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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Suggested by Société Francaise d'Immunologie
June 25, 2014 9:48 AM
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Pillars Article: Genetic Analysis of Autoimmune Type 1 Diabetes Mellitus in Mice. Nature. 1991. 351: 542-547 [PILLARS OF IMMUNOLOGY]

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1991 a pillar

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Scooped by Gilbert C FAURE
June 22, 2014 8:27 AM
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Interferon-α-induced B-lymphocyte stimulator expression and mobilization in healthy and SLE monocytes. http://t.co/iBwyzBRF8o
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Scooped by Gilbert C FAURE
June 20, 2014 9:07 AM
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Circulating Autoantibodies to Endothelial Progenitor Cells: Binding Characteristics and Association with Risk Factors for Atherosclerosis

Circulating Autoantibodies to Endothelial Progenitor Cells: Binding Characteristics and Association with Risk Factors for Atherosclerosis | AUTOIMMUNITY | Scoop.it
by Jacob George, Marco Matucci-Cerinic, Iris Bar, Sara Shimoni
Objective Endothelial progenitor cells (EPC) are committed to transform into EC promoting vasculogenic ischemic repair.
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Rescooped by Gilbert C FAURE from Immunology and Biotherapies
June 18, 2014 8:35 AM
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Biogen Idec and AbbVie Announce Positive Top-Line Results from Phase 3 ... - Wall Street Journal

Biogen Idec and AbbVie Announce Positive Top-Line Results from Phase 3 ... - Wall Street Journal | AUTOIMMUNITY | Scoop.it
Biogen Idec and AbbVie Announce Positive Top-Line Results from Phase 3 ...
Scooped by Gilbert C FAURE
June 18, 2014 3:04 AM
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Early events in Sjögren's Syndrome pathogenesis: th... [Cytokine. 2014] - PubMed - NCBI

Early events in Sjögren's Syndrome pathogenesis: th... [Cytokine. 2014] - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
June 16, 2014 10:14 AM
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MacroGenics & Takeda Develop Bi-Specific Antibodies For Autoimmune Diseases - Asian Scientist Magazine

Asian Scientist Magazine MacroGenics & Takeda Develop Bi-Specific Antibodies For Autoimmune Diseases Asian Scientist Magazine “We are very pleased to be collaborating with MacroGenics, given the company's expertise in exploring ways to harness the...
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Scooped by Gilbert C FAURE
June 16, 2014 10:12 AM
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Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ... - Science Codex

Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ... - Science Codex | AUTOIMMUNITY | Scoop.it
Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ...
Science Codex
The hallmark of systemic lupus erythematosus (SLE) is the presence of high levels of anti-double-stranded DNA autoantibody (anti-dsDNA) in sera.
Gilbert C FAURE's insight:

bis?

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June 16, 2014 3:29 AM
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IDO2 is a critical mediator of autoantibody production and ...

IDO2 is a critical mediator of autoantibody production and ... | AUTOIMMUNITY | Scoop.it
Reciprocal adoptive transfer studies confirm that autoantibody production and arthritis are modulated by IDO2 expression in a cell type extrinsic to the T cell. Taken together, our results, provide important insights into IDO2 ...
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June 16, 2014 3:25 AM
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Common variable immunodeficiency and autoimmun... [Autoimmun Rev. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Société Francaise d'Immunologie's comment, June 16, 2014 4:42 AM
Coexisting morbidities in CVID include bronchiectasis, autoimmunity and malignancies. The incidence of autoimmune disease in CVID patients may approach 20% of cases. The most common autoimmune disease found in CVID patients is autoimmune cytopenia, but rheumatoid arthritis, lupus, and now primary biliary cirrhosis have also been reported
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June 14, 2014 4:28 PM
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‘That Obscure Object of Desire’: in systemic lupus erythematosus B-cell activating factor/B-lymphocyte stimulator is targeted both by the immune system and by physicians

‘That Obscure Object of Desire’: in systemic lupus erythematosus B-cell activating factor/B-lymphocyte stimulator is targeted both by the immune system and by physicians | AUTOIMMUNITY | Scoop.it
‘That Obscure Object of Desire’: in systemic lupus erythematosus B-cell activating factor/B-lymphocyte stimulator... http://t.co/yl432MOyX8
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Scooped by Gilbert C FAURE
June 13, 2014 3:03 PM
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Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ... - EurekAlert (press release)

Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ... - EurekAlert (press release) | AUTOIMMUNITY | Scoop.it
Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ...
EurekAlert (press release)
Systemic lupus erythematosus (SLE) is a complicated multifactorial autoimmune disease influenced by many genetic and environmental factors.
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June 12, 2014 3:28 PM
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Lymphocyte subsets in primary immu... [Blood Coagul Fibrinolysis. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
June 11, 2014 3:48 PM
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Frequency of intrinsic factor ant... [J Coll Physicians Surg Pak. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Suggested by Société Francaise d'Immunologie
June 25, 2014 9:48 AM
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The Thyroxine-Containing Thyroglobulin Peptide (aa 2549-2560) Is a Target Epitope in Iodide-Accelerated Spontaneous Autoimmune Thyroiditis [AUTOIMMUNITY]

