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teaching and learning immunology, fundamental and clinical
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Scooped by Gilbert Faure au nom de l'ASSIM
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Immunology: teaching and learning immunology

Our first and ambitious Scoop.it topic!

 

It covers fundamental immunology, molecular and cellular

with now more than 4600 posts

 

Thanks viewers (> 20000 views ! ), visitors (> 13300) and followers!

I had the objective of reaching 60000 views of the topics curated at the end of the year.

This objective was reached before Xmas! with many new visitors interested in Immunology.

Welcome all wherever you are

after chinese new year, >4700 posts, >25000 views, >18000 visitors

 

Feel free to visit other relevant topics links underneath.

please react and comment, what you would like to see

 

We had been GOLD twice in the past months!

and then

GOLD again may 13!

GOLD again, september 14!!

GOLD again november 18, after losing it for one week!!

thanks!

Gilbert Faure au nom de l'ASSIM's insight:

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Scooped by Gilbert Faure au nom de l'ASSIM
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New T Cell Type Controls Kidney Transplantation Tolerance

New T Cell Type Controls Kidney Transplantation Tolerance | immunology | Scoop.it
Columbia University Medical Center (CUMC) researchers have pinpointed the immune system mechanism that allows a kidney transplant to be accepted without lifelong immunosuppressive drugs.
Gilbert Faure au nom de l'ASSIM's insight:
In the current study, the CUMC researchers identified the donor-reactive T cells in each patient's blood before transplant and repeated the test after transplant at three intervals (six, 12, and 18 months). Three of the four patients who underwent CKBMT showed a decrease in donor-reactive T cells from pre-transplant to post-transplant. All three tolerated the transplant. In the fourth CKBMT patient, the donor-reactive cells did not significantly decline over time, and the patient, unlike the others, rejected the donor kidney. The two patients who had the kidney transplant alone had an increase in donor-reactive T cell receptors. "Our findings suggest that deletion of a specific set of donor-reactive T cells is a major mechanism governing tolerance of donor tissue," said Dr. Sykes. "The study also supports the approach of combining kidney transplants with bone marrow transplants, with its resultant elimination of donor-reactive T cells. This approach needs further study, but so far, all signs indicate that it could eliminate the need for lifelong immunosuppression."
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A new receptor for LPS : Nature Immunology : Na...

A new receptor for LPS : Nature Immunology : Na... | immunology | Scoop.it
A surface-localized lectin S-domain receptor kinase confers recognition of lipopolysaccharide in plants.
Gilbert Faure au nom de l'ASSIM's insight:
A surface-localized lectin S-domain receptor kinase confers recognition of lipopolysaccharide in plants. The innate immune system's ability to recognize infectious non-self molecules relies on the sensitive perception of conserved pathogen-associated molecular patterns (PAMPs) by host pattern-recognition receptors (PRRs). A stereotypical bacterial PAMP recognized by mammalian cells is lipopolysaccharide (LPS)1, the major constituent of the outer cell envelope of Gram-negative bacteria. Although plants are also able to perceive LPS and mount innate immune responses2, 3, 4, no plant receptor for LPS was known until now. In this issue of Nature Immunology, Ranf et al.5
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Expression of inhibitory regulators of innate immunity in patients ... - PubMed - NCBI

BMC Infect Dis. 2015 Dec;15(1):833. doi: 10.1186/s12879-015-0833-z. Epub 2015 Feb 26.
Gilbert Faure au nom de l'ASSIM's insight:
with tuberculosis
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Control of adaptive immunity by the innate immune system : Nature Immunology : Nature Publishing Group

Control of adaptive immunity by the innate immune system : Nature Immunology : Nature Publishing Group | immunology | Scoop.it
Iwasaki and Mezhitov provide an update of their classic 2004 Review looking at the control of adaptive immunity by the innate immune system
Gilbert Faure au nom de l'ASSIM's insight:
Microbial infections are recognized by the innate immune system both to elicit immediate defense and to generate long-lasting adaptive immunity. To detect and respond to vastly different groups of pathogens, the innate immune system uses several recognition systems that rely on sensing common structural and functional features associated with different classes of microorganisms. These recognition systems determine microbial location, viability, replication and pathogenicity. Detection of these features by recognition pathways of the innate immune system is translated into different classes of effector responses though specialized populations of dendritic cells. Multiple mechanisms for the induction of immune responses are variations on a common design principle wherein the cells that sense infections produce one set of cytokines to induce lymphocytes to produce another set of cytokines, which in turn activate effector responses. Here we discuss these emerging principles of innate control of adaptive immunity.
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Frontiers | Environmental and Metabolic Sensors That Control T Cell Biology | T Cell Biology

