AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
June 11, 2014 8:10 AM
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Relationship between retinal morphological ... [Jpn J Ophthalmol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Société Francaise d'Immunologie's comment, June 11, 2014 8:39 AM
Compared with controls, eyes with pSS showed thinning of pRNFL and mGCIPL thicknesses. The degree of thinning correlated with increased numbers of the positive autoantibody.
Suggested by Société Francaise d'Immunologie
June 10, 2014 7:28 AM
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IFN Priming Is Necessary but Not Sufficient To Turn on a Migratory Dendritic Cell Program in Lupus Monocytes [AUTOIMMUNITY]

Blood monocytes from children with systemic lupus erythematosus (SLE) behave similar to dendritic cells (DCs), and SLE serum induces healthy monocytes to differentiate into DCs in a type I IFN–dependent manner.
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Scooped by Gilbert C FAURE
June 9, 2014 12:48 PM
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Voltage-gated potassium channel antibody-associated limbic encephalitis

Voltage-gated potassium channel antibody-associated limbic encephalitis | AUTOIMMUNITY | Scoop.it
RT @ageingnews: Voltage-gated potassium channel antibody-associated limbic encephalitis http://t.co/AUtpk7XB9i #ageing
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Scooped by Gilbert C FAURE
June 5, 2014 4:29 PM
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JCI - Enhanced sphingosine-1-phosphate receptor 2 expression ...

Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the CNS that has a strong sex bias, with the female to male ratio currently ranging from 3:1 to 4:1 (1–3). Relapsing-remitting MS (RRMS), the most common ...
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Scooped by Gilbert C FAURE
June 4, 2014 2:10 PM
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Arena Kicks Off Study of Autoimmune Diseases Drug - Drug Discovery & Development

Arena Kicks Off Study of Autoimmune Diseases Drug Drug Discovery & Development S1P1 receptors have been demonstrated to be involved in the modulation of several biological responses, including lymphocyte trafficking from lymph nodes to the...
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Scooped by Gilbert C FAURE
June 2, 2014 3:44 PM
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Endogenous Antibodies for Tumor Detection : Scientific Reports : Nature Publishing Group

Endogenous Antibodies for Tumor Detection : Scientific Reports : Nature Publishing Group | AUTOIMMUNITY | Scoop.it
The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies.
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Scooped by Gilbert C FAURE
June 2, 2014 2:06 PM
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Welcome ~ APS Foundation of America, Inc

Welcome ~ APS Foundation of America, Inc | AUTOIMMUNITY | Scoop.it
The APS Foundation of America, Inc. is the only United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS), the major cause of multiple miscarriages, thrombosis, young strokes and...
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Scooped by Gilbert C FAURE
June 2, 2014 2:45 AM
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Reconceiving autoimmunity: An overview. [J Theor Biol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
June 1, 2014 2:43 PM
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Impact of autoantibody glycosylation in autoim... [Autoimmun Rev. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:

a review on the role of glycosylation...

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Scooped by Gilbert C FAURE
May 31, 2014 4:58 AM
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RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies - MedPage Today

RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies - MedPage Today | AUTOIMMUNITY | Scoop.it
MedPage Today RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies MedPage Today This week in rheumatology, researchers from around the world reported on the use of curcuminoids for osteoarthritis, autoantibody monitoring for drug-induced lupus,...
Gilbert C FAURE's insight:

Routine monitoring for antinuclear antibodies (ANA) did not help predict the development of drug-induced lupus among patients with rheumatoid arthritis receiving TNF inhibitors, British researchers reported.

Among 454 patients enrolled in a U.K. biologic database who underwent serial testing for the development of ANA, 83 seroconverted by a median time of 2 years, and six developed antibodies to double-stranded DNA (dsDNA). Three patients were diagnosed with lupus, according to Maya H. Buch, MBChB, PhD, of Leeds University, and colleagues.

 

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Scooped by Gilbert C FAURE
May 28, 2014 3:39 PM
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Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis

Background:
Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may present with pulmonary involvement ranging from mild to life-threatening disease such as diffuse alveolar hemorrhage.
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Scooped by Gilbert C FAURE
May 28, 2014 10:30 AM
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Report From San Francisco I: The "Father of Autoimmunity" Speaks - Simmaron Research

Report From San Francisco I: The "Father of Autoimmunity" Speaks - Simmaron Research | AUTOIMMUNITY | Scoop.it
The "Father of Autoimmunity' Speaks at the IACFS/ME Conference on Chronic Fatigue Syndrome (ME/CFS) (Dr. Noel Rose M.D., PhD the researched who introduced the concept of autoimmunity in 1957 on GF diet: “the gluten...
Gilbert C FAURE's insight:

what is circulating on CFS after Noel Rose autoimmunity talk in SF

 

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Scooped by Gilbert C FAURE
May 26, 2014 2:49 PM
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Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO : Nature Immunology : Nature Publishing Group

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO : Nature Immunology : Nature Publishing Group | AUTOIMMUNITY | Scoop.it
NF-[kappa]B activity is regulated by multiple ubiquitin-dependent regulatory steps. Cao and colleagues show that the rhomboid protein Rhbdd3 recognizes K27-linked ubiquitin and prevents IL-6-mediated autoimmunity by recruiting the deubiquitinase A20 to NEMO (IKK[gamma]) kinase complexes.
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Suggested by Société Francaise d'Immunologie
June 10, 2014 7:28 AM
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Type I Interferon in the Pathogenesis of Lupus [BRIEF REVIEWS]

