Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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Mucosal Immunity

is the most recent part of Immunology!

It appeared less than 40 years ago, while systemic immunity exploded 60  years ago.

It is still a minor part of Immunology teaching and research, while the mucosal immune system is at the frontline of encounters with germs, antigens... in other words the environment.

major keywords

IgA http://www.scoop.it/t/mucosal-immunity?q=IgA

tolerance http://www.scoop.it/t/mucosal-immunity?q=tolerance

microbiome http://www.scoop.it/t/mucosal-immunity?q=microbiome

 

july 2015: almost 2100 scoops, more than 1700 visitors, more than 3900 views

december 2015, more than 4700 views by more than 2000 visitors of more than 2300 scoops

november 2016, more than 7;2K views more than 2750 scoops

november 2017 >10K views of >3300 scoops

Gilbert C FAURE's insight:

This topic complements the more general Immunology topic.

 http://www.scoop.it/t/immunology

 

It includes also reproductive immunology searchable on

http://www.scoop.it/t/mucosal-immunity?q=reproductive

https://www.scoop.it/t/mucosal-immunity/?&tag=REPRODUCTION


and  also covers lung immunology

http://www.scoop.it/t/mucosal-immunity?q=lung

 

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New study identifies CD40 molecule as key entry point for dangerous bacteria

New study identifies CD40 molecule as key entry point for dangerous bacteria | Mucosal Immunity | Scoop.it
A new study identifies a single molecule as a key entry point used by two types of dangerous bacteria to break through cellular barriers and cause disease.
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Identifying True Celiac Disease and Wheat Allergy in the Era of Fashion Driven Gluten-Free Diets - Abstract - International Archives of Allergy and Immunology - Karger Publishers

Identifying True Celiac Disease and Wheat Allergy in the Era of Fashion Driven Gluten-Free Diets - Abstract - International Archives of Allergy and Immunology - Karger Publishers | Mucosal Immunity | Scoop.it
<b><i>Background:</i></b> Diagnosing both celiac disease (CD) and wheat allergy (WA) might be challenging due to the increasingly popular gluten-free diets.<b><i>Objectives:</i></b> This study invest...
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Bacteria and innate immune factors in birth canal, cervix may be key to predicting preterm births

Bacteria and innate immune factors in birth canal, cervix may be key to predicting preterm births | Mucosal Immunity | Scoop.it
Spontaneous preterm birth, defined as birth before 37 weeks of gestation, and the related complications, are the largest contributors to infant death in the United States and worldwide, according to the World Health Organization.
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Regulatory T cell adaptation in the intestine and skin

Regulatory T cell adaptation in the intestine and skin | Mucosal Immunity | Scoop.it
The skin and intestine are unique environments at the front line of the immune system. Powrie and colleagues review the distinctive adaptations acquired by regulatory T cells at these barrier surfaces.
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Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems

Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems | Mucosal Immunity | Scoop.it
Recently, the risk of viral infection has dramatically increased owing to changes in human ecology such as global warming and an increased geographical movement of people and goods. Howev-er, the efficacy of vaccines and remedies for infectious diseases ...
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A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

Al Nabhani et al. find that the changes in the intestinal microbiota at weaning induced
a vigorous immune response—a “weaning reaction”—that is programmed in time. The weaning
reaction is associated with the induction of regulatory T cells, and its perturbation
results in increased susceptibility to immunopathologies later in life.
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Acute respiratory distress syndrome

Acute respiratory distress syndrome | Mucosal Immunity | Scoop.it
Acute respiratory distress syndrome (ARDS) is the rapid onset of noncardiogenic pulmonary oedema, hypoxaemia and the need for mechanical ventilation in hospitalized patients. This Primer describes the risk factors for ARDS, the underlying pulmonary damage and repair in ARDS and the long-term consequences for survivors.
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Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review. - PubMed - NCBI

Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review. - PubMed - NCBI | Mucosal Immunity | Scoop.it
World J Gastroenterol. 2019 Mar 7;25(9):1142-1157. doi: 10.3748/wjg.v25.i9.1142.
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Early-life exposure to microbiota restricts colon cancer later in life, study finds

Early-life exposure to microbiota restricts colon cancer later in life, study finds | Mucosal Immunity | Scoop.it
Exposure to microbiota, or microorganisms such as bacteria, in the early stages of life plays a crucial role in establishing optimal conditions in the intestine that inhibit the development of colon cancer in adulthood, according ...
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Regulatory cytokine function in the respiratory tract

Regulatory cytokine function in the respiratory tract | Mucosal Immunity | Scoop.it
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Pore-forming small molecules offer a promising way to tackle cystic fibrosis

Pore-forming small molecules offer a promising way to tackle cystic fibrosis | Mucosal Immunity | Scoop.it
A natural molecule that facilitates ion transport aids lung function.