Enhanced iodide ingestion is known to accelerate the incidence and severity of spontaneous autoimmune thyroiditis [iodide-accelerated spontaneous autoimmune thyroiditis (ISAT)] in NOD.H2h4 mice.
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Scooped by Gilbert C FAURE
June 22, 2014 4:10 AM
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Frequency of Autoantibodies and Connective Tissue Diseases in Chinese Patients with Optic Neuritis

Frequency of Autoantibodies and Connective Tissue Diseases in Chinese Patients with Optic Neuritis | AUTOIMMUNITY | Scoop.it
by Hongyang Li, Yan Zhang, Zuohuizi Yi, Dehui Huang, Shihui Wei
Background Optic neuritis (ON) is often associated with other clinical or serological markers of connective tissue diseases (CTDs).
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Scooped by Gilbert C FAURE
June 19, 2014 4:48 AM
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Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat - Nature.com

Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat Nature.com These Iddm26 subloci also regulated various immune phenotypes, including the proportion of splenic macrophages by Iddm26.1, and the proportion of activated T-cells in...
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Scooped by Gilbert C FAURE
June 18, 2014 8:28 AM
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Driving Mass Spec-Based Multiplexed Protein Biomarker Tests to the Clinic - Genetic Engineering News

Driving Mass Spec-Based Multiplexed Protein Biomarker Tests to the Clinic - Genetic Engineering News | AUTOIMMUNITY | Scoop.it
Genetic Engineering News Driving Mass Spec-Based Multiplexed Protein Biomarker Tests to the Clinic Genetic Engineering News In 20–30% of these patients, the presence of anti-thyroglobulin autoantibodies interferes with the standard immunoassay used...
Gilbert C FAURE's insight:

mass spec not only for microbiology, but also proteomics

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Scooped by Gilbert C FAURE
June 17, 2014 7:30 AM
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Rash, Myalgia, and Weakness

Rash, Myalgia, and Weakness | AUTOIMMUNITY | Scoop.it
In the latest Case Record of the Massachusetts General Hospital, a 32-year-old man was admitted to this hospital because of a violaceous eruption that was followed by muscle pain and weakness, leading to respiratory failure.
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Scooped by Gilbert C FAURE
June 16, 2014 10:13 AM
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Clinical and epidemiological links with calcinosis in adult dermatomyositis - 2 Minute Medicine

Clinical and epidemiological links with calcinosis in adult dermatomyositis - 2 Minute Medicine | AUTOIMMUNITY | Scoop.it
2 Minute Medicine Clinical and epidemiological links with calcinosis in adult dermatomyositis 2 Minute Medicine Study Rundown: DM is an autoimmune disease that occasionally involves calcinosis, a sign that results from calcium deposition in the...
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Scooped by Gilbert C FAURE
June 16, 2014 10:11 AM
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Reversal of type 1 diabetes in mice may eventually help humans - Medical Xpress

Reversal of type 1 diabetes in mice may eventually help humans - Medical Xpress | AUTOIMMUNITY | Scoop.it
Medical Daily Reversal of type 1 diabetes in mice may eventually help humans Medical Xpress Researchers say the incidence of Type 1 diabetes and autoimmunity in general has risen rapidly since the mid-20th century, possibly the result of...
Gilbert C FAURE's insight:

anti-TLR4... ubiquitous innate molecule, take care of potential side effects

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June 16, 2014 3:26 AM
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Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity - Ponto - Clinical & Experimental Immunology - Wiley Online Library

Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity - Ponto - Clinical & Experimental Immunology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
Thyroidassociated orbitopathy is linked to gastrointestinal autoimmunity Ponto Clinical & Experimental Immunology http://t.co/W55xI4it3b
Société Francaise d'Immunologie's comment, June 16, 2014 4:41 AM
In patients with TAO, celiac disease is the most prevalent co-morbid autoimmune condition and rates are increased compared to GD patients without TAO.
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June 16, 2014 3:25 AM
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Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0

Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0 | AUTOIMMUNITY | Scoop.it
Thyroid autoimmunity does not independently predict cardiovascular risk. It needs to cause hypothyrodism first http://t.co/70Y0UzVqTj
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Scooped by Gilbert C FAURE
June 13, 2014 3:09 PM
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HCV Infection Enhances Th17 Commitment, Which Could Affect the Pathogenesis of Autoimmune Diseases

HCV Infection Enhances Th17 Commitment, Which Could Affect the Pathogenesis of Autoimmune Diseases | AUTOIMMUNITY | Scoop.it
by Yasuteru Kondo, Masashi Ninomiya, Osamu Kimura, Keigo Machida, Ryo Funayama, Takeshi Nagashima, Koju Kobayashi, Eiji Kakazu, Takanobu Kato, Keiko Nakayama, Michael M. C.
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June 13, 2014 2:57 PM
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SLAP deficiency decreases dsDNA autoantibody production - Europe PMC Article - Europe PubMed Central

FULL TEXT Abstract: Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels...
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Scooped by Gilbert C FAURE
June 11, 2014 4:08 PM
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Linear IgA Bullous Disease — NEJM

Linear IgA Bullous Disease — NEJM | AUTOIMMUNITY | Scoop.it
Images in Clinical Medicine from The New England Journal of Medicine — Linear IgA Bullous Disease ("Linear IgA Bullous Disease" http://t.co/YzDlYeZwra)...
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