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teaching and learning immunology, fundamental and clinical
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Scooped by Gilbert Faure au nom de l'ASSIM
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Immunology: teaching and learning immunology

Our first and ambitious Scoop.it topic.

 

It covers mainly fundamental immunology, molecular and cellular with more than 4160 posts

 

Thanks viewers (> 12500 views ! ), visitors (7790) and followers!

We have been GOLD twice in the past months!

GOLD again may 13!

Gilbert Faure au nom de l'ASSIM's insight:

Other successful topics in the field, either general or regional

Mucosal Immunity: http://www.scoop.it/t/mucosal-immunity

and

Autoimmunity

http://www.scoop.it/t/autoimmunity

Allergy and (so-called) clinical immunology:

 http://www.scoop.it/t/allergy-and-clinical-immunology

Immunology and Biotherapies

http://www.scoop.it/t/immunology-and-biotherapies

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Scooped by Gilbert Faure au nom de l'ASSIM
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Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5 ... - Nature.com

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5 ...
Nature.com
Lastly, to assess the physiological importance of our findings, we studied the innate immune response to reovirus infection in MDA5- or MAVS-deficient cells and mice.
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Scooped by Gilbert Faure au nom de l'ASSIM
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SFI-AFC 2014 - 4-6 novembre 2014 - Lille, France

SFI-AFC 2014 - 4-6 novembre 2014 - Lille, France | immunology | Scoop.it
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Rescooped by Gilbert Faure au nom de l'ASSIM from Cancer Immunotherapy Review
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Dendritic cells & Immunity Poster


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Rescooped by Gilbert Faure au nom de l'ASSIM from Complement
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Complement Patent Database


Via John D. Lambris
Gilbert Faure au nom de l'ASSIM's insight:

thanks for sharing this curated database of patents specifically dedicated to complement

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Aegean Conferences: 12th Innate Immunity Conference

Aegean Conferences: 12th Innate Immunity Conference | immunology | Scoop.it

Tthe 12th Annual International Innate Immunity Conference will be held at the Avra Hotel in Chania, Greece , from June 19-24, 2015. The Conference is under the sponsorship of Aegean Conferences (www.aegeanconferences.org), a non-profit educational organization promoting science through focused scientific conferences (please visit www.aegeanconferences.org and click on News, on the top right hand corner, for meeting reports  of previous Aegean Conferences.

The topics to be covered during the next meeting are:

·  Evolution of innate immune systems

·  Structural biology

·  Host-microbe interactions

·  Pattern-recognition receptors

·  Crosstalk pathways in innate immunity

·  Interactions with adaptive immunity

·  Inflammation and pathophysiology

·  Therapeutic applications


The purpose of the 12th Innate Immunity is to bring together scientists from all over the world to discuss their latest findings on the various aspects of Innate Immunity. The specific topics include:  Evolution of the innate immune system,  Host-microbe interactions, Interactions with adaptive immunity, Pathophysiology-Inflammation, Structural biology, and Therapeutic applications. Abstracts are invited from the international community for all these topics. The scientific sessions will convene in the mornings and early afternoons and will include lectures by invited speakers, as well as talks and poster presentations selected from submitted abstracts. The conference has limited participation and a scientific and social program that will maximize scientific interchange. In order to encourage the participation of young scientists, the Aegean Conferences is offering Trainee Travel Awards to offset a portion of the travel expenses to the Conference. The Conference Organizing Committee will select the Award recipients based on the scientific merit of abstracts submitted by applicants.


Via John D. Lambris
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IL-17/Th17 Pathway Is Activated in Acne Lesions

IL-17/Th17 Pathway Is Activated in Acne Lesions | immunology | Scoop.it
by Hanna-Leena Kelhälä, Riitta Palatsi, Nanna Fyhrquist, Sari Lehtimäki, Juha P. Väyrynen, Matti Kallioinen, Minna E.
Gilbert Faure au nom de l'ASSIM's insight:

juxtacrine cytokine activity?!

