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Scooped by
Gilbert C FAURE
August 18, 2016 3:25 PM
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Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most pressing problems of developed societies with aging populations. Neurons carry out essential functions such as signal transmission and network integration in the central nervous system and are the main targets of neurodegenerative disease. In this Review, I address how the neuron’s environment also contributes to neurodegeneration. Maintaining an optimal milieu for neuronal function rests with supportive cells termed glia and the blood-brain barrier. Accumulating evidence suggests that neurodegeneration occurs in part because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation. These observations indicate that therapies targeting glial cells might provide benefit for those afflicted by neurodegenerative disorders.
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Scooped by
Gilbert C FAURE
August 14, 2016 2:25 PM
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Nearly 90 percent of the brain is composed of glial cells, not neurons. Andrew Koob argues that these overlooked cells just might be the source of the imagination
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Scooped by
Gilbert C FAURE
August 12, 2016 11:22 AM
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Scooped by
Gilbert C FAURE
August 11, 2016 7:53 AM
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N-Methyl-D-Aspartate receptor Autoimmunity Affects Cognitive Performance in herpes simplex encephalitis https://t.co/W3YSWcxMGl
Case Rep Ophthalmol. 2016 Jul 11;7(2):345-53. doi: 10.1159/000447086.
RESULTS: A 48-year-old male was referred to Ophthalmology in January 2015 for an absolute scotoma in the superior quadrant of the visual field in his right eye. Visual acuity was 20/50 in the right eye and 20/20 in the left. Fundus examination was unremarkable bilaterally. Spectral domain optical coherence tomography revealed a normal macular retina structure. Visual field examination revealed a superior hemianopsia in the right eye. Head magnetic resonance imaging showed findings compatible with optic neuritis. The visual evoked potentials confirmed the presence of optic neuritis. The patient had been under therapy with adalimumab since January 2014, for Crohn's disease. Suspension of adalimumab was recommended, and it was substituted with tapered deltacortene, from 1 mg/kg/day. After 1 month, the scotoma was resolved completely.
CONCLUSIONS: TNFα antagonists can provide benefit to patients with inflammatory autoimmune diseases. However, they can also be associated with severe adverse effects. Therefore, adequate attention should be paid to neurological abnormalities in patients treated with TNFα antagonists.
KEYWORDS: Adalimumab; Optic neuritis; Tumor necrosis factor antagonists
Via Krishan Maggon , Gilbert C FAURE
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Scooped by
Gilbert C FAURE
August 6, 2016 5:42 AM
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Scooped by
Gilbert C FAURE
July 28, 2016 10:08 AM
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Amplified neuroinflammatory responses following an immune challenge occur with normal aging and can elicit or exacerbate neuropathology. The mechanisms mediating this sensitized or "primed" immune response in the aged brain are not fully understood.
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Scooped by
Gilbert C FAURE
July 28, 2016 10:03 AM
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Just in stark economic terms, depression is eye-wateringly expensive. The Australian Psychological Society estimates that every year the disorder drains $12.
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Scooped by
Gilbert C FAURE
July 26, 2016 5:12 AM
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MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to image molecules within cells or take a wider view of the long-range connections between neurons.
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Scooped by
Gilbert C FAURE
July 25, 2016 4:34 AM
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Sci Rep. 2016 Jul 20;6:29847. doi: 10.1038/srep29847.
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Scooped by
Gilbert C FAURE
July 22, 2016 5:09 AM
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Credit: Biozentrum, University of Basel
Prof. Fiona Doetsch's research team at the Biozentrum, University of Basel, has discovered that the choroid plexus, a largely ignored structure in the b..
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Scooped by
Gilbert C FAURE
July 20, 2016 9:52 AM
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Inserm Unit U919, directed by Professor Denis Vivien has developed an antibody with potential therapeutic effects against multiple sclerosis. The study, directed by Fabian Docagne and published in Brain, paves the way for a new strategy to control the disease.
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Scooped by
Gilbert C FAURE
July 19, 2016 8:43 AM
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Iran J Allergy Asthma Immunol. 2016 Jun;15(3):251-6.
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Scooped by
Gilbert C FAURE
August 18, 2016 3:58 AM
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Information and help on Multiple Sclerosis (MS) Disease Modifying Drug Therapy Medications
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Scooped by
Gilbert C FAURE
August 12, 2016 2:15 PM
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Objective
Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility.
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Scooped by
Gilbert C FAURE
August 12, 2016 7:33 AM
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Educational booklet about how neurons develop, function, and die, prepared by the National Institute of Neurological Disorders and Stroke (NINDS). Includes illustrations.
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Scooped by
Gilbert C FAURE
August 11, 2016 7:53 AM
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J Immunol. 2016 Aug 8. pii: 1600876. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
August 8, 2016 7:58 AM
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Research offers hints that infection could alter brain chemistry and function, but research funding is hard to achieve.
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Scooped by
Gilbert C FAURE
July 29, 2016 4:44 AM
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Malignant brain tumors continue to represent a devastating diagnosis with no real chance for cure. Despite an increasing list of potential salvage therapies, standard-of-care for these patients has not changed in over a decade.
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Scooped by
Gilbert C FAURE
July 28, 2016 10:06 AM
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Piancone F, Saresella M, Marventano I, La Rosa F, Zoppis M, Agostini S, Longhi R, Caputo D, Mendozzi L, Rovaris M, Clerici M.B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity.
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Scooped by
Gilbert C FAURE
July 26, 2016 5:19 AM
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Scooped by
Gilbert C FAURE
July 25, 2016 5:00 AM
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Giant cell arteritis (GCA), or temporal arteritis, is an affliction of older people. It results in headache and, more worryingly, blindness and stroke. The diagnosis of GCA is a clinical one.
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Scooped by
Gilbert C FAURE
July 23, 2016 3:29 AM
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A CART-Bicycle-Made-For-2 Double Whammy Mitigates Antigen Escape! @CelentyxLtd #immunooncology #glioblastoma https://t.co/V4YXPSAtJN
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Scooped by
Gilbert C FAURE
July 22, 2016 4:38 AM
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Prof. Fiona Doetsch's research team at the Biozentrum, University of Basel, has discovered that the choroid plexus, a largely ignored structure in the brain that produces the cerebrospinal fluid, is an important regulator of adult neural stem cells.
The virus may rely on particular receptors to infect neural stem cells—but scientists still have more questions than answers.
Via Krishan Maggon
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![Myeloid cells [mdash] targets of medication in multiple sclerosis : Nature Reviews Neurology : Nature Research | NeuroImmunology | Scoop.it](https://img.scoop.it/s_qx90q5mfpDkReji0XNyjl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
