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Scooped by
Gilbert C FAURE
September 13, 2011 4:34 AM
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Regulation of antigen-expressing dendritic cells by double negative regulatory T cells http://t.co/PbjUKhR #EJITCB...
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Scooped by
Gilbert C FAURE
September 11, 2011 3:36 AM
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MD News (press release)UF Researchers Find Chemical Signals that Initiate the Body's Immune ResponseMD News (press release)The innate immune response is more generic and wasn't thought to convey any long-lasting immunity to specific threats.
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Scooped by
Gilbert C FAURE
September 10, 2011 3:45 PM
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Adipose tissue, innate immunity and inflammation – a nutrigenomics perspective of the metabolic syndrome Lecture in Scheveningen 2 Sept 2011 (RT @nutrigenomics: Bonus upload: Adipose tissue innate immunity & inflammation: a nutrigenomics perspective...
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Scooped by
Gilbert C FAURE
September 10, 2011 3:37 PM
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Tollip: a multitasking protein in innate immunity and protein trafficking (Tollip: a multitasking protein in innate immunity and protein trafficking http://t.co/60V6r9y...)...
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Scooped by
Gilbert C FAURE
September 9, 2011 4:32 AM
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Perspective from The New England Journal of Medicine — HIV Vaccine Development — Improving on Natural Immunity (@NIAIDNews in @NEJM on #HIV #vaccines: Neu antibody induction "gold standard for vaccine-induced protection"
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Scooped by
Gilbert C FAURE
September 7, 2011 7:53 AM
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A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers have determined.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:24 AM
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Specific immune responses include immunoglobulin class switching and secretion by B lymphocytes/plasma cells and T lympho- cyte responses (including antigen recognition, clonal proliferation, and cytokine synthesis resulting in B cell ...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:20 AM
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Amazon.com: Autoimmunity eBook: Andrzej Górski, Hubert Krotkiewski, Michal Zimecki: Kindle Store (Autoimmunity: This book presents an excellent review of the mechanisms underlying the phenomena of autoimmunit...)...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:17 AM
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PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:13 AM
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The market for antibody-drug conjugates (ADC) has mostly been cornered Seattle Genetics and Immunogen. Each boasts a long list of corporate partners and extensive clinical pipeline fueled by collaborations.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:08 AM
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Through five best selling editions, readers worldwide have appreciated this books in depth yet straightforward, richly illustrated approach to this complex subject. Now, sweeping updates incorporate the latest discoveries about innate immunity ...
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Scooped by
Gilbert C FAURE
September 5, 2011 4:54 AM
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Human Solid Tumors Contain High Endothelial Venules: Association with Lymphocyte Infiltration in Breast Cancer http://t.co/hFcOQIc...
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Scooped by
Gilbert C FAURE
September 2, 2011 7:49 AM
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Dr.(Md) Magdalena Trzcinska, "Kidney Transplantation - New Perspectives" InTech | 2011 | ISBN: 9789533076843 | 334 pages | PDF | 14,7 MB.
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Scooped by
Gilbert C FAURE
September 12, 2011 6:23 AM
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To systematically investigate innate immune signaling networks regulating production of type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty-eight baits were associated with 260 interacting ...
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Scooped by
Gilbert C FAURE
September 10, 2011 3:49 PM
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Kidney transplantation (RTx) leads to amelioration of endothelial function in patients with advanced renal failure. Endothelial progenitor cells (EPCs) may play a key role in this repair process. The aim of this study was to ...
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Gilbert C FAURE
September 10, 2011 3:38 PM
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This review focuses primarily on PD-1 and its ligands, which form a crucial inhibitory costimulatory pathway for maintaining peripheral tolerance, and their contribution to autoimmunity. Since 1992, when PD-1 was isolated, ...
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Scooped by
Gilbert C FAURE
September 9, 2011 4:36 AM
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The Food and Drug Administration has updated the boxed warning for all tumor necrosis factor-alpha inhibiting drugs to reflect the risk of infection from the bacteria Legionella and Liste (RT @robbwolf: Common #autoimmunity #drugs increase dangerous...
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Scooped by
Gilbert C FAURE
September 9, 2011 4:30 AM
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revolution antibody drugs to enter the brain Antibodies, from molecules to high therapeutic potential, typically cannot penetrate into the brain, but withscientists have developed a method to lift this blockade.
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Scooped by
Gilbert C FAURE
September 7, 2011 7:52 AM
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Scientists Develop Prototype Bactericidal Tuberculosis Vaccine that Elicits ...Genetic Engineering NewsA team at the Albert Einstein College of Medicine's Howard Hughes Medical Institute (HHMI) removed the bacterium's own esx-3 gene region, which...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:22 AM
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MEDICAL PPTX: Acquired Immunity,Free online medical powerpoint presentations for medical students and post graduates (Acquired Immunity: Defensive mechanisms include :
1) Innate immunity (Natural or Non specific)
2) Acquired...)...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:19 AM
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Immunobiology of Organ Transplantation (Price: $253.97, Pages: 672). Isbn: 0306483289, 9780306483288. Publisher: Springer. Publication date: 2004-06-24.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:16 AM
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As splenectomy is a cornerstone treatment of ITP, the immune effect of RTX on this major secondary lymphoid organ were investigated in 18 spleens removed from ITP patients that were treated or not with RTX.
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Scooped by
Gilbert C FAURE
September 6, 2011 4:12 AM
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Antiphospholipid antibodies are directed against phospholipid-protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Antiphospholipid antibody syndrome is a ...
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Scooped by
Gilbert C FAURE
September 6, 2011 4:07 AM
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Previous research had suggested that mycobacteria need esx-3 to protect themselves from their hosts' innate immune systems, a first-line defense against pathogens that responds to invaders quickly, but non-specifically.
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Scooped by
Gilbert C FAURE
September 2, 2011 7:58 AM
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Los Angeles TimesBaruj Benacerraf dies at 90; Nobelist made key discoveries about immune systemLos Angeles TimesHe was injecting the animals with a specific foreign substance similar to an antigen, intending to provoke an immune response in them.
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TCRαβ+CD3+CD4−CD8−NK1.1− double negative (DN) Tregs comprise 1–3% of peripheral T lymphocytes in mice and humans. It has been demonstrated that DN Tregs can suppress allo-, xeno- and auto-immune responses in an Ag-specific fashion. However, the mechanisms by which DN Tregs regulate immune responses remain elusive. Whether DN Tregs can regulate DCs has not been investigated previously. In this study, we demonstrate that DN Tregs express a high level of CTLA4 and are able to down-regulate costimulatory molecules CD80 and CD86 expressed on Ag-expressing mature DCs (mDCs). DN Tregs from CTLA4 KO mice were not able to downregulate CD80 and CD86 expression, indicating that CTLA4 is critical for DN Treg-mediated downregulation of costimulatory molecule expression on Ag-expressing mature DCs. Furthermore, DN Tregs could kill both immature and mature allogeneic DCs, as well as Ag-loaded syngeneic DCs, in an Ag-specific manner in vitro and in vivo, mainly through the Fas-FasL pathway. These data demonstrate, for the first time, that DN Tregs are potent regulators of DCs and may have the potential to be developed as a novel immune suppression treatment.