Investigations of patients with systemic lupus erythematosus have applied insights from studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator, as central to the pathogenesis of this prototype systemic autoimmune...
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Scooped by Gilbert C FAURE
June 9, 2014 2:21 PM
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Dr. Bruce Richardson Selected as the Second Recipient of the Lupus Insight Prize

Dr. Bruce Richardson Selected as the Second Recipient of the Lupus Insight Prize | AUTOIMMUNITY | Scoop.it
From BioPortfolio:  Bruce Richardson, M.D., Ph.D., of The University of Michigan, has been selected as the second recipient of the Lupus Insight Prize. The award... (News: Dr.
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Rescooped by Gilbert C FAURE from Immunology
June 9, 2014 12:46 PM
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Myeloid Glycosylation Defects Lead to a Spontaneous Common Variable Immunodeficiency-like Condition with Associated Hemolytic Anemia and Antilymphocyte Autoimmunity [AUTOIMMUNITY]

Common variable immunodeficiency (CVID), the most frequent symptomatic primary immune deficiency in humans, is a heterogeneous group of immunologic disorders estimated to affect 1:10,000–1:50,000.
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Scooped by Gilbert C FAURE
June 4, 2014 2:38 PM
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Pediatric Rheumatology | Abstract | Clinical features of childhood ...

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), belongs to the group of ANCA-associated necrotizing vasculitides. This study describes the clinical picture of the disease in a large ...
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Scooped by Gilbert C FAURE
June 3, 2014 2:37 PM
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Severe refractory autoimmune hemolytic anemia with five-year ...

His blood tests revealed elevated lactic dehydrogenase and bilirubin, a hemoglobin level of 7.4g/dL, and a positive Coombs test for complement C3 and immunoglobulin G antibody. A diagnosis of autoimmune hemolytic ...
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Scooped by Gilbert C FAURE
June 2, 2014 2:08 PM
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ChemoCentryx's Orally-Administered Complement 5a Receptor Inhibitor ... - MarketWatch

ChemoCentryx's Orally-Administered Complement 5a Receptor Inhibitor ... - MarketWatch | AUTOIMMUNITY | Scoop.it
ChemoCentryx's Orally-Administered Complement 5a Receptor Inhibitor ...
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Scooped by Gilbert C FAURE
June 2, 2014 6:05 AM
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IgG Stable With Rituxan in Autoimmune Disease - MedPage Today

IgG Stable With Rituxan in Autoimmune Disease - MedPage Today | AUTOIMMUNITY | Scoop.it
MedPage Today IgG Stable With Rituxan in Autoimmune Disease MedPage Today The B-cell depleting monoclonal antibody rituximab has increasingly been used as a treatment for various types of autoimmune disease, and while the treatment often is...
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Scooped by Gilbert C FAURE
June 1, 2014 2:48 PM
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Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis

Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis | AUTOIMMUNITY | Scoop.it
by Motomu Hashimoto, Takao Fujii, Masahide Hamaguchi, Moritoshi Furu, Hiromu Ito, Chikashi Terao, Keiichi Yamamoto, Wataru Yamamoto, Takashi Matsuo, Masato Mori, Koichiro Ohmura, Hiroshi Kawabata, Tsuneyo Mimori Objective To compare the effect of...
Gilbert C FAURE's insight:

by reducing inflammatory anemia...?

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Scooped by Gilbert C FAURE
May 31, 2014 2:37 PM
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Vaccine Turns Off Autoimmunity in Type 1 Diabetes

Vaccine Turns Off Autoimmunity in Type 1 Diabetes | AUTOIMMUNITY | Scoop.it
A reverse vaccine that shuts down the destructive immune response against insulin-producing beta cells helped preserve pancreatic function in patients with type 1 diabetes, researchers reported.
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Scooped by Gilbert C FAURE
May 29, 2014 2:43 PM
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Arthritis drug abatacept slows type 1 diabetes progression

Arthritis drug abatacept  slows type 1 diabetes progression | AUTOIMMUNITY | Scoop.it
The rheumatoid arthritis drug, abatacept, has shown evidence that it can delay the progression of type 1 diabetes a year after discontinuation of the treatment.
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Scooped by Gilbert C FAURE
May 28, 2014 10:32 AM
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MacroGenics and Takeda to Develop DART for Treatment of Autoimmune ... - Pharmaceutical Processing

MacroGenics and Takeda to Develop DART for Treatment of Autoimmune ... - Pharmaceutical Processing | AUTOIMMUNITY | Scoop.it
MacroGenics and Takeda to Develop DART for Treatment of Autoimmune ...
Gilbert C FAURE's insight:

DART for ?

Dual-Affinity Re-Targeting (DART(R)) to simultaneously engage CD32B and CD79B, which are two B-cell surface proteins. MGD010 is currently in pre-clinical development for the treatment of autoimmune diseases.

 

Gilbert C FAURE's curator insight, May 28, 2014 10:34 AM

Dual-Affinity Re-Targeting (DART(R)) to simultaneously engage CD32B and CD79B, which are two B-cell surface proteins. MGD010 is currently in pre-clinical development for the treatment of autoimmune diseases.

Scooped by Gilbert C FAURE
May 28, 2014 8:35 AM
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Lupus Therapies Continue to Evolve

Lupus Therapies Continue to Evolve | AUTOIMMUNITY | Scoop.it
May is National Lupus Awareness Month, a time to think about lupus and the challenges it presents to patients. Learn about this chronic, autoimmune disease and the promise of future therapies. (May is National #Lupus Awareness Month.
Gilbert C FAURE's insight:

for laypeople from FDA

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