The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene product, binds to its receptors and exerts the opposing biologic functions of mature BDNF.
NeuroImmunology
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Neuroscience News has recent neuroscience research articles, brain research news, neurology studies and neuroscience resources for neuroscientists, students, and science fans and is always free to join.
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Clusters of immune cells in the brain previously associated with Alzheimer's actually protect against the disease by containing the spread of damaging amyloid plaques, a new Yale University School of Medicine study shows.
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Alzheimers Dement (Amst). 2016;2:86-94.Epub 2016 Jan 19 Authors: Teunissen CE, Elias N, Koel-Simmelink MJ, Durieux-Lu S, Malekzadeh A, Pham TV, Piersma SR, Beccari T, Meeter LH, Dopper EG, van Swieten JC, Jimenez CR, Pijnenburg YA PubMed: 27239539...
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Extracellular vesicles (EVs) act as key mediators of intercellular communication and are secreted and taken up by all cell types in the central nervous system
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Neural Regen Res. 2016 Apr;11(4):534-7.
Authors: Balusu S, Brkic M, Libert C, Vandenbroucke RE PubMed: 27212900 Submit Comment
Gilbert C FAURE's insight:
only one citation by serot et al
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A new study from Massachusetts General Hospital (MGH) investigators provides additional evidence that amyloid-beta protein - which is deposited in the form of beta-amyloid plaques in the brains of patients with Alzheimer's disease - is a normal...
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Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by chronic neuroinflammation, demyelination, and axonal damage.
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Intravenous administration of bone marrow derived mesenchymal stem cells (MSCs) has been shown to reduce blood brain barrier compromise and improve neurocognition following traumatic brain injury (TBI).
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Yale scientists have solved a puzzle of the immune system: how antibodies enter the nervous system to control viral infections.
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CLARITY enables immunofluorescent labelling and imaging of large volumes of tissue to provide a better insight into the three dimensional relationship between cellular morphology and spatial interactions between different cell types.
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BWH researchers find evidence that diet and gut microbes can influence brain inflammation | Using pre-clinical models for multiple sclerosis and samples from MS patients, a Harvard-affiliated team found evidence that changes in diet and gut flora...
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Background
In the field of Alzheimer's disease (AD), the validation of biomarkers for early AD diagnosis and for use as a surrogate outcome in AD clinical trials is of considerable research interest.
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J Neurochem. 2016 Jun 1. doi: 10.1111/jnc.13667. [Epub ahead of print] REVIEW
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The development of therapies for multiple sclerosis targeting pathogenic T cell responses remains imperative. Previous studies have shown that estrogen receptor (ER) β ligands could inhibit experimental autoimmune encephalomyelitis.
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Alzheimers Dement (Amst). 2016 Apr 12;3:51-62. doi: 10.1016/j.dadm.2016.03.002. eCollection 2016.
Gilbert C FAURE's insight:
OPEN
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Stanford researchers studying the effect of stem cells injected directly into the brains of stroke patients said on Thursday that they were "stunned" by the success of the treatment in some patients.
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This meta-analysis study examines the effects of transplanting olfactory ensheathing cells in rodents with experimental spinal cord injury, finding evidence for significant recovery and identifying aspects of the procedure that influence the...
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J Vis Exp. 2016 May 6;(111)
Authors: Dinner S, Borkowski J, Stump-Guthier C, Ishikawa H, Tenenbaum T, Schroten H, Schwerk C PubMed: 27213495 Submit Comment
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Multiple Sclerosis (MS) is a neurological disease, characterised by demyelination and the onset of chronic, neurodegenerative damage of the central nervous system.
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Nat Commun. 2016 May 20;7:11639. doi: 10.1038/ncomms11639.
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Involvement of the nervous system is reported in 5 to 15% of patients with sarcoidosis, although autopsy series indicate that the frequency of lesions in the nervous system may be higher.
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ObjectiveAntibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility.
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NEW YORK (AP) — A study in Brazil found nearly 90 percent of people with a rare paralyzing condition said they had symptoms of Zika earlier — contributing to...
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