Protein fragment could provide a defense when antibiotics fail | Researchers at Harvard-affiliated Boston Children’s Hospital are looking at new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.
Immunology
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Teaching and Learning Immunology. Information you never would have searched for!
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Gilbert C FAURE
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The complement system, crosstalk connections, the involvement of complement in clinical conditions and promising therapeutic approaches. Review by Ricklin, Reis and Lambris, free to access for a limited time.
Gilbert C FAURE's insight:
thanks John L
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The 6th Winter School on Advanced Immunology, Singapore Frontier Research center, 22-26 January 2017, Singapore
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From
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Researchers at North Carolina State University have discovered that therapeutic stem cells exit the bloodstream in a different manner than was previously thought.
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Nat Immunol. 2016 Jun 21;17(7):783-789. doi: 10.1038/ni.3484.
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Nat Immunol. 2016 Jun 21;17(7):775-782. doi: 10.4038/ni.3481. REVIEW
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Abstract Dynamic interactions between B and T cells underpin the development of adaptive humoral immune responses to infections and vaccines. Recent advances in the molecular and spatiotemporal control of these interactions during primary responses have contributed greatly to elucidating the molecular pathogenesis of numerous immunodeficiency and autoimmune diseases. The next challenge is to determine how and where memory B and T cells interact during secondary responses to facilitate the rapid and robust response that characterizes anamnestic immunity.
Via Krishan Maggon
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The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes.
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Cancer development is a multi-step process characterized by genetic and epigenetic alterations during tumor initiation and progression. The stromal microenvironment can promote tumor development.
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... Mast cells, widely distributed throughout all tissues, are a stromal component of many solid and hematologic tumors. Mast cells can be found in human and mouse models of skin cancers such as melanoma, basal and squamous cell carcinomas, primary cutaneous lymphomas, hemangiomas and Merkel cell carcinoma. However, human and animal studies addressing potential functions of mast cells and their mediators in skin cancers have provided conflicting results. In several studies mast cells play a pro-tumorigenic role, whereas in others they play an anti-tumorigenic role. Other studies have failed to demonstrate a clear role for tumor-associated mast cells. Many unanswered questions need to be addressed before we understand whether tumor-associated mast cells are adversaries, allies or simply innocent bystanders in different types and subtypes of skin cancers.
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The classical view of immune activation is that innate immune cells, such as macrophages and dendritic cells, recognize invading microbes and then alert adaptive immune cells, such as T cells, to respond. Arbore et al. now show that innate and adaptive immunity converge in human and mouse T cells. Activated T cells express components of the complement cascade, which in turn leads to the assembly of NLRP3 inflammasomes—both critical components of innate immunity that help hosts detect and eliminate microbes. In T cells, complement and inflammasomes work together to push T cells to differentiate into a specialized subset of T cells important for eliminating intracellular bacteria.
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Author Summary Human and wildlife diseases can be tracked by looking at incidence, which is the number of new infections per time unit (typically day, week or month).
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Gilbert C FAURE
July 10, 2016 4:19 AM
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Progress in the use of swine in developmental immunology of B and T lymphocytes
Marek Sinkora, John E. Butler
Developmental &
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of pigs and humans!
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Gilbert C FAURE
July 9, 2016 2:09 AM
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Sepsis is the dysregulated systemic inflammatory and immune response to infection that produces organ injury.
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Gilbert C FAURE
June 22, 2016 3:20 PM
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The transcription factor PLZF [promyelocytic leukemia zinc finger, encoded by zinc finger BTB domain containing 16 (Zbtb16)] is induced during the development of innate and innate-like lymphocytes to direct their acquisition of a T-helper effector...
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Gilbert C FAURE
June 22, 2016 1:23 PM
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Nat Immunol. 2016 Jun 21;17(7):758-764. doi: 10.1038/ni.3482. REVIEW
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Gilbert C FAURE
June 22, 2016 6:41 AM
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Scientific knowledge, like air, water or even disease, does not respect borders drawn on a map. Science is inherently an international endeavour, and this is particularly true for immunology. Researchers have always discovered more working together than in isolation, and have worked hard to build a strong, global scienti c community. That the UK is a world-leader, ranking rst amongst the G7 countries for the quality of our research in infection and immunology,1 is a cause of celebration. The strength of our immunological science is an asset we are able to project to attract the best and the brightest minds from around the world – minds that contribute to the success of our institutions and, ultimately, to the innovations and knowledge that keep the UK at the forefront of immunological science.
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Gilbert C FAURE
June 21, 2016 12:01 PM
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Female mice lacking an immune receptor are better than males at fighting certain viral infections.
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Société Francaise d'Immunologie
June 20, 2016 8:37 AM
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Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: A semi-mature and myeloid-like subset imbalance
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Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses Theresa R. Wilhelm, Adriano Taddeo, Oliver Winter, Axel Ronald Schulz, Julia-Nora Mälzer, Cristina Domingo, Robert Biesen, Tobias Alexander, Andreas Thiel, Andreas Radbruch, Falk Hiepe, Velia Gerl Clinical Immunology, Volume 163, February 2016, Pages 42–51 Full article on Science Direct - free access until 18 August 2016
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Gilbert C FAURE
June 18, 2016 9:25 AM
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Articles from the current issue of @J_Immunol #STEM #Immunology mTORC2 in Thymic Epithelial Cells Controls Thym... https://t.co/D8io3hDzAM
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Gilbert C FAURE
June 17, 2016 5:05 AM
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When the body is fighting an invading pathogen, white blood cells--including T cells--must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated.
