 Your new post is loading...
Your new post is loading...
Scoop.it!
Matthieu Perreau and colleagues show that HIV-infected lymph node PD-1+ and follicular helper T cells account for the major source of replication-competent HIV-1 in individuals who have been treated with antiretroviral drugs. 
No comment yet.
Sign up to comment
Scoop.it!
Nature Reviews Immunology | doi:10.1038/nri.2016.48
Gilbert C FAURE's insight:
Online access to this article has been provided by the nature.com content sharing initiative.
Scoop.it!
Exp Cell Res. 2016 May 26. pii: S0014-4827(16)30128-8. doi: 10.1016/j.yexcr.2016.05.018. [Epub ahead of print]
Scoop.it!
Scientists have found proteins in the body that promote lung inflammation which helps the bacteria that causes TB to spread throughout the lung.
Scoop.it!
Despite recombinant protein technology development, proteins isolated from natural sources remain important for structure and activity determination. Ficolins represent a class of proteins that are difficult to isolate.
Scoop.it!
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22R expressed by non-hematopoietic cells. A growing body of evidence points towards a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.
Scoop.it!
Author Summary Dengue is a globally important viral disease. Despite this, there is still much unknown about the immunology, virology and epidemiology of dengue.
Gilbert C FAURE's insight:
dengue
Scoop.it!
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response -- a discovery that may pave the way for new treatments for many human diseases.
Scoop.it!
Phosphorylation-dependent interaction between antigenic peptides and MHC class I Curator: Larry H.
Via Krishan Maggon
Scoop.it!
Natural Killer (NK) cells are classified as a member of the innate lymphoid cells (ILC) group 1. ILCs have been recently identified and grouped on the basis of their phenotypical and functional characteristics.
Scoop.it!
Natural killer (NK) cells have long been considered to be a homogenous population of innate lymphocytes with limited phenotypic and functional diversity. However, recent findings have revealed that these cells comprise a large number of distinct populations with diverse characteristics. Some of these characteristics may relate to their developmental origin, and others represent differences in differentiation that are influenced by factors such as tissue localization and imprints by viral infections. In this Review, we provide a comprehensive overview of the emerging knowledge about the development, differentiation and function of human NK cell populations, with a particular focus on NK cells in peripheral tissues.
Gilbert C FAURE's insight:
Niklas K. Björkström, Hans-Gustaf Ljunggren & Jakob Michaëlsson AffiliationsCorresponding authors Nature Reviews Immunology 16, 310–320 (2016) doi:10.1038/nri.2016.34 Published online 28 April 2016
Scoop.it!
Gilbert C FAURE's insight:
belated but offline?
Scoop.it!
Medicine (Baltimore). 2016 May;95(19):e3548. doi: 10.1097/MD.0000000000003548.
|
Scoop.it!
Immunology. 2016 Feb;147(2):152-64. doi: 10.1111/imm.12556. Review
Scoop.it!
From
www
Highlights
•T cell survival was increased in Selplg−/− mice after chronic virus infection •Multi-functional anti-viral T cells in Selplg−/− mice promoted viral control •Ligating PSGL-1 on exhausted CD8+ T cells silenced TCR signals •PSGL-1-deficiency enhanced T cell anti-tumor immunity to melanoma Via Krishan Maggon
Gilbert C FAURE's insight:
psgl-1 again
Scoop.it!
Objective. Measuring NKG2C+CD57+ natural killer (NK) cell expansion to investigate NK responses against human cytomegalovirus (HCMV) and assessing relationships with adaptive immunity against HCMV. Methods.
Scoop.it!
This year the French Society for Immunology will celebrate its 50th anniversary and its Annual Meeting - SFI2016 *50* - will therefore be an exceptional event. We invite you to join the celebration! SFI 2016 *50*, will take place at the Cité des Sciences at La Villette in Paris, from 28-30 November 2016.
Gilbert C FAURE's insight:
For this occasion, we have put together an exciting scientific program featuring presentations by more than forty renowned researchers in basic and clinical immunology. Joint sessions will be held with the German Society for Immunology (DGfI) and the Swiss Society for Allergology and Immunology (SSAI), whereas our third Women in Immunology Session will feature debates fueled by an outstanding female personality. A special Young Immunologist session has been organized and we have put special emphasis on providing young researchers with the opportunity to present their work, selected from submitted abstracts, during the parallel sessions. Prizes for the best oral and poster presentations will be awarded at the end of the meeting. A Continuous Medical Education session (DPC) in the field of clinical immunology has been scheduled on 28 November. The meeting will be followed by the traditional one-day ‘atelier’ workshop on 1 December 2016.
Scoop.it!
The immunological synapse (IS), a dynamic and organized junction between T-cells and antigen presenting cells (APCs), is critical for initiating adaptive immunity.
Gilbert C FAURE's insight:
immunological synapse
Scoop.it!
From
www
Expression of the transcription factor Helios by Tregs ensures stable expression of a suppressive and anergic phenotype in the face of intense inflammatory responses, whereas Helios-deficient Tregs display diminished lineage stability, reduced...
Scoop.it!
Research led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a new regulator of immune responses.
Gilbert C FAURE's insight:
psgl-1
Scoop.it!
HIV: Identification of key immune response receptors in patients spontaneously controlling infection
A small number of patients infected by HIV spontaneously control viral replication without antiretroviral therapy, and do not develop the disease. The ability of these rare patients, known as "HIV controllers", to suppress HIV replication appears to be down to a highly effective immune response. Scientists from the Institut Pasteur and Inserm observed that CD4+ T immune cells in these patients, recruited from the ANRS CO21 CODEX cohort, were capable of recognizing tiny quantities of the virus.
Scoop.it!
From
scienmag
Flaviviruses--such as Zika, dengue, and yellow fever--have emerged as human (and other primate) pathogens because of their ability to specifically overcome our anti-viral defenses. In the case of Zika.. Via Kenzibit
Gilbert C FAURE's insight:
zika anf IFNs! ... one of the virus's seven non-structural proteins (NS5) is singularly responsible for blocking the action of interferons (proteins that stop viral replication) in human cells, while mouse cells are unaffected.
Scoop.it!
Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis.
Gilbert C FAURE's insight:
apoptosis fundamental
Scoop.it!
![KLF2 controls mature NK cell homeostasis [Immunology and Inflammation] | Immunology | Scoop.it](https://img.scoop.it/6hAIyT1DVyNTg8xl8M72Pjl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
Natural killer (NK) cells are innate lymphocytes that recognize and lyse virally infected or transformed cells.
Scoop.it!
The complement receptor 2 (CR2, CD21) is part of a complex (CD21/CD19/CD81) acting as a co-receptor to the B cell receptor (BCR). Simultaneous triggering of the BCR and CD21 lowers the threshold for B cell activation.
|
