Immunology
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Teaching and Learning Immunology. Information you never would have searched for!
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Scooped by Gilbert C FAURE
April 15, 2016 1:13 PM
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An Overview of B-1 Cells as Antigen-Presenting Cells

An Overview of B-1 Cells as Antigen-Presenting Cells | Immunology | Scoop.it
From journal.frontiersin.org - April 15, 2016 11:38 AM
Ana F. Popi, Ieda M. Longo-Maugéri, Mario Mariano
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Gilbert C FAURE's insight:
The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response.
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Scooped by Gilbert C FAURE
April 14, 2016 3:50 PM
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RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity: Cell Reports

RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity: Cell Reports | Immunology | Scoop.it
From www.cell.com - April 14, 2016 3:50 PM
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Scooped by Gilbert C FAURE
April 14, 2016 9:44 AM
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Frontiers | An Overview of B-1 Cells as Antigen-Presenting Cells | B Cell Biology | Cancer Immunotherapy Review

Frontiers | An Overview of B-1 Cells as Antigen-Presenting Cells | B Cell Biology | Cancer Immunotherapy Review | Immunology | Scoop.it
From www.scoop.it - April 12, 2016 11:51 AM
The role of B cells as antigen-presenting cells has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as antigen-presenting cells is beginning to be explored.
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Scooped by Gilbert C FAURE
April 11, 2016 5:02 AM
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Innate immunity in vertebrates: an overview - Riera Romo - 2016 - Immunology - Wiley Online Library

Innate immunity in vertebrates: an overview - Riera Romo - 2016 - Immunology - Wiley Online Library | Immunology | Scoop.it
From onlinelibrary.wiley.com - April 10, 2016 7:08 AM
RT @britsocimm: "Innate immunity in vertebrates: an overview" https://t.co/gzbFwHx39V #immunology #science #scicomms #phdchat https://t.co/…
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Scooped by Gilbert C FAURE
April 10, 2016 3:59 AM
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Table of Contents — January 2016, 28 (1)

Table of Contents — January 2016, 28 (1) | Immunology | Scoop.it
From intimm.oxfordjournals.org - April 10, 2016 3:59 AM
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Scooped by Gilbert C FAURE
April 9, 2016 9:36 AM
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International Day of Immunology, Melbourne (Australia)

International Day of Immunology, Melbourne (Australia) | Immunology | Scoop.it
From www.dayofimmunology.org.au - April 9, 2016 1:13 AM
Melbourne (Australia) will celebrate the International Day of Immunology on Friday 29 April 2016. Find out about events in Melbourne and learn about immunology.
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Scooped by Gilbert C FAURE
April 3, 2016 4:41 AM
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Cell Research - Ubiquitin signaling in immune responses

Cell Research - Ubiquitin signaling in immune responses | Immunology | Scoop.it
From www.nature.com - March 31, 2016 8:00 PM
Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis.
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Gilbert C FAURE's insight:
Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological processes, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor signaling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including autoimmune and inflammatory diseases.
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Kenzibit's curator insight, April 3, 2016 10:51 PM
Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological processes, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor signaling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including autoimmune and inflammatory diseases.
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Scooped by Gilbert C FAURE
April 1, 2016 4:11 AM
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GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii

GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii | Immunology | Scoop.it
From journals.plos.org - March 30, 2016 6:25 AM
Toxoplasma gondii is a widespread parasite responsible for causing clinical diseases especially in pregnant and immunosuppressed individuals.
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Scooped by Gilbert C FAURE
March 31, 2016 3:05 PM
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Dendritic Cells in the Context of Human Tumors: Biology and Experimental Tools. - PubMed - NCBI

Dendritic Cells in the Context of Human Tumors: Biology and Experimental Tools. - PubMed - NCBI | Immunology | Scoop.it
From www.ncbi.nlm.nih.gov - March 24, 2016 6:14 AM
Int Rev Immunol. 2016 Mar 3;35(2):116-135.
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Scooped by Gilbert C FAURE
March 23, 2016 2:42 PM
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Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory: Immunity

