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Scooped by
Gilbert C FAURE
July 25, 2014 4:41 AM
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Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test (New article: Severe hypersensitivity reactions to cetuximab #LibertasAcademica #anaphylaxis
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Scooped by
Gilbert C FAURE
June 26, 2014 2:51 PM
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New treatment option in development for individuals with food allergy EurekAlert (press release) Ongoing trials are exploring options for oral immunotherapy (OIT) for desensitization in the treatment of Immunoglobulin E (IgE)-mediated food allergy,...
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Scooped by
Gilbert C FAURE
April 28, 2014 1:39 PM
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dog non-seasonal pruritic dermatitis #food_allergies: allergen-specific lymphocyte proliferation & IgE useful http://t.co/Z0enUJzqsj
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Scooped by
Gilbert C FAURE
April 15, 2014 3:03 PM
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Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review - up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment, Headlines, Recipes and more.
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Scooped by
Gilbert C FAURE
April 8, 2014 3:19 AM
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Allergen-specific immunotherapy (SIT) offers a disease specific causative treatment by inducing tolerance to the allergen and preventing progression of allergic diseases. It may be considered in patients allergic to furry animals. Current mammalian allergy vaccines are still prepared from relatively poorly defined allergen extracts and may induce immediate and late phase side effects. Although the mechanisms of SIT are still not fully understood, the more recent approaches report different strategies to reduce both allergen-specific IgE as well as T cell reactivity. The availability of recombinant allergens and synthetic peptides from mammalian species has contributed to formulating new allergy vaccines to improve SIT for furry animal allergy. The majority of studies have focused on the major cat allergen Fel d 1 due to it’s extensively characterization in terms of IgE and T-cell epitopes and to its dominant role in cat allergy. Here we review the most recent approaches, e.g. synthetic peptides, recombinant allergen derivatives, different hypoallergenic molecules, recombinant allergens coupled to virus-like particles or immunomodulatory substances as well as strategies targeting the allergen to Fc receptors and the MHC class II pathway using a new route for administration. Many of the new vaccines hold promise but only a few of them have been investigated in clinical trials which will be the gold standard for evaluation of safety and efficacy in allergic patients.
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Suggested by
Société Francaise d'Immunologie
April 6, 2014 4:59 AM
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Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules.
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Suggested by
Société Francaise d'Immunologie
March 10, 2014 7:37 AM
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The TLR4 ligand LPS causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4.
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Scooped by
Gilbert C FAURE
February 13, 2014 7:11 AM
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Allergy, Asthma & Clinical Immunology · Volume 9 ... In the presented case, history, symptoms, and results of skin testing strongly suggested an IgE-mediated allergic hypersensitivity against different heparins.
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Scooped by
Gilbert C FAURE
December 20, 2013 11:09 AM
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Researchers Developing Equine Sweet Itch Test TheHorse.com But recent studies have led to the hope that, in the near future, a reliable test for diagnosing insect bite hypersensitivity (IBH), also known as summer eczema or sweet itch, will be...
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Scooped by
Gilbert C FAURE
December 12, 2013 11:34 AM
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Schneider et al hypothesized that treatment with an anti-IgE monoclonal antibody (mAb) such as omalizumab may contribute to a more rapid desensitization with greater success (Journal of Allergy and Clinical Immunology ...
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Scooped by
Gilbert C FAURE
December 2, 2013 9:13 AM
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A topic dedicated to allergy
ouvert dans le contexte du DESC d'Immunologie clinique et allergologie en France opened for 10 years, > 2800 Highly selected scoops in an evolving and controversial field >14.4 K Views by > 4.4 K viewers
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Scooped by
Gilbert C FAURE
November 13, 2013 2:34 PM
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Anti-IgE Drug Scratches Itch of Chronic Hives
MedPage Today
BALTIMORE -- The anti-immunoglobulin E (IgE) monoclonal antibody omalizumab (Xolair) durably eased itch severity in chronic urticaria uncontrolled by antihistamines, a pivotal trial showed.
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Scooped by
Gilbert C FAURE
August 29, 2013 3:41 PM
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High concentrations of plasmatic IgE have been related to distinct systemic inflammatory conditions that frequently predispose individuals to hypersensitivity reactions. Although effects of IgE have been suggested to relay on ...
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A highly-sensitive method has been developed that can quickly and accurately identify proteins that cause allergic reactions even at very low concentrations.
Via JIB Biology
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Scooped by
Gilbert C FAURE
May 28, 2014 3:43 PM
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Modified food challenge for peanut allergy could determine thresholds Healio Peanut- and Ara h 2-specific IgE levels, skin prick test responses, basophil activation, and TH2 cytokine production by peripheral blood mononuclear cells were...
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Scooped by
Gilbert C FAURE
April 20, 2014 5:35 AM
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Immunology: IgE antibodies to alpha‐gal in the general adult population. Relationship with tick bites, atopy, ... http://t.co/O6tW7a1LF7
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Scooped by
Gilbert C FAURE
April 11, 2014 5:28 AM
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by Jyoti Balhara, Naresh Singh Redhu, Lianyu Shan, Abdelilah S.
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Scooped by
Gilbert C FAURE
April 6, 2014 12:44 PM
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Hypersensitivity and desensitization, Allergy/Clinical Immunology, journals , abstracts, epgonline (Background: Desensitization to antineoplastic agents is becoming a standard of care. Efforts to establish and...
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Scooped by
Gilbert C FAURE
March 22, 2014 3:04 PM
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Antigen-Conjugated Human IgE Induces Antigen-Specific T Cell Tolerance in a Humanized Mouse Model... http://t.co/c9f7FghgUV #jimmTCB
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Suggested by
Société Francaise d'Immunologie
February 25, 2014 5:22 AM
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Current treatments for allergies include epinephrine and antihistamines, which treat the symptoms after an allergic response has taken place; steroids, which result in local and systemic immune suppression; and IgE-depleting therapies, which can be...
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Scooped by
Gilbert C FAURE
January 14, 2014 1:40 PM
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PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Scooped by
Gilbert C FAURE
December 20, 2013 5:17 AM
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Studies performed on subjects with IgE-mediated hypersensitivity to penicillins have demonstrated a 1% rate of... http://t.co/B1DWSKIAx4
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Scooped by
Gilbert C FAURE
December 9, 2013 3:18 PM
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Heska Announces New Advancement in Allergy IgE Detection 4-traders (press release) "As the innovators of serum allergy testing in the veterinary industry, Heska provides veterinarians with an accurate, easy, cost-effective testing solution for...
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Scooped by
Gilbert C FAURE
December 1, 2013 1:13 PM
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Allergy, Asthma & Clinical Immunology · Volume 9 .... Clinically, majority of asthma patients show a significant increase in ASM bundles, likely due to increase in cell number, collectively contributing to airway remodeling [4].
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Scooped by
Gilbert C FAURE
October 9, 2013 10:55 AM
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... patients with severe atopic asthma. Antagonism of IgE is an effective strategy.
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