Allergy (and clinical immunology)
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Allergy (and clinical immunology)
Ressources et Actualités pour la spécialité Allergie
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Scooped by Gilbert C FAURE
October 27, 2014 6:46 AM
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French developer of 'peanut allergy patch' makes US debut - Reuters

French developer of 'peanut allergy patch' makes US debut - Reuters | Allergy (and clinical immunology) | Scoop.it
PARIS (Reuters) - French biotech firm DBV Technologies - developer of what it says is a breakthrough treatment for peanut allergy sufferers - makes its U.S.
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Scooped by Gilbert C FAURE
October 24, 2014 5:29 AM
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Peanut in house dust linked to allergy in children with skin gene mutation - The University of Manchester (press release)

Peanut in house dust linked to allergy in children with skin gene mutation - The University of Manchester (press release) | Allergy (and clinical immunology) | Scoop.it
Peanut in house dust linked to allergy in children with skin gene mutation The University of Manchester (press release) The study, published this month in the Journal of Allergy and Clinical Immunology, was carried out in 557 children from the...
Gilbert C FAURE's insight:

.... from the Manchester Asthma and Allergy Study (MAAS) – a flagship study from the University of Manchester and University Hospital of South Manchester led by Professors Adnan Custovic and Angela Simpson – who have been followed from birth (1996/7) to the present day.

The children in MAAS, who are representative of the normal population, have been thoroughly assessed for peanut allergy with skin prick tests, blood tests and in some cases oral food challenge tests and peanut allergy was diagnosed in 3% of them.

They have undergone genetic tests and 9% of them carry mutations in the FLG gene. In addition, dust samples were collected from their home environment in early life, in which it was possible to quantify peanut protein.

Peanut protein is present on hands and in saliva for up to three hours after peanuts or peanut-based food has been eaten, and can persist on table surfaces and sofa or pillow dust even after routine cleaning.

By combining information on genetics and the environment, it was possible to gain insights on risk factors for peanut allergy. For children who did not carry an FLG mutation, the amount of peanut protein in the house dust had no significant effect on whether or not the child developed peanut allergy.

For children with an FLG mutation, higher levels of peanut protein in household dust in infancy increased the likelihood of peanut allergy in childhood. For example, a three-fold increase in house dust peanut exposure during infancy was associated with a three-fold increase in risk of peanut allergy.

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Scooped by Gilbert C FAURE
September 28, 2014 1:28 PM
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Dry roasting enhances peanut-induced allergic sensitization across mucosal and cutaneous routes in mice - Journal of Allergy and Clinical Immunology

Dry roasting enhances peanut-induced allergic sensitization across mucosal and cutaneous routes in mice - Journal of Allergy and Clinical Immunology | Allergy (and clinical immunology) | Scoop.it
Dry roasting enhances peanut-induced allergic sensitization - Journal of Allergy and Clinical Immunology http://t.co/VwFWzMjtVj
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Scooped by Gilbert C FAURE
September 20, 2014 4:12 PM
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IL-9 differentiated peanut allergy, peanut sensitivity in children - Healio

IL-9 differentiated peanut allergy, peanut sensitivity in children - Healio | Allergy (and clinical immunology) | Scoop.it
IL-9 differentiated peanut allergy, peanut sensitivity in children
Healio
Interleukin-9 best differentiated children with peanut allergy from those with peanut sensitivity and atopic children without peanut allergy, according to recent study results.
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Scooped by Gilbert C FAURE
August 18, 2014 9:56 AM
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Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children - Journal of Allergy and Clinical Immunology

Gilbert C FAURE's insight:

BAT in peanut-allergic children showed a peanut dose-dependent upregulation of CD63 and CD203c while there was no significant response to peanut in peanut-sensitized but tolerant (P < .001) and non–peanut-sensitized nonallergic children (P < .001). BAT optimal diagnostic cutoffs showed 97% accuracy, 95% positive predictive value, and 98% negative predictive value. BAT allowed reducing the number of required OFCs by two-thirds. BAT proved particularly useful in cases in which specialists could not accurately diagnose peanut allergy with SPT and sIgE to peanut and to Arah2. Using a 2-step diagnostic approach in which BAT was performed only after equivocal SPT or Arah2-sIgE, BAT had a major effect (97% reduction) on the number of OFCs required.