The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient sensing serine/threonine kinases AMPK (adenosine monophosphate-activa...
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Symposium on Breakthroughs in Clinical & Translational Immunology

Symposium on Breakthroughs in Clinical & Translational Immunology | immunology | Scoop.it
A cutting-edge symposium on advances in clinical and translational immunology.
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CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells: Immunity

CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells @ImmunityCP http://t.co/Yzi4GhEw3x
Gilbert Faure au nom de l'ASSIM's insight:
Highlights•CXCR3 ligands are upregulated in VV-infected skin•Cxcr3−/− mice have normal T cell numbers in infected skin but enhanced infection•Cxcr3−/− T cells are defective in locating virus-infected cells for killing in situ•Transfer of wild-type CD8+ T cells restores viral control in Cxcr3−/− animals
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Stressed mitochondria sound the alarm - Nature.com

Stressed mitochondria sound the alarm - Nature.com | immunology | Scoop.it
Immunology and Cell Biology focuses on the general functioning of the immune system in its broadest sense, with a particular emphasis on its cell biology.
Gilbert Faure au nom de l'ASSIM's insight:

Mitochondria are a central hub for antiviral immune defense. For example, the elimination of infected cells is, at least in part, driven by mitochondria-dependent (intrinsic) apoptosis. Mitochondria also act as a platform for the assembly of protein signaling complexes that drive the production of type I interferons (IFNs), potent antiviral cytokines which limit viral replication. In a recent issue of Nature, West et al.1 describe an additional role for mitochondria and their unique genome in mediating antiviral immunity.

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The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis: Cell

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis: Cell | immunology | Scoop.it
The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis: Cell http://t.co/Esvuhn4uyy
Gilbert Faure au nom de l'ASSIM's insight:
Highlights

 

•Resource of heritabilities and genetic associations of 80,000 immune traits in 669 twins•Genetic associations with immune cell frequencies and surface protein expression levels•Of the top 150 traits, 11 genetic loci explained up to 36% of variation of 19 traits•Loci include autoimmune susceptibility genes, providing etiological hypotheses
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Evolutionary genetics of insect innate immunity

Evolutionary genetics of insect innate immunity | immunology | Scoop.it
Evolutionary genetics of insect innate immunity #review http://t.co/3gpkuelNVD
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Gene networks specific for innate immunity define post-traumatic st... - PubMed - NCBI

Mol Psychiatry. 2015 Mar 10. doi: 10.1038/mp.2015.9. [Epub ahead of print]
Gilbert Faure au nom de l'ASSIM's insight:

stress syndrom

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Women’s Initiative Mentoring Program | Australasian Society for Immunology |

Women’s Initiative Mentoring Program | Australasian Society for Immunology | | immunology | Scoop.it
Are you a female immunologist looking for a mentor? @ASImmunology has a great mentoring program that can help http://t.co/NRwtUDFebn”
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Today is World TB Day - The Hans India

Today is World TB Day - The Hans India | immunology | Scoop.it
Tuberculosis continues to claim over 1000 lives every single day and is also one of the leading causes of deaths in the country. Adding to the woes is the worrisome trend of extremely drug resistance and total drug resistant strains.
Gilbert Faure au nom de l'ASSIM's insight:
Despite the declining number of cases, TB is still a life-threatening disease in the world. World TB Day is observed on March 24 every year. The event commemorates the date in 1882 when Dr Robert Koch announced the discovery of bacillus that causes tuberculosis. This year’s theme is “Find TB. Treat TB. Working together to eliminate TB.”
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Rescooped by Gilbert Faure au nom de l'ASSIM from Immunology and Biotherapies
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Access : FOXP3|[plus]| regulatory T cells and their functional regulation : Cellular & Molecular Immunology

Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not limited to, clinical immunology, comparative immunology, immunobiology, immunogenetics, immunological techniques, immunopathology, immunopharmacology, infection immunology, neuroimmunology, transplantation immunology, tumor immunology, and veterinary immunology.