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ECI 2015

ECI 2015 | immunology | Scoop.it
4th European Congress of Immunology (ECI) Vienna 2015
Gilbert Faure au nom de l'ASSIM's insight:

The 4th ECI will cover all fields of modern immunology and adhere to a 4-track structure covering the topics innate immunity, adaptive immunity, diseases of the immune system and immune interventions. The 4-track program will streamline symposia, workshops as well as poster sessions enabling easy crosstalk between topics and types of sessions planned. In fact, novel forms of immune interventions represent one of the most exciting success stories of modern medicine. Thus, a special focus of the 4th ECI will be put on the fine balance between basic and applied/translational research. Delegates will be offered 150+ talks by invited speakers, plenary lectures by ‘immunology icons’, more than 400 oral presentations selected from abstracts, as well as guided poster walks.

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B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk [Elife. 2014]

Summary

Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of events resulting in B cell activation. How the BCR becomes signaling-competent upon antigen binding is still a matter of controversy. Using a high-resolution proximity ligation assay (PLA) to monitor the conformation of the BCR and its interactions with co-receptors at a 10-20 nm resolution, we provide direct evidence for the opening of BCR dimers during B cell activation. We also show that upon binding Syk opens the receptor by an inside-out signaling mechanism that amplifies BCR signaling. Furthermore, we found that on resting B cells, the coreceptor CD19 is in close proximity with the IgD-BCR and on activated B cells with the IgM-BCR, indicating nanoscale reorganization of receptor clusters during B cell activation

Gilbert Faure au nom de l'ASSIM's insight:

Talk at FEMS/EMBO Paris next week

http://www.febs-embo2014.org/programme/gene-diversification-and-immune-recognition/85

Sensing the unknown: How B cells are activated by a large set of different ligands

Since the discovery of antibodies (first in the form of antitoxins in 1890) immunologists have always wondered how our body can produce antibodies against so many different substances that they summarize with the word antigen. In 1956 Burnet proposed that a specific antibody response is established by a selection process that out of a large population of diverse B cells activates those with the right cognate B cell antigen receptor (BCR). The antigen-dependent stimulation of these cells results in their clonal outgrowth and differentiation to antibody producing plasma cells. How the BCR diversity is generated in the B cell population was explained by the finding of the V(D)J rearrangement and somatic hypermutation mechanisms of the immunoglobulin genes over the last decades. What is less well understood is how the many different antigens can activate the BCR in a way that is independent of the spatial organization of epitopes on the antigen molecules. This is quite different from most other receptors that have only one ligand whose structure helps to of bring or stabilize the receptor in an active conformation. As a solution for this problem, we have proposed the Dissociation Activation Model (DAM) according to which it is the opening of a pre-organized receptor cluster (oligomer) that activates the BCR independently of the structural input of the antigen. With the Fab base proximity ligation assay (Fab-PLA) we have developed a method which allows us to reliably monitor the conformation of the BCR on the surface of normal B cells at 10-20 nanometer distances. With this and other methods we found that the BCR exits indeed as an ordered oligomer on the surface of B cells and that in contact to antigen this oligomer is opened thus initiating the signaling process. Furthermore we discovered that the majority of the roughly 120.000 BCR on the surface of B cells are not opened by antigen but rather by the spleen tyrosine kinase (Syk) via an inside-out signaling mechanism. The details of this process will be discussed during my lecture.

Yang, J. and Reth, M. (2010). The dissociation activation model of B cell antigen receptor triggering. FEBS Letters 584: 4872. Klaesener, K., P. Maity, et al. (2014). "B cell activation involve nanoscale receptor reorganizations and i out signaling by Syk." eLife, on-line in June.

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RIP kinases: key decision makers in cell death and innate immunity - Nature.com

RIP kinases: key decision makers in cell death and innate immunity
Nature.com
Innate immunity represents the first line of defence against invading pathogens.
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Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation [ANTIGEN RECOGNITION AND RESPONSES]

Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c).
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Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses [IMMUNE REGULATION]

Lymph node (LN) stromal cells (LNSCs) form the functional structure of LNs and play an important role in lymphocyte survival and the maintenance of immune tolerance.
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Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection

Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection | immunology | Scoop.it
by René H. M. Raeven, Jolanda Brummelman, Jeroen L. A. Pennings, Olaf E. M. Nijst, Betsy Kuipers, Laura E. R. Blok, Kina Helm, Elly van Riet, Wim Jiskoot, Cecile A. C. M. van Els, Wanda G. H. Han, Gideon F.
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Informa Healthcare

Informa Healthcare | immunology | Scoop.it
RT @EmmaPettengale: Using the shark immune system to fight human disease - from Shark VNARs to adaptive immunology http://t.co/j6WqXjTZeA
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TxCell gets 5 new patents in US, Asia & Australia for core technology and ... - pharmabiz.com

TxCell gets 5 new patents in US, Asia & Australia for core technology and ...
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Rescooped by Gilbert Faure au nom de l'ASSIM from Cancer Immunotherapy Review
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The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing : Nature Reviews Immunology : Nature Publishing Group

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing : Nature Reviews Immunology : Nature Publishing Group | immunology | Scoop.it

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.