From www.cell.com - March 23, 2016 9:03 AM
In press from @ImmunityCP #STEM #Immunology Independent Roles of Switching and Hypermutation in the Development... https://t.co/SrOnWwkztm
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Scooped by Gilbert C FAURE
March 23, 2016 6:00 AM
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A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles: Immunity

A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles: Immunity | Immunology | Scoop.it
From www.cell.com - June 27, 2013 9:37 AM
A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection,… #immunology https://t.co/1ZykK7EGrC
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Krishan Maggon 's curator insight, March 23, 2016 6:15 AM
Immunity   Volume 38, Issue 6, p1129–1141, 27 June 2013 

A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles 

Diego Forni, Rachele Cagliani, Uberto Pozzoli, Marta Colleoni, Stefania Riva, Mara Biasin, Giulia Filippi, Luca De Gioia, Federica Gnudi, Giacomo P. Comi, Nereo Bresolin, Mario Clerici, Manuela Sironicorrespondenceemail 
Kerry Winslet's curator insight, March 30, 2016 4:36 AM
Immunity   Volume 38, Issue 6, p1129–1141, 27 June 2013 

A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles 

Diego Forni, Rachele Cagliani, Uberto Pozzoli, Marta Colleoni, Stefania Riva, Mara Biasin, Giulia Filippi, Luca De Gioia, Federica Gnudi, Giacomo P. Comi, Nereo Bresolin, Mario Clerici, Manuela Sironicorrespondenceemail 
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Scooped by Gilbert C FAURE
March 10, 2016 2:49 PM
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Speaking Up For Science: Trends in Immunology

From www.cell.com - March 8, 2016 7:00 PM
Communicating science and being an advocate for public support of research are critical roles for scientists. However, despite having the most relevant expertise, many of us do not get involved in matters bridging science and policy.
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Scooped by Gilbert C FAURE
March 9, 2016 1:30 PM
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Immunology - High Yield Questions – USMLE Step 1

Immunology - High Yield Questions – USMLE Step 1 | Immunology | Scoop.it
From www.lecturio.com - March 2, 2016 1:09 PM
Study "Immunology - High Yield Questions" whenever and wherever suits you. This course by " Lecturio USMLE" will boost your knowledge. Try for free!
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Scooped by Gilbert C FAURE
April 15, 2016 7:03 AM
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Welcome! | LinkedIn

Welcome! | LinkedIn | Immunology | Scoop.it
From www.linkedin.com - April 15, 2016 7:03 AM
photo de groupe du cours nord africain d'Immunologie sur "Tolérance et Autoimmunité" IUIS-FAIS ImmunoTunisia, 4-8 Avril 2016 Hammamet
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IUIS inside
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Hatem Masmoudi Chef de Service Immunologie chez CHU Habib Bourguiba de Sfax TunisiaMedical Practice Current Faculté de Médecine, CHU Habib Bourguiba de Sfax
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Scooped by Gilbert C FAURE
April 14, 2016 10:01 AM
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New research explains why HIV is not cleared by the immune system

New research explains why HIV is not cleared by the immune system | Immunology | Scoop.it
From medicalxpress.com - April 14, 2016 7:12 AM
Scientists at the University of North Carolina (UNC) School of Medicine and Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a human (host) protein that weakens the immune response to HIV and othe...
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Scooped by Gilbert C FAURE
April 11, 2016 5:22 AM
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Engaging the Public with Your Research: Trends in Immunology

Engaging the Public with Your Research: Trends in Immunology | Immunology | Scoop.it
From www.cell.com - April 10, 2016 3:26 PM
Engaging the #Public with Your #Research #pint16 https://t.co/yTQB2ND8N0
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Scooped by Gilbert C FAURE
April 11, 2016 4:53 AM
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Frontiers | Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells | T Cell Biology