Via Piet Van de Steen, Gilbert Faure au nom de l'ASSIM
Gilbert Faure au nom de l'ASSIM's insight:
FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and cancer.
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The lymph node filter revealed - Nature.com

The lymph node filter revealed
Nature.com
The first level is related mainly to innate immunological functions and operates at the subcapsular sinus, the site into which afferent lymph is discharged.
Gilbert Faure au nom de l'ASSIM's insight:
Stromal cells in the subcapsular sinus of the lymph node 'decide' which cells and molecules are allowed access to the deeper parenchyma. The glycoprotein PLVAP is a crucial component of this selector function.
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Specificity-Verified Monoclonal Antibodies - Bioscience Technology

Specificity-Verified Monoclonal Antibodies - Bioscience Technology | immunology | Scoop.it
AMSBIO has announced the availability of ultraspecific and extensively validated monoclonal antibodies under the UltraMAB™ brand.
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T Cells of the Skin - The Scientist

T Cells of the Skin - The Scientist | immunology | Scoop.it
A census of adaptive immune system components in human skin reveals a variety of resident and traveling memory T cells.
Gilbert Faure au nom de l'ASSIM's insight:
A staggering 20 billion or so memory T cells are part of the immune cell repertoire of human skin, defending the host from a multitude of infectious agents. And now, those skin memory T cells have been analyzed and categorized in a paper published today (March 18) in Science Translational Medicine. This paper is “a critical and groundbreaking redefinition of the cutaneous immune system,” dermatologist James Krueger of Rockefeller University in New York City, who was not involved in the work, wrote in an e-mail to The Scientist.
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Rescooped by Gilbert Faure au nom de l'ASSIM from Cancer Immunotherapy Review
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Intertwined regulation of angiogenesis and immunity by myeloid cells: Trends in Immunology

Highlights

 

•Tumor-infiltrating myeloid cells link angiogenesis and immune tolerance to drive tumor growth.•Hypoxia fuels proangiogenic and immune-suppressive programming of myeloid cells in tumors.•Immune-suppressive myeloid cells can drive tumor resistance to antiangiogenic therapy.•Antiangiogenic therapy efficacy may partly depend on promoting an immune-stimulating environment.

 

Angiogenesis is a hallmark of cancer because its induction is indispensable to fuel an expanding tumor. The tumor microenvironment contributes to tumor vessel growth, and distinct myeloid cells recruited by the tumor have been shown not only to support angiogenesis but also to foster an immune suppressive environment that supports tumor expansion and progression. Recent findings suggest that the intertwined regulation of angiogenesis and immune modulation can offer therapeutic opportunities for the treatment of cancer. We review the mechanisms by which distinct myeloid cell populations contribute to tumor angiogenesis, discuss current approaches in the clinic that are targeting both angiogenic and immune suppressive pathways, and highlight important areas of future research.


Via Krishan Maggon
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Krishan Maggon 's curator insight, March 18, 3:30 AM
ReviewTrends in immunology 2015Intertwined regulation of angiogenesis and immunity by myeloid cellsLee B. Rivera, Gabriele Bergers DOI: http://dx.doi.org/10.1016/j.it.2015.02.005Publication stage: In Press Corrected Proof
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Cytomegalovirus generates long-lived antigen-specific NK cells with... - PubMed - NCBI

J Exp Med. 2014 Dec 15;211(13):2669-80. doi: 10.1084/jem.20141172. Epub 2014 Nov 24. Research Support, N.I.H., Extramural
Gilbert Faure au nom de l'ASSIM's insight:
Natural killer (NK) cells play a key role in the host response to cytomegalovirus (CMV) and can mediate an enhanced response to secondary challenge with CMV. We assessed the ability of mouse CMV (MCMV)-induced memory Ly49H(+) NK cells to respond to challenges with influenza, an acute viral infection localized to the lung, and Listeria monocytogenes, a systemic bacterial infection. MCMV-memory NK cells did not display enhanced activation or proliferation after infection with influenza or Listeria, as compared with naive Ly49H(+) or Ly49H(-) NK cells. Memory NK cells also showed impaired activation compared with naive cells when challenged with a mutant MCMV lacking m157, highlighting their antigen-specific response. Ex vivo, MCMV-memory NK cells displayed reduced phosphorylation of STAT4 and STAT1 in response to stimulation by IL-12 and type I interferon (IFN), respectively, and IFN-γ production was reduced in response to IL-12 + IL-18 compared with naive NK cells. However, costimulation of MCMV-memory NK cells with IL-12 and m157 antigen rescues their impaired response compared with cytokines alone. These findings reveal that MCMV-primed memory NK cells are diminished in their response to cytokine-driven bystander responses to heterologous infections as they become specialized and antigen-specific for the control of MCMV upon rechallenge.
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Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury | immunology | Scoop.it
Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

