesis of pro-IL-1β, but not its secretion; while DAMPs can stimulate assembly of an inflammasome containing, usually, a Nod-like receptor (NLR) member, and activation of the protease caspase-1, which cleaves pro-IL-1β into IL-1β, allowing its secretion. Other NLR members do not participate in formation of inflammasomes but play other essential roles in regulation of the innate immune response.

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Frontiers | Ebola virus outbreak: what to do now?

Frontiers | Ebola virus outbreak: what to do now? | immunology | Scoop.it
The immunological community should become involved in the Ebola virus outbreak.
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Immunity to RSV in Early-Life. [Front Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Atypical MHC class II-expressing antigen-pre... [Nat Rev Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert Faure au nom de l'ASSIM's insight:
Abstract

Dendritic cells, macrophages and B cells are regarded as the classical antigen-presenting cells of the immune system. However, in recent years, there has been a rapid increase in the number of cell types that are suggested to present antigens on MHC class II molecules to CD4+ T cells. In this Review, we describe the key characteristics that define an antigen-presenting cell by examining the functions of dendritic cells. We then examine the functions of the haematopoietic cells and non-haematopoietic cells that can express MHC class II molecules and that have been suggested to represent 'atypical' antigen-presenting cells. We consider whether any of these cell populations can prime naive CD4+ T cells and, if not, question the effects that they do have on the development of immune responses.

  
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TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity: Immunity

TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity: Immunity | immunology | Scoop.it
Degli-Esposti & co show regulatory NK cell activity limits autoimmunity in chronic viral infection http://t.co/o2gI6c2BUI
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Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-γ

Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-γ | immunology | Scoop.it
Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 ... http://t.co/qg7Yt00UDb
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Decrepit DCs - Nature.com

Decrepit DCs
Nature.com
Aging is associated with dysfunction of the immune system at various levels.
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CD4+ T cells promote antibody production but not sustained affinity maturation during Borrelia burgdorferi infection

CD4+ T Cells Promote Antibody Production but Not Sustained Affinity Maturation during B. burgdorferi Infection http://t.co/PIoQqBtq9B
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T cell antigen discovery using soluble vaccinia pr... [J Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Ebola control: effect of asymptomatic infection and acquired immunity : The Lancet

Ebola control: effect of asymptomatic infection and acquired immunity. By - Steve E Bellan, Juliet R C Pulliam, Jonathan Dushoff, Lauren Ancel Meyers
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NF-{kappa}B-Inducing Kinase in Thymic Stroma Establishes Central Tolerance by Orchestrating Cross-Talk with Not Only Thymocytes but Also Dendritic Cells [AUTOIMMUNITY]

Essential roles of NF-B–inducing kinase (NIK) for the development of medullary thymic epithelial cells (mTECs) and regulatory T cells have been highlighted by studies using a strain of mouse bearing a natural mutation of the NIK gene (aly mice).
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Campaign for full clinical immunology services in Scottish region

Campaign for full clinical immunology services in Scottish region | immunology | Scoop.it
Immunology services in Lothian region of Scotland.
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Immunobiology of IL-37: mechanism of action and clinical perspectives, Expert Review of Clinical Immunology, Informa Healthcare

Immunobiology of IL-37: mechanism of action and clinical perspectives, Expert Review of Clinical Immunology, Informa Healthcare | immunology | Scoop.it
Immunobiology of IL-37: mechanism of action and clinical perspectives: Expert Review of Clinical Immunology, A... http://t.co/wNyprHwnB0
Gilbert Faure au nom de l'ASSIM's insight:
This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules.

Read More: http://informahealthcare.com/doi/abs/10.1586/1744666X.2014.971014
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Autonomous Stimulation of Cancer Cell Plasticity by... [PLoS One. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert Faure au nom de l'ASSIM's insight:

The stimulatory NKG2D receptor on lymphocytes promotes tumor immune surveillance by targeting ligands selectively induced on cancer cells. Progressing tumors counteract by employing tactics to disable lymphocyte NKG2D. This negative dynamic is escalated as some human cancer cells co-opt expression of NKG2D, thereby complementing the presence of its ligands for autonomous stimulation of oncogenic signaling. Clinical association data imply relationships between cancer cell NKG2D and metastatic disease.

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25-Hydroxycholesterols in innate and adaptiv... [Nat Rev Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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De novo fatty acid synthesis controls the fate between regulatory T and T ... - Nature.com

De novo fatty acid synthesis controls the fate between regulatory T and T ...
Nature.com
Cells were stained for intracellular IL-17 and Foxp3 and were gated on live CD4+ T cells. (b) Representative flow cytometry.
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Toward understanding of rice innate immunity ag...

Toward understanding of rice innate immunity ag... | immunology | Scoop.it
Abstract The blast fungus, Magnaporthe oryzae, causes serious disease on a wide variety of grasses including rice, wheat and barley.
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Transcriptomic analysis of mononuclear phagocyte... [Immunol Rev. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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