NeuroImmunology
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:10 PM
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Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis

Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis | NeuroImmunology | Scoop.it
RT @GreenJournal: Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with MS
http://t.co/QHzAbHjHWv #Neurology htt…
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:09 PM
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Frontiers | Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity | Frontiers in Neuroendocrine Science

For centuries after its first description by Galen, the thymus was considered as only a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the development of T (thymo-dependent) lymphocytes.
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:08 PM
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Mast cells, glia and neuroinflammation: partners in crime? - Skaper - Immunology - Wiley Online Library

Mast cells, glia and neuroinflammation: partners in crime? - Skaper - Immunology - Wiley Online Library | NeuroImmunology | Scoop.it
RT @BSIHQ: Partners in crime? Mast cells, glia and neuroinflammation. Free article from #immunology http://t.co/Loe3UyyAeX http://t.co/JhUu…;
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:07 PM
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GABAB receptor autoantibody frequency in service serologic evaluation

GABAB receptor autoantibody frequency in service serologic evaluation | NeuroImmunology | Scoop.it
RT @GreenJournal: GABAB receptor autoantibody frequency in service serologic evaluation
http://t.co/Wyd9qA1OEp #Neurology http://t.co/GPf…;
Gilbert C FAURE's insight:

Conclusion: GABABR autoantibody is a marker of an uncommon but treatable paraneoplastic neurologic disorder, usually occurring in the setting of limbic encephalitis and SCLC.

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January 5, 2014 2:06 PM
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Paraneoplastic neurological syndromes - Leypoldt - Clinical & Experimental Immunology - Wiley Online Library

Paraneoplastic neurological syndromes - Leypoldt - Clinical & Experimental Immunology - Wiley Online Library | NeuroImmunology | Scoop.it
Paraneoplastic neurological syndromes Leypoldt Clinical & Experimental Immunology Wiley Online Library http://t.co/C9NgBxJuBn
Gilbert C FAURE's insight:

Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the central or peripheral nervous systems, or both, directed originally against the tumour itself. They have been known for more than 40 years, but recently the discovery of new subgroups of paraneoplastic encephalitis syndromes with a remarkably good response to immune therapy has ignited new clinical and scientific interest. Knowledge of these subgroups and their associated autoantibodies is important in therapeutic decision-making. However, the abundance of new autoantibodies and syndromes can be confusing. This review paper summarizes current knowledge and new developments in the field of paraneoplastic neurological syndromes, their classification, pathophysiology and treatment.

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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:05 PM
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TRPM4 mRNA expression levels in peripheral blood mononuclear cells from multiple sclerosis patients

TRPM4 mRNA expression levels in peripheral blood mononuclear cells from multiple sclerosis patients | NeuroImmunology | Scoop.it
Journal of Neuroimmunology, Volume null, Issue null, Pages null, null, Authors:S. Malhotra; J. Castilló; L. Negrotto; C. Merino-Zamorano; J. Montaner; A. Vidal-Jordana; X. Montalban; M.
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:04 PM
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Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis Associated with IgM Antibodies to the Epstein-Barr Virus Viral Capsid Antigen

Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis Associated with IgM Antibodies to the Epstein-Barr Virus Viral Capsid Antigen | NeuroImmunology | Scoop.it
Case Reports in Neurological Medicine is a peer-reviewed, open access journal that publishes case reports in all areas of neurological medicine.
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:03 PM
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JAMA Network | JAMA Neurology | Neuromyelitis Optica and Non–Organ-Specific Autoimmunity

JAMA Network | JAMA Neurology | Neuromyelitis Optica and Non–Organ-Specific Autoimmunity | NeuroImmunology | Scoop.it
JAMA Network | JAMA Neurology | Neuromyelitis Optica and Non–Organ-Specific Autoimmunity http://t.co/znvxGkKDFZ
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:02 PM
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Utility of aquaporin-4 antibody assay in patients with neuromyelitis optica spectrum disorders

Sung-Min Kim, Patrick Waters, Mark Woodhall, Jee-Young Kim, Jee-Eun Kim, Ji Won Yang, Jun-Soon Kim, Jung-Joon Sung, Kyung Seok Park, Kwang-Woo LeeJan 17, 2013; 0:135245851-135245851 (Utility of aquaporin-4 antibody assay in patients with neuromyelitis...
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:01 PM
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JNI | Abstract | The history of neuromyelitis optica

The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO).
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:01 PM
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ScienceDirect.com - Journal of Autoimmunity - Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE

ScienceDirect.com - Journal of Autoimmunity - Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE | NeuroImmunology | Scoop.it
Ped Neuro Res Alison Christy MD/PhD published in Journal of Autoimmunity. Check it out here: http://t.co/s3uZJJNp #MDCHAT #MEDED #hcsm
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:00 PM
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Autoimmunity and Brain Function: New Insights from Studying a ...

