Author Summary While numerous studies have addressed the response to primary virus infections, we know relatively little about the interplay between recurrent and/or persistent infections and the memory humoral immune response on professional...
Immunology
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Teaching and Learning Immunology. Information you never would have searched for!
Curated by
Gilbert C FAURE
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![PI3K[delta] and primary immunodeficiencies : Nature Reviews Immunology : Nature Research | Immunology | Scoop.it](https://img.scoop.it/oErux0qAoD4xT4X0ZW9YuDl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
Our Review of Activated PI3Kδ Syndrome @NatRevImmunol now online: https://t.co/QGSIkws1Dm
#PI3K, #Immunology https://t.co/wCPy11WYgk 
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During normal and pathologic immune responses, lymph nodes can swell considerably.
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Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor–driven (TCR-driven) actin polymerization.
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Using unsupervised analysis of flow cytometry and mass cytometry data obtained from
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TGF-β Receptor Maintains CD4 T Helper Cell Identity during Chronic Viral Infections https://t.co/cps2OoMoDa
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Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent
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The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants.
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Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not...
Gilbert C FAURE's insight:
the red queen and Alice
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Human Langerhans cells express CD1a, but those in mice do not, which makes determination of its function on these cells challenging in vivo. Through the use of a transgenic mouse that expresses CD1a, Winau and colleagues demonstrate that Langerhans cells use CD1a to present contact allergens and self lipid antigens and thereby worsen inflammatory skin conditions.
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Rare and sometimes lethal disease affects young children
Gilbert C FAURE's insight:
a new disease?
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Calabro et al. demonstrate that, upon immunization, dendritic cell subsets in the
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Influenza still remains a current concern. To be prepared for the next outbreak the understanding of viral mechanisms, host-pathogen interactions and immunological pathways is essential.
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A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis
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Clinical & Translational Immunology <br/><br/><br/>Innate immune cells have a critical role in defense against infection and disease.
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The formation of germinal center B cells is crucial to the production of high-affinity
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We all produce as many as 100,000 different types of cancer cells every day, which are recognized and eliminated by our extraordinarily efficient immune system.
Via Krishan Maggon
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Gilbert C FAURE's insight:
HLA antigens or genes
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Background and Aim
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is an acute deterioration of liver function on chronic liver disease with immune disorder.
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ABSTRACT Cytokine-induced neutrophil mobilization from the bone marrow to circulation is a critical event in acute inflammation, but how it is accurately controlled remains poorly understood. In this study, we report that CXCR2 ligands are responsible for rapid neutrophil mobilization during early-stage acute inflammation. Nevertheless, although serum CXCR2 ligand concentrations increased during inflammation, neutrophil mobilization slowed after an initial acute fast phase, suggesting a suppression of neutrophil response to CXCR2 ligands after the acute phase. We demonstrate that granulocyte colony-stimulating factor (G-CSF), usually considered a prototypical neutrophil-mobilizing cytokine, was expressed later in the acute inflammatory response and unexpectedly impeded CXCR2-induced neutrophil mobilization by negatively regulating CXCR2-mediated intracellular signaling. Blocking G-CSF in vivo paradoxically elevated peripheral blood neutrophil counts in mice injected intraperitoneally with Escherichia coli and sequestered large numbers of neutrophils in the lungs, leading to sterile pulmonary inflammation. In a lipopolysaccharide-induced acute lung injury model, the homeostatic imbalance caused by G-CSF blockade enhanced neutrophil accumulation, edema, and inflammation in the lungs and ultimately led to significant lung damage. Thus, physiologically produced G-CSF not only acts as a neutrophil mobilizer at the relatively late stage of acute inflammation, but also prevents exaggerated neutrophil mobilization and the associated inflammation-induced tissue damage during early-phase infection and inflammation. Submitted: 16 March 2016
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The immune system tailors its responses according to the level of threat. Lemaitre and colleagues identify a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria.
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From
phys
Similarly to cars, cells need a steering mechanism that guides them towards a certain target or direction. Scientists at the Center for Cognition and Sociality (Institute for Basic Science, IBS), and KAIST, led by Prof.
Gilbert C FAURE's insight:
moving cells
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Researchers use new experimental models and analytical tools to investigate genes regulated by Foxn1, becoming the first to identify the DNA sequence bound by the transcription factor.
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