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Sci Rep. 2015 Jul 9;5:11483. doi: 10.1038/srep11483. 
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Proteomics. 2015 Jul 7. doi: 10.1002/pmic.201400142. [Epub ahead of print]
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The prognosis of cognitive improvement after cerebrospinal fluid (CSF) shunting in idiopathic normal pressure... http://t.co/gMeL6axc6C
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J Cereb Blood Flow Metab. 2015 Jul;35(7):1055-68. doi: 10.1038/jcbfm.2015.76. Epub 2015 Apr 22. Review
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The History Of Multiple Sclerosis Its Early Years Back in the 19th century, people would only listen to and believe hearsay, superstition and the wisdom of
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Cytokine. 2015 Jun 30. pii: S1043-4666(15)00245-8. doi: 10.1016/j.cyto.2015.06.010. [Epub ahead of print]
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Neurol Sci. 2015 Jul 1. [Epub ahead of print]
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PLoS One. 2015 Jun 29;10(6):e0131557. doi: 10.1371/journal.pone.0131557. eCollection 2015.
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RT @NatRevNeurol: Cerebrospinal fluid tau and amyloid-beta1-42 in a large Swedish cohort of patients with #dementia. http://t.co/qCihYQSUSF…
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RT @GreenJournal: The growing spectrum of antibody-associated inflammatory brain diseases in children http://t.co/lUCWf39DsP #Neurology
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J Neuroinflammation. 2015 Jun 16;12(1):119. [Epub ahead of print]
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A major epidemiological registry-based study indicates that Parkinson's disease begins in the gastrointestinal tract. The study is the largest in the field so far.
Gilbert C FAURE's insight:
"We have conducted a registry study of almost 15,000 patients who have had the vagus nerve in their stomach severed. Between approximately 1970-1995 this procedure was a very common method of ulcer treatment. If it really is correct that Parkinson's starts in the gut and spreads through the vagus nerve, then these vagotomy patients should naturally be protected against developing Parkinson's disease," explains postdoc at Aarhus University Elisabeth Svensson on the hypothesis behind the study. A hypothesis that turned out to be correct "Our study shows that patients who have had the the entire vagus nerve severed were protected against Parkinson's disease. Their risk was halved after 20 years. However, patients who had only had a small part of the vagus nerve severed where not protected. This also fits the hypothesis that the disease process is strongly dependent on a fully or partially intact vagus nerve to be able to reach and affect the brain," she says.
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RT @NeuroOncNews: I support a real effort to understand the role, if any, of CMV in glioblastoma
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Learn how our state of mind and stress can influence our body's defense system.
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This cohort study assesses cerebrospinal fluid biomarkers of Alzheimer disease and their association with cognitive decline in cognitively normal middle-aged individuals.
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JTM | Full text | Identification and proteomic profiling of exosomes in human cerebrospinal fluid - http://t.co/UTVnbPeMYf
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Correct function of neuronal networks is enabled by a delicate interplay among neurons communicating with each other. One of the keys is the communication at chemical synapses where neurotransmitte...
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When American artist William Utermohlen was diagnosed with Alzheimer's in 1995, he decided to make the best use of his limited time and memory. He began ...
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A brain drain
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From
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Phys.org Science News Wire : Novel method for quantifying cerebrospinal fluid flow dynamics uses magnetic resonance image analysis -- a press release is provided to you ìas isî with little or no review from Phys.org staff.
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Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis: Multiple sclerosis (MS) is a ch... http://t.co/EsvhuUAquS
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Neuroscience. 2015 Jun 20. pii: S0306-4522(15)00554-0. doi: 10.1016/j.neuroscience.2015.05.081. [Epub ahead of print]
Gilbert C FAURE's insight:
The immune response is an important component of the cochlear response to stress. As an important player in the cochlear immune system, the basilar membrane immune cells reside on the surface of the scala tympani side of the basilar membrane. At present, the immune cell properties in this region and their responses to stress are not well understood. Here, we investigated the functional role of these immune cells in the immune response to acoustic overstimulation. This study reveals that tissue macrophages are present in the entire length of the basilar membrane under steady-state conditions. Notably, these cells in the apical and the basal sections of the basilar membrane display distinct morphologies and immune protein expression patterns. Following acoustic trauma, monocytes infiltrate into the region of the basilar membrane, and the infiltrated cells transform into macrophages. While monocyte infiltration and transformation occurs in both the apical and the basal sections of the basilar membrane, only the basal monocytes and macrophages display a marked increase in the expression of MHC II and CIITA, a MHC II production cofactor, suggesting the site-dependent activation of antigen-presenting function. Consistent with the increased expression of the antigen-presenting proteins, CD4+ T cells, the antigen-presenting partner, infiltrate into the region of the basilar membrane where antigen-presenting proteins are upregulated. Further pathological analyses revealed that the basal section of the cochlea displays a greater level of sensory cell damage, which is spatially correlated with the region of antigen-presenting activity. Together, these results suggest that the antigen-presenting function of the mononuclear phagocyte population is activated in response to acoustic trauma, which could bridge the innate immune response to adaptive immunity.
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Mol Psychiatry. 2015 Jun 23. doi: 10.1038/mp.2015.81. [Epub ahead of print]
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