immunology
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Teaching and Learning Immunology. Information you never would have searched for!
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Gilbert C FAURE's insight:

This topic is focusing mainly on fundamental systemic immunology.

 

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History of Immunology

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Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance

Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance | immunology | Scoop.it
Author Summary Dengue is a globally important viral disease. Despite this, there is still much unknown about the immunology, virology and epidemiology of dengue.
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dengue
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You are what you eat: Immune cells remember their first meal

You are what you eat: Immune cells remember their first meal | immunology | Scoop.it
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response -- a discovery that may pave the way for new treatments for many human diseases.
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Rescooped by Gilbert C FAURE from Top Selling Monoclonal Antibodies 2014
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Phosphorylation-dependent interaction between antigenic peptides and MHC class I

Phosphorylation-dependent interaction between antigenic peptides and MHC class I | immunology | Scoop.it
Phosphorylation-dependent interaction between antigenic peptides and MHC class I Curator: Larry H.
Via Krishan Maggon
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Frontiers | A New Biological Feature of Natural Killer Cells: The Recognition of Solid Tumor-Derived Cancer Stem Cells | NK Cell Biology

Frontiers | A New Biological Feature of Natural Killer Cells: The Recognition of Solid Tumor-Derived Cancer Stem Cells | NK Cell Biology | immunology | Scoop.it
Natural Killer (NK) cells are classified as a member of the innate lymphoid cells (ILC) group 1. ILCs have been recently identified and grouped on the basis of their phenotypical and functional characteristics.
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NATURE REVIEWS IMMUNOLOGY | REVIEW Emerging insights into natural killer cells in human peripheral tissues

Natural killer (NK) cells have long been considered to be a homogenous population of innate lymphocytes with limited phenotypic and functional diversity. However, recent findings have revealed that these cells comprise a large number of distinct populations with diverse characteristics. Some of these characteristics may relate to their developmental origin, and others represent differences in differentiation that are influenced by factors such as tissue localization and imprints by viral infections. In this Review, we provide a comprehensive overview of the emerging knowledge about the development, differentiation and function of human NK cell populations, with a particular focus on NK cells in peripheral tissues.
Gilbert C FAURE's insight:
Niklas K. Björkström, Hans-Gustaf Ljunggren & Jakob Michaëlsson AffiliationsCorresponding authors Nature Reviews Immunology 16, 310–320 (2016) doi:10.1038/nri.2016.34 Published online 28 April 2016
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Infections Revealing Complement Deficiency in Adults: A French Nationwide Study Enrolling 41 Patients. - PubMed - NCBI

Infections Revealing Complement Deficiency in Adults: A French Nationwide Study Enrolling 41 Patients. - PubMed - NCBI | immunology | Scoop.it
Medicine (Baltimore). 2016 May;95(19):e3548. doi: 10.1097/MD.0000000000003548.
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Post-transcriptional Regulation of Immunological Responses through Riboclustering

Post-transcriptional Regulation of Immunological Responses through Riboclustering | immunology | Scoop.it
Koelina Ganguly, Jeevan Giddaluru, Avery August, Nooruddin Khan
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Immune 'signature' unique to Ebola fatalities identified by scientists

Immune 'signature' unique to Ebola fatalities identified by scientists | immunology | Scoop.it
Recognising difference in immune response between survivors and fatalities raises hope that current anti-cancer drug could be used to treat Ebola patients
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Zika may cause microcephaly by activating TLR3

Zika may cause microcephaly by activating TLR3 | immunology | Scoop.it
Research shows that inhibiting this mechanism reduces brain cell damage, hinting at a new therapy to mitigating the effects of prenatal Zika virus infection
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Société Francaise d'Immunologie's comment, May 8, 5:48 AM
perhaps major finding
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T cells use 'handshakes' to sort friends from foes

T cells use 'handshakes' to sort friends from foes | immunology | Scoop.it
T cells, the security guards of the immune system, use a kind of mechanical "handshake" to test whether a cell they encounter is a friend or foe, a new study finds.
Gilbert C FAURE's insight:
my comparison of cells being like buyers and sellers in a rural market is physically supported! Great
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Advancing immunology and primary immunodeficiencies in the genomic era: The importance of being collaborative

Advancing immunology and primary immunodeficiencies in the genomic era: The importance of being collaborative | immunology | Scoop.it
We celebrate the day of Immunology with an interview with Sergio Rosenzweig, Deputy Chief of the Immunology Service at the Clinical Center, NIH and the Co-Director of the Primary Immunodeficiency Clinic, NIAID, NIH and Associate Editor for...
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Helios-deficient Tregs and antitumor immunity [Immunology and Inflammation]

Expression of the transcription factor Helios by Tregs ensures stable expression of a suppressive and anergic phenotype in the face of intense inflammatory responses, whereas Helios-deficient Tregs display diminished lineage stability, reduced...
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SBP scientists discover new regulator of immune responses

SBP scientists discover new regulator of immune responses | immunology | Scoop.it
Research led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a new regulator of immune responses.
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psgl-1
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Rescooped by Gilbert C FAURE from Institut Pasteur de Tunis-معهد باستور تونس
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HIV: Identification of key immune response receptors in patients spontaneously controlling infection

HIV: Identification of key immune response receptors in patients spontaneously controlling infection | immunology | Scoop.it
A small number of patients infected by HIV spontaneously control viral replication without antiretroviral therapy, and do not develop the disease. The ability of these rare patients, known as "HIV controllers", to suppress HIV replication appears to be down to a highly effective immune response. Scientists from the Institut Pasteur and Inserm observed that CD4+ T immune cells in these patients, recruited from the ANRS CO21 CODEX cohort, were capable of recognizing tiny quantities of the virus.

