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Pendant la grossesse, le fœtus, qui porte pour moitié des marqueurs cellulaires paternels, étrangers pour le système immunitaire maternel, peut être assimilé à un risque et rejeté. Comment le fœtus est-il protégé contre ces défenses immunitaires de la mère? L’équipe de Nabila Jabrane-Ferrat, au Centre de physiopathologie de Toulouse Purpan, révèle le mécanisme qui confère, au niveau de l’utérus, un rôle bénéfique aux cellules du système immunitaire dites tueuses naturelles, ou Natural Killer. Cette étude est publiée dans la revue Nature Communications.
Via Le CNRS Occitanie Ouest
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Gilbert C FAURE
March 9, 2016 5:39 AM
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A new method in single-cell genomics, TraCeR, provides a powerful tool for research into immune response, vaccination, cancer and autoimmunity.
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Gilbert C FAURE
March 8, 2016 4:38 AM
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Many viral diseases tend to become chronic -- including infections with the HI virus. In persons affected, the immune response is not sufficient to eliminate the virus permanently.
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Gilbert C FAURE
March 5, 2016 5:55 AM
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Endogenous retroviruses in the human genome can regulate genes involved in innate immune responses.
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Gilbert C FAURE
March 4, 2016 1:45 PM
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Natural killer (NK) cells are a unique lymphocyte lineage with remarkable agility in the rapid destruction of virus-infected cells. They are also the most poorly understood class of lymphocyte.
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Gilbert C FAURE
March 3, 2016 10:00 AM
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The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro.
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Gilbert C FAURE
February 26, 2016 5:05 AM
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CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal peptides with either L-proline or L-alanine at the penultimate position.
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Gilbert C FAURE
February 25, 2016 8:09 AM
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The SLAMF Family (SLAMF) of cell surface glycoproteins is comprised of nine glycoproteins and whilst SLAMF1, 3, 5, 6, 7, 8, 9 are self-ligand receptors, SLAMF2 and SLAMF4 interact with each other. Their interactions induce signal transduction networks in trans, thereby shaping immune cell-cell communications. Collectively, these receptors modulate a wide range of functions, such as myeloid cell and lymphocyte development and, T and B cell responses to microbes and parasites. In addition, several SLAMF receptors serve as microbial sensors, which either positively or negatively modulate the function of macrophages, dendritic cells, neutrophils and NK cells in response to microbial challenges. The SLAMF receptor-microbe interactions contribute both to intracellular microbicidal activity as well as to migration of phagocytes to the site of inflammation. In this review, we describe the current knowledge on how the SLAMF receptors and their specific adapters SAP and EAT-2 regulate innate and adaptive immune responses to microbes.
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Gilbert C FAURE
February 25, 2016 7:57 AM
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Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not...
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Gilbert C FAURE
February 25, 2016 7:11 AM
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After two successive and well received MIMIC Congresses, we are honored to invite you to Turkish Society of Immunology sponsored "3rd International Molecular Immunology & Immunogenetics Congress MIMIC-III" in Antalya, a renowned touristic and historical site in southern seashore of Turkey. The congress venue is a popular holiday resort, Papillon Ayscha Hotel.
As one of the traditions of MIMIC, recent trends and emerging topics on molecular and applied immunology as well as immunogenetics will be discussed. MIMIC Congresses put special effort to connect acclaimed international scientists and immunologists with new faculty and young researchers in a friendly and relaxed environment, aiming to foster exchange of ideas along with facilitating collaborations.
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Gilbert C FAURE
February 23, 2016 1:06 PM
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Gilbert C FAURE
February 22, 2016 3:55 AM
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When it comes to selecting for B cells that produce antibodies to hostile viruses and bacteria, the immune
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Gilbert C FAURE
February 20, 2016 2:47 AM
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J Immunol. 2016 Feb 17. pii: 1502106. [Epub ahead of print]
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Gilbert C FAURE
March 9, 2016 5:40 AM
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Proficiency in art and illustration was once considered an essential skill for biologists, because text alone often could not suffice to describe observations of biological systems.
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Gilbert C FAURE
March 8, 2016 1:35 PM
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Gilbert C FAURE
March 7, 2016 1:15 PM
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T cell activation within immunological synapses is a complex process whereby different types of signals are transmitted from antigen presenting cells to T cells.
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Gilbert C FAURE
March 5, 2016 5:53 AM
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Targeting CD44, a major leukocyte adhesion molecule, using specific Abs has been shown beneficial in several models of autoimmune and inflammatory diseases.
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Gilbert C FAURE
March 3, 2016 10:06 AM
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Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not...
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Gilbert C FAURE
March 1, 2016 8:44 AM
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Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge.
Abstract The thymus is the site of T cell development and selection. In addition to lymphocytes, the thymus is composed of several types of stromal cells that are exquisitely organized to create the appropriate environment and microenvironment to support the development and selection of maturing T cells. Thymic epithelial cells (TECs) are one of the more important cell types in the thymic stroma, and they play a critical role in selecting functional T cell clones and supporting their development. In this study, we used a mouse genetics approach to investigate the consequences of deleting the Pten tumor suppressor gene in the TEC compartment of the developing thymus. We found that PTEN deficiency in TECs results in a smaller thymus with significantly disordered architecture and histology. Accordingly, loss of PTEN function also results in decreased T cells with a shift in the distribution of T cell subtypes towards CD8+ T cells. These experiments demonstrate that PTEN is critically required for the development of a functional thymic epithelium in mice. This work may help better understand the effects that certain medical conditions or clinical interventions have upon the thymus and immune function
Via Krishan Maggon
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Gilbert C FAURE
February 25, 2016 7:58 AM
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Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in evolution and characterized by a cyclic multimeric structure.
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Gilbert C FAURE
February 25, 2016 7:54 AM
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J Biol Chem. 2016 Feb 22. pii: jbc.M115.693119. [Epub ahead of print]
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Gilbert C FAURE
February 24, 2016 1:10 PM
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Cancer patients harbor tumor mutation-specific PD1+ CD8 T cells in the peripheral blood
When our organs age or wear out, their renewal usually depends on a few stem cells in the tissue, because the vast majority of differentiated cells have lost their ability to divide and generate new cells.
Via Krishan Maggon
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Gilbert C FAURE
February 20, 2016 2:49 AM
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Boston Children's Hospital scientists are using structural biology tools to understand the inflammasome and other tools of the innate immune response.
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Schéma: Modèle montrant les deux types de cellules NK avec une cellule NK tueuse dans le sang et une cellule NK bénéfique dans l’utérus.
© Nabila Jabrane-Ferrat
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