Frontiers | Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells | T Cell Biology | Immunology | Scoop.it
From journal.frontiersin.org - April 9, 2016 12:35 PM
Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement.
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Scooped by Gilbert C FAURE
April 10, 2016 3:35 AM
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cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells | Immunology | Scoop.it
From journals.plos.org - April 8, 2016 5:00 PM
Author Summary Human cytomegalovirus (HCMV) has been shown to induce type I interferon (IFN-I) responses in myeloid cells such as plasmacytoid dendritic cells (pDC).
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Gilbert C FAURE's insight:
Recent studies indicated that during viral infection the cyclic GMP/AMP synthase (cGAS) senses cytosolic DNA and catalyzes formation of the cyclic di-nucleotide cGAMP, which triggers stimulator of interferon genes (STING) and thus induces antiviral type I interferon (IFN-I) responses. We found that plasmacytoid dendritic cells (pDC) as well as monocyte-derived DC and macrophages constitutively expressed cGAS and STING. HCMV infection further induced cGAS, whereas STING expression was only moderately affected.
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Scooped by Gilbert C FAURE
April 3, 2016 4:44 AM
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Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells : Nature Communications : Nature Publishing Group

Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells : Nature Communications : Nature Publishing Group | Immunology | Scoop.it
From www.nature.com - March 22, 2016 8:00 PM
The diversity of antigen receptor specificities is largely generated by random recombination of its segments.
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Gilbert C FAURE's insight:
The adaptive immune system’s capability to protect the body requires a highly diverse lymphocyte antigen receptor repertoire. However, the influence of individual genetic and epigenetic differences on these repertoires is not typically measured. By leveraging the unique characteristics of B, CD4+ T and CD8+ T-lymphocyte subsets from monozygotic twins, we quantify the impact of heritable factors on both the V(D)J recombination process and on thymic selection. We show that the resulting biases in both V(D)J usage and N/P addition lengths, which are found in naïve and antigen experienced cells, contribute to significant variation in the CDR3 region. Moreover, we show that the relative usage of V and J gene segments is chromosomally biased, with ~1.5 times as many rearrangements originating from a single chromosome. These data refine our understanding of the heritable mechanisms affecting the repertoire, and show that biases are evident on a chromosome-wide level.
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Scooped by Gilbert C FAURE
April 1, 2016 3:50 AM
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FoxO1-mediated autophagy is required for NK cell development and innate immunity : Nature Communications : Nature Publishing Group

FoxO1-mediated autophagy is required for NK cell development and innate immunity : Nature Communications : Nature Publishing Group | Immunology | Scoop.it
From www.nature.com - March 23, 2016 8:00 PM
Natural killer cells are a major component of the innate immune response. Here, Wang et al .
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Scooped by Gilbert C FAURE
March 31, 2016 2:49 PM
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CD47 and PD-L1 work in tandem with MYK to keep T cells at bay

CD47 and PD-L1 work in tandem with MYK to keep T cells at bay | Immunology | Scoop.it
From davidusharauli.blogspot.com - March 12, 2016 5:44 PM
This week Science published a short study examining the role of MYK in tumor immune evasion mechanisms [MYC is a transcription factor that regulates the expression of a multitude of gene products involved in cell proliferation, growth,...
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Scooped by Gilbert C FAURE
March 23, 2016 6:27 AM
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Murine Splenic Natural Killer Cells Do Not Develop Immunological Memory after Re-Encounter with Mycobacterium bovis BCG

Murine Splenic Natural Killer Cells Do Not Develop Immunological Memory after Re-Encounter with Mycobacterium bovis BCG | Immunology | Scoop.it
From journals.plos.org - March 21, 2016 10:59 AM
Several lines of evidence have recently suggested that natural killer (NK) cells develop immunological memory against viral infections.
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Scooped by Gilbert C FAURE
March 11, 2016 2:20 PM
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Identifying Immune Cells in Blood that Recognize Tumors

Identifying Immune Cells in Blood that Recognize Tumors | Immunology | Scoop.it
From www.cancer.gov - March 11, 2016 12:05 PM
NCI scientists have developed a novel strategy for identifying immune cells circulating in the blood that recognize specific proteins on tumor cells, a finding they believe may have potential implications for immune-based therapies.
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Scooped by Gilbert C FAURE
March 9, 2016 1:32 PM
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Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens: Cell

Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens: Cell | Immunology | Scoop.it
From www.cell.com - February 29, 2016 9:18 AM
And we thought tumor cells were sneaky... Anti-Immunology: Evasion of the host immune system. #immunology https://t.co/tG5zRRbmhQ
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