Autoimmunity and Brain Function: New Insights from Studying a ... | NeuroImmunology | Scoop.it
Brain auto-antibodies Autoimmunity were proposed to clarify SLE neuropsychiatric disorders and found for being elevated prior to the start of clinical symptoms. The investigators assessed cognition in Caucasian SLE women ...
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 1:59 PM
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CANCER-RELATED NEUROPATHIES (1) « geenabhud

With a few exceptions, antineuronal antibodies are believed to be “markers” for autoimmunity but probably do not directly mediate neuronal injury. For some syndromes recent evidence implicates cellular-mediated ...
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:09 PM
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Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment

Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment | NeuroImmunology | Scoop.it
Rheumatology Medical Article: Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment (RT @MDLinx: Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment: Inte...
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January 5, 2014 2:09 PM
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Mechanisms of autoimmunity in the central nervous system: Disturbance of natural autoimmunity, infectious agents, cell contribution and antibody signatures - Ortega-Hernandez - 2013 - Clinical and ...

Mechanisms of autoimmunity in the central nervous system: Disturbance of natural autoimmunity, infectious agents, cell contribution and antibody signatures - Ortega-Hernandez - 2013 - Clinical and ... | NeuroImmunology | Scoop.it
Mechanisms of autoimmunity in the central nervous system: 2013 Clinical and Experimental Neuroimmunology http://t.co/ssl82WabFE
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:07 PM
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A case with anti-galactocerebroside antibody-posi... [Neurol Sci. 2012] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:07 PM
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Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica

Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica | NeuroImmunology | Scoop.it
RT @NatRevNeurol: Recombinant antigen-based assay improves detection of AQP4 antibodies in patients with NMO http://t.co/Nj6jUGuCz1 via @fe…
Gilbert C FAURE's insight:

Conclusions: Serological tests using recombinant AQP4 antigen are significantly more sensitive than tissue-based IIF for detecting AQP4-IgG. Testing should precede immunotherapy; if negative, later-drawn specimens should be tested. AQP4-IgG–seronegative NMO is less frequent than previously reported and is clinically similar to AQP4-IgG–seropositive NMO.

Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:06 PM
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BMC Neurology | Abstract | Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study

Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA).
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:04 PM
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The spectrum of MOG autoantibody-associated demyelinating diseases : Abstract : Nature Reviews Neurology

And Reindl et al. review the spectrum of MOG antibody-associated demyelinating diseases http://t.co/tP5Iz4v36e (£) #newfromnrneurol
Gilbert C FAURE's insight:

Myelin oligodendrocyte glycoprotein (MOG) has been identified as a target of demyelinating autoantibodies in animal models of inflammatory demyelinating diseases of the CNS, such as multiple sclerosis (MS). Numerous studies have aimed to establish a role for MOG antibodies in patients with MS, although the results have been controversial. Cell-based immunoassays using MOG expressed in mammalian cells have demonstrated the presence of high-titre MOG antibodies in paediatric patients with acute disseminated encephalomyelitis, MS, aquaporin-4-seronegative neuromyelitis optica, or isolated optic neuritis or transverse myelitis, but only rarely in adults with these disorders. These studies indicate that MOG antibodies could be associated with a broad spectrum of acquired human CNS demyelinating diseases. This Review article discusses the current literature on MOG antibodies, their potential clinical relevance, and their role in the pathogenesis of MOG antibody-associated demyelinating disorders.

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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:03 PM
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ScienceDirect.com - Journal of Autoimmunity - Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway

ScienceDirect.com - Journal of Autoimmunity - Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway | NeuroImmunology | Scoop.it
Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway [Journal of Autoimmunity] http://t.co/dTZcLltGNy
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:02 PM
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Changes to anti-JCV antibody levels in a Swedish national MS cohort -- Warnke et al. -- Journal of Neurology, Neurosurgery & Psychiatry

Open Access: Changes to anti-JCV antibody levels in a Swedish national MS cohort [MULTIPLE SCLEROSIS] http://t.co/wUQpUtXu4N
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:02 PM
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Nerve Injury-related Autoimmunity Activation Leads to Chroni ...

Nerve Injury-related Autoimmunity Activation Leads to Chroni ... | NeuroImmunology | Scoop.it
Background: Peripheral nerve injuries that provoke neuropathic pain are associated with chronic infl.
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:01 PM
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Chronic pain as a manifestation of potassium chann... [Neurology. 2012] - PubMed - NCBI

PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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January 5, 2014 2:00 PM
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N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis - Prüss - 2012 - Annals of Neurology - Wiley Online Library

N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis - Prüss - 2012 - Annals of Neurology - Wiley Online Library | NeuroImmunology | Scoop.it
Does viral encephalitis induce autoimmunity?
http://t.co/vm2KnpsM
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Scooped by Gilbert C FAURE from AUTOIMMUNITY
January 5, 2014 2:00 PM
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Novel cerebrospinal fluid and serum autoantibody... [J Neurochem. 2012] - PubMed - NCBI

PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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