Via Krishan Maggon
Gilbert Faure au nom de l'ASSIM's insight:

neutrophils are back.. 

and present on this topic

http://www.scoop.it/t/immunology?q=neutrophil

 

club de la SFI?

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Krishan Maggon 's curator insight, March 15, 8:46 AM

Citation: Kruger P, Saffarzadeh M, Weber ANR, Rieber N, Radsak M, et al. (2015) Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury. PLoS Pathog 11(3): e1004651. doi:10.1371/journal.ppat.1004651


Phagocytosis, Neutrophil Extracellular Traps (NETs)


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Dengue-Targeting T Cells Home to Skin | The Scientist Magazine®

Dengue-Targeting T Cells Home to Skin | The Scientist Magazine® | immunology | Scoop.it
Immune cells specific for the virus are present in the skin of infected patients, a study shows.
Gilbert Faure au nom de l'ASSIM's insight:

CLA + and to the mucosae?

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Rescooped by Gilbert Faure au nom de l'ASSIM from Cancer Immunotherapy Review
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Post-translational structural modifications of immunoglobulin G and their effect on biological activity - Springer

Post-translational structural modifications of immunoglobulin G and their effect on biological activity - Springer | immunology | Scoop.it
Post-translational structural modifications of immunoglobulin G, effect on biological activity #mAbs PTMs #biobetters http://t.co/CETawRCCB0

Via Krishan Maggon
Gilbert Faure au nom de l'ASSIM's insight:

biologic and biotherapeutic applications

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Krishan Maggon 's curator insight, March 13, 8:36 AM
Analytical and Bioanalytical ChemistryJanuary 2015, Volume 407, Issue 1, pp 79-94Date: 10 Sep 2014Post-translational structural modifications of immunoglobulin G and their effect on biological activityLaura K. Hmiel, Kurt A. Brorson, Michael T. Boyne II
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Prolonged access to thymic epithelial MHCI seals CD8 + lineage commitment - Nature.com

Prolonged access to thymic epithelial MHCI seals CD8 + lineage commitment - Nature.com | immunology | Scoop.it
Immunology and Cell Biology focuses on the general functioning of the immune system in its broadest sense, with a particular emphasis on its cell biology.
Gilbert Faure au nom de l'ASSIM's insight:

The stage of thymocyte maturation when commitment to the CD8+ lineage is consolidated by recognition of major histocompatibility complex class I (MHCI) on thymic epithelial cells has been elucidated in a study published in Immunology and Cell Biology.1

Development of αβ T cells is blocked at the CD4+CD8+ double-positive (DP) stage in mice lacking Zap70.2 By complementing the defect in Zap70–/– mice via an inducible Zap70 transgene (Tet-Zap70), the authors previously examined the kinetics of phenotypic progressions during thymocyte development.3 This confirmed that CD4+ single-positive (SP) cells form earlier than CD8SP cells4 and enabled delineation of DP thymocytes into three substages (DP1–DP3) based on CD5 and TCRβ expression. DP1 (CD5−TCRβ−) encompasses the major population of unselected cells, DP2 (CD5hiTCRβint) is the population from which CD4+ T cells differentiate directly and DP3 (CD5intTCRβhi) cells represent direct precursors of CD8+ T cells.3

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Introduction to Western Blotting

Introduction to Western Blotting | immunology | Scoop.it
Western blotting, also known as immunoblotting is a core technique in cell and molecular biology. Our guide provides an overview for performing successful Western blots
Gilbert Faure au nom de l'ASSIM's insight:

educational

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