Via Krishan Maggon
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Krishan Maggon 's curator insight, August 29, 10:17 AM

NATURE REVIEWS IMMUNOLOGY | REVIEW

 

The IL-23–IL-17 immune axis: from mechanisms to therapeutic testingSarah L. Gaffen,Renu Jain,Abhishek V. Garg& Daniel J. CuaAffiliationsCorresponding authorNature Reviews Immunology 14, 585–600 (2014) doi:10.1038/nri3707Published online 22 August 2014
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Contractile activity of human follicular dendritic cells - Nature.com

Contractile activity of human follicular dendritic cells
Nature.com
Original Article. Immunology and Cell Biology advance online publication 26 August 2014; doi: 10.1038/icb.2014.61. Contractile activity of human follicular dendritic cells.
Gilbert Faure au nom de l'ASSIM's insight:

Follicular dendritic cells (FDCs) present antigens to B cells in the lymphoid follicle and inhibit B-cell apoptosis....

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Researchers discover fever's origin - EurekAlert (press release)

Researchers discover fever's origin - EurekAlert (press release) | immunology | Scoop.it
Researchers discover fever's origin EurekAlert (press release) Firstly, that it comes from prostaglandins circulating in the blood, secondly that it comes from immune cells in the brain, and thirdly Engblom's theory, which stresses the importance...
Gilbert Faure au nom de l'ASSIM's insight:

fever in inflammation

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Frontiers | RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis | Molecular Innate Immunity

Bovine tuberculosis (BTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries.
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Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes

Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes | immunology | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
Gilbert Faure au nom de l'ASSIM's insight:

These data highlight the existence of at least two distinctive populations of LECs within human LNs. Of the other LEC markers, we confirmed VEGFR3 was not specific for LECs, and CD144 and CD31 stained both LECs and blood vascular endothelial cells (BECs); in contrast, CD59 and CD105 stained BECs but not LECs. We also showed that antigen-presenting cells (APCs) in the sinuses could be clearly distinguished from LECs by their expression of CD169, and their lack of expression of PROX1 and STAB2, or endothelial markers such as CD144. However, both LECs and sinus APCs were stained with DCN46, an antibody commonly used to detect CD209.

CD209 is DC-SIGN

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ESID 2014 - Immunodeficiencies Meeting, Prague

The 16th Biennial Meeting of the European Society for Immunodeficiencies (ESID 2014) will take place in Prague, Czech Republic, from 29 October - 1 November, 2014.
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Sugary bugs subvert antibodies - Science Codex

Sugary bugs subvert antibodies - Science Codex | immunology | Scoop.it
Science Codex
Sugary bugs subvert antibodies
Science Codex
A group of researchers at the University of Birmingham, England, now find that the antibody response to Pseudomonas can get in its own way.
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TAK1 control of cell death - Nature.com

TAK1 control of cell death
Nature.com
Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol 2013; 34: 307–316. | Article | PubMed |; Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K.
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Marginal Zone B Cells Transport IgG3-Immune Complexes to Splenic Follicles [IMMUNE REGULATION]

Ag administered together with specific IgG3 induces a higher Ab response than Ag administered alone, an effect requiring the presence of complement receptors 1 and 2 (CR1/2).
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New LPS receptors discovered - Nature.com

New LPS receptors discovered
Nature.com
Lipopolysaccharide (LPS) is an outer membrane component of Gram-negative bacteria that is classically recognized by immune cells via the pattern recognition receptor Toll-like receptor 4 (TLR4).
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Complement Activation by Merozoite Antigens of Plasmodium falciparum

Complement Activation by Merozoite Antigens of Plasmodium falciparum | immunology | Scoop.it
by Jackson C. Korir, Nancy K. Nyakoe, George Awinda, John N.
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