Conclusions

BAT proved to be superior to other diagnostic tests in discriminating between peanut allergy and tolerance, particularly in difficult cases, and reduced the need for OFCs.

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Scooped by Gilbert C FAURE
July 21, 2014 2:26 PM
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Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells: Immunity

Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells: Immunity | Allergy (and clinical immunology) | Scoop.it
Peanut antibody makes T cells worse. What about pathogen specific antibody in chronic infection? #allergy #HIV http://t.co/zz1gxzFhqH
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Scooped by Gilbert C FAURE
June 14, 2014 12:02 PM
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Basophil activation testing measured peanut oral immunotherapy desensitization | Allergy Immunology

Basophil activation testing measured peanut oral immunotherapy desensitization | Allergy Immunology | Allergy (and clinical immunology) | Scoop.it
Allergy Immunology | Basophil activation testing showed that decrease in the log-transformed area under the curve measurements correlated with desensitization in peanut oral immunotherapy, according to research presented at the European Academy of...
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Scooped by Gilbert C FAURE
May 18, 2014 9:48 AM
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Experts mystified by blow-out in food allergies

Experts mystified by blow-out in food allergies | Allergy (and clinical immunology) | Scoop.it
Tens of thousands more boys suffer from peanut allergies than girls, ground-breaking data shows, but doctors are at a loss to explain the figures or define how to stop the soaring allergy ''epidemic''.
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Scooped by Gilbert C FAURE
March 19, 2014 2:46 PM
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Peanut oral immunotherapy results in ... [J Allergy Clin Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
February 5, 2014 1:56 PM
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Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

The Journal of Allergy and Clinical Immunology, Volume 133, Issue 2, Pages 500-510.e11, February 2014, Authors:Aleena Syed, BSc; Marco A. Garcia, BSc; Shu-Chen Lyu, MSc; Robert Bucayu, BSc; Arunima Kohli, BSc; Satoru Ishida, PhD; Jelena P.
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Scooped by Gilbert C FAURE
February 1, 2014 2:39 PM
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DNA of peanut-allergic kids changes with immune therapy, study finds - Medical Xpress

DNA of peanut-allergic kids changes with immune therapy, study finds - Medical Xpress | Allergy (and clinical immunology) | Scoop.it
University Herald
DNA of peanut-allergic kids changes with immune therapy, study finds
Medical Xpress
31 in the Journal of Allergy and Clinical Immunology.
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Scooped by Gilbert C FAURE
January 31, 2014 1:28 PM
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Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial : The Lancet

Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. By - Katherine Anagnostou PhD, Sabita Islam PhD,...
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Scooped by Gilbert C FAURE
December 2, 2013 9:13 AM
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A topic dedicated to allergy

ouvert dans le contexte du DESC d'Immunologie clinique et allergologie en France

 

opened for 10 years, 

> 2800 Highly selected scoops in an evolving and controversial field

 >14.4 K Views by > 4.4 K viewers

 

Gilbert C FAURE's insight:

Il peut être complêté par les topics suivants, couvrant des domaines fondamentaux et/ou appliqués

 

Immunology: http://www.scoop.it/t/immunology

 

Mucosal immunity: http://www.scoop.it/t/mucosal-immunity

 

Immunology and Biotherapies: http://www.scoop.it/t/immunology-and-biotherapies

 

quelques pistes de ressources

 

IgE https://www.scoop.it/topic/allergy-and-clinical-immunology?q=IgE

 

asthma  https://www.scoop.it/topic/allergy-and-clinical-immunology?q=asthma

 

peanut https://www.scoop.it/topic/allergy-and-clinical-immunology?q=peanut

 

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Scooped by Gilbert C FAURE
October 27, 2014 6:45 AM
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Will This Doctor-Turned-Entrepreneur Cure Peanut Allergies? - Forbes

Will This Doctor-Turned-Entrepreneur Cure Peanut Allergies? - Forbes | Allergy (and clinical immunology) | Scoop.it
French doctor turned entrepreneur Pierre-Henri Benhamou led his team to an IPO on the Nasdaq this week as part of his mission to expand his biotech startup on US soil.
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Scooped by Gilbert C FAURE
October 13, 2014 4:37 AM
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Understanding and Applying the Newest Guidelines for Food Allergy - HCPLive