Via Krishan Maggon
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3D epithelial barrier assays in vitro: How to get the best balance between practicability and physiological relevance

3D epithelial barrier assays in vitro: How to get the best balance between practicability and physiological relevance | Mucosal Immunity | Scoop.it
Barrier assays are an important tool for in vitro drug development and drug safety testing, e.g. assessing the absorption of a drug candidate through the intestinal wall or the corrosion of chemical compounds on skin.
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Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches | Protocol

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches | Protocol | Mucosal Immunity | Scoop.it
In this study, we present a novel and effective protocol for the isolation of lymphocytes from Peyer's Patches (PPs), which can be...
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IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection

IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection | Mucosal Immunity | Scoop.it
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MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques | Mucosal Immunity | Scoop.it
Mucosal-associated invariant T (MAIT) cells are nonconventional T lymphocytes that recognize bacterial metabolites presented by MR1. Whereas gut bacterial translocation and the loss/dysfunction of peripheral MAIT cells in HIV infection is well described, MAIT cells in nonhuman primate models are...
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Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice | Mucosal Immunity | Scoop.it
Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate mucosal immune responses. The molecular machinery and biological significance of M cell differentiation, however, remain to be fully elucidated. Here, we demonstrate that Sox8, a member of the SRY-related HMG box transcription factor family, is specifically expressed by M cells in the intestinal epithelium. The expression of Sox8 requires activation of RANKL-RelB signaling. Chromatin immunoprecipitation and luciferase assays revealed that Sox8 directly binds the promoter region of Gp2 to increase Gp2 expression, which is the hallmark of functionally mature M cells. Furthermore, genetic deletion of Sox8 causes a marked decrease in the number of mature M cells, resulting in reduced antigen uptake in Peyer’s patches. Consequently, juvenile Sox8 -deficient mice showed attenuated germinal center reactions and antigen-specific IgA responses. These findings indicate that Sox8 plays an essential role in the development of M cells to establish mucosal immune responses.
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Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin | Mucosal Immunity | Scoop.it
The role of IFN-λ in adaptive immunity is not well characterized. Staeheli and colleagues show that in the lungs, IFN-λ elicits production of the cytokine TSLP from M cells and that this in turn is essential for effective adaptive immunity and control of infection with influenza virus.
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Identifying the Patterns of Pattern Recognition Receptors. - PubMed - NCBI

Identifying the Patterns of Pattern Recognition Receptors. - PubMed - NCBI | Mucosal Immunity | Scoop.it
Immunity. 2018 Sep 18;49(3):389-391. doi: 10.1016/j.immuni.2018.08.027. Comment
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The alarmins IL-1 and IL-33 differentially regulate the functional specialisation of Foxp3 + regulatory T cells during mucosal inflammation

The alarmins IL-1 and IL-33 differentially regulate the functional specialisation of Foxp3 + regulatory T cells during mucosal inflammation | Mucosal Immunity | Scoop.it
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Exploring human host–microbiome interactions in health and disease—how to not get lost in translation | Genome Biology | Full Text

Exploring human host–microbiome interactions in health and disease—how to not get lost in translation | Genome Biology | Full Text | Mucosal Immunity | Scoop.it
A meeting report on the 7th Wellcome Trust conference on Exploring Human Host–Microbiome Interactions in Health and Disease, held at Hinxton, UK, 5–7 December 2018.
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Precision immunoprofiling to reveal diagnostic signatures for latent tuberculosis infection and reactivation risk stratification | Integrative Biology | Oxford Academic

Precision immunoprofiling to reveal diagnostic signatures for latent tuberculosis infection and reactivation risk stratification | Integrative Biology | Oxford Academic | Mucosal Immunity | Scoop.it
Abstract. Latent tuberculosis infection (LTBI) is estimated in nearly one quarter of the world’s population, and of those immunocompetent and infected ~10% wil
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Neonatal intestinal immune regulation by the commensal bacterium, P. UF1

Neonatal intestinal immune regulation by the commensal bacterium, P. UF1 | Mucosal Immunity | Scoop.it
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Anti-commensal IgG Drives Intestinal Inflammation and Type 17 in Ulcerative Colitis

Castro-Dopico et al. find a profound induction of anti-commensal IgG in the colonic
mucosa of UC patients and outline a pathway whereby FcγR receptor activation by IgG
leads to IL-1β production, type 17 immunity, and the exacerbation of inflammation.
Their findings reveal an important contribution of IgG-mediated inflammation in an
IgA-dominated organ.
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MAIT cells and microbial immunity - Meermeier - 2018 - Immunology & Cell Biology - Wiley Online Library

Special Feature Review MAIT cells and microbial immunity Erin W Meermeier Melanie J Harriff Elham Karamooz David M Lewinsohn First published: 16 February 2018 Cited by: 3 Abstract Mucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T‐cell receptor (TCR) triggering as well as cytokine stimulation in response to a host of microbial products. In this review, we specifically discuss MAIT cell responses to bacterial and fungal infections, with a focus on responses that are both MR1‐dependent and ‐independent, the evidence for diversity in MAIT TCR usage in response to discrete microbial products, protective immunity induced by MAIT cells, and MAIT cell antimicrobial functions in the context of these infections. Citing Literature Number of times cited according to CrossRef: 3 Samantha J Winter, Heike Kunze‐Schumacher, Esther Imelmann, Zoe Grewers, Tabea Osthues and Andreas Krueger, MicroRNA miR‐181a/b‐1 controls MAIT cell development, Immunology & Cell Biology, 97, 2, (190-202), (2018). Wiley Online Library David J. Morgan, Joshua Casulli, Christine Chew, Emma Connolly, Sylvia Lui, Oliver J. Brand, Rizwana Rahman, Christopher Jagger and Tracy Hussell, Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia, Frontiers in Immunology, 10.3389/fimmu.2018.02943, 9, (2018). Crossref Clara Malka-Ruimy, Ghada Ben Youssef, Marion Lambert, Marie Tourret, Liana Ghazarian, Albert Faye, Sophie Caillat-Zucman and Véronique Houdouin, Mucosal-Associated Invariant T Cell Levels Are Reduced in the Peripheral Blood and Lungs of Children With Active Pulmonary Tuberculosis, Frontiers in Immunology, 10.3389/fimmu.2019.00206, 10, (2019). Crossref Volume96, Issue6 July 2018 Pages 607-617 Journal of the Australasian Society for Immunology
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