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Scooped by
Gilbert C FAURE
November 6, 2016 3:04 PM
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Once thought only to attack neurons, immune cells turn out to be vital for central nervous system function.
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Scooped by
Gilbert C FAURE
October 25, 2016 12:52 AM
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The Inn and Spa at Loretto is the only building in New Mexico to honor the dedication of the Alzheimer’s Foundation of America’s mission to bring awareness to and treat those affected by the life-changing, deadly disease.
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Scooped by
Gilbert C FAURE
October 19, 2016 9:48 AM
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Credit: Nikolaos Patsopoulos
BETHESDA, MD - In a large-scale, genome-wide analysis of more than 110,000 samples, a worldwide consortium of scientists has identified 200 genetic loci associated with..
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Scooped by
Gilbert C FAURE
October 6, 2016 4:11 PM
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An abstract is unavailable.
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Scooped by
Gilbert C FAURE
September 29, 2016 3:24 PM
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Therapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosis Stanley Cohan1,2,3 1Providence Multiple Sclerosis Center, 2Providence Brain and Spine Institute, 3Providence Health & Services, Portland, OR, USA Abstract: Despite the availability of multiple disease-modifying therapies for relapsing multiple sclerosis (MS), there remains a need for highly efficacious targeted therapy with a favorable benefit–risk profile and attributes that encourage a high level of treatment adherence. Daclizumab is a humanized monoclonal antibody directed against CD25, the α subunit of the high-affinity interleukin 2 (IL-2) receptor, that reversibly modulates IL-2 signaling. Daclizumab treatment leads to antagonism of proinflammatory, activated T lymphocyte function and expansion of immunoregulatory CD56bright natural killer cells, and has the potential to, at least in part, rectify the imbalance between immune tolerance and autoimmunity in relapsing MS. The clinical pharmacology, efficacy, and safety of subcutaneous daclizumab have been evaluated extensively in a large clinical study program. In pivotal studies, daclizumab demonstrated superior efficacy in reducing clinical and radiologic measures of MS disease activity compared with placebo or intramuscular interferon beta-1a, a standard-of-care therapy for relapsing MS. The risk of hepatic disorders, cutaneous events, and infections was modestly increased. The monthly subcutaneous self-injection dosing regimen of daclizumab may be advantageous in maintaining patient adherence to treatment, which is important for optimal outcomes with MS disease-modifying therapy. Daclizumab has been approved in the US and in the European Union and represents an effective new treatment option for patients with relapsing forms of MS, and is currently under review by other regulatory agencies. Keywords: daclizumab, disease-modifying therapy, humanized monoclonal antibody, relapsing multiple sclerosis, therapeutic use
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Scooped by
Gilbert C FAURE
from AUTOIMMUNITY
September 21, 2016 2:00 PM
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Semin Neurol. 2016 Aug;36(4):382-396. Epub 2016 Sep 19.
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Scooped by
Gilbert C FAURE
September 17, 2016 4:27 AM
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Which drug had a good effect on slowing loss of hand function? P746 - An exploratory analysis of 12- and 24-week composite confirme
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Scooped by
Gilbert C FAURE
September 16, 2016 2:43 PM
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The placenta is an incredible organ that develops in a woman’s uterus during pregnancy.
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Scooped by
Gilbert C FAURE
September 14, 2016 2:27 AM
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Scooped by
Gilbert C FAURE
September 8, 2016 2:58 PM
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Neuroinflammation is common to various diseases of the central nervous system (CNS),
but its imprecise definition has led to many misconceptions in research and clinical
approaches. It is now recognized that neuroinflammation in chronic neurodegenerative
conditions, including Alzheimer's disease (AD) and age-related dementia, is distinct
from the inflammation that accompanies relapsing–remitting multiple sclerosis (RRMS),
and its experimental animal model, experimental autoimmune encephalomyelitis (EAE).
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Scooped by
Gilbert C FAURE
August 23, 2016 3:37 AM
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A technique that shrinks a dead body and makes it see-through could enable us to inspect human brains and bodies in greater detail than ever before
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Gilbert C FAURE
August 20, 2016 8:20 AM
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Neuro Oncol. 2015 Nov;17 Suppl 7:vii3-vii8. doi: 10.1093/neuonc/nov175. Review
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Scooped by
Gilbert C FAURE
August 19, 2016 5:04 AM
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To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. A research group at the University of Basel now describes for the first time a mechanism by which hippocampa
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Scooped by
Gilbert C FAURE
November 4, 2016 3:13 PM
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Neuroscience News has recent neuroscience research articles, brain research news, neurology studies and neuroscience resources for neuroscientists, students, and science fans and is always free to join.
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Scooped by
Gilbert C FAURE
October 23, 2016 11:32 AM
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Review treatment for multiple sclerosis, including the new oral agents and up-and-coming investigational treatments.
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Scooped by
Gilbert C FAURE
October 12, 2016 9:23 AM
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Lemtrada™ (alemtuzumab) is a prescription medication approved by the Food and Drug Administration (FDA) in November 2014 for treating adults wit
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Scooped by
Gilbert C FAURE
October 1, 2016 12:54 PM
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RT @NatRevNeurol: The neuroinflammatory component of gray matter pathology in multiple sclerosis https://t.co/lIczEjaAfb | Multiple sclerosis New Drugs Review
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Scooped by
Gilbert C FAURE
September 23, 2016 11:36 AM
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J Invest Dermatol. 2016 Sep 17. pii: S0022-202X(16)32451-4. doi: 10.1016/j.jid.2016.09.010. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
September 20, 2016 1:49 PM
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Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available.
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Scooped by
Gilbert C FAURE
September 16, 2016 3:02 PM
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Scooped by
Gilbert C FAURE
September 15, 2016 2:12 PM
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Researchers at VIB and Ghent University have discovered an important mechanism of sepsis, an overreaction of the body's immune system to an infection.
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Scooped by
Gilbert C FAURE
September 11, 2016 2:22 PM
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Translational Psychiatry explores the more translational area between the research in neuroscience and conceptually novel treatments
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Scooped by
Gilbert C FAURE
August 24, 2016 5:21 AM
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Can treating the immune system lead to a revolution in treating depression?
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Scooped by
Gilbert C FAURE
August 23, 2016 3:37 AM
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Neuroscience News has recent neuroscience research articles, brain research news, neurology studies and neuroscience resources for neuroscientists, students, and science fans and is always free to join.
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Scooped by
Gilbert C FAURE
August 19, 2016 5:22 AM
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Acta Neuropathologica - Acta Neuropathologica publishes manuscripts dealing with disease mechanisms, general, experimental, comparative, and molecular pathology of the nervous tissue. Papers on surgical neuropathology are als
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