Understanding and Applying the Newest Guidelines for Food Allergy - HCPLive | Allergy (and clinical immunology) | Scoop.it
HCPLive Understanding and Applying the Newest Guidelines for Food Allergy HCPLive Evaluation of sudden IgE allergy requires a careful history, physical examination, tests and background knowledge of common triggers such as peanut, tree nut, milk,...
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Scooped by Gilbert C FAURE
September 23, 2014 1:48 PM
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The dry-roasting process may trigger peanut allergies, a new Oxford study says - Washington Post

The dry-roasting process may trigger peanut allergies, a new Oxford study says - Washington Post | Allergy (and clinical immunology) | Scoop.it
Medical News Today
The dry-roasting process may trigger peanut allergies, a new Oxford study says
Washington Post
Peanut allergies are extremely common — and can be extremely dangerous.
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Scooped by Gilbert C FAURE
August 26, 2014 9:54 AM
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Peanut allergy prevalence in US children continues to rise - Healio

Peanut allergy prevalence in US children continues to rise - Healio | Allergy (and clinical immunology) | Scoop.it
Peanut allergy prevalence in US children continues to rise
Healio
Prevalence of peanut allergy among US children ranged from 2% to 5% based on testing criteria, reflecting higher than previously reported estimates.
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Scooped by Gilbert C FAURE
July 29, 2014 1:03 PM
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Basophil activation tests effectively distinguished peanut allergy from ... - Healio

Basophil activation tests effectively distinguished peanut allergy from ... - Healio | Allergy (and clinical immunology) | Scoop.it
Basophil activation tests effectively distinguished peanut allergy from ...
Healio
“BAT [basophil activation test] was performed using flow cytometry, and its diagnostic performance was evaluated in relation to allergy vs.
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Scooped by Gilbert C FAURE
June 17, 2014 5:44 AM
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Hypoallergenic peanuts offer hope for peanut allergy sufferers

Hypoallergenic peanuts offer hope for peanut allergy sufferers | Allergy (and clinical immunology) | Scoop.it
Hypoallergenic peanuts could someday help peanut allergy sufferers lead a more normal life (Hypoallergenic peanuts offer hope for peanut allergy sufferers http://t.co/FEAS3djk9g)...
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Scooped by Gilbert C FAURE
May 28, 2014 3:43 PM
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Modified food challenge for peanut allergy could determine thresholds - Healio

Modified food challenge for peanut allergy could determine thresholds - Healio | Allergy (and clinical immunology) | Scoop.it
Modified food challenge for peanut allergy could determine thresholds Healio Peanut- and Ara h 2-specific IgE levels, skin prick test responses, basophil activation, and TH2 cytokine production by peripheral blood mononuclear cells were...
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Scooped by Gilbert C FAURE
May 7, 2014 2:07 PM
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Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children

The Journal of Allergy and Clinical Immunology, Volume 133, Issue 5, Pages 1373-1382, May 2014, Authors:Supinda Bunyavanich, MD, MPH; Sheryl L. Rifas-Shiman, MPH; Thomas A. Platts-Mills, MD; Lisa Workman, BA; Joanne E.
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Scooped by Gilbert C FAURE
February 18, 2014 6:23 AM
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Abstract | Variably severe systemic allergic reactions after ...

Lupin allergy remains a significant cause of food-induced allergic reactivity and anaphylaxis. Previous work suggests a strong association with legume allergy and peanut allergy in particular. Both doctors and the public have ...
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Scooped by Gilbert C FAURE
February 4, 2014 2:43 PM
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JACI Journal Club: Peanut oral immunotherapy increases Tregs and ...

Each month, the Editors of the Journal of Allergy and Clinical Immunology will select two JACI articles for discussion. Readers are invited to send in their ...
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Scooped by Gilbert C FAURE
February 1, 2014 2:37 PM
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Blood Test Might Help Tell When Peanut Allergy Is Gone: Study - Philly.com

Blood Test Might Help Tell When Peanut Allergy Is Gone: Study - Philly.com | Allergy (and clinical immunology) | Scoop.it
Blood Test Might Help Tell When Peanut Allergy Is Gone: Study
Philly.com
FRIDAY, Jan.
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Scooped by Gilbert C FAURE
December 12, 2013 11:34 AM
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JACI Journal Club: Treatment of peanut allergy with omalizumab

Schneider et al hypothesized that treatment with an anti-IgE monoclonal antibody (mAb) such as omalizumab may contribute to a more rapid desensitization with greater success (Journal of Allergy and Clinical Immunology ...
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