Via Institut Pasteur de Tunis - معهد باستور تونس‎
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Rescooped by Gilbert C FAURE from Virology and Bioinformatics from Virology.ca
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Why humans (and not mice) are susceptible to Zika - Scienmag

Why humans (and not mice) are susceptible to Zika - Scienmag | immunology | Scoop.it
Flaviviruses--such as Zika, dengue, and yellow fever--have emerged as human (and other primate) pathogens because of their ability to specifically overcome our anti-viral defenses. In the case of Zika..

Via Kenzibit
Gilbert C FAURE's insight:
zika anf IFNs!
... one of the virus's seven non-structural proteins (NS5) is singularly responsible for blocking the action of interferons (proteins that stop viral replication) in human cells, while mouse cells are unaffected.
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Your neighbours matter – non-autonomous control of apoptosis in development and disease

Your neighbours matter – non-autonomous control of apoptosis in development and disease | immunology | Scoop.it
Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis.
Gilbert C FAURE's insight:
apoptosis fundamental
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KLF2 controls mature NK cell homeostasis [Immunology and Inflammation]

KLF2 controls mature NK cell homeostasis [Immunology and Inflammation] | immunology | Scoop.it
Natural killer (NK) cells are innate lymphocytes that recognize and lyse virally infected or transformed cells.
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CD21–/low B cells in human blood are memory cells

CD21–/low B cells in human blood are memory cells | immunology | Scoop.it
The complement receptor 2 (CR2, CD21) is part of a complex (CD21/CD19/CD81) acting as a co-receptor to the B cell receptor (BCR). Simultaneous triggering of the BCR and CD21 lowers the threshold for B cell activation.
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The remarkable language of cells | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights

The remarkable language of cells | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | immunology | Scoop.it
The remarkable language of cells includes many elements such as touching, cytokines, neurotransmitters, hormones, vesicles, photons, electricity & nanotubes | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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EuroStemCell: We hear from Thymistem scientist Maria Antica on why she felt translation was important for her country and the unfolding events of the Day of Immunology celebration.

EuroStemCell: We hear from Thymistem scientist Maria Antica on why she felt translation was important for her country and the unfolding events of the Day of Immunology celebration. | immunology | Scoop.it
() The thymus is a little known organ, something that Maria Antica, Thymistem scientist, knew well when chatting with her friends and family in Croatia.
Gilbert C FAURE's insight:
another language!
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Platelets Guide Leukocytes to Their Sites of Extravasation

Platelets Guide Leukocytes to Their Sites of Extravasation | immunology | Scoop.it
This study identifies a previously unanticipated role for platelets as pathfinders, guiding leukocytes to the sites at which they can exit the microvasculature; this process appears to be critical for an effective immune response.
Gilbert C FAURE's insight:
for inflammation explained
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EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells : Nature : Nature Publishing Group

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells : Nature : Nature Publishing Group | immunology | Scoop.it
T follicular helper (Tfh) cells are a subset of T cells carrying the CD4 antigen; they are important in supporting plasma cell and germinal centre responses. The initial induction of Tfh cell properties occurs within the first few days after activation by antigen recognition on dendritic cells, although how dendritic cells promote this cell-fate decision is not fully understood. Moreover, although Tfh cells are uniquely defined by expression of the follicle-homing receptor CXCR5 (refs 1, 2), the guidance receptor promoting the earlier localization of activated T cells at the interface of the B-cell follicle and T zone has been unclear. Here we show that the G-protein-coupled receptor EBI2 (GPR183) and its ligand 7α,25-dihydroxycholesterol mediate positioning of activated CD4 T cells at the interface of the follicle and T zone. In this location they interact with activated dendritic cells and are exposed to Tfh-cell-promoting inducible co-stimulator (ICOS) ligand. Interleukin-2 (IL-2) is a cytokine that has multiple influences on T-cell fate, including negative regulation of Tfh cell differentiation. We demonstrate that activated dendritic cells in the outer T zone further augment Tfh cell differentiation by producing membrane and soluble forms of CD25, the IL-2 receptor α-chain, and quenching T-cell-derived IL-2. Mice lacking EBI2 in T cells or CD25 in dendritic cells have reduced Tfh cells and mount defective T-cell-dependent plasma cell and germinal centre responses. These findings demonstrate that distinct niches within the lymphoid organ T zone support distinct cell fate decisions, and they establish a function for dendritic-cell-derived CD25 in controlling IL-2 availability and T-cell differentiation.
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Designing A Faster, Better, Stronger Immune Response

Designing A Faster, Better, Stronger Immune Response | immunology | Scoop.it
It is the antibodies that detect pathogens in order to fight infections and prevent disease, but there is an entire team of immune cells that work together
Via Krishan Maggon
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