J Neuropathol Exp Neurol. 2016 Jul 13. pii: nlw063.
NeuroImmunology
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Immune dysfunction is commonly associated with several neurological and mental disorders. Although the mechanisms by which peripheral immunity may influence neuronal function are largely unknown, recent findings implicate meningeal immunity influencing behaviour, such as spatial learning and memory. Here we show that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions. Associations between rodent transcriptomes from brain and cellular transcriptomes in response to T-cell-derived cytokines suggest a strong interaction between social behaviour and interferon-γ (IFN-γ)-driven responses. Concordantly, we demonstrate that inhibitory neurons respond to IFN-γ and increase GABAergic (γ-aminobutyric-acid) currents in projection neurons, suggesting that IFN-γ is a molecular link between meningeal immunity and neural circuits recruited for social behaviour. Meta-analysis of the transcriptomes of a range of organisms reveals that rodents, fish, and flies elevate IFN-γ/JAK-STAT-dependent gene signatures in a social context, suggesting that the IFN-γ signalling pathway could mediate a co-evolutionary link between social/aggregation behaviour and an efficient anti-pathogen response. This study implicates adaptive immune dysfunction, in particular IFN-γ, in disorders characterized by social dysfunction and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.
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Researchers at The Salk Institute authored a new study that marijuana legalization advocates will be sure to puff up and pass around.
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Neurol Neuroimmunol Neuroinflamm. 2016 Jun 1;3(4):e245. doi: 10.1212/NXI.0000000000000245. eCollection 2016.
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Ependymal cells are epithelial support cells that line the central canal and ventricular cavities of the central nervous system, providing the interface between the cerebrospinal fluid and the parenchyma of the brain and spinal cord.
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Alzheimer’s disease (AD) currently affects 5.5 million people in the U.S. over the age of 65, and that number will continue to grow unless a disease-
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Researchers report preclinical PET imaging can provide a visual map of inflammatory disease and may be used to investigate novel therapies. | Multiple sclerosis New Drugs Review
Gilbert C FAURE's insight:
imagerie PET
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Alpert Medical School Office of CME, Providence, RI. 36 likes · 2 talking about this · 1 was here. The Warren Alpert Medical School is accredited b
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Brain Behav Immun. 2016 Jul;55:166-78. doi: 10.1016/j.bbi.2016.05.016. Epub 2016 May 30. Review
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Editorial: The Emerging Role of Monocyte-Derived Cells in the Central Nervous System
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() As part of an international clinical trial, researchers at the Sheffield Teaching Hospital recently reported interesting developments in multiple sclerosis therapy.
Via Krishan Maggon
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Progressive multifocal leukoencephalopathy (PML) caused by reactivation of the JC virus (JCV), a human polyomavirus, occurs in autoimmune disorders, most frequently in systemic lupus erythematosus (SLE).
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Known gene operates at a crossroad between disease and autoimmunity | Harvard researchers have found evidence that bone marrow transplantation may one day be beneficial to a subset of patients suffering from ALS.
Claire Dubois's curator insight,
January 8, 2023 10:58 AM
Après les injections de LTregs vu dans l’article précédent, on parle désormais de greffes de moelle osseuse qui permettrait donc de régénérer le système immunitaire. Les effets observés semblent bénéfiques, c’est pourquoi c’est un sujet majeur qui va certainement mené à de nouveaux essais cliniques.
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J Neuroimmunol. 2016 Mar 15;292:27-33. doi: 10.1016/j.jneuroim.2015.12.007. Epub 2016 Jan 14. Research Support, Non-U.S. Gov't; Review
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Blogger and globetrotter Trevis Gleason and the Life With MS blog have been on the international stage of late, reaching out to others with multiple sclerosis.
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This review summarizes the relevance of resveratrol in the pathophysiology of AD.
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Ever wonder about exercise and autoimmunity? New #RRID paper out from @JNeurosciRes using @mgi_mouse https://t.co/L29An9UBhN
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Increasing evidence suggests that neuro-immune and neuro-glial interactions are critically involved in chronic pain sensitization.
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A new study reports neurological symptoms associated with early HIV infection are more extensive, but milder, than previously thought.
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Genes and Immunity is a journal dedicated to functional genetics of the immune response.
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Acute oligodendrocyte (OL) death after traumatic spinal cord injury (SCI) is followed by robust neuron–glial antigen 2 (NG2)-positive OL progenitor proliferation and differentiation into new OLs.
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ASN Neuro. 2015 Oct 21;7(5). pii: 1759091415609613. doi: 10.1177/1759091415609613. Print 2015 Sep-Oct. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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METHODS:Screening for anti-natalizumab antibodies was performed using a standardized bridging ELISA. Antibody-positive samples were further analyzed for IgM and IgG1-4 antibodies using ELISA and ImmunoCAP®.
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Radiology. 2016 May 31;:152244.
Authors: van de Haar HJ, Burgmans S, Jansen JF, van Osch MJ, van Buchem MA, Muller M, Hofman PA, Verhey FR, Backes WH PubMed: 27243267 Submit Comment
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